Article
Gastroenterology & Hepatology
Shaodong Wei, Martin Iain Bahl, Simon Mark Dahl Baunwall, Jens Frederik Dahlerup, Christian Lodberg Hvas, Tine Rask Licht
Summary: This study aimed to explore the relationship between early changes in the intestinal microbiota and clinical outcomes following fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (CDI). The results showed that patients with sustained resolution after FMT had different microbial diversity, abundance, and gut microbiota dysbiosis compared to non-responders. Additionally, a constructed index based on clinically feasible methods successfully predicted treatment failure. It was also found that FMT had a more pronounced impact on the gut microbiota compared to antibiotic monotherapy. Therefore, early identification of microbial community structures after FMT is clinically valuable for predicting treatment response.
Article
Medicine, General & Internal
Pei-Chang Lee, Tien-En Chang, Yen-Po Wang, Kuei-Chuan Lee, Yi-Tsung Lin, Jen-Jie Chiou, Chi-Wei Huang, Ueng-Cheng Yang, Fen-Yau Li, Hui-Chun Huang, Chun-Ying Wu, Yi-Hsiang Huang, Ming-Chih Hou
Summary: This study aimed to investigate the efficacy of FMT for treating rCDI and its association with microbial changes. The research found that successful FMT was related to treatment outcomes and led to dynamic changes in fecal microbial composition.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Biotechnology & Applied Microbiology
Qiaomai Xu, Shumeng Zhang, Jiazheng Quan, Zhengjie Wu, Silan Gu, Yunbo Chen, Beiwen Zheng, Longxian Lv, Lanjuan Li
Summary: Vancomycin is the preferred treatment for CDI but has a high recurrence rate. FMT has emerged as a successful treatment for recurrent CDI. Our study suggests that FMT can better restore gut microbiota and metabolites, promoting the recovery of colonization resistance in mice compared to vancomycin.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Surgery
Liping Yang, Wenrui Li, Xianzhuo Zhang, Jinhui Tian, Xiaojia Ma, Lulu Han, Huaping Wei, Wenbo Meng
Summary: This study evaluated the efficacy of different types of fecal microbiota transplantation for the treatment of RCDAD. The results showed that fresh fecal bacteria were the best treatment option, while frozen and lyophilized fecal bacteria had similar effects. Fecal microbiota transplantation is a promising approach for clinical and commercial application.
FRONTIERS IN SURGERY
(2022)
Article
Immunology
Elizabeth S. Aby, Byron P. Vaughn, Eva A. Enns, Radha Rajasingham
Summary: This study assessed the cost-effectiveness of fecal microbiota transplantation (FMT) for first recurrent Clostridioides difficile infection (CDI). The findings indicate that FMT is a cost-effective treatment strategy for first recurrent CDI.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Raseen Tariq, Pritish. K. K. Tosh, Darrell. S. S. Pardi, Sahil Khanna
Summary: We conducted an updated study to examine the occurrence of urinary tract infections (UTIs) in patients with recurrent Clostridioides difficile infection (CDI) who underwent fecal microbiota transplantation (FMT) for CDI treatment. Our findings revealed a significant decrease in the incidence of UTIs following FMT compared to patients treated with antibiotics for CDI. Furthermore, there was a trend towards reduced antibiotic resistance in UTI-causing organisms after FMT.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Maribeth R. Nicholson, Suchitra K. Hourigan, Maire Conrad, Alka Goyal, Kyle Jensen, Judith Kelsen, Melissa Kennedy, Madison Weatherly, Stacy A. Kahn
Summary: The impact of the 2019 US FDA safety alert and the COVID-19 pandemic on the use of FMT in children has led to changes in practices for many pediatric gastroenterologists, with a majority of programs being halted as a result.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Paul Feuerstadt, Thomas J. Louie, Bret Lashner, Elaine E. L. Wang, Liyang Diao, Jessica A. Bryant, Matthew Sims, Colleen S. Kraft, Stuart H. Cohen, Charles S. Berenson, Louis Y. Korman, Christopher B. Ford, Kevin D. Litcofsky, Mary-Jane Lombardo, Jennifer R. Wortman, Henry Wu, John G. Aunins, Christopher W. J. McChalicher, Jonathan A. Winkler, Barbara H. McGovern, Michele Trucksis, Matthew R. Henn, Lisa von Moltke
Summary: SER-109 microbiome therapy is superior to placebo in reducing the risk of recurrent C. difficile infection, and has a similar safety profile as placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Colleen R. Kelly, Monika Fischer, Jessica R. Allegretti, Kerry LaPlante, David B. Stewart, Berkeley N. Limketkai, Neil H. Stollman
Summary: This article discusses the causes and management of Clostridioides difficile infection, as well as the official practice recommendations of the American College of Gastroenterology. The guidelines were evaluated using the Grading of Recommendations Assessment, Development, and Evaluation process.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Tanveer Singh, Prabhjot Bedi, Karandeep Bumrah, Darshan Gandhi, Tanureet Arora, Nikita Verma, Mary Schleicher, Manoj P. Rai, Rajat Garg, Beni Verma, Madhusudhan R. Sanaka
Summary: Fecal microbiota transplantation (FMT) is effective in the treatment of recurrent Clostridium difficile infection (CDI), but not significant in primary CDI.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Avnish Sandhu, Teena Chopra
Summary: Clostridioides difficile infection (CDI) is a major cause of hospital-acquired infections, with recurrent CDI (rCDI) posing a challenge in treatment. Fecal microbiota transplantation (FMT) is suggested for second episodes of rCDI, showing promise compared to traditional treatments like vancomycin or fidaxomicin. However, concerns over infections, adverse events, and new diagnoses remain, requiring further study for long-term safety and efficacy of FMT in clinical practice.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Aravind Gokul Tamilarasan, Thanuja Krishnananthan
Summary: In recent years, significant progress has been made in the study of the intestinal microbiota, with research moving beyond the laboratory and into clinical applications like fecal microbiota transplantation. Studies have shown interesting associations between imbalances in the intestinal microbiota and disease development, highlighting the potential therapeutic benefits of fecal microbiota transplantation in reversing this process.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jessica El Halabi, Nathan Palmer, Kathe Fox, Isaac Kohane, Maha R. Farhat
Summary: This study found that the cases of CDI in the US have been increasing over the past decade, with a changing treatment landscape due to the adoption of FMT. FMT is strongly associated with a decrease in CDI recurrence compared to anti-CDI antibiotics, with potential gastrointestinal complications and sepsis in the short term post FMT.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Olle Bjorkqvist, Ignacio Rangel, Lena Serrander, Cecilia Magnusson, Jonas Halfvarson, Torbjorn Noren, Malin Bergman-Jungestrom
Summary: The study found that FMT can increase the relative abundance of Faecalibacterium prausnitzii in patients with recurrent CDI, and this microbial shift persists for several months later. Further research is needed to determine whether Faecalibacterium prausnitzii actively contributes to the resolution of CDI.
Article
Gastroenterology & Hepatology
Christian Bestfater, Maria J. G. T. Vehreschild, Andreas Stallmach, Kester Tueffers, Andreas Erhardt, Thorsten Frank, Thomas Glueck, Felix Goeser, Gernot Sellge, Philipp Solbach, Herbert Eisenlohr, Martin Storr
Summary: Simultaneous bidirectional FMT showed superior primary cure rates compared to standard unidirectional approaches for recurrent Clostridioides difficile infection, highlighting the importance of treatment route in optimizing patient outcomes. Further prospective studies are needed to confirm these findings.
DIGESTIVE AND LIVER DISEASE
(2021)