Article
Clinical Neurology
Mehran Nematizadeh, Hossein Ghorbanzadeh, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi, Shahin Akhondzadeh
Summary: The main aim of this study was to investigate the additional effects of L-theanine on OCD symptoms in combination with fluvoxamine. The results suggest that L-theanine can be a relatively safe and effective adjuvant therapy for moderate to severe OCD.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Psychiatry
Marjan Shokrani, Sanaz Askari, Negin Eissazade, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: This study aimed to evaluate the efficacy and safety of agomelatine augmentation of sertraline in the treatment of patients with moderate to severe OCD. The results showed that while agomelatine did not improve OCD symptoms, the combination treatment was safe and effective compared to placebo.
Article
Medicine, General & Internal
Matthew W. McCarthy, Susanna Naggie, David R. Boulware, Christopher J. Lindsell, Thomas G. Stewart, G. Michael Felker, Dushyantha Jayaweera, Mark Sulkowski, Nina Gentile, Carolyn Bramante, Upinder Singh, Rowena J. Dolor, Juan Ruiz-Unger, Sybil Wilson, Allison DeLong, April Remaly, Rhonda Wilder, Sean Collins, Sarah E. Dunsmore, Stacey J. Adam, Florence Thicklin, George Hanna, Adit A. Ginde, Mario Castro, Kathleen McTigue, Elizabeth Shenkman, Adrian F. Hernandez
Summary: This study aimed to evaluate the efficacy of low-dose fluvoxamine (50 mg twice daily for 10 days) compared with placebo for the treatment of mild to moderate COVID-19. The results showed that treatment with fluvoxamine did not improve the time to sustained recovery compared with placebo. These findings do not support the use of fluvoxamine at this dose and duration in patients with mild to moderate COVID-19.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Clinical Neurology
Erfaneh Hajian Tilaki, Alireza Hasanzadeh, Mohammadreza Shalbafan, Hossein Sanjari Moghaddam, Ahmad Shamabadi, Mahsa Boroon, Shahin Akhondzadeh
Summary: This study evaluates the effectiveness and tolerability of reboxetine in combination with fluoxetine for treating OCD. The results indicate that the combination therapy effectively improves symptoms in OCD patients and is well-tolerated. However, further studies with larger sample sizes and longer follow-up periods are needed to confirm these findings.
CLINICAL NEUROPHARMACOLOGY
(2023)
Article
Psychiatry
Yinhuan Xu, Ruiping Zheng, Huirong Guo, Yarui Wei, Baohong Wen, Shufan Dai, Shaoqiang Han, Jingliang Cheng, Yan Zhang
Summary: Changes in gray matter volume and functional connections are common in patients with obsessive compulsive disorder. However, different grouping methods and a lack of multimodal neuroimaging studies have led to diverse findings about the pathophysiology of OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Infectious Diseases
Ramin Hamidi Farahani, Ali Ajam, Alireza Ranjbar Naeini
Summary: In this study, we evaluated the effect of fluvoxamine on neuropsychiatric symptoms of post-COVID syndrome (PCS). The results showed that taking fluvoxamine during active COVID-19 can reduce the chance of fatigue, but there were no significant advantages for other symptoms. Further studies are necessary to confirm these preliminary results.
BMC INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Emma Guttman-Yassky, Eric L. Simpson, Kristian Reich, Kenji Kabashima, Ken Igawa, Tetsuya Suzuki, Hirotaka Mano, Takeshi Matsui, Ehsanollah Esfandiari, Masutaka Furue
Summary: This study evaluated the efficacy and safety of the anti-OX40 antibody rocatinlimab in patients with moderate-to-severe atopic dermatitis. The results showed significant reductions in EASI score at week 16 in patients receiving rocatinlimab compared to placebo. The treatment led to progressive improvements in atopic dermatitis, which were maintained in most patients after treatment discontinuation, and it was well tolerated.
Article
Psychiatry
Sanaz Askari, Saba Mokhtari, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: The effectiveness of memantine as an adjunct therapy to sertraline for patients with obsessive-compulsive disorder (OCD) was investigated. The results showed that memantine had a positive effect on executive function but did not support its efficacy as an adjunctive agent to sertraline for OCD symptoms.
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Ala Ghobadian, Saba Mokhtari, Behnam Shariati, Leila Kamalzadeh, Mohsen Shati, Mehrdad Eftekhar Ardebili, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: The study aimed to investigate the effectiveness of granisetron as an adjunct therapy to selective serotonin reuptake inhibitors for improving symptoms of OCD. The results showed that the addition of granisetron led to a greater reduction in obsession scores and a higher proportion of patients showing complete response compared to the placebo group.
BMC PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Critical Care Medicine
Dermot A. Linden, Hong Guo-Parke, Michael C. Mckelvey, Gisli G. Einarsson, Andrew J. Lee, Derek J. Fairley, Vanessa Brown, Gavin Lundy, Christina Campbell, Danielle Logan, Margaret McFarland, Dave Singh, Daniel F. McAuley, Clifford C. Taggart, Joseph C. Kidney
Summary: Valaciclovir is shown to be safe and effective for suppressing EBV in COPD, and it may reduce inflammatory cell infiltration in sputum. Further research is needed to evaluate its long-term clinical outcomes.
Article
Psychology, Clinical
Shiu F. Wong, Sandra Krause, David Marishel, Jessica R. Grisham
Summary: This study aimed to examine the effectiveness of reducing disgust through modifying disgust appraisals in individuals with moderate to high OCD-relevant contamination fears. Results indicated that interventions targeting secondary disgust appraisals showed significantly less disgust-related avoidance and reported significantly less disgust compared to primary appraisal conditions.
JOURNAL OF ANXIETY DISORDERS
(2021)
Article
Rheumatology
Victoria P. Werth, Roy Fleischmann, Michael Robern, Zahi Touma, Iyabode Tiamiyu, Oksana Gurtovaya, Alena Pechonkina, Afsaneh Mozaffarian, Bryan Downie, Franziska Matzkies, Daniel Wallace
Summary: This study explores the safety and efficacy of filgotinib and lanraplenib in the treatment of cutaneous lupus erythematosus. The results show that filgotinib has a more significant treatment response compared to the placebo in select subgroups. Both lanraplenib and filgotinib are well tolerated.
Article
Pharmacology & Pharmacy
Julie Leising, Alasdair M. Barr, Ric M. Procyshyn, Nicholas J. Ainsworth, Randall F. White, William Honer, Fidel Vila-Rodriguez
Summary: The study shows the potential benefits of high-dose fluvoxamine augmentation of clozapine in patients with treatment-resistant psychosis, despite high variability of responses and adverse effects observed among patients.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Kenneth B. Gordon, Peter Foley, James G. Krueger, Andreas Pinter, Kristian Reich, Ronald Vender, Veerle Vanvoorden, Cynthia Madden, Katy White, Christopher Cioffi, Andrew Blauvelt
Summary: The study demonstrated that Bimekizumab showed high levels of response in patients with moderate to severe plaque psoriasis, with durable effects over 56 weeks under both maintenance dosing schedules (every 4 weeks and every 8 weeks). Additionally, Bimekizumab was well tolerated with no unexpected safety issues, further supporting its therapeutic value for this patient population.
Article
Psychiatry
Babak Najand, Andrew Christensen, Michael Martin, Mark Spelman
Summary: This study found that in patients with psychiatric disorders, misdiagnosed temporal lobe epilepsy was identified through electroencephalogram examination, which had been assumed as part of other psychiatric co-morbidities. This discovery emphasizes the importance of considering the biological etiologies of mental illnesses in the initial assessments in psychiatric and neurological practice.
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
(2023)
Article
Substance Abuse
Mohammadali Nikoo, Kiana Kianpoor, Nooshin Nikoo, Sanam Javidanbardan, Alireza Kazemi, Fiona Choi, Marc Vogel, Ali Gholami, Saeed Tavakoli, James S. H. Wong, Ehsan Moazen-Zadeh, Reza Givaki, Majid Jazani, Fatemeh Mohammadian, Nader Markazi Moghaddam, Christian Schuetz, Kerry Jang, Shahin Akhondzadeh, Michael Krausz
Summary: This study aimed to compare the effectiveness of opium tincture (OT) and methadone in retaining participants in opioid agonist treatment (OAT). The results showed that OT retained 60% of participants to the end of the 85-day follow-up period and was superior to methadone in reducing self-reported opioid use outside of treatment. However, the study did not find sufficient evidence to conclude the non-inferiority of OT compared to methadone.
Article
Pharmacology & Pharmacy
Parnia Ebrahimi, Homa Seyedmirzaei, Kamyar Moradi, Sayna Bagheri, Mahdi Moeini, Mohammad-Reza Mohammadi, Shahin Akhondzadeh
Summary: This study aimed to evaluate the therapeutic effects of cilostazol on aberrant behaviors in children with autism spectrum disorder (ASD) and its safety profile. A double-blind, randomized clinical trial was conducted with 66 confirmed ASD children. The results showed that cilostazol had beneficial effects on hyperactivity in children with ASD and higher levels of hyperactivity, with no significant adverse effects observed.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Amir Hossein Behnoush, Kamran Yazdani, Amirmohammad Khalaji, Hamed Tavolinejad, Arya Aminorroaya, Arash Jalali, Masih Tajdini
Summary: This study conducted a systematic review and network meta-analysis to compare the pharmacologic therapies for vasovagal syncope and found that midodrine and fluoxetine showed efficacy in reducing syncopal events, while midodrine and atomoxetine were superior in the positive head-up tilt test.
Letter
Clinical Neurology
Hossein Sanjari Moghaddam, Shahin Akhondzadeh
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Environmental Sciences
Edward Adinkrah, Babak Najand, Arash Rahmani, Najmeh Maharlouei, Tavonia Ekwegh, Sharon Cobb, Hossein Zare
Summary: This study suggests that financial difficulties have a stronger impact on the health status of African American communities in economically constrained urban environments than education and income, which lose their protective effects.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Cardiac & Cardiovascular Systems
Masih Tajdini, Hamed Tavolinejad, Arya Aminorroaya, Zahra Aryan, Arash Jalali, Farshid Alaeddini, Saeed Sadeghian, Somayeh Yadangi, Ali Vasheghani-Farahani, Parvin Kalhor, Ali Bozorgi
Summary: Recent research has found a high incidence of injuries in patients with vasovagal syncope (VVS), but the clinical associations of these injuries are not well-established. This study analyzed data from VVS patients and identified characteristics associated with VVS-related injuries. The results showed that a history of VVS-related injuries, standing position, and female sex were associated with higher risk of injury, while recurrent VVS and syncope occurring in the noon/afternoon and evening/night were associated with lower risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pediatrics
Edward Adinkrah, Babak Najand, Angela Young-Brinn
Summary: While high parental education is associated with better health, this association may be weaker for ethnic minority than for ethnic majority families. It is unknown whether the association between parental education and adolescents' asthma also varies by ethnicity. This study found that higher parental education was predictive of adolescents' asthma, but this association was weaker for Latino adolescents compared to non-Latino adolescents.
Article
Public, Environmental & Occupational Health
Akbar Shafiee, Alireza Oraii, Arash Jalali, Farshid Alaeddini, Soheil Saadat, Farzad Masoudkabir, Masih Tajdini, Haleh Ashraf, Negar Omidi, Amirhossein Heidari, Alireza Sepehri Shamloo, Saeed Sadeghian, Mohamamdali Boroumand, Ali Vasheghani-Farahani, Abbasali Karimi, Oscar H. Franco
Summary: This study examined the prevalence of tobacco use in Tehran, Iran. The results showed that the current tobacco use rate was 19.8%, with cigarette smoking being the most common at 14.9%. Men had a significantly higher tobacco use rate compared to women, and younger age, higher education, opium use, and alcohol consumption were associated with higher tobacco use.
Article
Clinical Neurology
Mehran Nematizadeh, Hossein Ghorbanzadeh, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi, Shahin Akhondzadeh
Summary: The main aim of this study was to investigate the additional effects of L-theanine on OCD symptoms in combination with fluvoxamine. The results suggest that L-theanine can be a relatively safe and effective adjuvant therapy for moderate to severe OCD.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Pediatrics
Edward Adinkrah, Babak Najand, Angela Young-Brinn, Samrand Salimi
Summary: This study compared the association between school achievement and tobacco use susceptibility among African American, Latino, and Non-Latino White adolescents in the US. The findings suggest that the correlation between educational success and lower tobacco use susceptibility is weaker for ethnic minorities compared to Non-Latino White adolescents.
Article
Health Care Sciences & Services
Hafifa Siddiq, Mona Darvishi, Babak Najand
Summary: Multiple studies have shown a link between high education and better self-rated health. However, recent studies suggest that immigrants may experience a weaker association between education and self-rated health compared to native-born individuals. This study investigates the inverse association between education and self-rated health and examines whether immigration status moderates this association using a national sample of US older adults.
Article
Clinical Neurology
Ahmad Shamabadi, Farnaz Kafi, Melika Arab Bafrani, Hassan Asadigandomani, Fatemeh A. Basti, Shahin Akhondzadeh
Summary: This study found that adjunctive L-theanine, when combined with sertraline, showed better efficacy in treating major depressive disorder (MDD) compared to placebo. The L-theanine group demonstrated significant improvement in depression symptoms and a greater reduction in depression scores compared to the placebo group at weeks 2, 4, and 6. Furthermore, the L-theanine group had higher remission and response rates at week 6. These findings suggest that L-theanine is a safe and effective adjunctive therapy for MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Sara Momtazmanesh, Sahar Ansari, Zahra Izadi, Parnian Shobeiri, Venus Vatankhah, Arash Seifi, Fereshteh Ghiasvand, Mahboobeh Bahrami, Mohammdreza Salehi, Ahmad Ali Noorbala, Shahin Akhondzadeh
Summary: This study investigates the efficacy and safety of famotidine in improving cognitive impairment, depression, and anxiety symptoms post-COVID-19. The results show that patients in the famotidine group had significantly higher MMSE and MoCA scores, as well as reduced HAM-D and HAM-A scores, compared to the placebo group. The study suggests that famotidine is safe and effective in treating cognitive impairment, depression, and anxiety symptoms induced by COVID-19.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Obstetrics & Gynecology
Sophia Esalatmanesh, Ladan Kashani, Maryam Khooshideh, Hossein Sanjari Moghaddam, Sahar Ansari, Shahin Akhondzadeh
Summary: The study aimed to assess the effects of adjunctive celecoxib with cognitive behavioral therapy (CBT), an anti-inflammatory agent, in the treatment of postpartum depression. The results showed that adjunctive celecoxib is effective in improving postpartum depressive symptoms.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)