Role of Spinal Neurotransmitter Receptors in Itch: New Insights into Therapies and Drug Development

Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

(2010) Omer Yanarates et al.   ANESTHESIOLOGY

The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice

(2010) Robson Costa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy of intrathecal morphine with epidural ropivacaine infusion for postcesarean analgesia

(2010) Ikuomi Mikuni et al.   JOURNAL OF CLINICAL ANESTHESIA

Antipruritic treatment with systemic μ-opioid receptor antagonists: A review

(2010) Ngoc Quan Phan et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Absence of Histamine-Induced Itch in the African Naked Mole-Rat and “Rescue” by Substance P

(2010) Ewan St John Smith et al.   Molecular Pain

Targeting the Neurokinin Receptor 1 with Aprepitant: A Novel Antipruritic Strategy

(2010) Sonja Ständer et al.   PLoS One

Treatment of Neuropathic Pain: An Overview of Recent Guidelines

(2009) Alec B. O'Connor et al.   AMERICAN JOURNAL OF MEDICINE

Serotonin Receptor Antagonists for the Prevention and Treatment of Pruritus, Nausea, and Vomiting in Women Undergoing Cesarean Delivery with Intrathecal Morphine: A Systematic Review and Meta-Analysis

(2009) Ronald B. George et al.   ANESTHESIA AND ANALGESIA

Gastrin-releasing peptide: Different forms, different functions

(2009) Joseph Ischia et al.   BIOFACTORS

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Histamine, histamine receptors and their role in immune pathology

(2009) M. Jutel et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

(2009) Jeffery M. Cowden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Excitation of Mouse Superficial Dorsal Horn Neurons by Histamine and/or PAR-2 Agonist: Potential Role in Itch

(2009) Tasuku Akiyama et al.   JOURNAL OF NEUROPHYSIOLOGY

Activation of Superficial Dorsal Horn Neurons in the Mouse by a PAR-2 Agonist and 5-HT: Potential Role in Itch

(2009) T. Akiyama et al.   JOURNAL OF NEUROSCIENCE

Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist

(2009) Katsunori Yamaura et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Itch without pain—a labeled line for itch sensation?

(2009) Hermann O. Handwerker et al.   Nature Reviews Neurology

Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a Phase III, randomized, double-blind, placebo-controlled study

(2009) H. Kumagai et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Enhanced morphine-induced antinociception in histamine H3 receptor gene knockout mice

(2009) Jalal Izadi Mobarakeh et al.   NEUROPHARMACOLOGY

Nalfurafine prevents 5′-guanidinonaltrindole- and compound 48/80-induced spinal c-fos expression and attenuates 5′-guanidinonaltrindole-elicited scratching behavior in mice

(2009) S. Inan et al.   NEUROSCIENCE

Aprepitant as an Antipruritic Agent?

(2009) Arnaud Duval et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

Plasticity of NMDA receptor NR2B subunit in memory and chronic pain

(2009) Min Zhuo   Molecular Brain

Localization of histamine H4 receptors in the central nervous system of human and rat

(2008) Marina I. Strakhova et al.   BRAIN RESEARCH

Effect of prophylactic 5-HT3 receptor antagonists on pruritus induced by neuraxial opioids: a quantitative systematic review †

(2008) M.-P. Bonnet et al.   BRITISH JOURNAL OF ANAESTHESIA

Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice

(2008) R Costa et al.   BRITISH JOURNAL OF PHARMACOLOGY

Histamine H4receptor antagonism reduces hapten-induced scratching behaviour but not inflammation

(2008) Kristine Roßbach et al.   EXPERIMENTAL DERMATOLOGY

Intrathecal morphine in anesthesia for cesarean delivery: dose-response relationship for combinations of low-dose intrathecal morphine and spinal bupivacaine

(2008) Nermin K. Girgin et al.   JOURNAL OF CLINICAL ANESTHESIA

Effects of Atypical  -Opioid Receptor Agonists on Intrathecal Morphine-Induced Itch and Analgesia in Primates

(2008) M.-C. Ko et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

(2008) Robin L. Thurmond et al.   NATURE REVIEWS DRUG DISCOVERY

Different dorsal horn neurons responding to histamine and allergic itch stimuli

(2008) Tasuku Nakano et al.   NEUROREPORT

Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors

(2007) Chizuko Watanabe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY