期刊
CLINICS IN LIVER DISEASE
卷 17, 期 4, 页码 609-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2013.07.008
关键词
Drug-induced liver injury; Antibiotics; Drug safety; Monitoring
Collectively, the various classes of antibiotics are a leading cause of drug-induced liver injury (DILI). However, acute antibiotic-associated DILI can be difficult to diagnose, as the course of therapy is usually brief, and other confounding factors are often present. In addition to the broad clinicopathologic spectrum of hepatotoxicity associated with the antimicrobials, the underlying infectious disease being treated may itself be associated with hepatic dysfunction and jaundice. This review provides summarized information on several classes of antimicrobial agents, highlighting new agents causing DILI and updating information on older agents.
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