Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Norio Sugawara, Naoto Adachi, Yukihisa Kubota, Yoichiro Watanabe, Kazuhira Miki, Takaharu Azekawa, Koji Edagawa, Eiichi Katsumoto, Seiji Hongo, Eiichiro Goto, Hitoshi Ueda, Masaki Kato, Reiji Yoshimura, Atsuo Nakagawa, Toshiaki Kikuchi, Takashi Tsuboi, Koichiro Watanabe, Kazutaka Shimoda, Norio Yasui-Furukori
Summary: This study investigated the long-term clinical outcomes of patients with bipolar disorder (BD) and identified several predictors of these outcomes. The findings can assist clinicians in predicting the course of the illness based on demographic and clinical characteristics.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Andrea Escelsior, Samuele Tardito, Bruno Sterlini, Tiziana Altosole, Alice Trabucco, Valentina Marozzi, Gianluca Serafini, Andrea Aguglia, Andrea Amerio, Beatriz Pereira da Silva, Daniela Fenoglio, Gilberto Filaci, Martino Belvederi Murri, Mario Amore
Summary: This study found that CNR1 expression is higher and less variable in mania than in depression, which can help distinguish individuals in different illness phases from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Erika F. H. Saunders, Dahlia Mukherjee, Daniel A. Waschbusch, Duanping Liao, Amanda M. Pearl, Errol Aksu, Edward O. Bixler
Summary: The use of structured interviews helped physicians identify major depressive disorder by the second visit in patients with complex psychopathology. Patients with high complexity/severity of symptoms and more difficulty with functioning were less commonly identified with bipolar disorder even with the assistance of a structured interview.Structured assessment tools may improve the detection of psychiatric illness by clinicians at the first visit.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Medicine, General & Internal
Napoleon Waszkiewicz
Summary: Although the influence of weather on psychiatric patients has been seen, the relationships between seasonal weather factors and mental states have not been systematized. This article explores the seasonal changes in immune responses and their impact on depression, mania, psychosis, and anxiety. The imbalance between the Th1 and Th2 immune systems may play a potential role in triggering these conditions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
James A. Karantonis, Susan L. Rossell, Michael Berk, Tamsyn E. Van Rheenen
Summary: The study found a significant increase in subjective cognitive dysfunction in patients with bipolar disorder during the COVID-19 pandemic, but no substantial differences were observed in mood symptoms, fear of COVID-19, lifestyle factors, and social rhythms between patients and healthy controls, indicating a degree of resilience in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Lisa T. Eyler, Farren B. S. Briggs, Annemiek Dols, Soham Rej, Osvaldo P. Almeida, Alexandra J. M. Beunders, Hilary P. Blumberg, Brent P. Forester, Regan E. Patrick, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Eduard Vieta, Benoit H. Mulsant, Sigfried Schouws, Nadine P. G. Paans, Sergio Strejilevich, Ashley Sutherland, Shangying Tsai, Martha Sajatovic
Summary: This study analyzed the symptom mixity in older-age bipolar disorder (OABD) and its association with everyday function. The results showed that mixed features are predominant in OABD and are associated with worse everyday function. Among those with mixed symptoms, the severity of depression is the main driver of poorer functioning.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychiatry
Roberto Palacios-Garran, Vicent Llorca-Bofi, Gara Arteaga-Henriquez, Enrique Del Agua
Summary: The study aimed to evaluate the efficacy and safety of cariprazine in combination with mood stabilizers for treating Female Emotional Dysregulation. The results showed that over half of the patients demonstrated adherence to treatment, indicating good safety and effectiveness of the treatment approach.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Anna Grunze, Sergey Mosolov, Heinz Grunze, Christoph Born
Summary: This narrative review examines the epidemiology, consequences, and treatment options of tobacco use disorder (TUD) and nicotine dependence (ND) in individuals with bipolar disorder (BD). The study found that smoking rates are 2-3 times higher in individuals with BD compared to community samples. Smoking has a detrimental impact on both mental and physical health as well as mortality in individuals with BD. Treatment options include pharmacological interventions and psychosocial interventions.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Valerio Brunetti, Jessica Marotta, Giorgia Simoncini Malucelli, Giuseppe Marano, Marianna Mazza, Giacomo Della Marca
Summary: Pitolisant, a histamine 3-receptor antagonist/inverse agonist, is effective and safe for treating excessive daytime sleepiness and cataplexy in narcolepsy. However, our report highlights that caution should be exercised when prescribing pitolisant to patients with a predisposition to psychiatric disorders, especially during the initial phase of treatment. Considering the high prevalence of psychiatric comorbidities in narcolepsy, it is important to carefully evaluate the psychiatric background of narcoleptic patients.
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
(2023)
Review
Neurosciences
Delfina Janiri, Lorenzo Moccia, Silvia Montanari, Valentina Zani, Claudia Prinari, Laura Monti, Daniela Chieffo, Marianna Mazza, Alessio Simonetti, Georgios D. D. Kotzalidis, Luigi Janiri
Summary: This review investigates the use of lithium in pediatric bipolar disorder (BD) and other externalizing childhood-related disorders. The results suggest that lithium is an efficacious and generally well-tolerated treatment in pediatric BD and conduct disorder (CD), but the evidence is limited due to the paucity of available data.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Medicine, Legal
Rossana Cecchi, Vittoria Masotti, Matilde Sassani, Alessandra Sannella, Giulia Agugiaro, Tomoya Ikeda, Davide Maria Pressanto, Emanuele Caroppo, Maria Laura Schirripa, Marianna Mazza, Toshikazu Kondo, Pietro De Lellis
Summary: This paper applies a proposed definition of femicide to a cohort of cases to characterize femicides and female homicides and evaluate if femicides can be considered as a distinct entity. Comparisons between female and male homicides reveal common and distinctive features, such as a higher prevalence of indoor homicides and asphyxiation in female homicides. The study suggests that femicide and female homicide can be regarded as separate victimological phenomena.
Article
Medicine, General & Internal
Paola Aceto, Andrea Russo, Claudia Galletta, Chiara Schipa, Bruno Romano, Ersilia Luca, Emilio Sacco, Angelo Totaro, Carlo Lai, Marianna Mazza, Bruno Federico, Liliana Sollazzi
Summary: This study evaluated the use of the middle cerebral artery pulsatility index (Pi) in 60 elderly patients undergoing robotic-assisted laparoscopic prostatectomy (RALP) and found that the occurrence of delayed neurocognitive recovery (dNCR) was associated with alterations in cerebral blood flow caused by a steep Trendelenburg position and pneumoperitoneum. Specifically, the study found that the Pi significantly increased after 1 hour of the steep Trendelenburg position and pneumoperitoneum in 20 patients who experienced dNCR compared to those without dNCR, indicating the vulnerability of cerebral circulation in this situation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Lorenzo Moccia, Georgios D. Kotzalidis, Giovanni Bartolucci, Sara Ruggiero, Laura Monti, Marco Biscosi, Beatrice Terenzi, Ottavia M. Ferrara, Marianna Mazza, Marco Di Nicola, Delfina Janiri, Alessio Simonetti, Emanuele Caroppo, Luigi Janiri, Gabriele Sani
Summary: Psychosis is a complex condition characterized by delusions, hallucinations, and disorganized thought, speech, or behavior. There is increasing concern about the potential link between COVID-19 and the development of new-onset psychosis. This article reviews the current evidence on the association between SARS-CoV-2 and the risk of psychosis as an acute or post-infectious manifestation of COVID-19. It also discusses the challenges in determining a causal pathogenic relationship between SARS-CoV-2 infection and new-onset psychosis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Health Care Sciences & Services
Marianna Mazza, Carla Avallone, Georgios Demetrios Kotzalidis, Giuseppe Marano, Lorenzo Moccia, Anna Maria Serio, Marta Balocchi, Ilenia Sessa, Delfina Janiri, Ilaria De Luca, Caterina Brisi, Maria Chiara Spera, Laura Monti, Angela Gonsalez del Castillo, Gloria Angeletti, Daniela Chieffo, Lucio Rinaldi, Luigi Janiri, Antonio Lanzone, Giovanni Scambia, Eugenio Maria Mercuri, Gabriele Sani
Summary: This study aimed to examine the incidence of depressive symptomatology during pregnancy and to evaluate the role of affective temperament traits and psychosocial risk factors in predicting them. The prevalence of depressive symptomatology in our sample was 41.45% and the prevalence of depression was 9.85%, with 6.75% experiencing mild depression and 3.10% experiencing moderate depression. Several factors were found to be significantly associated with the development of depressive symptoms during pregnancy.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Ambra Craba, Marianna Mazza, Giuseppe Marano, Maria Luigia Crosta, Federica Moroni, Salvatore Di Pietro, Marta Balocchi, Silvia Della Casa, Lucio Rinaldi, Luigi Janiri, Gabriele Sani
Summary: Dysfunctional parenting styles are risk factors for eating disorders. In this study, the researchers examined the relationship between perception of parental bonding and defense mechanisms in patients with anorexia and bulimia. The results showed that maternal care was associated with immature defense mechanisms, while paternal overprotection was associated with mature defense mechanisms. Patients with eating disorders tend to utilize more neurotic and primitive defense mechanisms, which are associated with greater severity of eating symptomatology.
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2023)
Review
Nutrition & Dietetics
Giuseppe Marano, Marianna Mazza, Francesco Maria Lisci, Michele Ciliberto, Gianandrea Traversi, Georgios Demetrios Kotzalidis, Domenico De Berardis, Lucrezia Laterza, Gabriele Sani, Antonio Gasbarrini, Eleonora Gaetani
Summary: There is increasing interest in the role of intestinal microbiota and autoimmune processes in psychiatric diseases. Altered communication between the microbiota-gut-brain axis may be a cause of psychiatric disorders. This review explores the evidence for the involvement of gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Changes in gut microbiota composition can lead to increased intestinal permeability, resulting in a cytokine storm, systemic inflammation, and immune response. These events can affect neurotransmitter release, alter the hypothalamic-pituitary-adrenal axis, and reduce trophic brain factors. Further research is needed to understand the underlying mechanisms connecting gut microbiota and psychiatric disorders.
Review
Biochemistry & Molecular Biology
Gabriele Sani, Stella Margoni, Andrea Brugnami, Ottavia Marianna Ferrara, Evelina Bernardi, Alessio Simonetti, Laura Monti, Marianna Mazza, Delfina Janiri, Lorenzo Moccia, Georgios D. Kotzalidis, Daniela Pia Rosaria Chieffo, Luigi Janiri
Summary: There is growing interest in the involvement of antioxidative systems, particularly Nrf2, in protecting against depression. Through a PubMed search, 89 eligible articles out of 208 results were identified. These studies suggest that Nrf2 is lower in depression and that antidepressant methods can increase its levels.
Article
Health Care Sciences & Services
Ambra Craba, Giuseppe Marano, Georgios D. Kotzalidis, Carla Avallone, Francesco Maria Lisci, Maria Luigia Crosta, Antonino Callea, Laura Monti, Domenico De Berardis, Carlo Lai, Marta Balocchi, Ilenia Sessa, Desiree Harnic, Gabriele Sani, Marianna Mazza
Summary: This study aimed to investigate the correlation between attachment and resilience in patients with major depressive disorder (MDD) and bipolar disorder (BD). The results showed that patients had lower resilience than healthy controls, and a lower proportion of secure attachment was found among patients. These findings suggest that early life experiences and attachment play a crucial role in the development of resilience in individuals with mood disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Psychiatry
Laura Monti, Elisa Marconi, Maria Grazia Bocci, Georgios Demetrios Kotzalidis, Marianna Mazza, Carolina Galliani, Sara Tranquilli, Giovanni Vento, Giorgio Conti, Gabriele Sani, Massimo Antonelli, Daniela Pia Rosaria Chieffo
Summary: The COVID-19 pandemic has had significant impacts on the psychological well-being of ICU patients, their relatives, and healthcare staff. Increased stress, distress, and worry about infection have been observed in these groups. The use of digital tools and virtual reality interventions is becoming increasingly important in ICU settings. Psychologists play an essential role in providing psychological support in ICUs.
WORLD JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Alessio Simonetti, Marijn Lijffijt, Sherin Kurian, Johanna Saxena, Delfina Janiri, Marianna Mazza, Giulio Carriero, Lorenzo Moccia, Benson Mwangi, Alan C. Swann, Jair C. Soares
Summary: This study investigated the neural correlates of the late positive potential (LPP) in youth with pediatric bipolar disorder (PBD). The results showed that PBD patients had a stronger LPP response to happy faces and thinner cortex in prefrontal areas compared to healthy controls. Furthermore, the LPP amplitude was associated with variations in cortical thickness and deep gray matter volumes. These findings suggest that the dysregulation of emotion processing and control in PBD may be related to abnormalities in specific brain regions.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Domenico De Berardis, Anna Ceci, Emanuela Zenobi, Dosolina Rapacchietta, Manuela Pisanello, Filippo Bozzi, Lia Ginaldi, Viviana Marasco, Maurizio Di Giosia, Maurizio Brucchi, Guendalina Graffigna, Jacopo Santambrogio, Antonio Ventriglio, Marianna Mazza, Giovanni Muttillo
Summary: This study aimed to assess the frequency of and relationships between alexithymia, burnout, and hopelessness in healthcare workers during the third wave of COVID-19 in Italy. The findings showed that individuals with alexithymia and higher levels of burnout were more likely to experience hopelessness. Higher working seniority, emotional exhaustion, irritability, depression, anxiety, and difficulty in describing feelings were associated with higher levels of hopelessness. It is important to implement comprehensive strategies to support healthcare workers' mental health and mitigate the negative consequences of alexithymia, burnout, and hopelessness.
Letter
Endocrinology & Metabolism
Angelo Emilio Claro, Clelia Palanza, Marianna Mazza, Alessandro Rizzi, Linda Tartaglione, Andrea Corsello, Giuseppe Marano, Giovanna Elsa Ute Muti Schuenemann, Marta Rigoni, Paola Muti, Alfredo Pontecorvi, Luigi Janiri, Gabriele Sani, Dario Pitocco
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Angelo Emilio Claro, Clelia Palanza, Marianna Mazza, Andrea Corsello, Alessandro Rizzi, Linda Tartaglione, Chiara de Waure, Giuseppe Marano, Simone Piciollo, Giovanna Elsa Ute Muti Schuenemann, Marta Rigoni, Paola Muti, Alfredo Pontecorvi, Luigi Janiri, Gabriele Sani, Dario Pitocco
Summary: This is the first study in Italy to investigate the prevalence of CPDs in patients with T2D. The study found that the prevalence of CPDs in T2D patients is higher than in the general population. Higher BMI and not implementing lifestyle changes were associated with an increased likelihood of having CPDs.
ACTA DIABETOLOGICA
(2023)
