期刊
CLINICS IN CHEST MEDICINE
卷 35, 期 4, 页码 811-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2014.08.016
关键词
Muscle weakness; Neuromuscular disease; Critical illness; ARDS; Intensive care unit; Early rehabilitation
资金
- Canadian Institutes of Health Research [MOP-106545]
- Ontario Thoracic Society [OTS2010/2011/2012]
- Physicians' Services Incorporated Foundation [PSI 09-21]
- Early Research Award from the Ministry of Research and Innovation of Ontario, Canada [ERA/MRI 2011]
Survivors of acute respiratory distress syndrome often sustain muscle wasting and functional impairment related to intensive care unit (ICU)-acquired weakness (ICUAW) and this disability may persist for years after ICU discharge. Early diagnosis in cooperative patients by physical examination is recommended to identify patients at risk for weaning failure and to minimize prolongation of risk factors for ICUAW. When possible, early rehabilitation in critically ill patients improves functional outcomes, likely by reducing disuse atrophy. Interventions designed to correct the functional impairment are lacking and further research to delineate the molecular pathways that give rise to ICUAW are needed.
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