Article
Behavioral Sciences
Kateryna Murlanova, Mikhail Pletnikov
Summary: Schizophrenia is a complex disorder influenced by both genetic vulnerability and environmental risk factors. The interaction of multiple environmental adversities can impact neurodevelopment and increase the risk of developing schizophrenia. Rodent models combining maternal immune activation with other adverse environmental exposures provide insights into the interplay between genetics and the environment in schizophrenia.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychiatry
Gonca Dokuz, Ayse Sakalli Kani, Omer Uysal, Mehmet Kemal Kuscu
Summary: Adverse childhood experiences increase vulnerability to psychosis, and this study found that childhood maltreatment has negative effects on daily stress, emotional intensity, and psychotic symptoms in psychotic patients.
PSYCHIATRY RESEARCH
(2022)
Review
Psychiatry
Vera Gergov, Branka Milic, Henriette Loeffler-Stastka, Randi Ulberg, Eleni Vousoura, Stig Poulsen
Summary: This systematic review evaluates the effectiveness of psychological interventions for young people with psychotic disorders, with cognitive remediation therapy showing more improvement in cognitive functioning but not superior in reducing symptom severity. Integrative interventions may be effective in treating young people with psychotic disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Markku Lahteenvuo, Ari Ahola-Olli, Kimmo Suokas, Minna Holm, Zuzanna Misiewicz, Tuomas Jukuri, Teemu Maennynsalo, Asko Wegelius, Willehard Haaki, Risto Kajanne, Aija Kyttala, Annamari Tuulio-Henriksson, Kaisla Lahdensuo, Katja Hakkinen, Jarmo Hietala, Tiina Paunio, Jussi Niemi-Pynttari, Tuula Kieseppa, Juha Veijola, Jouko Lonnqvist, Erkki Isometsa, Olli Kampman, Jari Tiihonen, Steven Hyman, Benjamin Neale, Mark Daly, Jaana Suvisaari, Aarno Palotie
Summary: The purpose of this study is to establish a large Finnish collection of psychosis cases, including diverse populations from Asia, Latin America, and Africa, in addition to known population isolates like Finland. A total of 10,474 individuals aged 18 years or older were recruited and genotyped. The future plans of this study include investigating the effects of common variants, rare variants, and copy number variations on the severity of psychotic illness, as well as tracking the longitudinal course of illness based on nationwide register data.
Review
Neurosciences
Baptiste Pignon, Andrei Szoke, Benson Ku, Maria Melchior, Franck Schurhoff
Summary: This qualitative literature review examines the relationship between psychotic disorders and urbanicity, with a focus on recent findings. Longitudinal studies consistently show a significant association between urbanicity and the risk for psychotic disorders, with a relative risk between 2 and 2.5. Social fragmentation and social capital at the neighborhood level may partially explain this association, along with exposure to air pollution (positively associated) and green space (negatively associated). More studies are needed to understand the factors that explain the association between urbanicity and the risk of psychotic disorders, including the role of genetic factors.
DIALOGUES IN CLINICAL NEUROSCIENCE
(2023)
Article
Psychiatry
Manel Monsonet, Nicholas J. Rockwood, Thomas R. Kwapil, Neus Barrantes-Vidal
Summary: This study supports psychological models of psychosis by emphasizing the relevance of affective disturbances in the risk and expression of psychosis. Furthermore, it identifies specific influences of different negative emotional states, which could enhance psychological treatments.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Immunology
Noam Matalon, Elfi Vergaelen, Shachar Shani, Shira Dar, Ehud Mekori-Domachevsky, Hadar Segal-Gavish, Yehonatan Hochberg, Doron Gothelf, Ann Swillen, Michal Taler
Summary: This study aimed to assess the interaction between 22q11.2 Deletion Syndrome (22q11.2DS), oxidative stress (OS), and schizophrenia. The results showed significantly higher levels of Myeloperoxidase (MPO) in 22q11.2DS individuals, as well as reduced resilience to induced OS in Peripheral Blood Mononuclear Cells (PBMCs) of 22q11.2DS individuals with psychotic disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Health Care Sciences & Services
Alban Lejeune, Benoit -Marie Robaglia, Michel Walter, Sofian Berrouiguet, Christophe Lemey
Summary: The study found that social media data could be used to improve care for patients with schizophrenia, but there are limitations in the current research that require more accurate methods to obtain unbiased results.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Psychiatry
Patrick Koeck, Elisabeth Lang, Valerie-Noelle Trulley, Frieder Dechent, Katja Mercer-Chalmers-Bender, Priska Frei, Christian Huber, Stefan Borgwardt
Summary: Psychotic disorders are often accompanied by substance use disorders, with the use of THC-rich cannabis linked to a higher risk of psychosis. While previous studies suggest CBD as a potential antipsychotic agent, this trial investigated the effects of smoked CBD-cigarettes as adjunctive therapy for psychotic symptoms, indicating a possible antipsychotic medication-sparing effect. However, the small sample size limited further statistical analysis and suggests the need for larger studies with more rigorous study design.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Katie N. Sampson, Rachel Upthegrove, Ahmad Abu-Akel, Sayeed Haque, Stephen J. Wood, Renate Reniers
Summary: The study found a positive correlation between sub-clinical autistic and positive psychotic traits. Autistic traits and psychotic traits independently predict depression, self-harm, and suicidality. Interestingly, a negative interaction between the autistic trait of attention to detail and psychotic traits was associated with depression.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Bruce M. Cohen, Dost Ongur, Suzann M. Babb, Peter Q. Harris
Summary: The study found that a minority of psychiatrists frequently used the term "schizophrenia", opting instead for alternative terms such as "psychosis" or descriptions of thinking and perceptual problems. Similarly, only a small proportion of psychiatrists frequently used the specific terms for Cluster B personality disorder subtypes, preferring alternative descriptions such as emotional dysregulation or traits of sensitivity and reactivity.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Amri Sabharwal, Roman Kotov, Aprajita Mohanty
Summary: This study investigated the relationship between amygdala functional connectivity during explicit emotional face perception and symptoms and functioning deficits in psychotic disorders. Results showed differences in task performance and brain activation between patients and individuals with no psychosis history, with connectivity changes associated with symptoms and deficits transcending diagnostic categories in psychotic disorders.
SCHIZOPHRENIA RESEARCH
(2021)
Review
Immunology
Livia J. De Picker, Gerardo Mendez Victoriano, Rhys Richards, Alexander J. Gorvett, Simeon Lyons, George R. Buckland, Tommaso Tofani, Jeanette L. Norman, David S. Chatelet, James A. R. Nicoll, Delphine Boche
Summary: The study investigated the immunophenotype of immune cells in the brains of schizophrenia patients, finding that microglia in these patients expressed more immune receptors, suggesting the importance of communication between central and peripheral immune systems in schizophrenia. Additionally, the symptomatic state and age of patients also affected the alterations in the immune environment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Psychiatry
Kerem Boge, David J. Hallford, Matthias Pillny
Summary: The relationship between mindfulness, psychological flexibility (PF), and psychopathology in schizophrenia spectrum disorders (SSD) is not clear. A study with 43 participants with SSD and 43 controls found that SSD patients had lower mindfulness and PF. Mindfulness was associated with higher PS, anticipatory pleasure, behavioral activation, and lower depressive and negative symptoms. PS was associated with lower depressive and negative symptoms and higher anticipatory pleasure and behavioral activation. The findings suggest that targeting mindfulness and PF may help alleviate the amotivational psychopathology seen in SSD.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Maryse Badan Ba, Logos Curtis, Giuseppe Pellizzer
Summary: Schizophrenia patients have difficulty with processing visuo-spatial information, which is reflected in increased errors and response times in mental rotation tasks. This deficit may explain the difficulties these patients have in perspective-taking and inferring other people's viewpoints, thoughts, or intentions.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychology, Clinical
Gudrun Eisele, Hugo Vachon, Ginette Lafit, Daphne Tuyaerts, Marlies Houben, Peter Kuppens, Inez Myin-Germeys, Wolfgang Viechtbauer
Summary: This study indicates that repeated self-report measures used in daily life may lead to changes in response behavior, affect, and emotional awareness. However, the effects of these changes vary depending on individual characteristics and sampling protocol. Further research is needed to determine whether these changes affect the validity of self-report measurement data.
PSYCHOLOGICAL ASSESSMENT
(2023)
Article
Psychiatry
Julie J. Janssens, Inez Myin-Germeys, Ginette Lafit, Robin Achterhof, Noemi Hagemann, Karlijn S. F. M. Hermans, Anu P. Hiekkaranta, Aleksandra Lecei, Olivia J. Kirtley
Summary: This study examined the relationship between parental and peer attachment and lifetime and current self-harm thoughts and behaviors in adolescents. The results showed that parental attachment was associated with these self-harm outcomes, while peer attachment was not significantly related.
CRISIS-THE JOURNAL OF CRISIS INTERVENTION AND SUICIDE PREVENTION
(2023)
Article
Psychology, Developmental
Celine Samaey, Aleksandra Lecei, Robin Achterhof, Noemi Hagemann, Karlijn S. F. M. Hermans, Anu P. P. Hiekkaranta, Olivia J. J. Kirtley, Ulrich Reininghaus, Bart Boets, Inez Myin-Germeys, Ruud van Winkel
Summary: Childhood adversity is closely associated with a combination of depressive, anxiety, and psychosis symptoms, and it can impact identity formation during adolescence. This study examined the relationship between childhood adversity, identity formation, and psychopathology in Flemish adolescents. The findings showed that childhood interpersonal adversity was linked to increased identity confusion and decreased identity synthesis. Additionally, identity confusion mediated the association between childhood adversity and psychopathology. Therefore, promoting healthy identity formation is crucial for adolescents, regardless of their exposure to adverse childhood experiences.
JOURNAL OF ADOLESCENCE
(2023)
Article
Psychology, Developmental
Noemi Hagemann, Olivia J. Kirtley, Ginette Lafit, Davy Vancampfort, Martien Wampers, Jeroen Decoster, Catherine Derom, Sinan Guloksuz, Marc De Hert, Nele Jacobs, Claudia Menne-Lothmann, Bart P. F. Rutten, Evert Thiery, Jim van Os, Ruud van Winkel, Marieke Wichers, Inez Myin-Germeys
Summary: This study examined the impact of coping styles and locus of control on daily sleep quality. The findings showed that disengagement, passive reaction, and emotion-focused coping were associated with poorer sleep quality, while state locus of control did not mediate these effects. These results suggest the importance of considering coping strategies in young individuals with sleep problems.
JOURNAL OF ADOLESCENCE
(2023)
Article
Computer Science, Cybernetics
Jeroen Weermeijer, Glenn Kiekens, Martien Wampers, Peter Kuppens, Inez Myin-Germeys
Summary: Facilitating the use of technological advances is crucial for counseling and clinical psychology to meet the demand for community-based and person-centered care. The Experience Sampling Method (ESM) could be a valuable tool in this transition, but how it will be utilized by practitioners remains unclear. In this study, focus groups were conducted with mental health practitioners to explore the use of ESM in clinical practice. The findings revealed various clinical applications, challenges in visualizing ESM data, and identified barriers and facilitators for implementing ESM in clinical practice.
BEHAVIOUR & INFORMATION TECHNOLOGY
(2023)
Article
Psychiatry
Jara Bouws, Ann Henrard, Mariken de Koning, Frederike Schirmbeck, Sophia van Ghesel Grothe, Evelyne van Aubel, Ulrich Reininghaus, Lieuwe de Haan, Inez Myin-Germeys
Summary: The aim of this qualitative study was to explore patients' perspectives on Acceptance and Commitment Therapy (ACT) for early stages of psychosis. The study found that ACT improved patients' awareness and acceptance of their thoughts and feelings, and helped them align their actions with their personal values. However, there is still room for improvement in the protocol and understanding of ACT when dealing with active psychotic symptoms.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Correction
Psychiatry
Wesley Chor-yin Tang, Corine Sau-man Wong, Ting-yat Wong, Christy Lai-ming Hui, Stephanie Ming -yin Wong, Yi-nam Suen, Sherry Kit-wa Chan, Wing-chung Chang, Edwin Ho-ming Lee, Simon Sai-yu Lui, Kai -tai Chan, Michael Tak-hing Wong, Inez Myin-Germeys, Eric Yu-hai Chen
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Lena de Thurah, Glenn Kiekens, Rob Sips, Ana Teixeira, Zuzana Kasanova, Inez Myin-Germeys
Summary: The Experience sampling method (ESM) has the potential to support person-centered care of psychotic disorders, but the lack of user involvement in the design of ESM tools hampers clinical implementation. This qualitative study explored the perspective of nine people with lived experiences of psychosis. Participants reported a need to monitor a diverse range of daily-life experiences and indicated that ESM should allow for personalization to be clinically useful. Although participants recognized the potential of ESM to increase awareness and control over their mental health, concerns were voiced about the validity and burden of monitoring one's own mental health.
PSYCHIATRY RESEARCH
(2023)
Editorial Material
Psychology, Clinical
S. Siddi, R. Bailon, I. Gine-Vazquez, F. Matcham, F. Lamers, S. Kontaxis, E. Laporta, E. Garcia, F. Lombardini, P. Annas, M. Hotopf, B. W. J. H. Penninx, A. Ivan, K. M. White, S. Difrancesco, P. Locatelli, J. Aguilo, M. T. Penarrubia-Maria, V. A. Narayan, A. Folarin, D. Leightley, N. Cummins, S. Vairavan, Y. Ranjan, A. Rintala, G. de Girolamo, S. K. Simblett, T. Wykes, I. Myin-Germeys, R. Dobson, J. M. Haro
Summary: This 2-year study examined the intra-individual variations in heart rate (HR) parameters and their relationship with depression severity in individuals with recurrent major depressive disorder. The results showed that decreased HR variation during resting periods during the day was associated with increased depression severity, and higher mean HR during resting at night was observed in participants with more severe depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Glenn Kiekens, Laurence Claes, Steffie Schoefs, Nian D. F. Kemme, Koen Luyckx, Evan M. Kleiman, Matthew K. Nock, Inez Myin-Germeys
Summary: The DAILY project aims to understand the short-term course and correlates of self-injurious behavior in daily life, as well as its association with disordered eating, substance use, and suicidal thoughts and behaviors. The project will provide valuable insights for clinical practice and the development of real-time intervention approaches for individuals who self-injure.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Health Care Sciences & Services
Shaoxiong Sun, Amos A. Folarin, Yuezhou Zhang, Nicholas Cummins, Rafael Garcia-Dias, Callum Stewart, Yatharth Ranjan, Zulqarnain Rashid, Pauline Conde, Petroula Laiou, Heet Sankesara, Faith Matcham, Daniel Leightley, Katie M. White, Carolin Oetzmann, Alina Ivan, Femke Lamers, Sara Siddi, Sara Simblett, Raluca Nica, Aki Rintala, David C. Mohr, Inez Myin-Germeys, Til Wykes, Josep Maria Haro, Brenda W. J. H. Penninx, Srinivasan Vairavan, Vaibhav A. Narayan, Peter Annas, Matthew Hotopf
Summary: This study aimed to analyze smartphone and wearable data from patients with major depressive disorder (MDD) and address the challenges in analyzing this data. The study found that at least 8 days of data were needed to reliably calculate most features. It also observed that different features had varying degrees of correlation with depression, both cross-sectionally and longitudinally. Furthermore, participants could be stratified into distinct clusters based on their behavioral differences between periods of depression and no depression.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychiatry
Sophie A. Bogemann, Lara M. C. Puhlmann, Carolin Wackerhagen, Matthias Zerban, Antje Riepenhausen, Goeran Koeber, Kenneth S. L. Yuen, Shakoor Pooseh, Marta A. Marciniak, Zala Reppmann, Aleksandra Ugciko, Jeroen Weermeijer, Dionne B. Lenferink, Julian Mituniewicz, Natalia Robak, Nina C. Donner, Merijn Mestdagh, Stijn Verdonck, Rolf van Dick, Birgit Kleim, Klaus Lieb, Judith M. C. van Leeuwen, Dorota Kobylinska, Inez Myin-Germeys, Henrik Walter, Oliver Tuescher, Erno J. Hermans, Ilya M. Veer, Raffael Kalisch
Summary: This study examined the relationship between psychosocial resilience factors (RFs) and psychological health responses in the aftermath of the COVID-19 pandemic in several European countries. The findings showed that RFs were negatively associated with mental health reactivity, both cross-sectionally and longitudinally. Some specific factors were found to have a positive impact on stress response. These results highlight the importance of psychosocial resilience factors in enhancing psychological well-being.
JMIR MENTAL HEALTH
(2023)
Article
Psychology, Multidisciplinary
Anu P. Hiekkaranta, Olivia J. Kirtley, Gudrun Eisele, Marlies Houben, Ginette Lafit, Inez Myin-Germeys
Summary: Contextual factors play a role in how people regulate their everyday emotions. This study found that higher stressfulness of negative events is associated with higher use of distraction within- and between-persons, as well as more reappraisal between persons. Time of day and weekday were not associated with reappraisal or distraction use. However, tiredness was positively associated with both distraction and reappraisal use within persons. Exploratory analyses also suggested that time pressure and physical discomfort are related to less use of distraction and reappraisal, respectively.
CURRENT PSYCHOLOGY
(2023)
Article
Health Care Sciences & Services
Carolin Wackerhagen, Ilya M. Veer, Judith M. C. van Leeuwen, Zala Reppmann, Antje Riepenhausen, Sophie A. Boegemann, Netali Mor, Lara M. C. Puhlmann, Aleksandra Usci Ko, Matthias Zerban, Julian Mituniewicz, Avigail Lerner, Kenneth S. L. Yuen, Goeran Koeber, Marta A. Marciniak, Shakoor Pooseh, Jeroen Weermeijer, Alejandro Arias-Vasquez, Harald Binder, Walter de Raedt, Birgit Kleim, Inez Myin-Germeys, Karin Roelofs, Jens Timmer, Oliver Tuescher, Talma Hendler, Dorota Kobylinska, Erno J. Hermans, Raffael Kalisch, Henrik Walter
Summary: This multicenter study aims to investigate psychological resilience in healthy but susceptible young adults over 9 months, with the goal of improving strategies for preventing and treating mental disorders. Resilience is conceptualized as the maintenance of mental health or quick recovery from mental health perturbations upon exposure to stressors. The study will provide a methodological framework and data set to identify predictors and mechanisms of mental resilience. Rating: 8 out of 10.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Psychiatry
Victoria Bell, Eva Velthorst, Jorge Almansa, Inez Myin-Germeys, Sukhi Shergill, Anne-Kathrin Fett
Summary: This study investigates the effects of loneliness and social exclusion on the development of paranoia, and finds that negative affect may mediate the relationship between these factors. The study reveals a significant association between loneliness, social exclusion, and paranoia, and that negative affect partially mediates this association.
SCHIZOPHRENIA RESEARCH-COGNITION
(2023)
