Article
Medicine, General & Internal
Mahdieh Sadeghi, Zakaria Zakariaei, Mostafa Soleymani, Abdollah Malakian
Summary: This article describes a case of a 2-year-old infant who developed cholinergic syndrome after accidental ingestion of donepezil tablets and was discharged in stable condition.
CLINICAL CASE REPORTS
(2022)
Article
Emergency Medicine
Priya Srihari, Alicia B. Minns, Han T. Gao, Allyson A. Kreshak
Summary: Hydroxychloroquine overdose is rare but potentially lethal, characterized by central nervous system and cardiac toxicity, as well as hypokalemia. This case report of a 14-year-old girl who ingested 10 g of hydroxychloroquine and survived provides additional information for establishing the toxic and lethal doses of hydroxychloroquine ingestion.
JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Emergency Medicine
Bart Hammig, Ches Jones, Sydney Haldeman
Summary: The legalization of marijuana products has led to an increase in emergency department visits by children due to unintentional ingestion. Most poisonings involve edible marijuana products and the majority of patients require hospital admission. Therefore, it is necessary to implement legislation or company policies to limit the appeal of these products to toddlers and rely on parents and caregivers for safe storage, as well as strengthen public health education.
JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Oncology
Dongqin Wu, Di Gao, Haitao Yu, Guilin Pi, Rui Xiong, Huiyang Lei, Xin Wang, Enjie Liu, Jinwang Ye, Huilin Yu, Yang Gao, Ting He, Tao Jiang, Fei Sun, Jingfen Su, Guoda Song, Wenju Peng, Ying Yang, Jian-Zhi Wang
Summary: The study found a causal relationship between tau accumulation and cholinergic neuron impairment in Alzheimer's disease. Overexpression of hTau protein in the medial septum of mice resulted in spatial memory impairment and reduction of cholinergic neurons over time. Treatment with donepezil showed improvement in spatial memory deficits induced by hTau accumulation, potentially suggesting a new disease-modifying effect.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Mihaela Corlade-Andrei, Paul Lucian Nedelea, Theodora Daniela Ionescu, Tamara Solange Rosu, Alexandra Hauta, Gabriela Raluca Grigorasi, Teofil Blaga, Ivona Sova, Ovidiu Tudor Popa, Diana Cimpoesu
Summary: This study aimed to review risk factors leading to poisoning in children. A retrospective review of all pediatric poisoning cases was conducted at the Children's emergency department of St Mary Hospital over a two-year period. The results showed that the highest incidence of poisoning was in the 1-3 years and 12-18 years age groups. The distribution of voluntary versus unintentional poisonings was relatively balanced, with ingestion being the most common route of exposure to toxic substances.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Food Science & Technology
Nikolaus Schreiber, Gerald Hackl, Alexander C. Reisinger, Ines Zollner-Schwetz, Kathrin Eller, Claudia Schlagenhaufen, Ariane Pietzka, Christoph Czerwenka, Timo D. Stark, Markus Kranzler, Peter Fickert, Philipp Eller, Monika Ehling-Schulz
Summary: This study reports cases of food poisoning caused by Bacillus cereus contamination in fried rice balls. The patients showed a range of symptoms, from vomiting and diarrhea to life-threatening acute liver failure and acute tubular necrosis of the kidney. The report highlights the biological hazard of contaminated rice meals and the necessity of a multidisciplinary approach in such cases.
Article
Environmental Sciences
Karina Sommerfeld-Klatta, Wiktoria Jiers, Magdalena Lukasik-Glebocka, Artur Tezyk, Klaudia Dolinska-Kaczmarek, Kamil Walter, Pawel Swiderski, Szymon Rzepczyk, Barbara Zielinska-Psuja, Czeslaw Zaba
Summary: In recent years, the administration of fentanyl in transdermal drug delivery systems for chronic pain treatment has increased significantly. This study presents three cases of fentanyl poisonings, including two deaths, due to abuse of transdermal fentanyl delivery systems. The various routes of administration and toxic effects highlight the potential dangers of fentanyl in transdermal drug delivery systems.
Review
Neurosciences
Marina Katsari, Georgia Angelopoulou, Nikolaos Laskaris, Constantin Potagas, Dimitrios Kasselimis
Summary: Despite the lack of studies on pharmacotherapy in aphasia, there is evidence suggesting that pharmaceutical agents could be a promising treatment option for language disorders. Cholinergic drugs have shown meaningful results in treating chronic aphasic deficits. This review provides an overview of existing literature on the common neuroanatomical substrate of cholinergic pathways and language-related brain areas, aiming to interpret the efficacy of cholinergic pharmacotherapy interventions in post-stroke aphasia.
Article
Toxicology
A. K. Pannu, A. Bhalla, R. I. Vishnu, D. P. Dhibar, N. Sharma, R. Vijayvergiya
Summary: Despite being the most common cause of acute poisoning in low- and middle-income countries, data on organophosphate induced delayed neuropathy (OPIDN) are limited. This study aimed to investigate the long-term effects of organophosphates on the peripheral nervous system following an acute cholinergic crisis in adults. The results showed that peripheral nerve involvement is not uncommon after recovery from a cholinergic crisis in chlorpyrifos self-poisoning, with some patients experiencing debilitating symptoms. Detection of subclinical injury on nerve conduction studies may offer an early opportunity to prevent severe symptomatic neuropathy.
CLINICAL TOXICOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Leah Utyasheva, Dilli Sharma, Rakesh Ghimire, Ayanthi Karunarathne, Gael Robertson, Michael Eddleston
Summary: Nepal recorded 5754 suicides in 2018-19, with over 24% of these suicides by poisoning, mainly from ingestion of highly concentrated agricultural pesticides. Despite a ban on methyl-parathion in 2006, it remains the key pesticide responsible for pesticide self-poisoning in Nepal. The country has seen a significant increase in suicide rates since 1980, with fatal pesticide self-poisoning increasing by 13-fold.
Article
Behavioral Sciences
Balazs Knakker, Vilmos Olah, Attila Trunk, Balazs Lendvai, Gyorgy Levay, Istvan Hernadi
Summary: The study found that the acetylcholinesterase inhibitor donepezil partially rescued the scopolamine-induced impairments of visual working memory (VWM) performance, while scopolamine-induced impairments of VWM maintenance are delay-dependent, especially affecting the time range of 15 to 33 seconds.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Physiology
Aaron J. Polichnowski, Geoffrey A. Williamson, Tesha E. Blair, Donald B. Hoover
Summary: Donepezil induces significant bradycardia and hypothermia in conscious mice through activation of muscarinic receptors, while also increasing arterial pressure. The autonomic and cholinergic pathways responsible for these effects require further elucidation.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Article
Environmental Sciences
Ioana-Cezara Caba, Violeta Streanga, Mona-Elisabeta Dobrin, Cristina Jitareanu, Alexandra Jitareanu, Bianca-Stefania Profire, Maria Apotrosoaei, Alin-Viorel Focsa, Bogdan Caba, Luminita Agoroaei
Summary: Pesticide poisoning in pediatric patients is a significant problem in Romania, and this study aims to increase awareness of the toxicological impact of pesticides on children's health. The study analyzed the demographic characteristics, clinical assessment, and outcomes of pediatric patients with acute pesticide poisoning at a children's hospital in Iasi. Accidental ingestion of pesticide products was the most common exposure route, and diazinon was the most frequently involved pesticide. The primary clinical manifestations included toxic encephalopathy, coma, depressive disorder, gastric disorders, and respiratory failure.
Article
Pharmacology & Pharmacy
Nesrine S. El-Mezayen, Rehab. A. Abd el Moneim, Safaa H. El-Rewini
Summary: The cholinergic hypothesis is still the fundamental explanation for the etiopathology of Alzheimer's disease. B12 has the ability to aggregate cholinergic receptors and may be a promising therapeutic agent for AD. B12 also restores blood brain barrier integrity by lowering homocysteine levels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Plant Sciences
Jiajia Zhao, Kun Li, Yingying Wang, Dan Li, Qianwen Wang, Shengsheng Xie, Jianxin Wang, Zhong Zuo
Summary: The study found that co-treatment of EGb 761 and donepezil significantly improved cognitive function, increased brain levels of superoxide dismutase, and decreased brain levels of acetylcholinesterase and malondialdehyde in scopolamine-induced cognitive impairment rats. Despite these beneficial pharmacodynamic outcomes, the co-treatment did not alter the plasma pharmacokinetics and brain uptake of donepezil or bilobalide.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Anesthesiology
Adam C. Pomerleau, Lewis S. Nelson, Jason A. Hoppe, Matthew Salzman, Paul S. Weiss, Jeanmarie Perrone
Letter
Critical Care Medicine
Bryan D. Hayes, Lewis S. Nelson
JOURNAL OF INTENSIVE CARE MEDICINE
(2016)
Article
Emergency Medicine
R. S. Wightman, L. S. Nelson, J. D. Lee, L. M. Fox, S. W. Smith
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2018)
Editorial Material
Substance Abuse
Lewis S. Nelson
Article
Clinical Neurology
Lindsay Fox, Lewis S. Nelson
Editorial Material
Emergency Medicine
Maryann Mazer-Amirshahi, Sergey Motov, Lewis S. Nelson
ACADEMIC EMERGENCY MEDICINE
(2020)
Article
Medicine, Legal
Gregory G. Davis, Amy B. Cadwallader, Corinne L. Fligner, Thomas P. Gilson, Emma R. Hall, Kent E. Harshbarger, Robert Kronstrand, Craig T. Mallak, Jerri L. McLemore, Robert A. Middleberg, Owen L. Middleton, Lewis S. Nelson, Agnieszka Rogalska, Eric Tonsfeldt, Jeff P. Walterscheid, Ruth E. Winecker
AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY
(2020)
Article
Toxicology
Christopher W. Meaden, Christine Ramdin, Bruce Ruck, Lewis S. Nelson, Chloe Soukas, Mitchell Hirsch, Peter Alsharif, David Beckford, Diane P. Calello
Summary: Poison Centers are able to respond to public health threats like COVID-19 pandemic due to their operational hotlines. NJPIES operated New Jersey Coronavirus Hotline and analyzed call patterns, subject matter, and strategies. The centers can adapt rapidly and meet the needs of the public during times of health threats.
CLINICAL TOXICOLOGY
(2021)
Letter
Toxicology
David Loughran, Jeena Jacob, Diane Calello, Lewis Nelson
CLINICAL TOXICOLOGY
(2022)
Review
Medicine, General & Internal
Joseph D'Orazio, Lewis Nelson, Jeanmarie Perrone, Rachel Wightman, Rachel Haroz
Summary: The translation of this passage introduces the background and usage of Xylazine, as well as its widespread use in illicitly manufactured fentanyl. The review discusses the pharmacology, clinical effects, and the management of related issues during treatment.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Toxicology
Maryann Mazer-Amirshahi, Erin R. Fox, Lewis S. Nelson, Silas W. Smith, Andrew I. Stolbach
JOURNAL OF MEDICAL TOXICOLOGY
(2020)
Article
Substance Abuse
Joseph J. Palamar, Patricia Acosta, Austin Le, Charles M. Cleland, Lewis S. Nelson
INTERNATIONAL JOURNAL OF DRUG POLICY
(2019)
Article
Public, Environmental & Occupational Health
Frederick W. Nagel, Jessica A. Kattan, Shivani Mantha, Lewis S. Nelson, Hillary V. Kunins, Denise Paone
JOURNAL OF PUBLIC HEALTH MANAGEMENT AND PRACTICE
(2018)
Article
Psychology, Clinical
Cary J. Blum, Lewis S. Nelson, Robert S. Hoffman
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2016)
Article
Toxicology
Nicholas J. Connors, Lewis S. Nelson
JOURNAL OF MEDICAL TOXICOLOGY
(2016)