Article
Medicine, Research & Experimental
Steven Blake, Paul T. Bremer, Bin Zhou, Nikolai Petrovsky, Lauren C. Smith, Candy S. Hwang, Kim D. Janda
Summary: This study demonstrates the use of endogenously generated antibodies through active vaccination to reduce the effect of opioids, while exploring different adjuvants and storage conditions to improve opioid vaccine efficacy and shelf life. The results show promising advancements towards a clinically feasible opioid vaccine.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Hyeri Park, Mingliang Lin, Jian Zhou, Lisa M. Eubanks, Bin Zhou, Kim D. Janda
Summary: Opioid use disorders and overdose have become a major public health concern. U-47700, a new psychoactive substances opioid, is identified as a new threat in the drug supply due to its potency and abuse potential. The development of a U-47700 vaccine has shown promising results in rodents, generating antibodies that effectively mitigate drug-induced effects and prevent the drug from entering the brain.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Wen-Hung Wang, Aspiro Nayim Urbina, Chih-Yen Lin, Zih-Syuan Yang, Wanchai Assavalapsakul, Arunee Thitithanyanont, Po-Liang Lu, Yen-Hsu Chen, Sheng-Fan Wang
Summary: The development of dengue vaccines is crucial in preventing and controlling the global health threat caused by Dengue virus. Current approved vaccines have demonstrated low efficacy in certain populations, leading to ongoing investigation and development of novel strategies for dengue vaccines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Jonaid Ahmad Malik, Almas Hanif Mulla, Tahmeena Farooqi, Faheem Hyder Pottoo, Sirajudheen Anwar, Kannan R. R. Rengasamy
Summary: The article discusses the importance of developing vaccines against SARS-CoV-2, potential antigen targets, challenges encountered in vaccine development, and methods for overcoming these challenges.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Mohamad M. Alkadi, Abdullah Hamad, Hafedh Ghazouani, Mostafa Elshirbeny, Mohamed Y. Ali, Tarek Ghonimi, Rania Ibrahim, Essa Abuhelaiqa, Abdul Badi Abou-Samra, Hassan Al-Malki, Adeel A. Butt
Summary: This study aimed to determine the effectiveness of COVID-19 mRNA vaccines against confirmed SARS-CoV-2 infection in hemodialysis patients in Qatar. The results showed that receiving two doses of COVID-19 mRNA vaccines was 94.7% effective in preventing SARS-CoV-2 infection in the hemodialysis population.
Article
Biology
Rehab I. Moustafa, Ahmed H. I. Faraag, Reem El-Shenawy, Mona M. Agwa, Hassan Elsayed
Summary: COVID-19 has spread globally with varying severity. Computational analysis has been used to design a multiple-epitope vaccine against COVID-19. The study identified highly conserved regions of the virus spike protein and predicted antigenic parts to develop an effective vaccination strategy.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Immunology
Mahnoor Malik, Saifullah Khan, Asad Ullah, Muhammad Hassan, Mahboob ul Haq, Sajjad Ahmad, Alhanouf I. I. Al-Harbi, Samira Sanami, Syed Ainul Abideen, Muhammad Irfan, Muhammad Khurram
Summary: The ongoing antibiotic-resistance crisis is a global problem affecting public health. Urgent efforts are needed to design novel therapeutics against pathogenic bacterial species. Brucella melitensis, the etiological agent of brucellosis, is a major concern for both animal and human health, and the development of safer and effective vaccines is a priority.
Article
Infectious Diseases
Torsten Hansen, Ulf Titze, Nidhi Su Ann Kulamadayil-Heidenreich, Sabine Glombitza, Johannes Josef Tebbe, Christoph Roecken, Birte Schulz, Michael Weise, Ludwig Wilkens
Summary: An 86-year-old man who was previously asymptomatic received the COVID-19 vaccine and tested positive for SARS-CoV-2 postmortem, showing immunogenicity without sterile immunity. Despite the cause of death being acute bronchopneumonia and tubular failure, characteristic morphological features of COVID-19 were not observed.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
Isabel Neale, Mohammad Ali, Barbara Kronsteiner, Stephanie Longet, Priyanka Abraham, Alexandra S. Deeks, Anthony Brown, Shona C. Moore, Lizzie Stafford, Susan L. Dobson, Megan Plowright, Thomas A. H. Newman, Mary Y. Wu, Edward J. Carr, Rupert Beale, Ashley D. Otter, Susan Hopkins, Victoria Hall, Adriana Tomic, Rebecca P. Payne, Eleanor Barnes, Alex Richter, Christopher J. A. Duncan, Lance Turtle, Thushan I. de Silva, Miles Carroll, Teresa Lambe, Paul Klenerman, Susanna Dunachie, PITCH Consortium
Summary: This study examines the T cell and antibody immune responses associated with protection against Delta variant vaccine breakthrough infection. The findings suggest a protective role for CD4+ and CD8+ T cells, as well as antibodies, in preventing breakthrough infections. Additionally, cross-reactive T cells may also play a role in vaccine breakthrough.
Article
Clinical Neurology
Riccardo Nistri, Elena Barbuti, Virginia Rinaldi, Laura Tufano, Valeria Pozzilli, Antonio Ianniello, Fabiana Marinelli, Giovanna De Luca, Luca Prosperini, Valentina Tomassini, Carlo Pozzilli
Summary: This study described a temporal association between COVID-19 vaccination and MS relapses in 16 patients, with 3 patients experiencing their first episode post-vaccination and 13 already diagnosed with MS. All relapses occurred 3 days to 3 weeks after vaccination, with evidence of radiological activity on MRI in all patients. The nature of this association, whether causal or incidental, remains to be determined.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Rabab Batool, Mohammad Tahir Yousafzai, Sonia Qureshi, Miqdad Ali, Tahira Sadaf, Junaid Mehmood, Per Ashorn, Farah Naz Qamar
Summary: The study assessed the effectiveness of Typhoid Conjugate Vaccine against culture-confirmed S. Typhi in a peri-urban community in Karachi, Pakistan, finding an age and sex-adjusted vaccine effectiveness of 72%. Additionally, frequent consumption of meals prepared outside home was associated with the development of culture-confirmed typhoid.
Article
Biotechnology & Applied Microbiology
Susana Barbosa-Mendez, Maura Matus-Ortega, Ricardo Hernandez-Miramontes, Alberto Salazar-Juarez
Summary: Animal studies have shown the need for new opioid-vaccine formulations to generate robust immune responses. One strategy is to co-administer vaccines with different but complementary properties to produce a strong immune response. Two formulations, M-6-TT and M-3-TT, have been developed to recognize heroin and morphine and reduce the likelihood of drug relapse.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Microbiology
Shalini Iyer, Rajesh Yadav, Smriti Agarwal, Shashank Tripathi, Rachit Agarwal
Summary: Researchers have used bioengineering techniques to synthesize vaccines against respiratory viral pathogens. These vaccines enhance immunogenicity by controlling their physicochemical properties and have shown promising results in treating diseases such as COVID-19. The feasibility of using materials such as polymeric particles, liposomes, and virus-like particles for vaccine development has been explored.
CLINICAL MICROBIOLOGY REVIEWS
(2022)
Article
Biochemical Research Methods
Noah Powers, Casey Massena, Bethany Crouse, Mira Smith, Linda Hicks, Jay T. Evans, Shannon Miller, Marco Pravetoni, David Burkhart
Summary: Currently approved pharmacotherapies and overdose reversal agents are insufficient to combat the spread of opioid use disorders. This study demonstrates that coconjugation of a Toll-like receptor 7/8 agonist and a fentanyl-based hapten on a carrier protein significantly increases the production of high-affinity fentanyl-specific antibodies, providing enhanced protection against fentanyl challenges. These findings suggest that Toll-like receptor 7/8 agonist conjugates could be a promising strategy to combat opioid use disorders.
BIOCONJUGATE CHEMISTRY
(2023)
Review
Microbiology
Hasnat Tariq, Sannia Batool, Saaim Asif, Mohammad Ali, Bilal Haider Abbasi
Summary: Virus-like particles (VLPs) are nanostructures with various applications in therapeutics, immunization, and diagnostics. Recent advancements in biomedical engineering have made commercially available VLP-based vaccines widely used in combating infectious diseases. However, there are production and fabrication challenges that need to be addressed before VLP-based approaches can be widely used. This review provides insights into the characteristics, expression systems, and potential applicability of VLP-based vaccines, emphasizing their potential as ideal candidates to combat emerging virulent pathogens and induce immunity against them.
FRONTIERS IN MICROBIOLOGY
(2022)
