Article
Clinical Neurology
Ming-Chun Yu, Yi-Fang Chuang, Shu-Ching Wu, Cheng-Feng Ho, Yi-Chien Liu, Chia-Ju Chou
Summary: This study aimed to investigate the moderating effect of APOE genotype status on the relationship between white matter hyperintensities (WMHs) and cognitive impairment in individuals with Alzheimer's disease (AD). The results showed that WMHs were associated with dementia severity in APOE e4 carriers, but the association was weaker in non-carriers.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Qiushan Tao, Ting Fang Alvin Ang, Samia C. Akhter-Khan, Indira Swetha Itchapurapu, Ronald Killiany, Xiaoling Zhang, Andrew E. Budson, Katherine W. Turk, Lee Goldstein, Jesse Mez, Michael L. Alosco, Wei Qiao Qiu
Summary: This study revealed the interactive effects of plasma CRP and APOE genotype on cognition and AD biomarkers, showing that elevated CRP in carriers of 2 APOE epsilon 4 alleles was associated with lower cognitive scores and increased tau protein levels in CSF. Conversely, elevated CRP in individuals with no APOE epsilon 4 alleles was associated with decreased tau protein levels in CSF. These findings suggest that CRP may play a role in AD neurodegeneration in APOE epsilon 4 carriers and could potentially be targeted for drug interventions.
Article
Endocrinology & Metabolism
Carolyn S. Kaufman, Robyn A. Honea, Joseph Pleen, Rebecca J. Lepping, Amber Watts, Jill K. Morris, Sandra A. Billinger, Jeffrey M. Burns, Eric D. Vidoni
Summary: Aerobic exercise can significantly improve hippocampal blood flow for hypertensive APOE4 carriers, with no significant effect on non-carriers. Additionally, multiple regression analysis showed an increase in hippocampal blood flow for APOE4 carriers in response to reductions in systolic blood pressure.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Eric Stallard, Mary F. Feitosa, Nicole Schupf, Kaare Christensen, Irina Culminskaya
Summary: Age-related diseases are complex polygenic traits with intricate genetic architectures. We examined the impact of multiple combinations of genotypes on the chances of living to older ages and found that specific combinations of genetic variants were associated with increased risk for Alzheimer's disease and decreased survival chances.
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, Alzheimer's Disease Neuroimaging Initiative Alzheimers Dis Neuroimaging Initiative
Summary: This study examined the associations of APOE alleles and polygenic profiles with cerebrospinal fluid and plasma biomarkers, revealing differential effects of specific alleles on different biomarkers.
Article
Medicine, General & Internal
Ziyi Zhang, William Robert Kwapong, Le Cao, Zijuan Feng, Bo Wu, Junfeng Liu, Shuting Zhang
Summary: Early identification of APOE-related microvascular pathology is important for studying its contribution to Alzheimer's disease and finding therapeutic targets. Retinal microvasculature parameters differ between APOE e4 carriers and non-carriers, and cognitive impairment is associated with reduced microvascular densities.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Lara J. Mentink, Joao P. O. F. T. Guimaraes, Myrthe Faber, Emma Sprooten, Marcel G. M. Olde Rikkert, Koen Haak, Christian F. Beckmann
Summary: The study failed to replicate early findings of Filippini et al. but revealed increased functional activation in APOE epsilon 4-carriers during encoding of recollected items, which was also positively associated with polygenic risk score. The results suggest limited genetic effects on brain structure and function in young adults and highlight the complexity of interactions among genetic risk, biomarkers, aging, and lifestyle factors in Alzheimer's disease development.
Article
Neurosciences
Kylie R. Kadey, John L. Woodard, Allison C. Moll, Kristy A. Nielson, J. Carson Smith, Sally Durgerian, Stephen M. Rao
Summary: The study showed that individuals carrying APOEε4 are more likely to convert to MCI or dementia over time compared to non-carriers, with a decline in BMI over five years associated with an increased risk, particularly for APOEε4 carriers.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Geriatrics & Gerontology
G. M. Fote, N. R. Geller, A. M. Reyes-Ortiz, L. M. Thompson, J. S. Steffan, J. D. Grill
Summary: Research suggests that adherence to a Mediterranean diet may help slow cognitive decline in APOE ε4 carriers, while ketogenic agents appear to be ineffective. Diets high in saturated fats may be particularly harmful for APOE ε4 carriers.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Article
Geriatrics & Gerontology
Jin Ho Jung, Seun Jeon, Kyoungwon Baik, Yang Hyun Lee, Seok Jong Chung, Han Soo Yoo, Seong Ho Jeong, Young H. Sohn, Phil Hyu Lee, Byoung Seok Ye
Summary: APOE4 is associated with beta-amyloid deposition and increased risk of various disease subtypes, interacting with LBD and AD to cause different regional beta-amyloid deposition and affect cognition and memory function.
NEUROBIOLOGY OF AGING
(2021)
Article
Clinical Neurology
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill
Summary: The study found that longer duration trials are associated with lower completion rates, especially in AD and MCI trials, where the dropout rates in the treatment arms were higher than in the placebo arms.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Young-gun Lee, Mincheol Park, Seong Ho Jeong, Sung Woo Kang, Kyoungwon Baik, Jin Ho Jung, Phil Hyu Lee, Young Ho Sohn, Byoung Seok Ye
Summary: High serum uric acid levels may have a protective effect on individuals with cognitive impairment, particularly in female patients with mild cognitive impairment, where it is associated with slower cognitive decline and brain metabolism reductions, as well as with APOE4 carriers.
NEUROBIOLOGY OF AGING
(2021)
Article
Behavioral Sciences
Nahid Zokaei, Alexander G. Board, Ellie Slavkova, Clare E. Mackay, Anna Christina Nobre, Masud Husain
Summary: The APOE gene is associated with individual cognitive health in aging, with the ε2 allele potentially protecting against Alzheimer's disease. Individuals carrying the ε2 allele show a significant memory advantage in short-term memory tasks, regardless of difficulty level and age, suggesting a phenotypical effect on cognition independent of later-life genetic effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Evangelia Stanitsa, Alexandra Economou, Ion Beratis, Dionysia Kontaxopoulou, Stella Fragkiadaki, Vicky Papastefanopoulou, Dimosthenis Pavlou, Panagiotis Papantoniou, Christos Kroupis, John Papatriantafyllou, Leonidas Stefanis, George Yannis, Sokratis G. Papageorgiou
Summary: This study compared the driving performance of APOE4 carriers and non-carriers, finding that APOE4 carriers had lower speed variability, potentially indicating a compensatory strategy. Simulated driving may be a sensitive method for detecting performance differences in the absence of cognitive differences.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Genetics & Heredity
Rosie M. Walker, Kadi Vaher, Mairead L. Bermingham, Stewart W. Morris, Andrew D. Bretherick, Yanni Zeng, Konrad Rawlik, Carmen Amador, Archie Campbell, Chris S. Haley, Caroline Hayward, David J. Porteous, Andrew M. McIntosh, Riccardo E. Marioni, Kathryn L. Evans
Summary: The study identified DNA methylation differences between APOE ε4 and ε2 carriers in blood, including multiple genes in a 169kb region. Further analysis suggested that these differences may affect lipid-related processes and be associated with the metabolism of high-density lipoprotein cholesterol.
Correction
Clinical Neurology
G. J. Francis, J. A. Martinez, W. Q. Liu, K. Xu, A. Ayer, J. Fine, U. Tuor, G. Glazner, L. R. Hanson, W. H. Frey, C. Toth
Article
Neurosciences
J. M. Fine, A. C. Forsberg, D. B. Renner, K. A. Faltesek, K. G. Mohan, J. C. Wong, L. C. Arneson, J. M. Crow, W. H. Frey, L. R. Hanson
Review
Clinical Neurology
Jessica Freiherr, Manfred Hallschmid, William H. Frey, Yvonne F. Bruenner, Colin D. Chapman, Christian Hoelscher, Suzanne Craft, Fernanda G. De Felice, Christian Benedict
Article
Pharmacology & Pharmacy
Leah R. Hanson, Jared M. Fine, John D. Hoekman, Thuhien M. Nguyen, Rachel B. Burns, Paula M. Martinez, Jens Pohl, William H. Frey
Editorial Material
Clinical Neurology
William H. Frey
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2013)
Article
Pharmacology & Pharmacy
Dan B. Renner, Aleta L. Svitak, Nathan J. Gallus, Marna E. Ericson, William H. Frey, Leah R. Hanson
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2012)
Article
Neurosciences
Zhongwu Liu, Yi Li, Li Zhang, Hongqi Xin, Yisheng Cui, Leah R. Hanson, William H. Frey, Michael Chopp
NEUROBIOLOGY OF DISEASE
(2012)
Article
Neurosciences
Dan B. Renner, William H. Frey, Leah R. Hanson
NEUROSCIENCE LETTERS
(2012)
Review
Chemistry, Multidisciplinary
Colin D. Chapman, William H. Frey, Suzanne Craft, Lusine Danielyan, Manfred Hallschmid, Helgi B. Schithoth, Christian Benedict
PHARMACEUTICAL RESEARCH
(2013)
Article
Neurosciences
J. M. Fine, A. M. Baillargeon, D. B. Renner, N. S. Hoerster, J. Tokarev, S. Colton, A. Pelleg, A. Andrews, K. A. Sparley, K. M. Krogh, W. H. Frey, L. R. Hanson
EXPERIMENTAL BRAIN RESEARCH
(2012)
Article
Pharmacology & Pharmacy
Helgi B. Schioth, William H. Frey, Samantha J. Brooks, Christian Benedict
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2012)
Article
Cell Biology
Gayane Hrachia Buniatian, Ralf Weiskirchen, Thomas S. Weiss, Ute Schwinghammer, Martin Fritz, Torgom Seferyan, Barbara Proksch, Michael Glaser, Ali Lourhmati, Marine Buadze, Erawan Borkham-Kamphorst, Frank Gaunitz, Christoph H. Gleiter, Thomas Lang, Elke Schaeffeler, Roman Tremmel, Holger Cynis, William H. Frey, Rolf Gebhardt, Scott L. Friedman, Wolfgang Mikulits, Matthias Schwab, Lusine Danielyan
Article
Chemistry, Medicinal
Henning Johannes Drews, Roman Klein, Ali Lourhmati, Marine Buadze, Elke Schaeffeler, Thomas Lang, Torgom Seferyan, Leah R. Hanson, William H. Frey II, Tom C. G. M. de Vries, Inge A. E. W. Thijssen-van Loosdregt, Christoph H. Gleiter, Matthias Schwab, Lusine Danielyan
Summary: ARBs have shown neuroprotective benefits in AD models, with variable effects on memory deficits, cholinergic activity, neurogenesis, and A beta clearance. Systemic administration of losartan resulted in decreased A beta plaques, A beta 42, and inflammatory cytokines, while improving neurogenesis and astrocyte motility. Therapeutic features of losartan appear independent of delivery route.
Review
Chemistry, Medicinal
Indira Y. Rao, Leah R. Hanson, Julia C. Johnson, Michael H. Rosenbloom, William H. Frey
Summary: This study aims to examine the relationship between glucose hypometabolism (GHM) and brain iron accumulation (BIA) in different regions of the brain in late-onset Alzheimer's disease (AD) or Parkinson's disease (PD) patients. The findings suggest that GHM and BIA exist independently in various brain regions in both AD and PD, indicating that they may not always be necessary or sufficient to cause each other.