期刊
CLINICS IN LIVER DISEASE
卷 17, 期 1, 页码 129-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2012.09.008
关键词
Cyclophilin; Cyclophilin inhibitors; Debio 025; NIM 811; SCY-635; Alisporivir; Non-interferon; Interferon-free
This article highlights a unique time in the history of Hepatitis C therapy. In the last few years new families of direct-acting antivirals have emerged, that block different viral proteins to interrupt viral replication, such as protease, NS5A inhibitors, and NS5B inhibitors. There are few host-targeted agents in development; currently cyclophilin inhibitors are the only host-targeted agents in advanced development. One of these new agents has now progressed to phase 3 clinical trials; in this review article their potential role as a future therapy to cure Hepatitis C is discussed.
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