Article
Psychiatry
Juan Huang, Xiao-Meng Xie, Nan Lyu, Bing-Bing Fu, Qian Zhao, Ling Zhang, Gang Wang
Summary: This study evaluated the treatment outcomes of agomelatine on anhedonic state, anxiety/somatic symptoms, and sexual function in Chinese patients with major depressive disorder (MDD). The results showed that after 9 weeks of treatment, the response rate and remission rate of the agomelatine treatment group were 73.5% and 39.7% respectively, with significant improvement in somatic symptoms and anhedonia. The patients exhibited lower levels of disease severity and higher levels of quality of life during the follow-up period. No serious adverse events occurred during the treatment.
FRONTIERS IN PSYCHIATRY
(2023)
Editorial Material
Clinical Neurology
Dan J. Stein
Summary: Patients with depression require thorough clinical assessment for symptom profile, severity, comorbidity, and other factors. Co-existing anxiety symptoms in depressed patients are associated with more severe depression and worse outcomes. Agomelatine is an effective antidepressant that relieves depressive symptoms and supports recovery, and it is well tolerated in patients with depression and concomitant anxiety symptoms. Combining pharmacotherapy with psychotherapy is more effective than either alone. Persistence with treatment is important for patients.
NEUROLOGY AND THERAPY
(2023)
Review
Psychiatry
Raghava Kalyan Maddukuri, Chava Hema, Kondaveeti Sri Tejaswi, Mutthineni Venkata Mounika, Bindu Priyanka Vegesana
Summary: Agomelatine is a novel antidepressant with similar efficacy compared to currently used antidepressants, showing significant SMD and response rate in acute phase studies.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Martin A. Katzman, Francois Therrien, Erin M. MacKenzie, Fan Wang, Anne de Jong-Laird, Matthieu Boucher
Summary: This study found that adjunctive brexpiprazole can improve multiple symptom clusters in MDD patients who have inadequate response to antidepressant treatments. The improvements occur early and are sustained over 6 weeks.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Zhengping Pu, Qingmei Hou, Hui Yan, Yong Lin, Zilei Guo
Summary: This study aimed to explore the effect of high-frequency repetitive transcranial magnetic stimulation (rTMS) and agomelatine on the sleep quality of patients with mild to moderate depressive disorder (DD). The results showed that the high-frequency rTMS group had lower depression levels and better sleep quality compared to the sham rTMS group, and it also increased the levels of certain neurotransmitters and neurotrophic factors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yun Ho Choi, Kwang Ik Yang, Chang-Ho Yun, Won-Joo Kim, Kyoung Heo, Min Kyung Chu
Summary: This study found that participants with insomnia symptoms had a higher prevalence of depressive symptoms, while participants with depressive symptoms also had a higher prevalence of insomnia symptoms. Additionally, participants with both depressive and insomnia symptoms showed higher severity in both conditions.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Xiaowen Wang, Ahmed Arafa, Keyang Liu, Ehab S. Eshak, Yonghua Hu, Jia- Yi Dong
Summary: The meta-analysis found that a healthy lifestyle is associated with a reduced risk of depressive symptoms. Adherence to an overall healthy lifestyle is crucial for the primary prevention of depression in general populations.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Chemistry, Medicinal
Vahdad Varzaghani, Masoomeh Sharifi, Reza Hajiaghaee, Sara Bagheri, Saeideh Momtaz, Zahra Tarassoli, Ali Razmi
Summary: This study aimed to evaluate the efficacy and safety of propolis as a complementary therapy for depressive disorder. The results showed that propolis could safely attenuate symptoms of moderate-severe depression, possibly due to its rich content of phenolic acids and flavonoids.
PHYTOTHERAPY RESEARCH
(2022)
Article
Psychology, Clinical
William Magee, Philippa Clarke
Summary: Research suggests that smoking may have a negative effect on reducing depressive symptoms among women, but the effect is not statistically significant among men, with no observed differences across race. The reciprocal effect of depressive symptoms on smoking needs to be taken into account in analyses to fully understand the relationship.
ADDICTIVE BEHAVIORS
(2021)
Review
Nutrition & Dietetics
Francis Feldman, Mireille Koudoufio, Yves Desjardins, Schohraya Spahis, Edgard Delvin, Emile Levy
Summary: Polyphenols (PLPs), phytochemicals found in plant-based foods, have shown promising effects on lipid disorders in animal models. However, their effectiveness in human dyslipidemia is still unclear, highlighting the need for further research to clarify their potential role in managing lipid metabolism disorders.
Article
Medicine, General & Internal
Julian Hellmann-Regen, Vera Clemens, Michael Grozinger, Johannes Kornhuber, Andreas Reif, David Prvulovic, Roberto Goya-Maldonado, Jens Wiltfang, Oliver Gruber, Cornelius Schule, Frank Padberg, Marcus Ising, Manfred Uhr, Tim Friede, Cynthia Huber, Andre Manook, Thomas C. Baghai, Rainer Rupprecht, Isabella Heuser
Summary: Insufficient treatment response and resulting chronicity are major problems in depressive disorders. Anti-inflammatory interventions may be a rational treatment strategy. The efficacy of minocycline as an adjunct treatment for TRD patients needs further investigation.
Article
Gastroenterology & Hepatology
Sebastian Bruno Ulrich Jordi, Brian Matthew Lang, Bianca Auschra, Roland von Kanel, Luc Biedermann, Thomas Greuter, Philipp Schreiner, Gerhard Rogler, Niklas Krupka, Michael Christian Sulz, Benjamin Misselwitz, Stefan Begre
Summary: Patients with inflammatory bowel disease (IBD) have a higher risk of depression, which has been shown to impact disease progression. This study found that depression is a strong predictor of clinical deterioration in IBD patients, and genetic markers may play a role in this relationship.
INFLAMMATORY BOWEL DISEASES
(2022)
Review
Behavioral Sciences
Giulia Cattarinussi, Mohammad Hadi Aarabi, Hossein Sanjari Moghaddam, Maryam Homayoun, Mahnaz Ashrafi, Hamid Soltanian-Zadeh, Fabio Sambataro
Summary: Perinatal Depression (PND) has been found to impact the structure and function of offspring's brains, with alterations in gray matter and microstructure observed in regions such as the amygdala, frontal lobe, cingulum, longitudinal fasciculus, and fornix. However, the limited sample size and heterogeneity in populations and methodologies present constraints on the conclusions drawn from existing studies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Nursing
Anas Husam Khalifeh, Fadwa Naji Alhalaiqa, Shaher Hamad Hamaideh, Robert Horne, Ayman Mohammad Hamdan-Mansour
Summary: This study aimed to examine the effect of adherence therapy (AT) on medication adherence, health beliefs, self-efficacy, and depressive symptoms among patients diagnosed with major depressive disorder (MDD). The results showed that AT enhanced positive beliefs towards medication and illness, increased medication adherence self-efficacy, improved medication adherence, and decreased depressive symptoms.
INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
(2023)
Article
Medicine, Research & Experimental
Dan J. Stein, Jon-Paul Khoo, Francoise Picarel-Blanchot, Valerie Olivier, Michael Van Ameringen
Summary: The study found that agomelatine significantly reduced anxious symptoms and improved functional impairment in patients with generalized anxiety disorder. These effects were also significant in more severely anxious patients.
ADVANCES IN THERAPY
(2021)