Article
Immunology
Dulat Bekbolsynov, Beata Mierzejewska, Sadik Khuder, Obinna Ekwenna, Michael Rees, Robert C. Green, Stanislaw M. Stepkowski
Summary: The study used physicochemical immunogenicity of donor/recipient HLAs to select weakly immunogenic kidney transplants for Black patients, leading to an increase in the number of suitable donors for Black recipients while still providing good options for non-Black recipients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
L. Ebony Boulware, Debra L. Sudan, Tara S. Strigo, Patti L. Ephraim, Clemontina A. Davenport, Jane F. Pendergast, Iris Pounds, Jennie A. Riley, Margaret Falkovic, Aviel Alkon, Felicia Hill-Briggs, Ashley N. Cabacungan, Tyler M. Barrett, Dinushika Mohottige, Lisa McElroy, Clarissa J. Diamantidis, Matthew J. Ellis
Summary: The study found limited effectiveness of a transplant social worker intervention and financial assistance in activating potential donors among African Americans on the transplant waiting list.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Genetics & Heredity
Farid Rajabli, Gary W. Beecham, Hugh C. Hendrie, Olusegun Baiyewu, Adesola Ogunniyi, Sujuan Gao, Nicholas A. Kushch, Marina Lipkin-Vasquez, Kara L. Hamilton-Nelson, Juan I. Young, Derek M. Dykxhoorn, Karen Nuytemans, Brian W. Kunkle, Liyong Wang, Fulai Jin, Xiaoxiao Liu, Briseida E. Feliciano-Astacio, Gerard D. Schellenberg, Clifton L. Dalgard, Anthony J. Griswold, Goldie S. Byrd, Christiane Reitz, Michael L. Cuccaro, Jonathan L. Haines, Margaret A. Pericak-Vance, Jeffery M. Vance
Summary: African descent populations have a lower risk of developing Alzheimer's disease compared to other populations due to a specific genetic variant. The study identified a new locus that reduces the risk effect of ApoE epsilon 4 on Alzheimer's disease in African ancestry populations.
Article
Medicine, General & Internal
Hassan Ashktorab, Adeleye Folake, Antonio Pizuorno, Gholamreza Oskrochi, Philip Oppong-Twene, Nuri Tamanna, Maryam Mehdipour Dalivand, Lisa N. Umeh, Esther S. Moon, Abdoul Madjid Kone, Abigail Banson, Cassandra Federman, Edward Ramos, Eyitope Ola Awoyemi, Boubini Jones Wonni, Eric Otto, Guttu Maskalo, Alexandra Ogando Velez, Sheldon Rankine, Camelita Thrift, Chiamaka Ekwunazu, Derek Scholes, Lakshmi Gayathri Chirumamilla, Mohd Elmugtaba Ibrahim, Brianna Mitchell, Jillian Ross, Julencia Curtis, Rachel Kim, Chandler Gilliard, Joseph Mathew, Adeyinka Laiyemo, Angesum Kibreab, Edward Lee, Zaki Sherif, Babak Shokrani, Farshad Aduli, Hassan Brim
Summary: The study revealed a higher mortality rate among African Americans in COVID-19, with age and shortness of breath being key determinants. Elevated liver enzymes, ferritin, procalcitonin, and C-reactive protein were associated with poor prognosis, but gastrointestinal symptoms did not affect the outcome.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Urology & Nephrology
Lucy A. Plumb, Manish D. Sinha, Anna Casula, Carol D. Inward, Stephen D. Marks, Fergus J. Caskey, Yoav Ben-Shlomo
Summary: The study found that socioeconomic deprivation and geographic location are not associated with late presentation in children in the UK. While geographic location was not independently associated with preemptive transplantation, children from more affluent areas were more likely to receive a preemptive transplant.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Dwight D. Harris, Aaron Fleishman, Martha Pavlakis, Martin R. Pollak, Prabhakar K. Baliga, Vinayak Rohan, Liise K. Kayler, James R. Rodrigue
Summary: This study investigated the attitudes of African Americans towards ApoL1 testing. The results showed that most participants believed transplant programs should offer ApoL1 testing and supported potential kidney donors having the autonomy to make donation decisions or participate in shared decision-making. Furthermore, the majority of transplant candidates expressed reluctance to accept kidneys from individuals with the high-risk genotype.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Urology & Nephrology
Patrick Ahearn, Kirsten L. Johansen, Jane C. Tan, Charles E. McCulloch, Barbara A. Grimes, Elaine Ku
Summary: Women with kidney failure have lower access to kidney transplantation compared with men, especially notable among patients with kidney failure attributed to diabetes, while sex disparities in access to either the waitlist or transplantation were not observed in kidney failure secondary to cystic disease.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Aaron M. Delman, Kevin M. Turner, Latifa S. Silski, Ralph C. Quillin, Martha Estrada, Kristina Lemon, Madison C. Cuffy, Shimul A. Shah
Summary: This study developed a scalable metric to evaluate the performance of kidney transplant centers in providing equitable access to kidney transplant for minority patients. The results showed significant variations among transplant centers, with high KTEI centers performing more kidney transplants for minority and low socioeconomic status patients and having improved patient survival.
Article
Urology & Nephrology
Patrizia Natale, Manfred Hecking, Amelie Kurnikowski, Nicole Scholes-Robertson, Juan Jesus Carrero, Germaine Wong, Giovanni Strippoli, Allison Jaure
Summary: There is a gender disparity in access to kidney transplantation, with women being 20% less likely to receive a transplant compared to men across different backgrounds and socioeconomics. Nephrologists perceive that this disparity is exacerbated by gender norms, stigma, prejudice, and educational and financial disadvantages faced by women.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Sunjae Bae, Morgan Johnson, Allan B. Massie, Xun Luo, Carlton Haywood, Sophie M. Lanzkron, Morgan E. Grams, Dorry L. Segev, Tanjala S. Purnell
Summary: Patients with sickle cell disease-associated kidney failure have similar decreases in mortality associated with kidney transplantation compared with other kidney failure etiologies. However, this population is less likely to receive transplantation, even after waitlist registration.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Medicine, General & Internal
Jihan Sleiman, Gervasio Soler Pujol, Erika Montanez, Veronica Roatta, Gustavo Laham
Summary: Sex and gender are often used interchangeably, but gender is a more fluid and dynamic concept that encompasses psychosocial and cultural aspects. Inequality in medicine, particularly gender inequality, has been overlooked for a long time and is now a pressing concern. This study investigates gender equality in patients with chronic kidney disease (CKD) and highlights disparities in access to different treatment modalities.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Harpreet Kaur, Dana C. Crawford, Jingjing Liang, Penelope Benchek, Xiaofeng Zhu, Asha R. Kallianpur, William S. Bush
Summary: This study found that European-descent and African American populations share some genetic loci associated with blood pressure traits and hypertension. However, there are differences in OR and beta-coefficient estimates, and some associations are age-dependent. Further genetic studies of hypertension in African Americans are needed to identify new loci associated with hypertension and blood pressure traits in this population.
Article
Endocrinology & Metabolism
Kimberly Jacob Arriola, Tene T. Lewis, Bradley Pearce, Jason Cobb, Brianna Weldon, Madelyn I. Zapata Valentin, Janice Lea, Viola Vaccarino
Summary: The study found that acute race-related stress may be associated with autonomic arousal and inflammatory response among African American patients with chronic kidney disease, highlighting its potential impact in racial disparities.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Urology & Nephrology
Xiaomeng Chen, Nadia M. Chu, Pragyashree Sharma Basyal, Wasurut Vihokrut, Deidra Crews, Daniel C. Brennan, Sarah R. Andrews, Tracy D. Vannorsdall, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Depressive symptoms are common in kidney failure patients even without a clinical diagnosis of depression, and they may hinder the completion of kidney transplant evaluation. The severity of depressive symptoms is associated with age, with older candidates being less likely to report such symptoms. Regardless of age, candidates who report depressive symptoms have a lower chance of being listed for kidney transplant.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Surgery
Vinayak S. Rohan, Nicole Pilch, Deborah Cassidy, John McGillicuddy, Jared White, Angello Lin, Satish N. Nadig, David J. Taber, Derek Dubay, Prabhakar K. Baliga
Summary: This study describes the use of a virtual pretransplantation evaluation platform to facilitate kidney transplant waitlisting during the early peak of the COVID-19 pandemic. Between April and September 2020, 1,258 patients completed an evaluation, with 113 being placed on the waitlist. More evaluations were completed within the virtual platform compared to 2019, indicating the platform's value in maintaining access to kidney transplantation during the pandemic.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
Article
Surgery
Kevin Ferrari, Alice Aarnink, Carole Ayav, Luc Frimat, Cecile Couchoud, Benoit Audry, Corinne Antoine, Sophie Girerd
Summary: Continuation of immunosuppressive therapy after kidney allograft failure is associated with less change in HLA-sensitization and does not increase patient mortality.
CLINICAL TRANSPLANTATION
(2024)
Article
Surgery
Sandeep Sainathan, John Ryan, Leonardo Mullinari, Pablo Sanchez
Summary: Patients undergoing lung transplantation for pulmonary venous-occlusive disease (PVOD) had better initial survival compared to those with primary pulmonary hypertension (PPHTN), but this advantage disappeared after 1 year. The use of donation after circulatory death donors was associated with lower short-term survival rates.
CLINICAL TRANSPLANTATION
(2024)