Tapentadol in Pain Management

A thorough QT/QTc study of multiple doses of tapentadol immediate release in healthy subjects

(2011) C. Oh et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain

(2010) Bernd Lange et al.   ADVANCES IN THERAPY

Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee

(2010) Marc Afilalo et al.   CLINICAL DRUG INVESTIGATION

Population Pharmacokinetics of Tapentadol Immediate Release (IR) in Healthy Subjects and Patients with Moderate or Severe Pain

(2010) Xu Steven Xu et al.   CLINICAL PHARMACOKINETICS

Cost-effectiveness analysis of tapentadol immediate release for the treatment of acute pain

(2010) W. Jacqueline Kwong et al.   CLINICAL THERAPEUTICS

Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results of a randomized-withdrawal, placebo-controlled trial

(2010) Sherwyn Schwartz et al.   CURRENT MEDICAL RESEARCH AND OPINION

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

(2010) Wolfgang Schröder et al.   EUROPEAN JOURNAL OF PAIN

Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study

(2010) Robert Buynak et al.   EXPERT OPINION ON PHARMACOTHERAPY

Tapentadol immediate-release for acute pain

(2010) Craig T Hartrick   Expert Review of Neurotherapeutics

Interaction of morphine but not fentanyl with cerebral α2-adrenoceptors in α2-adrenoceptor knockout mice

(2010) Jan Höcker et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

In vitro and in vivo characterization of tapentadol metabolites

(2010) R. Terlinden et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Mu-opioid and noradrenergic α2-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats

(2010) Lucy A. Bee et al.   PAIN

Long-term Safety and Tolerability of Tapentadol Extended Release for the Management of Chronic Low Back Pain or Osteoarthritis Pain

(2010) James E. Wild et al.   Pain Practice

Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled study

(2009) Craig Hartrick et al.   CLINICAL THERAPEUTICS

A randomized, double-blind, placebo-controlled phase 3 study of the relative efficacy and tolerability of tapentadol IR and oxycodone IR for acute pain

(2009) Stephen Daniels et al.   CURRENT MEDICAL RESEARCH AND OPINION

A randomized, double-blind, phase III study comparing multiple doses of tapentadol IR, oxycodone IR, and placebo for postoperative (bunionectomy) pain

(2009) Stephen E. Daniels et al.   CURRENT MEDICAL RESEARCH AND OPINION

Tolerability of tapentadol immediate release in patients with lower back pain or osteoarthritis of the hip or knee over 90 days: a randomized, double-blind study

(2009) Martin Hale et al.   CURRENT MEDICAL RESEARCH AND OPINION

Tapentadol immediate release for the relief of moderate-to-severe acute pain

(2009) Craig T Hartrick   EXPERT OPINION ON PHARMACOTHERAPY

Cannabinoid receptor-mediated antinociception with acetaminophen drug combinations in rats with neuropathic spinal cord injury pain

(2009) Aldric T. Hama et al.   NEUROPHARMACOLOGY

Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain

(2009) Thomas Christoph et al.   NEUROSCIENCE LETTERS

Effects of Acetaminophen, Naproxen, and Acetylsalicylic Acid on Tapentadol Pharmacokinetics: Results of Two Randomized, Open-Label, Crossover, Drug-Drug Interaction Studies

(2009) Johan W Smit et al.   PHARMACOTHERAPY

Plasticity of NMDA receptor NR2B subunit in memory and chronic pain

(2009) Min Zhuo   Molecular Brain

Single Dose Analgesic Efficacy of Tapentadol in Postsurgical Dental Pain: The Results of a Randomized, Double-Blind, Placebo-Controlled Study

(2008) Regina Kleinert et al.   ANESTHESIA AND ANALGESIA

The efficacy and tolerability of multiple-dose tapentadol immediate release for the relief of acute pain following orthopedic (bunionectomy) surgery

(2008) Jens-Ulrich Stegmann et al.   CURRENT MEDICAL RESEARCH AND OPINION