Article
Biochemistry & Molecular Biology
Beatriz Ferrer, Harshini Suresh, Abel Santamaria, Joao Batista Rocha, Aaron B. Bowman, Michael Aschner
Summary: This study found that exposure to MeHg can induce STAT3 activation in mouse hypothalamic neuronal cells, exacerbating oxidative stress and antioxidant responses. It suggests that the STAT3 signaling pathway plays an important role in responding to MeHg-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Julieta Sturla Lompre, Pedro Moleiro, Lucia De Marchi, Amadeu M. V. M. Soares, Carlo Pretti, Federica Chielini, Eduarda Pereira, Rosa Freitas
Summary: The study evaluated the effects of rare earth elements and nanoparticles on clam species, showing no cellular damages but greater impact on antioxidant capacity in invasive clams, indicating potential risks to aquatic environments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Critical Care Medicine
Charikleia S. Vrettou, Alice G. Vassiliou, Maria Pratikaki, Chrysi Keskinidou, Stamatios Tsipilis, Parisis Gallos, Edison Jahaj, Stylianos E. Orfanos, Anastasia Kotanidou, Ioanna Dimopoulou
Summary: This study aims to investigate the role of neural injury biomarkers and compare them with inflammatory markers in predicting mortality in COVID-19 patients. The results show that among the investigated biomarkers, s100b demonstrated the best predictive ability for death in the intensive care unit. The overall biomarker profile suggests direct involvement of the nervous system by the novel coronavirus.
Article
Biochemistry & Molecular Biology
Dai Mizuno, Masahiro Kawahara, Keiko Konoha-Mizuno, Terumasa Ogawara, Ryoji Hama, Kentaro Yamazaki
Summary: This study compared the toxicities of Tl(I) and Tl(III) in a mouse neuronal cell line. Tl(III) was more toxic, leading to decreased cell viability and increased cytotoxicity. Both treatments induced oxidative stress-related apoptosis, but Tl(III) produced more MDA and showed stronger cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Mengyuan Liang, Junping Deng, Jie Gu, Jinlai Yang, Feng Ge, Caoxing Huang, Wenzhu Wu
Summary: TMBPF, a substitute for BPA, has been found to have similar or even stronger toxicity than BPA, posing potential harm to human health and the environment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Adriana Kubis-Kubiak, Benita Wiatrak, Agnieszka Piwowar
Summary: Recent research has highlighted the complexity of Alzheimer's disease and the involvement of a wide range of clinical manifestations and cellular and biochemical disturbances. The past decade has seen a focus on metabolic disturbances in early pathology, with attention to the potential role of the S100 protein family in neuronal metabolism and neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Murugesh Gayathri, Jesudass Sutha, Sundaram Mohanthi, Mathan Ramesh, Rama-Krishnan Poopal
Summary: The UV-filter Octocrylene has been found to cause developmental abnormalities, oxidative stress, neurotoxicity, and histopathological damage in embryonic zebrafish. High concentrations of Octocrylene resulted in decreased hatching and heartbeat rates, elevated oxidative damage and antioxidant enzyme activities, inhibited AChE activity, and induced apoptosis. These findings highlight the potential harm of Octocrylene on the development and health of aquatic organisms.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Peramaiyan Rajendran, Duaa Althumairy, Mohammad Bani-Ismail, Gamal M. Bekhet, Emad A. Ahmed
Summary: In this study, it was found that long-term exposure to aluminum chloride caused neurotoxicity and oxidative stress in mice. However, the natural furanocoumarin compound isoimperatorin (IMP) derived from plants such as lemon and lime oils was shown to have potential in combating this toxicity. IMP improved the damage caused by aluminum by reducing oxidative stress and regulating the inflammatory response, suggesting that it could be a promising treatment option for neurotoxicity and neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Madalena Andrade, Amadeu M. V. M. Soares, Montserrat Sole, Eduarda Pereira, Rosa Freitas
Summary: The study investigated the combined effects of salinity and Lanthanum on biochemical alterations in mussels, revealing that lower salinity levels enhanced the cellular damage and inhibition of antioxidant defenses caused by La exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Ping Ding, Chongdan Xiang, Xintong Li, Haibo Chen, Xiaoxia Shi, Xin Li, Chushan Huang, Yunjiang Yu, Jianying Qi, Adela Jing Li, Lijuan Zhang, Guocheng Hu
Summary: Microplastics (MPs) are pervasive environmental contaminants that induce neurotoxicity in various organisms. This study revealed that photoaged polystyrene (P-PS) caused more severe neurotoxic effects compared to virgin polystyrene (V-PS) in zebrafish. Exposure to P-PS altered antioxidant enzyme activity, neurotransmitter levels, and behavior in larval zebrafish. Furthermore, the expression of genes related to neurotransmission and oxidative stress was significantly affected by PS exposure. These findings provide new insights into the potential risks of MPs in the environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Hend Mohamed Hussien, Mokhtar Ibrahim Yousef
Summary: This study aimed to investigate the neuroprotective effect of ginseng extract against neurological and behavior abnormalities induced by cisplatin. The results showed that ginseng extract could alleviate the memory dysfunction and locomotor disability induced by cisplatin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Cell Biology
S. Ankul Singh, Swathi Suresh, Chitra Vellapandian
Summary: This review discusses the rising global ozone in densely populated areas of Asia and Africa, and explores the possible neurotoxicity and biomarkers associated with ozone-induced oxidative stress. It also examines the impact of ozone on blood circulation, antibacterial action, immune response, and other aspects, and suggests the need for further research on biomarkers related to ozone and the brain.
AGEING RESEARCH REVIEWS
(2023)
Article
Environmental Sciences
Carlos Villaorduna, Mariano Mendoza-Carlos, Manuel Chuyma, Jhon Aviles, Ayda Avalos-Diaz, Ronald Lozano-Reategui, Juan Garcia-Ruiz, Nadia Panduro-Tenazoa, Jessy Vargas, Ysabel Moran-Quintanilla, Jose-Luis Rodriguez
Summary: Ipconazole, an antifungal agrochemical, poses a hazard to human, animal, and environmental health due to its widespread use in agriculture and easy accumulation in the environment. Our study investigated the cytotoxic effects of ipconazole on SH-SY5Y neuroblastoma cells, revealing a dose-dependent reduction in cell viability, increased ROS production, and induction of cell death. These findings suggest that ipconazole exposure may contribute to neurotoxicity or neurodegeneration.
Article
Pharmacology & Pharmacy
Hericles Mesquita Campos, Michael da Costa, Lorrane Kelle da Silva Moreira, Hiasmin Franciely da Silva Neri, Cinthia Rio Branco da Silva, Letizia Pruccoli, Fernanda Cristina Alcantara dos Santos, Elson Alves Costa, Andrea Tarozzi, Paulo Cesar Ghedini
Summary: Chrysin exhibits antioxidant and neuroprotective effects, mitigating neurotoxicity induced by aluminum and improving cognitive function while reducing oxidative damage in the brain.
Article
Environmental Sciences
Yanxia Xiong, Chengyuan Wang, Mengyi Dong, Meifeng Li, Chengyu Hu, Xiaowen Xu
Summary: This study investigated the toxicity of chlorphoxim using zebrafish as a model. The results showed that chlorphoxim exposure had severe effects on the nervous system, survival rate, and growth and development of zebrafish embryos. It also induced oxidative stress and apoptosis. Furthermore, it was found that astaxanthin could alleviate the neurotoxicity of chlorphoxim.
ENVIRONMENTAL TOXICOLOGY
(2023)