Article
Pharmacology & Pharmacy
Robert J. Brosnan, Kimberly Ramos, Antonio Jose de Araujo Aguiar, Alessia Cenani, Heather K. Knych
Summary: The study found that mint extracts L-carvone and methyl salicylate can modulate the activity of ion channels and induce anesthesia in rats.
Review
Biochemistry & Molecular Biology
Andrea de Bartolomeis, Licia Vellucci, Mark C. Austin, Giuseppe De Simone, Annarita Barone
Summary: Schizophrenia is a neurodevelopmental disorder characterized by synaptic alterations and abnormal cortical-subcortical connections. Current treatment options mainly focus on dopamine D2 receptor occupancy, while glutamatergic abnormalities remain untargeted. In recent years, D-amino acids acting as NMDAR modulators have emerged as potential augmentation strategies for treatment-resistant schizophrenia (TRS), which affects around 30-40% of patients and is characterized by cognitive deficits and functional impairment. This systematic review explores the efficacy of D-amino acids and their impact on synaptic architecture, as well as compounds targeting D-amino acid oxidase and D-aspartate oxidase enzymes.
Review
Neurosciences
Alexey A. Murashko, Konstantin A. Pavlov, Olga V. Pavlova, Olga I. Gurina, Alexander Shmukler
Summary: The study found that different detection methods led to variations in the prevalence of NMDAR antibodies, with live cell-based assays potentially being more sensitive but with poorer specificity. Additionally, there may be links between AB-positive status and acute symptoms, and immunotherapy could be effective in AB-positive patients but further research is needed.
NEUROPSYCHOBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyu Ma, Chen Chen, Yaxin Lu, Ling Fang, Baohua Cao, Xueqiang Hu, Wei Qiu, Yaqing Shu
Summary: This study found that serum levels of GSDMD are elevated in patients with anti-NMDAR encephalitis and are associated with disease prognosis. After treatment, GSDMD levels decreased and clinical symptoms improved in patients, indicating a potential role of GSDMD in monitoring and predicting disease progression of anti-NMDAR encephalitis.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Xiao-Ting Huang, Jun-Xiao Yang, Zun Wang, Chen-Yu Zhang, Zi-Qiang Luo, Wei Liu, Si-Yuan Tang
Summary: The study highlights the role of the glutamate/NMDAR axis in obesity-related metabolic syndrome, with evidence showing that targeting NMDAR can be a promising therapeutic strategy. In obese mice, increased glutamate levels and blockade of NMDAR by Memantine improved insulin sensitivity and reduced hepatic steatosis, while NMDA treatment induced obesity and metabolic disorders. In vitro studies demonstrated that NMDAR activation promoted lipid accumulation and impaired fatty acid oxidation through PPARa signaling, suggesting a potential mechanism for NMDAR-mediated metabolic syndrome in obesity.
Review
Immunology
Fanshi Zhang, Mei Liu, Jinmei Tuo, Li Zhang, Jun Zhang, Changyin Yu, Zucai Xu
Summary: This article reviews how neuroinflammation mediates the development of levodopa-induced dyskinesia (LID) through the regulation of NMDA receptors. It also evaluates the potential of common anti-inflammatory drugs and NMDA receptor antagonists to mitigate the development of LID by regulating central neuroinflammation, providing a new theoretical basis for finding new therapeutic targets for LID.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Yingzhe Shao, Juan Du, Yajun Song, Yanfei Li, Lijun Jing, Zhe Gong, Ranran Duan, Yaobing Yao, Yanjie Jia, Shujie Jiao
Summary: This study aimed to explore the difference in coagulation function between healthy individuals and patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis and its relationship with disease severity. The results showed that serum D-dimer and neutrophil levels were independent predictors of disease severity in patients with first-attack anti-NMDAR encephalitis.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Tuo Ji, Zhi Huang, Yajun Lian, Chengze Wang, Qiaoman Zhang
Summary: This study investigated the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. The findings suggest that low FT3 levels upon admission may be associated with more severe disease progression and poorer outcomes in these patients. Monitoring FT3 levels could potentially aid in clinical prediction and decision-making in the treatment of anti-NMDAR encephalitis.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Oskar Stevens-Jones, Hana Mojzisova, Martin Elisak, Radu Constantinescu, Jitka Hanzalova, Markus Axelsson, David Krysl
Summary: This study aimed to discover clinically relevant biomarkers in NMDAR and LGI1 encephalitis using a proteomic approach. The results showed that SIRT2 may serve as a biomarker for NMDAR encephalitis and be associated with ovarian teratoma.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li
Summary: This article reviews the regulation of NMDAR and its possible mechanisms in epilepsy, discussing the role of NMDAR in onset, development, and treatment, and providing more evidence for future studies.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Bin Dong, Yang Yue, Han Dong, Yuehui Wang
Summary: NMDA receptors play a critical role in synaptic transmission and plasticity, and abnormalities in their expression and function can result in neurological disorders. NMDAR hypofunction is widely implicated in several disorders and is associated with disease progression and manifestation. Targeting NMDAR hypofunction could be a promising therapeutic approach.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Clinical Neurology
Stefan Macher, Tobias Zrzavy, Romana Hoeftberger, Patrick Altmann, Ekatarina Pataraia, Fritz Zimprich, Thomas Berger, Paulus Rommer
Summary: CSF-NfL levels in anti-NMDARE patients do not predict short-term outcomes, but are associated with ICU stay and extreme delta brushes. High CSF-NfL levels are associated with long-term outcomes, suggesting early aggressive immunotherapy to prevent neuroaxonal damage.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Behavioral Sciences
Sara de la Salle, Dhrasti Shah, Joelle Choueiry, Hayley Bowers, Judy McIntosh, Brooke Carroll, Vadim Ilivitsky, Verner Knott
Summary: This study demonstrated that ketamine administration affected P300 in healthy volunteers, with reductions in novelty processing P300 and negative correlations with dissociation symptoms. These findings suggest a potential role of NMDAR dysfunction in disrupted auditory attention in schizophrenia.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Clinical Neurology
Zhu Sha, Shi Jing, Gao Feng, Hongjun Hao, Xianzeng Liu
Summary: A case of neurosyphilis with positive anti-NMDAR antibody was reported in a 54-year-old man with acute memory deficits. The patient was initially diagnosed with acute ischemic stroke (AIS) and treated with rt-PA, but episodic memory and orientation disorder persisted. Positive results for syphilis and elevated leukocyte count and protein level in cerebrospinal fluid (CSF) were found. The patient was ultimately diagnosed with neurosyphilis with positive anti-NMDAR antibody and showed improvement with treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yan Zhang, Lili Cui, Weibi Chen, Huijin Huang, Gang Liu, Yingying Su, Johannes Boltze
Summary: This study aims to explore the clinical characteristics and outcome of SD in anti-NMDAR encephalitis. The results show that SD is rare in adult patients but is associated with severity and worse short-term outcomes. Early recognition of SD and timely treatment is crucial for shortening the recovery time.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nicolai Franzmeier, Jinyi Ren, Alexander Damm, Gemma Monte-Rubio, Merce Boada, Agustin Ruiz, Alfredo Ramirez, Frank Jessen, Emrah Duezel, Octavio Rodriguez Gomez, Tammie Benzinger, Alison Goate, Celeste M. Karch, Anne M. Fagan, Eric McDade, Katharina Buerger, Johannes Levin, Marco Duering, Martin Dichgans, Marc Suarez-Calvet, Christian Haass, Brian A. Gordon, Yen Ying Lim, Colin L. Masters, Daniel Janowitz, Cihan Catak, Steffen Wolfsgruber, Michael Wagner, Esther Milz, Sonia Moreno-Grau, Stefan Teipel, Michel J. Grothe, Ingo Kilimann, Martin Rossor, Nick Fox, Christoph Laske, Jasmeer Chhatwal, Peter Falkai, Robert Perneczky, Jae-Hong Lee, Annika Spottke, Henning Boecker, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Peter Nestor, Oliver Peters, Manuel Fuentes, Felix Menne, Josef Priller, Eike J. Spruth, Christiana Franke, Anja Schneider, Christine Westerteicher, Oliver Speck, Jens Wiltfang, Claudia Bartels, Miguel angel Araque Caballero, Coraline Metzger, Daniel Bittner, Stephen Salloway, Adrian Danek, Jason Hassenstab, Igor Yakushev, Peter R. Schofield, John C. Morris, Randall J. Bateman, Michael Ewers
Summary: The BDNFVal66Met mutation in Alzheimer's disease is associated with a greater impact on cognitive impairment, particularly through a decrease in hippocampal-medial-frontal connectivity. This finding was consistent across ADAD patients and elderly individuals with sporadically occurring Aβ, and was linked to lower global cognitive performance.
MOLECULAR PSYCHIATRY
(2021)
Article
Psychiatry
Elias Wagner, William G. Honer, Iris E. Sommer, Sanne Koops, Daniel M. Blumberger, Zafiris J. Daskalakis, Jozarni J. Dlabac-De Lange, Leonie Bais, Henderikus Knegtering, Andre Aleman, Tomas Novak, Monika Klirova, Christina Slotema, Jerome Brunelin, Emmanuel Poulet, Milenko Kujovic, Joachim Cordes, Thomas Wobrock, Dan Siskind, Peter Falkai, Thomas Schneider-Axmann, Alkomiet Hasan
Summary: The study found that rTMS did not show a beneficial effect over sham treatment for patients treated with clozapine, but there may be a possible beneficial effect for improving persistent auditory hallucinations.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda AdIi, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Bernhard T. Baune
Summary: The study found a significant association between polygenic susceptibility to major depression and response to lithium treatment in patients with bipolar disorder. Patients with a lower polygenic load for depression were more likely to respond well to lithium. This highlights the genetic contribution to lithium response in bipolar disorder and supports the concept of a lithium-responsive biotype.
MOLECULAR PSYCHIATRY
(2021)
Article
Clinical Neurology
Reinhard Steinberg, Peter Falkai
Summary: In 1886, King Ludwig II of Bavaria was diagnosed with paranoia by Bernhard von Gudden and three other expert psychiatrists, leading to his removal from power. The psychiatrists based their diagnosis on sworn eyewitness accounts, general knowledge about Ludwig's behavior, and his extravagance, unusual beliefs, and hallucinations. Despite not evaluating Ludwig in detail, the experts' diagnosis was considered correct in the context of the psychiatric knowledge and societal philosophy of the time.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Isabel Maurus, Alkomiet Hasan, Andrea Schmitt, Astrid Roeh, Daniel Keeser, Berend Malchow, Thomas Schneider-Axmann, Martin Hellmich, Sabine Schmied, Moritz Lembeck, Katriona Keller-Varady, Irina Papazova, Dusan Hirjak, Cristina E. Topor, Henrik Walter, Sebastian Mohnke, Bob O. Vogel, Wolfgang Woelwer, Frank Schneider, Karsten Henkel, Andreas Meyer-Lindenberg, Peter Falkai
Summary: Patients with schizophrenia often have negative symptoms and cognitive deficits, leading to poor outcomes. Aerobic endurance training is believed to have positive effects on various aspects of patients' health. This study aims to investigate the benefits of endurance training on the mental and physical health of patients with schizophrenia.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Article
Psychiatry
Daniel Martins-de-Souza, Paul C. Guest, Guilherme Reis-de-Oliveira, Andrea Schmitt, Peter Falkai, Christoph W. Turck
Summary: The study characterized the myelin proteome in schizophrenia patients and healthy controls, identifying new proteins associated with myelin. Changes in levels of proteins related to glial cell differentiation, metabolism/energy, synaptic vesicle function and neurodegeneration were observed between the two groups. The findings suggest disruptions in synaptic activity in schizophrenia, with implications for potential drug targets in psychiatric and neurodegenerative disorders.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2021)
Article
Substance Abuse
Daniela Reichl, Niklas Enewoldsen, Kiona K. Weisel, Sebastian Saur, Lukas Fuhrmann, Catharina Lang, Matthias Berking, Mathias Zink, Andreas Ahnert, Peter Falkai, Thomas Kraus, Thomas Hillemacher, Felix-N Muller, Stephan Lins, Dominikus Bonsch, Linda Kerkemeyer, Sabine Steins-Loeber
Summary: There is evidence that craving mediates the relationship between Impulsive Personality Traits (IPTs) and relapse during the treatment of an Alcohol Use Disorder (AUD). Lower emotion regulation competencies were found to mediate the relationship between attentional as well as non-planning IPTs and craving. These findings contribute to a deeper understanding of the underlying processes and may inform tailored interventions for AUD treatment.
SUBSTANCE USE & MISUSE
(2022)
Article
Cell Biology
Florian J. Raabe, Marius Stephan, Jan Benedikt Waldeck, Verena Huber, Damianos Demetriou, Nirmal Kannaiyan, Sabrina Galinski, Laura V. Glaser, Michael C. Wehr, Michael J. Ziller, Andrea Schmitt, Peter Falkai, Moritz J. Rossner
Summary: Compared with SOX10 alone, the combination of SON increases the number of induced oligodendrocytes (iOLs) and enhances their complexity and myelin-marker gene expression levels. RNA velocity analysis shows that SOX10 generates OPCs that are apparently more immature than those generated by SON, with distinct molecular properties.
Article
Hospitality, Leisure, Sport & Tourism
A. Lassner, I Papazova, B. Pross, J. Scherr, J. Schoenfeld, M. Halle, B. Haller, P. Falkai, A. Hasan, A. Roeh
Summary: Endurance sports carry a higher risk of exercise addiction compared to other physical activities. This study evaluated the risk of exercise addiction among amateur marathon runners and investigated its relationship with fitness measures, affect, and general level of functioning.
INTERNATIONAL JOURNAL OF SPORT AND EXERCISE PSYCHOLOGY
(2022)
Article
Cell Biology
Andrea Schmitt, Laura Tatsch, Alisa Vollhardt, Thomas Schneider-Axmann, Florian J. Raabe, Lukas Roell, Helmut Heinsen, Patrick R. Hof, Peter Falkai, Christoph Schmitz
Summary: This study utilized stereology to investigate the numbers and densities of different cell types in the brains of individuals with schizophrenia. The results indicated a reduction in oligodendrocytes in the CA4 region in schizophrenia patients, which was absent in the control group.
Editorial Material
Neurosciences
David Popovic, Peter Falkai
BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Andrea Schmitt, Peter Falkai, Sergi Papiol
Summary: Schizophrenia is a neurodevelopmental disorder influenced by genetic and environmental risk factors. The interaction between these factors during prenatal, perinatal, and adolescence periods contribute to the onset of symptoms in early adulthood. These factors lead to disturbances in brain connectivity and molecular/cellular abnormalities.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Editorial Material
Psychiatry
Andrea Fiorillo, Antonio Ventriglio, Gaia Sampogna, Peter Falkai
INTERNATIONAL REVIEW OF PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Johann Steiner, Andrea Schmitt, Peter Falkai
SCHIZOPHRENIA BULLETIN
(2023)