Article
Immunology
Marwa Ben Ali Gannoun, Meriem Mehdi, Hedia Zitouni, Manel Boussabah, Ines Zouari, Ali Jlali, Wassim Y. Almawi
Summary: This study tested the link between altered PlGF and sFLT-1 levels, and their ratio with PE and PE-associated features, and found that increased sFlt-1 levels and sFlt-1/PlGF ratio are independent risk factors for PE.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Alexandros Velegrakis, Elisavet Kouvidi, Persefoni Fragkiadaki, Stavros Sifakis
Summary: Preeclampsia (PE) is a serious complication of pregnancy with a high incidence rate and causes significant maternal and fetal health risks. Studies have shown that differences in maternal serum levels of angiogenic factors can be used as biomarkers to predict the development of PE. Specifically, the sFlt-1/PlGF ratio has been identified as the optimal predictive tool. However, further research is needed to enhance its clinical applicability and provide universal guidelines for consistent management of PE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Acoustics
K. Lau, A. Wright, M. Sarno, N. A. Kametas, K. H. Nicolaides
Summary: This study compared the predictive performance of serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio with the competing-risks model utilizing maternal risk factors, mean arterial pressure (MAP), and ophthalmic artery peak systolic velocity (PSV) ratio for predicting pre-eclampsia (PE) delivery. The results showed that ophthalmic artery Doppler combined with maternal risk factors and blood pressure could potentially replace the measurement of PlGF and sFlt-1/PlGF ratio in predicting imminent PE.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Fabienne Trottmann, Luigi Raio, Sofia Amylidi-Mohr, Beatrice Mosimann, Araceli Jarquin Campos, Franz H. Messerli, Lorenz Risch, Marc U. Baumann
Summary: In this study, pregnant women with AFLP had significantly higher sFlt-1 levels compared to those with HELLP syndrome. PlGF levels were also higher in AFLP patients. The sFlt-1 cutoff value of 31,100 pg/mL showed a sensitivity and specificity of 100% in distinguishing between AFLP and HELLP syndrome.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Sama Hussein, Weina Ju, Stephanie Pizzella, Michael Flory, Chu Chu, Yong Wang, Nanbert Zhong
Summary: The study found that the expression of sFLT-1 and PlGF was reduced in preterm birth cases, while the sFLT-1/PlGF ratio was increased in EVs-EXs, indicating a potential biomarker for predicting preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Article
Biochemistry & Molecular Biology
Eun S. Park, Sehee Kim, Derek C. Yao, Jude P. J. Savarraj, Huimahn Alex Choi, Peng Roc Chen, Eunhee Kim
Summary: This study found that sENG induces microglia to produce angiogenic/inflammatory factors and may be involved in the development of vascular malformations in brain arteriovenous malformations (bAVMs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Nikolina Docheva, Gabriel Arenas, Kristin M. Nieman, Joana Lopes-Perdigao, Kiang-Teck J. Yeo, Sarosh Rana
Summary: Preeclampsia is a leading cause of maternal and neonatal mortality and morbidity worldwide. The disease is characterized by abnormal placentation, angiogenic imbalance, and endothelial dysfunction. Angiogenic factors such as soluble fms-like tyrosine kinase-1 increase before the onset of the disease, while placental growth factor concentrations decrease. Multiple studies have investigated the use of angiogenic factors for predicting preeclampsia and adverse pregnancy outcomes.
CLINICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Lei Liu, Rencheng Wang, Ran Xu, Yuening Chu, Weirong Gu
Summary: Preeclampsia is a severe complication of pregnancy, and soluble endoglin and sFlt-1 play important roles in its pathogenesis. Procyanidin B2 can reduce the secretion of soluble endoglin and sFlt-1, alleviating endothelial dysfunction and impaired angiogenesis.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Obstetrics & Gynecology
A. Iannaccone, B. Reisch, L. Mavarani, M. Darkwah Oppong, R. Kimmig, P. Mach, B. Schmidt, A. Koeninger, A. Gellhaus
Summary: The angiogenic factors sFlt-1 and PlGF are known to play a role in the detection of preeclampsia (PE). Recent data suggests that sEng may also contribute to the development of PE. This study found a correlation between sEng and sFlt-1/PlGF, and observed higher levels of these factors in cases of PE and HELLP syndrome. The study concludes that sEng performs similarly to sFlt-1/PlGF in detecting placental dysfunctions.
HYPERTENSION IN PREGNANCY
(2022)
Article
Acoustics
B. Porter, D. Maulik, S. Babbar, T. Schrufer-Poland, J. Allsworth, S. Q. Ye, D. P. Heruth, T. Lei
Summary: This study found a significant decrease in maternal plasma sNRP1 concentration in growth-restricted pregnancies, suggesting a possible role of sNRP1 in modulating fetal growth and its potential as a biomarker for FGR.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Thanaphan Thitivichienlert, Chadakarn Phaloprakarn, Thananda Trakarnvanich
Summary: Preeclampsia can lead to renal function impairment, but the currently available biomarkers do not provide predictive value for long-term renal function, blood pressure, and urine albumin/creatinine ratio in patients with preeclampsia.
ANNALS OF MEDICINE AND SURGERY
(2022)
Article
Multidisciplinary Sciences
Jaekyoung Lee, Jin Gon Bae, Yu Cheol Kim
Summary: This study evaluated the correlation between ophthalmologic factors and the sFlt-1/PlGF ratio in preeclampsia patients using OCT and OCT-A. The high sFlt-1/PlGF ratio group had lower choroidal thickness, and a significant negative association was found between sFlt-1 and central subfield CT.
Article
Obstetrics & Gynecology
Carlos Jose Molina Perez, Ana Graciela Nolasco Leanos, Reyes Ismael Carrillo Juarez, Maria Guadalupe Berumen Lechuga, Irma Isordia Salas, Alfredo Leanos Miranda
Summary: In gestational hypertension pregnancies, the concentration of serum sEng may be a better predictor to assess the risk of adverse maternal and perinatal outcomes and progression to preeclampsia.
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
(2021)
Article
Obstetrics & Gynecology
Lisa Antonia Lorenz-Meyer, Lisa Frank, Dorota Sroka, Andreas Busjahn, Wolfgang Henrich, Stefan Verlohren
Summary: This study examined the correlation between serum levels of sFlt-1 and PlGF and placental weight, and found a positive relationship in preeclampsia-associated pregnancy disorders. The study results indicate that the serum sFlt-1/PlGF ratio increases with severity of the disease.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Nandor Gabor Than, Roberto Romero, Daniel Gyorffy, Mate Posta, Gaurav Bhatti, Bogdan Done, Piya Chaemsaithong, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Dahiana M. Gallo, Mariachiara Bosco, Bomi Kim, Yeon Mee Kim, Tinnakorn Chaiworapongsa, Simona W. Rossi, Andras Szilagyi, Offer Erez, Adi L. Tarca, Zoltan Papp
Summary: This study identified different molecular subclasses of preeclampsia through longitudinal proteomic profiling, laying the foundation for the development of new diagnostic and personalized tools for prevention.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Neurosciences
Steven J. Korzeniewski
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)