期刊
CLINICS IN PERINATOLOGY
卷 41, 期 1, 页码 47-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.clp.2013.09.007
关键词
Germinal matrix hemorrhage; Intraventricular hemorrhage; Astrocytes; Pericytes; Angiogenesis; Glucocorticoids; Premature infants; Indomethacin
资金
- NINDS NIH HHS [R01 NS071263] Funding Source: Medline
Intraventricular hemorrhage (IVH) is a major neurologic complication of prematurity. Pathogenesis of IVH is attributed to intrinsic fragility of germinal matrix vasculature and to the fluctuation in the cerebral blood flow. Germinal matrix exhibits rapid angiogenesis orchestrating formation of immature vessels. Prenatal glucocorticoid exposure remains the most effective means of preventing IVH. Therapies targeted to enhance the stability of the germinal matrix vasculature and minimize fluctuation in the cerebral blood flow might lead to more effective strategies in preventing IVH.
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