Article
Psychology, Clinical
Sheida Moradi, Mohammad Reza Falsafinejad, Ali Delavar, Vahid Rezaeitabar, Ahmad Borj'ali, Steven H. Aggen, Kenneth S. Kendler
Summary: This study explores the structural connectivity between symptoms of major depressive disorder (MDD) using two different network modeling approaches. The results suggest that depressed mood symptom has the highest centrality value and may act as a driving symptom for activating other symptoms. Somatic weight and appetite symptoms appear as the strongest connections in both networks.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Caroline W. Grant, Erin F. Barreto, Rakesh Kumar, Rima Kaddurah-Daouk, Michelle Skime, Taryn Mayes, Thomas Carmody, Joanna Biernacka, Liewei Wang, Richard Weinshilboum, Madhukar H. Trivedi, William Bobo, Paul E. Croarkin, Arjun P. Athreya
Summary: This study integrated genomics with metabolomics to analyze the differences between early and adult-onset depression, and identified potential biomarkers related to the development and treatment of depression.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Clinical Neurology
Igor Loniewski, Agata Misera, Karolina Skonieczna-Zydecka, Mariusz Kaczmarczyk, Karolina Kazmierczak-Siedlecka, Blazej Misiak, Wojciech Marlicz, Jerzy Samochowiec
Summary: One promising hypothesis regarding the pathogenesis of Major Depressive Disorder (MDD) is dysfunction in the gut-brain axis (GBA), particularly related to changes in the gut microbiota. This scoping review summarizes the current research on the relationship between MDD and gut microbiota. The findings suggest that alterations in the microbiota in MDD may be associated with various pathways related to inflammation, neurotransmitter production, and metabolic dysfunction. Further research is needed to clarify the mechanisms involved and to standardize research methods.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Laura K. M. Han, Richard Dinga, Tim Hahn, Christopher R. K. Ching, Lisa T. Eyler, Lyubomir Aftanas, Moji Aghajani, Andre Aleman, Bernhard T. Baune, Klaus Berger, Ivan Brak, Geraldo Busatto Filho, Angela Carballedo, Colm G. Connolly, Baptiste Couvy-Duchesne, Kathryn R. Cullen, Udo Dannlowski, Christopher G. Davey, Danai Dima, Fabio L. S. Duran, Verena Enneking, Elena Filimonova, Stefan Frenzel, Thomas Frodl, Cynthia H. Y. Fu, Beata R. Godlewska, Ian H. Gotlib, Hans J. Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Geoffrey B. Hall, Ben J. Harrison, Sean N. Hatton, Marco Hermesdorf, Ian B. Hickie, Tiffany C. Ho, Norbert Hosten, Andreas Jansen, Claas Kaehler, Tilo Kircher, Bonnie Klimes-Dougan, Bernd Kraemer, Axel Krug, Jim Lagopoulos, Ramona Leenings, Frank P. MacMaster, Glenda MacQueen, Andrew McIntosh, Quinn McLellan, Katie L. McMahon, Sarah E. Medland, Bryon A. Mueller, Benson Mwangi, Evgeny Osipov, Maria J. Portella, Elena Pozzi, Liesbeth Reneman, Jonathan Repple, Pedro G. P. Rosa, Matthew D. Sacchet, Philipp G. Saemann, Knut Schnell, Anouk Schrantee, Egle Simulionyte, Jair C. Soares, Jens Sommer, Dan J. Stein, Olaf Steinstraeter, Lachlan T. Strike, Sophia I. Thomopoulos, Marie-Jose van Tol, Ilya M. Veer, Robert R. J. M. Vermeiren, Henrik Walter, Nic J. A. van der Wee, Steven J. A. van der Werff, Heather Whalley, Nils R. Winter, Katharina Wittfeld, Margaret J. Wright, Mon-Ju Wu, Henry Voelzke, Tony T. Yang, Vasileios Zannias, Greig I. de Zubicaray, Giovana B. Zunta-Soares, Christoph Abe, Martin Alda, Ole A. Andreassen, Erlend Boen, Caterina M. Bonnin, Erick J. Canales-Rodriguez, Dara Cannon, Xavier Caseras, Tiffany M. Chaim-Avancini, Torbjorn Elvsashagen, Pauline Favre, Sonya F. Foley, Janice M. Fullerton, Jose M. Goikolea, Bartholomeus C. M. Haarman, Tomas Hajek, Chantal Henry, Josselin Houenou, Fleur M. Howells, Martin Ingvar, Rayus Kuplicki, Beny Lafer, Mikael Landen, Rodrigo Machado-Vieira, Ulrik F. Malt, Colm McDonald, Philip B. Mitchell, Leila Nabulsi, Maria Concepcion Garcia Otaduy, Bronwyn J. Overs, Mircea Polosan, Edith Pomarol-Clotet, Joaquim Radua, Maria M. Rive, Gloria Roberts, Henricus G. Ruhe, Raymond Salvador, Salvador Sarro, Theodore D. Satterthwaite, Jonathan Savitz, Aart H. Schene, Peter R. Schofield, Mauricio H. Serpa, Kang Sim, Marcio Gerhardt Soeiro-de-Souza, Ashley N. Sutherland, Henk S. Temmingh, Garrett M. Timmons, Anne Uhlmann, Eduard Vieta, Daniel H. Wolf, Marcus V. Zanetti, Neda Jahanshad, Paul M. Thompson, Dick J. Veltman, Brenda W. J. H. Penninx, Andre F. Marquand, James H. Cole, Lianne Schmaal
Summary: Major depressive disorder is associated with increased risk of brain atrophy, aging-related diseases, and mortality. This study found that MDD patients showed a higher brain-predicted age difference compared to controls, but this difference did not seem to be driven by specific clinical characteristics. Subtle patterns of age-related structural brain abnormalities in MDD were observed, highlighting the need for further longitudinal studies to assess the clinical value of these findings.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Victor M. Tang, Dengdeng Yu, Cory R. Weissman, Brett D. M. Jones, Guan Wang, Matthew E. Sloan, Daniel M. Blumberger, Zafiris J. Daskalakis, Bernard Le Foll, Daphne Voineskos
Summary: This study examined the treatment outcomes of patients with major depressive disorder (MDD) and comorbid alcohol use disorder (AUD). The results showed that patients with comorbid AUD had poorer response to antidepressant treatment. Addressing this comorbidity requires unique assessment and treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Computer Science, Interdisciplinary Applications
Sana Yasin, Syed Asad Hussain, Sinem Aslan, Imran Raza, Muhammad Muzammel, Alice Othmani
Summary: Mental disorders such as Major Depressive Disorder (MDD) and Bipolar Disorder (BD) are significant public health challenges, with the need for phenotypic characterization and biomarkers being crucial in understanding their pathophysiological mechanisms. The use of EEG signals in neural networks is discussed, providing valuable insights for the development of more accurate computational intelligence systems in psychiatry.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Seok-Won Jeoung, Hyun-Sun Park, Zae Young Ryoo, Dong-Hyung Cho, Hyun-Shik Lee, Hong-Yeoul Ryu
Summary: SUMOylation plays a significant role in maintaining neuronal function in the development of major depressive disorder (MDD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Floris Huider, Yuri Milaneschi, Matthijs D. Van der Zee, Eco J. C. De Geus, Quinta Helmer, Brenda W. J. H. Penninx, Dorret I. Boomsma
Summary: Through bivariate genetic analysis in extended twin pedigree data, genetic correlations were found between major depressive disorder and three lifestyle indicators (smoking behavior, physical inactivity, and obesity), indicating shared genetic etiology between MDD and lifestyle factors.
Article
Psychology, Clinical
Yicheng Long, Xuemei Li, Hengyi Cao, Manqi Zhang, Bing Lu, Yang Huang, Mengqi Liu, Ming Xu, Zhening Liu, Chaogan Yan, Jing Sui, Xuan Ouyang, Xinyu Zhou
Summary: This study aimed to investigate the common and distinct functional brain abnormalities across different age groups of major depressive disorder (MDD) patients. Findings revealed shared functional connectivity reductions among the sensorimotor, visual, and auditory networks across all three age groups of MDD patients. Moreover, unique functional connectivity alterations were observed in specific networks for each age group. The analysis of the whole pooled sample further demonstrated significant age group effects on functional connectivity and an age group x MDD diagnosis interaction on default-mode network connectivity.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Kody G. Kennedy, Megan Mio, Benjamin I. Goldstein, Paolo Brambilla, Giuseppe Delvecchio
Summary: This review and meta-analysis found that individuals with severe mental illness, especially schizophrenia, have wider retinal venules compared to controls, indicating a potential connection between cerebrovascular health and mental illness.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Oncology
Ziqi Chen, Xiaoqi Huang, Qiyong Gong, Bharat B. Biswal
Summary: Advancements in neuroimaging have led to the detection of numerous brain functional and structural alterations in MDD, with attempts to apply these findings to clinical practice. While evidence of cerebral changes related to MDD classification and subtyping is varied, the ACC and hippocampus are consistently suggested as important biomarkers for treatment selection and response prediction. This highlights the potential utility of brain biomarkers in clinical practice.
FRONTIERS OF MEDICINE
(2021)
Article
Psychology, Clinical
Thomas S. Blank, Bernhard M. Meyer, Marie-Kathrin Wieser, Ulrich Rabl, Paul Schoegl, Lukas Pezawas
Summary: This study found differences in brain structure and function between early-onset and adult-onset major depressive disorder patients. Early-onset patients showed abnormalities in the hippocampus and prefrontal cortex, which play a key role in emotion-regulation networks. Additionally, volumetric changes in early-onset patients were associated with insomnia symptoms. These results highlight the importance of adolescence as a pivotal developmental phase for major depressive disorder.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Lvchun Cui, Yun Wang, Lan Cao, Zhiguo Wu, Daihui Peng, Jun Chen, Haichen Yang, Han Rong, Tiebang Liu, Yiru Fang
Summary: This study examines the impact of age of onset (AOO) on symptomatology in major depressive disorder (MDD) using a machine learning approach and latent profile analysis (LPA). The findings indicate that the severity of neurovegetative symptoms is positively associated with AOO, while the severity of cognitive-behavioral symptoms is negatively associated with AOO. This research highlights the importance of considering AOO in clinical evaluations and early detection of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychology, Clinical
Taishiro Kishimoto, Katsuhiko Hagi, Shunya Kurokawa, John M. Kane, Christoph U. Correll
Summary: This study conducted a systematic review and meta-analysis on the use of antipsychotics as monotherapy and adjunctive therapy for major depressive disorder (MDD). The results suggest significant differences in treatment response and tolerability among different antipsychotics, which have important implications for clinical care.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Aleksander Kwasny, Adam Wlodarczyk, Alicja Dywel, Joanna Szarmach, Olivia Strandberg, Wieslaw Jerzy Cubala
Summary: The ultimate goal in MDD treatment is recovery, but some patients still experience residual symptoms such as insomnia, affecting their daily functioning. Residual insomnia, especially mid-nocturnal insomnia, is common in MDD patients and is associated with earlier relapse and poor prognosis. Several non-pharmacological treatments such as CBT-I, MBCT, BA, and pharmacological treatments like gabapentin and clonazepam have proven to be effective in mitigating residual insomnia. CBT-D has limited effectiveness in improving insomnia complaints. More research is needed to explore treatment options and understand different subtypes of insomnia in MDD.
FRONTIERS IN PSYCHIATRY
(2023)