Review
Allergy
Ritesh Agarwal, Valliappan Muthu, Inderpaul Singh Sehgal
Summary: Fungal sensitization is common in severe asthma, particularly in relation to Aspergillus fumigatus. The presence of A. fumigatus, its thermotolerant nature, smaller size of its conidia, and production of strong allergens contribute to the worsening of asthma control. Diagnosing fungal asthma is complex due to diverse clinical manifestations and lack of specific biomarkers. Diagnosis involves careful assessment of clinical history, immunological tests, and imaging. Treatment plans for fungal asthma vary based on severity and may include inhaled corticosteroids, bronchodilators, and antifungal therapy.
ALLERGOLOGY INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Elisa Lewington-Gower, Ley Chan, Anand Shah
Summary: Allergic bronchopulmonary aspergillosis is a pulmonary condition caused by hypersensitivity to Aspergillus sp. antigens, commonly found in patients with asthma or cystic fibrosis. Factors altering immune responses to the fungus contribute to chronic inflammation and fibrosis. Current treatments focus on reducing fungal burden and immune response, but many patients still suffer from recurrent exacerbations and lung damage. New therapies like antifungal agents and immunotherapies may offer better outcomes, but large-scale trials are needed.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Respiratory System
Wang Chun Kwok, James Chung Man Ho, Terence Chi Chun Tam, Mary Sau Man Ip, David Chi Leung Lam
Summary: The study revealed that patients with longer duration of non-cystic fibrosis bronchiectasis and those on proton pump inhibitors (PPIs) are more likely to have Pseudomonas aeruginosa colonization, leading to more extensive lung involvement and higher risks of exacerbation requiring hospitalization.
RESPIRATORY RESEARCH
(2021)
Article
Microbiology
Valentina Fainardi, Chiara Sodini, Michela Deolmi, Andrea Ciuni, Kaltra Skenderaj, Maria Bice Stabile, Cosimo Neglia, Elena Mariotti Zani, Cinzia Spaggiari, Nicola Sverzellati, Susanna Esposito, Giovanna Pisi
Summary: This study demonstrates the significant clinical impact of ABPA and Af sensitization on lung function and structural damage in CF patients, leading to more exacerbations and lower BMI.
Article
Medicine, General & Internal
Seung Jun Lee, Jong Hwan Jeong, Manbong Heo, Sunmi Ju, Jung-Wan Yoo, Yi Yeong Jeong, Jong Deog Lee
Summary: In patients with non-CF bronchiectasis, serum fibrinogen level is significantly associated with the severity and exacerbation of the disease, while adiponectin and angiopoietin-2 are not. High fibrinogen levels and Pseudomonas colonization are independent risk factors for future exacerbation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Chun-Yu Lin, Hung-Yu Huang, Meng-Heng Hsieh, Yueh-Fu Fang, Yu-Lun Lo, Shu-Min Lin, Yu-Tung Huang, Chih-Hsin Yeh, Chun-Hua Wang, Horng-Chyuan Lin
Summary: This study investigated the impact of nontuberculous mycobacteria (NTM) in non-cystic fibrosis bronchiectasis in Taiwan. The results showed that NTM were associated with frequent exacerbations and mortality in non-cystic fibrosis bronchiectasis patients, especially when coexisting with Pseudomonas aeruginosa and fungus. Additionally, the presence of single or multiple NTM isolates was an independent risk factor for mortality.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Infectious Diseases
Lauren C. Magee, Mariam Louis, Vaneeza Khan, Lavender Micalo, Nauman Chaudary
Summary: Cystic Fibrosis is a genetic disease caused by a mutation in the CFTR protein, leading to respiratory issues. CF patients are often colonized or infected with fungi, but diagnosing and treating fungal colonization and active infections in adult CF patients remains challenging. Limited data is available for eradication and treatment.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Medicine, General & Internal
Chun-Yu Lin, Meng-heng Hsieh, Yueh-Fu Fang, Chien-Wei Peng, Jia-Shiuan Ju, Yu-Lun Lo, Shu-Min Lin, Horng-Chyuan Lin
Summary: The BSI, FACED score, and DSP showed similar predictive power for mortality in non-CF bronchiectasis patients. However, DSP did not correlate with acute exacerbations and emergency department visits.
ANNALS OF MEDICINE
(2021)
Article
Medicine, General & Internal
Frederic Schlemmer, Agnes Hamzaoui, Sonia Zebachi, Aurelie Le Thuaut, Gilles Mangiapan, Isabelle Monnet, Amel Boudjema, Laurence Jabot, Bruno Housset, Sylvie Bastuji-Garin, Laurence Bassinet, Bernard Maitre
Summary: This study aimed to develop a clinical score to identify adult patients with bronchiectasis who are at higher risk of having cystic fibrosis or primary ciliary dyskinesia. Through diagnostic work-ups and logistic-regression analyses, specific factors associated with CF/PCD diagnosis were identified and a score was validated in a second cohort. The results showed that age at symptom onset, chronic ENT symptoms, digestive symptoms, and specific microbial isolates from sputum were significantly associated with CF or PCD diagnosis, with the developed score demonstrating good performance in identifying high-risk patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Salony Verma, Joseph L. Mathew, Pallab Ray
Summary: Cystic fibrosis (CF) bronchiectasis and non-CF bronchiectasis may have differences in microbial communities and antibiotic susceptibility patterns, studying these differences could help improve the management of both conditions.
SYSTEMATIC REVIEWS
(2021)
Article
Immunology
Patience Eschenhagen, Claudia Grehn, Carsten Schwarz
Summary: In this study, it was found that Af-specific IgG m3 could be a useful biomarker for acute ABPA and Af pneumonia in CF patients. The levels of Af-specific Gm3 were significantly higher in acute Af disease groups, with a calculated cut-off value of 78.05 mg/L to discriminate controls and patients with ABPA/pneumonia. Further studies with a larger multicenter cohort are needed to validate these results.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pediatrics
Kang Zhu, Yingkang Jin
Summary: SLC26A4 gene mutations are closely related to Pendred syndrome and bronchiectasis. The mutations disrupt the ion transport of chloride, iodide, and bicarbonate, leading to the acidification of airway surface fluid, compromised airway defense, and increased thickness of the fluid. This study describes the first case of co-occurrence of Pendred syndrome and non-cystic fibrosis bronchiectasis, highlighting the importance of considering the possibility of bronchiectasis in patients with SLC26A4 gene mutations.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Francesco Amati, Andrea Gramegna, Martina Contarini, Anna Stainer, Cristina Curcio, Stefano Aliberti, Angelo Guido Corsico, Francesco Blasi
Summary: This study investigated the prevalence of AAT deficiency in CF adults and found that AAT deficiency is not common among adults with CF.
Article
Pediatrics
Courtney Gushue, Mariah Eisner, Shasha Bai, Terri Johnson, Melissa Holtzlander, Karen McCoy, Shahid Sheikh
Summary: This study aimed to determine the impact of Elexacaftor-Tezacaftor-Ivacaftor (ETI) on clinical parameters and structural lung disease in people with cystic fibrosis (pwCF). The results showed that ETI therapy significantly improved ppFEV1 and BMI within 3 months and maintained the improvement throughout 1 year. Additionally, after 1 year of ETI therapy, there was a significant reduction in the presence of Pseudomonas aeruginosa and MRSA in pwCF's sputum. The chest CT scans did not worsen during 1 year of ETI therapy compared to baseline.
PEDIATRIC PULMONOLOGY
(2023)
Article
Obstetrics & Gynecology
Alena J. Haines, Peter G. Middleton
Summary: This chapter provides expert guidance on the interactions between pregnancy and different lung diseases, covering both physiological changes and specific diseases. Due to limited randomized control trials, the literature mainly consists of observational studies and case series. Other recently published guidelines may also be helpful for readers.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Oncology
Ioannis Gkiozos, Alexandra Kopitopoulou, Alexandros Kalkanis, Ioannis N. Vamvakaris, Marc A. Judson, Konstantinos N. Syrigos
JOURNAL OF THORACIC ONCOLOGY
(2018)
Editorial Material
Cardiac & Cardiovascular Systems
Marc A. Judson
RESPIRATORY MEDICINE
(2018)
Article
Cardiac & Cardiovascular Systems
Marc A. Judson, Brett M. Elicker, Thomas V. Colby, Sooyeon Kwon, Elizabeth de Windt, Spyros Chalkias, Claudia Prada, Karen Smirnakis, Priya Singhal
RESPIRATORY MEDICINE
(2019)
Article
Cardiac & Cardiovascular Systems
Marc A. Judson, Sara Preston, Kurt Hu, Robert Zhang, Stephanie Jou, Aakash Modi, Indrawattie Sukhu, Furqan Ilyas, Gavril Rosoklija, Recai Yucel
RESPIRATORY MEDICINE
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Marc A. Judson
RESPIRATORY MEDICINE
(2019)
Editorial Material
Medicine, General & Internal
M. A. Judson
JOURNAL OF INTERNAL MEDICINE
(2020)
Review
Critical Care Medicine
Rohit Gupta, Marc A. Judson, Robert P. Baughman
Summary: Advanced sarcoidosis is a form of sarcoidosis that poses a significant risk of organ function loss or death, with the lung being the most commonly affected organ. It can lead to complications such as pulmonary fibrosis and bronchiectasis. Although it affects a small proportion of patients, it is the leading cause of poor outcomes.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Brian Chu, Daniel M. O'Connor, Marilyn Wan, Ian Barnett, Haochang Shou, Marc Judson, Misha Rosenbach
Summary: The study utilized a smartphone app to investigate the impact of sarcoidosis on quality of life, physical activity, and medication usage. Findings showed that a significant number of participants experienced missed school or work days and financial impacts due to the disease.
JMIR MHEALTH AND UHEALTH
(2022)
Review
Medicine, General & Internal
Marc A. Judson
Summary: Sarcoidosis is a global idiopathic granulomatous disease that can affect any organ. Primary care physicians play a crucial role in assessing and managing sarcoidosis patients, as the symptoms are not specific. This article provides guidelines for the evaluation, treatment, and monitoring of sarcoidosis patients by primary care physicians.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Critical Care Medicine
Amit Chopra, Peter Doelken, Kurt Hu, John T. Huggins, Marc A. Judson
Summary: Pressure-dependent pneumothorax is a common occurrence after pleural drainage in patients with visceral pleural restriction, partial lung resection, or lobar atelectasis. It is important to recognize this type of pneumothorax as it does not require further intervention.
Editorial Material
Medicine, General & Internal
Marc A. Judson
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Ibrahim Khatim, Marc A. Judson, Artcar Htoo, Amit Chopra
Article
Respiratory System
Boris Shkolnik, Rou Sore, Muhammad Salick, Gowthami Kobbari, Sana Ghalib, Anoosh S. Parimi, Kenneth M. Fish, Robert Deluca, Recai Yucel, Marc A. Judson
Summary: This study retrospectively analyzed a cohort of patients with sarcoidosis and found that sACE is not reliable enough to be used as the sole determinant of treatment escalation.
Review
Medicine, General & Internal
Marc A. Judson
Summary: This manuscript provides a comprehensive review of the etiology, measurement, and treatment of common pulmonary symptoms associated with sarcoidosis. It emphasizes the importance of thorough assessment of symptoms, as they serve as useful tools in diagnosis and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Marc A. Judson, Jianwei Qiu, Camille L. Dumas, Jun Yang, Brion Sarachan, Jhimli Mitra
Summary: The AI/DL-based method using chest CT scan analysis shows promise in reliably distinguishing pulmonary sarcoidosis from negative lung cancer screening chest CT scans.
