Article
Cardiac & Cardiovascular Systems
Peter Kim, Luke Masha, Amanda Olson, Cezar Iliescu, Kaveh Karimzad, Saamir Hassan, Nicolas Palaskas, Jean-Bernard Durand, Cheuk Hong Leung, Juan Lopez-Mattei
Summary: The study reveals significantly prolonged QTc intervals in cancer patients, especially in the inpatient setting. Commonly prescribed QT prolonging medications such as ondansetron and methadone may have a causative role in the QT prolongation observed in cancer patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Oncology
Eline L. Giraud, Kaylee R. M. Ferrier, Nienke A. G. Lankheet, Ingrid M. E. Desar, Neeltje Steeghs, Rypko J. Beukema, Nielka P. van Erp, Elise J. Smolders
Summary: Patients with cancer are at risk of prolonged QT interval due to the use of anticancer drugs. This review provides a comprehensive overview of the QT-prolonging properties of anticancer drugs and practical recommendations for clinicians.
Article
Cardiac & Cardiovascular Systems
Thomas F. O'Connell, Christopher J. Bradley, Amr E. Abbas, Brian D. Williamson, Akash Rusia, Adam M. Tawney, Rick Gaines, Jason Schott, Alex Dmitrienko, David E. Haines
Summary: This study characterized QTc prolongation in hospitalized COVID-19 patients treated with HCQ/AZM. Several clinical factors were associated with greater QTc prolongation, but changes in QTc were not linked to increased risk of death.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Zachary R. Noel, Vincent Y. See, Alexander H. Flannery
Summary: Acute care pharmacists play a crucial role in identifying drug-drug interactions that may lead to QT prolongation, but there is a risk of overemphasis on the QTc interval in some cases.
ANNALS OF PHARMACOTHERAPY
(2021)
Review
Toxicology
Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary Gintant, James Willard, Christine Garnett, Matthew Skinner, Hugo M. Vargas, Todd Wisialowski, Michael K. Pugsley
Summary: This article compares the concordance between nonclinical repolarization assays and the clinical thorough QT (TQT) study and explores the mechanisms that may cause discrepancies. The study finds that although nonclinical assays have good specificity in predicting negative clinical QT prolongation, they have relatively poor sensitivity in predicting positive clinical QT prolongation. The article also provides an overview of mechanisms responsible for QT prolongation and outlines some best practices.
TOXICOLOGICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kaitlin Ryan, Paul Benz, Amy Zosel, Andrew Farkas, Jillian Theobald
Summary: By retrospectively reviewing cases of exposure to substances with known risks, we identified specific drugs that could cause QT interval prolongation and life-threatening dysrhythmias. Although exposure to these drugs is common, life-threatening dysrhythmias are rare.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sami Viskin, Ehud Chorin, Arie Lorin Schwartz, Piotr Kukla, Raphael Rosso
Summary: Cardiac memory is an interesting electrocardiographic phenomenon where T waves become abnormal in the opposite direction of wide QRS complex, and normalize at a later stage. Reduction of repolarizing potassium currents during cardiac memory may lead to prolonged QT syndrome and ventricular arrhythmias.
Article
Medicine, General & Internal
Sok-Sithikun Bun, Nathan Heme, Florian Asarisi, Fabien Squara, Didier Scarlatti, Pamela Moceri, Emile Ferrari
Summary: This study analyzed the clinical characteristics of patients with high-grade atrioventricular block (AVB) presenting with torsades de pointes (TdP), and found that the QTc(FR), JT, and Tpeak-to-end intervals were significantly prolonged in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Shihai Li, Zili Xu, Mingkun Guo, Menglong Li, Zhining Wen
Summary: Drug-induced prolongation of the QT interval is a common issue that hinders the understanding of its mechanism and the development of effective prediction strategies. To address this, a new model called DIQTA is proposed to stratify the risk of drug-induced QT interval prolongation. Potential applications of DIQTA include precision dosing in off-label use and therapeutic strategy optimization, as well as facilitating the development of predictive toxicity models based on artificial intelligence.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Pascal Champeroux, Raafat Fares, Thierry Bastogne, Serge Richard, Jean-Yves Le Guennec, Jerome Thireau
Summary: This study reveals the underlying mechanisms of ventricular arrhythmias triggered by Torsadogenic HERG blocking drugs. The autonomic changes induced by these drugs are a result of reflex compensatory mechanisms in response to mild haemodynamic side effects. Concealed QT prolongation, along with enhanced HFQT oscillations, contribute to the occurrence of ventricular arrhythmias.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Rani Khatib, Fatima R. N. Sabir, Caroline Omari, Chris Pepper, Muzahir Hassan Tayebjee
Summary: Many drug therapies can prolong the QT interval and increase the risk of Torsades de Pointes. Consideration of patient-related risk factors, the potential risk of QT prolongation with a drug, and co-prescribed medicines that may increase the risk are crucial when prescribing drugs associated with QT prolongation.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Simranjit S. Kahlon, Rabia Sikandar, Sreedevi Tejovath, Shaalina Nair, Danial Hassan, Khushbu K. Patel, Aishwarya Peddemul, Jihan A. Mostafa
Summary: TdP is a rare form of tachyarrhythmia that tends to degenerate into ventricular fibrillation, mainly occurring in patients with prolonged QT intervals, making it difficult to determine the significant risk factors. This study encourages further research into the implications of QT prolongation and how simple ECG monitoring and treatment can help save lives.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Medicine, General & Internal
Annette Wacker-Gussmann, Gretchen K. Eckstein, Janette F. Strasburger
Summary: The number of women diagnosed with ion channelopathy in childhood and effectively treated using beta blockers, sympathectomy, and cardiac pacemakers/defibrillators is increasing. Offspring of these women have a 50% risk of inheriting the disease, necessitating complex delivery room preparation in pregnancies with inherited arrhythmia syndromes. Fetal magnetocardiography now allows for the detection of various arrhythmias in susceptible fetuses, requiring specialists to have optimal knowledge and equipment for the care of these specialized pregnancies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Edi Prifti, Ahmad Fall, Giovanni Davogustto, Alfredo Pulini, Isabelle Denjoy, Christian Funck-Brentano, Yasmin Khan, Alexandre Durand-Salmon, Fabio Badilini, Quinn S. Wells, Antoine Leenhardt, Jean-Daniel Zucker, Dan M. Roden, Fabrice Extramiana, Joe-Elie Salem
Summary: The study aimed to enhance the prediction of drug-induced TdP and diagnosis of cLQTS using convolutional neural network models analyzing ECG alterations induced by sotalol. The CNN models outperformed QTc measurements and were particularly effective shortly after a diTdP episode.
EUROPEAN HEART JOURNAL
(2021)
Article
Psychiatry
Philipp Bohny, Soenke Boettger, Josef Jenewein
Summary: This study investigated the frequency and magnitude of QTc interval prolongation and clinically relevant side effects in delirium patients managed with haloperidol and/or pipamperone. The results showed that delirium treatment with antipsychotics did not increase the risk of QTc interval prolongation, but the prolongation magnitude was higher and correlated with dosage and the number of QT interval-prolonging substances. Polypharmacy was associated with increased risk of critical QTc prolongation and higher mortality during delirium.
FRONTIERS IN PSYCHIATRY
(2023)
