Article
Cell Biology
Natalia Mussi, Whitney L. Stuard, Jose Marcos Sanches, Danielle M. Robertson
Summary: This study investigated the temporal effects of hyperglycemia on mitochondrial metabolism in corneal epithelial cells. Chronic hyperglycemia leads to mitochondrial dysfunction and reduces the ability of corneal epithelial cells to respond to subsequent stress.
Article
Cell Biology
Mohammad Shamsul Ola
Summary: This study examined ROS generation and antioxidant enzyme activities in diabetic rat retinas under various conditions, highlighting a potential decrease in ROS generation and glucose oxidation rate in the short-term hyperglycemic state. However, an increase in ROS formation was observed in diabetic retinas compared to controls in vivo, indicating non-mitochondrial sources may play a significant role in ROS generation in diabetic retinas.
Article
Biochemistry & Molecular Biology
Kelei Li, Yan Shi, Suqin Zhu, Xianfeng Shao, Huiying Li, Xiaotong Kuang, Shan Li, Xiao-fei Guo, Duo Li
Summary: The study demonstrated that high-dose fish oil has a protective effect against diabetes-induced NTD in mice, potentially by improving neuroepithelial cell apoptosis, and the mechanism may involve increasing the anti-apoptosis protein Bcl-2 independently of Pax3 and P53.
Article
Medicine, Research & Experimental
Zehuan Ding, Naomi McCauley, Yushu Qin, Lauren Lawless, Shaodong Guo, Lanjing Zhang, Ke K. Zhang, Linglin Xie
Summary: FoxO1 is an important transcriptional factor that regulates cell survival and metabolism. Its role in placental development during mid-late gestation is unclear. Placental FoxO1 expression is increased in gestational diabetes patients and pregnant mice with hyperglycemia. The study investigated the effects of FoxO1 haploinsufficiency on placental development under normal and hyperglycemic conditions. FoxO1 haploinsufficiency increased term placental weight under both conditions, with different mechanisms observed under normoglycemia and hyperglycemia.
LABORATORY INVESTIGATION
(2023)
Review
Immunology
Xiaoyi Guo, Hui Zeng, Mengjuan Li, Yu Xiao, Guojing Gu, Zhenhui Song, Xuehong Shuai, Jianhua Guo, Qingzhou Huang, Bo Zhou, Yuefeng Chu, Hanwei Jiao
Summary: Brucellosis is a prevalent zoonotic disease in more than 170 countries and regions worldwide, causing significant economic losses to the animal husbandry industry. Recent studies have revealed that Brucella's ability to cause chronic infection depends on its interactions with the host's immune system, apoptosis, and metabolic control. Brucella can suppress the host's immune response and regulate apoptosis to avoid detection by the host immune system. It also utilizes specific proteins to fine-tune its metabolism and enhance its survival and replication within host cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ali A. Alshamrani, Mohammed A. Al-Hamamah, Norah A. Albekairi, Mohamed S. M. Attia, Sheikh F. Ahmad, Mohammed A. Assiri, Mushtaq A. Ansari, Ahmed Nadeem, Saleh A. Bakheet, Wael A. Alanazi, Sabry M. Attia
Summary: This study investigated the effects of saxagliptin and dapagliflozin treatments on the gonads in a male mouse model of diabetes. The results showed that dapagliflozin restored testicular abnormalities induced by diabetes, while saxagliptin exacerbated the reduction in sperm count and motility. Both drugs restored the gonadal redox imbalances in diabetic mice.
Review
Ophthalmology
Sayon Roy, Dongjoon Kim
Summary: Vascular basement membrane (BM) thickening is recognized as a prominent histological lesion in diabetic microangiopathy and early structural abnormality in diabetic retinopathy (DR). Excess accumulation of BM components and hyperglycemia may contribute to BM thickening, resulting in cell death and vascular leakage in the diabetic retina. Preventing BM thickening through gene regulatory approaches is being explored as a potential therapeutic strategy for alleviating characteristic lesions associated with DR.
PROGRESS IN RETINAL AND EYE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Yiwei Wu, Haidong Zou
Summary: Diabetic retinopathy is a significant complication of diabetes that can result in blindness. Mitochondria, the energy-producing organelles, play a crucial role in cellular metabolism and function. Under high glucose conditions, metabolic changes and epigenetic alterations in mitochondria-related genes can cause mitochondrial dysfunction and apoptosis. Additionally, mitophagy and mitochondrial dynamics also adaptively change. These mechanisms are likely to contribute to the development and progression of diabetic retinopathy and provide insights for its prevention and treatment.
Article
Chemistry, Multidisciplinary
Dong-zhuo Wei, Dan Li, Dan-meng Zheng, Zhen-ni An, Xue-jiao Xing, Ding-wen Jiang, Xi-fan Mei, Chang Liu
Summary: The accumulation of lipids in the myocardium can lead to cardiac dysfunctions and chronic diseases such as diabetic cardiomyopathy (DCM). Curcumin, although effective in reducing lipid accumulation, has limitations due to poor water solubility and biocompatibility. Gold nanoclusters (AuNCs) were used to improve the efficiency of Cur, leading to the development of Curcumin-AuNCs (AuCur). AuCur was found to effectively reduce intracellular lipid accumulation, reactive oxygen species (ROS) levels, mitochondrial division, and apoptosis in high-fat-induced myocardial cell damage, by downregulating the expression of peroxisome proliferator-activated receptors-alpha subtype (PPAR alpha). The therapeutic effects of AuCur were hindered when the expression of PPAR alpha was enhanced, suggesting that AuCur treats the toxic effects of high lipid on cardiomyocytes by regulating PPAR alpha, offering a new approach for treating DCM.
FRONTIERS IN CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Dongyang Wang, Zhengjiang Zhao, Yiru Shi, Junyi Luo, Ting Chen, Qianyun Xi, Yongliang Zhang, Jiajie Sun
Summary: This study evaluated the role of heat-induced circEZH2 in regulating milk fat metabolism. It was found that circEZH2 affects the proliferation, apoptosis, and lipid metabolism of mammary gland epithelial cells. The study also verified the targeting relationship between circEZH2 and miR378b-LPL and miR378b-CD36. These findings provide further understanding of circRNAs' role in milk fat regulation and a theoretical basis for mitigating the effects of heat stress on milk production in dairy cows.
Article
Cell & Tissue Engineering
Yinzhong Ma, Lisha Wang, Shilun Yang, Dongyu Liu, Yi Zeng, Lilong Lin, Linhui Qiu, Jiahao Lu, Junlei Chang, Zhihuan Li
Summary: The study revealed that MSCs derived from different tissue origins have significantly different therapeutic efficacy in ameliorating glucose and lipid metabolic disorders in type II diabetes. UC-MSCs showed the best improvement in blood glucose and insulin levels, while PU-MSCs and AD-MSCs had weaker effects in comparison.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Qi Li, Qi Tan, Yangfei Ma, Zehui Gu, Suxian Chen
Summary: This study assessed the effects of myricetin on non-tumor cells and ovarian cancer cells, and found that myricetin can suppress the proliferation, migration, and invasion of ovarian cancer cells by activating the p38/Sapla signaling pathway to reduce oxidative stress and ROS levels.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Eun-Jung Kim, Ji-Eun Lee, Semi Yoon, Dong-Joon Lee, Han Ngoc Mai, Hiroko Ida-Yonemochi, Jonghoon Choi, Han-Sung Jung
Summary: The study found that hypoxic tooth germs could be restored in media containing 20% oxygen nanobubbles, and ONBs rescued the damaged tooth germs; additionally, under hypoxic conditions, the glucose uptake by tooth germs significantly increased, and this can be restored to normal levels through ONBs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Wang, JiuLing Deng, Liang Chen, Ke Ding, Yi Wang
Summary: This study investigated the impact of acute glucose fluctuation on diabetic rats' hippocampus, demonstrating that it promotes neuron apoptosis and inflammation more significantly compared to continuous hyperglycemia. The findings shed new light on the importance of monitoring and managing blood glucose levels in preventing and treating diabetes.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Review
Nutrition & Dietetics
Eva Venusova, Adriana Kolesarova, Pavel Horky, Petr Slama
Summary: Punicalagin, a polyphenol found in pomegranate peel, has antioxidant, anti-inflammatory, anti-tumor activities, as well as hepatoprotective and anti-atherosclerotic effects.
Article
Biochemistry & Molecular Biology
Lixue Cao, Peiyan Liu, Kirandeep Gill, E. A. Reece, Amrita K. Cheema, Zhiyong Zhao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2016)
Article
Multidisciplinary Sciences
Gyuyoup Kim, Lixue Cao, E. Albert Reece, Zhiyong Zhao
SCIENTIFIC REPORTS
(2017)
Meeting Abstract
Obstetrics & Gynecology
Yuanning Cao, Zhiyong Zhao, Richard L. Eckert, E. Albert Reece
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Meeting Abstract
Obstetrics & Gynecology
Yuanning Cao, Zhiyong Zhao, Richard L. Eckert, E. Albert Reece
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Article
Obstetrics & Gynecology
Yuanning Cao, Zhiyong Zhao, Richard L. Eckert, Albert Reece
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2011)
Meeting Abstract
Obstetrics & Gynecology
Yuanning Cao, Zhiyong Zhao, E. Albert Reece
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Meeting Abstract
Obstetrics & Gynecology
Yuanning Cao, Zhiyong Zhao, Richard L. Reece, E. Albert Reece
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2012)
Article
Oncology
Zhiyong Zhao
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
(2010)
Article
Oncology
Zhiyong Zhao
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
(2012)
Article
Oncology
Zhiyong Zhao
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
(2013)
Article
Oncology
Zhiyong Zhao
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
(2014)
Article
Obstetrics & Gynecology
Yuanning Cao, Zhiyong Zhao, Richard L. Eckert, E. Albert Reece
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2012)
Article
Obstetrics & Gynecology
Zhiyong Zhao, Richard L. Eckert, E. Albert Reece
REPRODUCTIVE SCIENCES
(2012)
Article
Multidisciplinary Sciences
Lixue Cao, Chengyu Tan, Fantong Meng, Peiyan Liu, E. Albert Reece, Zhiyong Zhao
SCIENTIFIC REPORTS
(2016)