Article
Neurosciences
Shujun Shang, Fengqiang Sun, Yulin Zhu, Jingui Yu, Lingzhi Yu, Wei Shao, Zhijuan Wang, Xuecai Yi
Summary: This study aimed to investigate the influence of sevoflurane on the NLRP3 pathways in rats with cerebral ischemia/reperfusion (I/R) injury. The results indicated that sevoflurane could alleviate brain damage caused by cerebral I/R by inhibiting the ROS-NLRP3 pathway.
NEUROSCIENCE LETTERS
(2023)
Article
Biotechnology & Applied Microbiology
Guoning Su, Yan Qu, Gang Li, Min Deng
Summary: The study found that SEV has a protective effect on cerebral ischemia/reperfusion injury (CIRI) by modulating the miR-30 c-5p-HIPK1 axis. Inhibition of HIPK1 can reverse the effect of reduced miR-30 c-5p on CIRI.
Article
Multidisciplinary Sciences
Hye Youn Sung, Eun Nam Choi, Jihye Han, Yun Ju Chae, Sun-Wha Im, Hee-Sun Kim, Eun-Mi Park, Jung-Hyuck Ahn
Summary: Research suggests that ischemic preconditioning reduces brain ischemia-reperfusion injury by downregulating the expression of miR-33-5p and miR-135b-5p, which in turn protects neurons from apoptosis induced by oxygen-glucose deprivation. Inhibition of these two miRNAs significantly increases mRNA and protein levels of ABCA1 and reduces activation of the mitochondria-dependent apoptosis pathway.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Honglin Yan, Wenxian Huang, Jie Rao, Jingping Yuan
Summary: miR-21 exhibits anti-apoptotic and pro-survival effects in ischemia by regulating the p53/Bcl-2/Bax signaling pathway, suggesting it as an attractive therapeutic molecule for ischemic stroke treatment.
Article
Neurosciences
Ye Li, Zhi Liang, Shuyan Lei, Xiaoning Wu, Tao Yuan, Kai Ma, Kui Chi
Summary: The neuroprotective effects of sevoflurane on cerebral ischemia/reperfusion (I/R) injury were investigated. Sevoflurane pretreatment reduced PC12 cell damage after oxygen-glucose deprivation/reoxygenation (OGD/R) and improved behavioral deficits and neuronal apoptosis in rats challenged with I/R. This effect was mediated by inhibiting the surface expression of glutamate receptor 1 (GRIA1) and blocking calcium permeable-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (CP-AMPAR).
NEUROTOXICITY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xiaoyu Xiao, Dezhao Liu, Sufang Chen, Xiang Li, Mian Ge, Wenqi Huang
Summary: Sevoflurane preconditioning can reduce liver ischemia reperfusion injury by activating the HGF/Met-mediated autophagy pathway, highlighting the crucial role of autophagy in this protective effect.
CELLULAR SIGNALLING
(2021)
Article
Cell & Tissue Engineering
Jinting Yang, Lihui Tang, Fengjiang Zhang, Tingting Yang, Ting Lu, Kai Sun, Na Sun, Jinxuan Ren, Min Yan
Summary: Sevoflurane preconditioning can enhance MSCs to attenuate myocardial I/R injury through TRPC6-induced angiogenesis. It also promotes angiogenesis and anti-inflammatory effects of HUVECs, as well as improves left ventricle systolic function and reduces infarction and inflammation in mice subjected to I/R insult.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Eva Baranovicova, Petra Hnilicova, Dagmar Kalenska, Peter Kaplan, Maria Kovalska, Zuzana Tatarkova, Anna Tomascova, Jan Lehotsky
Summary: H-1 NMR metabolomics is a valuable tool for characterizing the distribution and alterations of metabolites induced by cerebral ischemic injury or its combination with hyperhomocysteinemia. The study found decreased neurotransmitter pool and increased tissue glutamine level in the brain tissue after ischemic injury. Metabolomic alterations were observed in the blood plasma, including decreased glycolytic intermediates and increased plasma ketone bodies. Ischemic preconditioning showed a lower extent of metabolomic changes. In hyperhomocysteinemic models, a decrease in several amino acids in plasma was associated with hippocampal neuropathology.
Article
Neurosciences
Jie Song, Ke He, Longqiu Yang, Jun Shen
Summary: This study demonstrates the neuroprotective effects of Sevoflurane in cerebral ischaemic injury. miR-203-3p enhances the protective effects of Sevo through up-regulation of Bcl-2 and down-regulation of HDAC4.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Keshav Jayaraman, Meizi Liu, Gregory J. Zipfel, Umeshkumar Athiraman
Summary: Studies have shown that pre-treatment with sevoflurane or desflurane can alleviate large artery vasospasm and neurologic deficits caused by SAH. Further research is needed to confirm and understand the mechanisms of these protective effects in both preclinical and clinical settings, considering the frequent clinical use and safety profile of these anesthetics.
Article
Medicine, Research & Experimental
Deming Xu, Changbi Zhou, Juanyun Lin, Wenhui Cai, Wei Lin
Summary: This study found that sevoflurane promotes apoptosis of astrocytes, while miR-367-3p can reverse this effect and inhibit apoptosis. This suggests that miR-367-3p and BCL2L11 may be effective targets for the study of anesthesia.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Oncology
Yan-Qing Zhang, Rong Li, Shou-Yuan Tian, Jie-Ping Lv, Bao-Zhong Yang, Jin Wang, Li Wang, Xiao-Jie Bai, Chun-Hui Wang, Qiang Wang
Summary: This study found that significant injury had occurred at 3 hours of myocardial ischemia/reperfusion (MI/R), which could be alleviated by Sevoflurane preconditioning (SevoPre) through enhancing the affinity between adiponectin receptor 1 and caveolin-3, and reducing endoplasmic reticulum stress in cardiomyocytes.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Mihaela Roxana Popescu, Bogdan Pavel, Gheorghita Isvoranu, Laura Cristina Ceafalan, Anca Maria Panaitescu, Ruxandra Irina Sava, Adelina Vlad, Leon Zagrean
Summary: The interrupted sevoflurane administration protocol for preconditioning was found to effectively protect the myocardium against ischemia/reperfusion injury, reducing fibrosis area and apoptosis degree. This suggests potential benefits for patients with increased cardiovascular risk to reduce perioperative or periprocedural ischemia.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Wang-Xia Wang, Joe E. Springer, Kevin W. Hatton
Summary: Aneurysmal subarachnoid hemorrhage is a serious hemorrhagic stroke affecting nearly 30,000 patients annually in the United States, with a high mortality rate. Studies have shown that miRNAs play an important role in this disease and its complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Rongrong Wang, Hailian Wang, Yaan Liu, Di Chen, Yangfan Wang, Marcelo Rocha, Ashutosh P. Jadhav, Amanda Smith, Qing Ye, Yanqin Gao, Wenting Zhang
Summary: This study successfully optimized the embolic middle cerebral artery occlusion (eMCAO) mouse model by modifying catheters to produce suitable fibrin-rich embolus and monitoring cerebral blood flow through laser doppler flowmetry and 2D laser speckle contrast imaging. The results showed that longer embolus resulted in higher mortality and compensatory increase in MCA territory perfusion after eMCAO. Cortical blood flow monitoring showed that the size of peri-core area at 3 h displayed the best correlation with infarct volume and predicted functional outcome after eMCAO.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Medicine, Research & Experimental
Christopher A. Maroun, Gangcai Zhu, Carole Fakhry, Christine G. Gourin, Tanguy Y. Seiwert, Peter S. Vosler, Marietta Tan, Wayne Koch, David W. Eisele, Drew M. Pardoll, Rajarsi Mandal
Summary: Young patients with OCSCC aged 45 years and younger exhibit an attenuated immune response, potentially due to a lower frequency of immunogenic mutations. This finding may contribute to the pathogenesis of these tumors and aid in informing personalized immune-based therapeutic strategies for young patients with OCSCC.
Article
Endocrinology & Metabolism
Hongjian Pu, Xuan Zheng, Xiaoyan Jiang, Hongfeng Mu, Fei Xu, Wen Zhu, Qing Ye, Yunneng Jizhang, T. Kevin Hitchens, Yejie Shi, Xiaoming Hu, Rehana K. Leak, C. Edward Dixon, Michael V. L. Bennett, Jun Chen
Summary: IL-4 has been found to promote white matter integrity restoration and play a positive role in neurological recovery after TBI. However, IL-4 treatment did not reduce macroscopic brain lesions, but instead preserved white matter structure and function mainly through oligodendrogenesis.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Plant Sciences
Hanyi Hua, Wenyi Zhang, Jiaying Li, Jiayi Li, Chang Liu, Yahui Guo, Yuliang Cheng, Fuwei Pi, Yunfei Xie, Weirong Yao, Yanqin Gao, He Qian
Summary: The study aimed to investigate the neuroprotective effect of the aqueous extract of turnip on cerebral ischemia/reperfusion. The results showed that the extract can reduce cerebral infarct volume, improve behavioral deficits in MCAO/R mice, and exhibit antioxidant effects in HT-22 cells, while enhancing cell survival by activating the PI3K/Akt/mTOR pathway in OGD/R-injured cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Neurosciences
Peng Jin, Shuixiang Deng, Mi Tian, Cameron Lenahan, Pengju Wei, Yao Wang, Jiaying Tan, Huimei Wen, Feng Zhao, Yanqin Gao, Ye Gong
Summary: The study demonstrates that INT-777 treatment reduces neuroinflammation and microglial cell activation while improving cognitive impairment in experimental sepsis rats. These findings suggest that TGR5 has translational potential as a therapeutic target to enhance neurological outcomes in sepsis survivors.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Oncology
Anirudh Saraswathula, Christine G. Gourin, Peter S. Vosler
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Immunology
Ligen Shi, Zeyu Sun, Wei Su, Fei Xu, Di Xie, Qingxiu Zhang, Xuejiao Dai, Kartik Iyer, T. Kevin Hitchens, Lesley M. Foley, Sicheng Li, Donna B. Stolz, Kong Chen, Ying Ding, Angus W. Thomson, Rehana K. Leak, Jun Chen, Xiaoming Hu
Summary: The study found that after experimental stroke, Treg cells infiltrate the brain in mice and promote white matter repair and functional recovery. Treg cells enhance microglial reparative activity, promoting oligodendrogenesis and white matter repair. Increasing Treg cell numbers can improve white matter integrity and rescue neurological functions in the long term.
Article
Clinical Neurology
Di Xie, Huan Liu, Fei Xu, Wei Su, Qing Ye, Fang Yu, Taylor J. Austin, Jun Chen, Xiaoming Hu
Summary: This study demonstrates the potential immune regulatory mechanism of IL33/ST2/STAT6 signaling axis in modulating microglia/macrophage activity, improving white matter integrity, and restoring long-term neurological functions after stroke.
Article
Endocrinology & Metabolism
Hongjian Pu, Cheng Ma, Yongfang Zhao, Yangfan Wang, Wenting Zhang, Wanying Miao, Fang Yu, Xiaoming Hu, Yejie Shi, Rehana K. Leak, T. Kevin Hitchens, C. Edward Dixon, Michael Vl Bennett, Jun Chen
Summary: The administration of exogenous IL-4 nanoparticles after controlled cortical impact in mice improved cognitive functions and hippocampal integrity by inducing beneficial Mi/M phi responses.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Dilidaer Misilimu, Wei Li, Di Chen, Pengju Wei, Yichen Huang, Sicheng Li, John Grothusen, Yanqin Gao
Summary: Salvinorin A (SA) provides neuroprotective effects after ischemic stroke by modulating the immune response and maintaining blood-brain barrier integrity, reducing brain infarct volume and improving neurological function. Experimental findings show that SA treatment inhibits brain pro-inflammatory factors expression, decreases peripheral immune cell infiltration, and preserves blood-brain barrier integrity.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2022)
Article
Oncology
Virginia Drake, Elaine Bigelow, Carole Fakhry, Melina Windon, Lisa M. Rooper, Patrick Ha, Brett Miles, Christine Gourin, Rajarsi Mandal, Wojciech Mydlarz, Nyall London, Peter S. Vosler, Siddhartha Yavvari, Tanya Troy, Tim Waterboer, David W. Eisele, Gypsyamber D'Souza
Summary: The study revealed that HPV positivity and small tumor size are significant predictors of ER alpha positivity in HNSCC. Male sex, overweight/obesity, and being married/living with a partner may also be associated with ER alpha positivity.
Article
Otorhinolaryngology
Gangcai Zhu, Neha Amin, Matthew E. Herberg, Christopher A. Maroun, Hao Wang, Meytal Guller, Christine G. Gourin, Lisa M. Rooper, Peter S. Vosler, Marietta Tan, Gypsyamber D'Souza, Wayne M. Koch, David W. Eisele, Tanguy Y. Seiwert, Carole Fakhry, Drew M. Pardoll, Rajarsi Mandal
Summary: In this study, HPV-positive status was associated with improved survival in OPSCC patients but not in non-OP HNSCC or CESC patients. HPV-positive OPSCCs showed higher tumor immune infiltration and immunomodulatory receptor expression compared to HPV-negative OPSCCs.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2022)
Article
Neurosciences
Yongfang Zhao, Cheng Ma, Caixia Chen, Sicheng Li, Yangfan Wang, Tuo Yang, R. Anne Steler, Michael V. L. Bennett, C. Edward Dixon, Jun Chen, Yejie Shi
Summary: Traumatic brain injury (TBI) induces inflammation in the brain, resulting in secondary injury and hindered tissue repair. This study investigates the role of transcription factor STAT1 in inflammatory responses after TBI and suggests it as a potential therapeutic target. The inhibition of STAT1 reduces inflammation and improves outcomes in TBI.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
John F. Ryan, Deborah X. Xie, Danielle F. Eytan, Edward F. McCarthy, Rajarsi Mandal, Christine G. Gourin, Evan J. Lipson, Christian F. Meyer, Peter S. Vosler
Summary: Metastatic melanoma should be considered in the differential diagnosis of hyoid masses in patients with a history of melanoma. Hyoid resection is well-tolerated and provides diagnostic and therapeutic benefits for tumors metastatic to the hyoid bone.
CLINICAL CASE REPORTS
(2021)
Review
Clinical Neurology
Junxuan Lyu, Xiaoyan Jiang, Rehana K. Leak, Yejie Shi, Xiaoming Hu, Jun Chen
Summary: Microglia, as a crucial part of the brain's immune system, must adapt to changes in the microenvironment during brain disorders, although extreme pro-inflammatory states may hinder their ability to clear debris and promote tissue repair. Research on microglia has intensified recently, aiming to develop potential therapeutics for brain injuries and neurological diseases.
TRANSLATIONAL STROKE RESEARCH
(2021)