Article
Biochemistry & Molecular Biology
Itzel Pamela Zavala-Guevara, Manolo Sibael Ortega-Romero, Juana Narvaez-Morales, Tania Libertad Jacobo-Estrada, Wing-Kee Lee, Laura Arreola-Mendoza, Frank Thevenod, Olivier Christophe Barbier
Summary: The study evaluated the uptake of CdMT complex through 24p3R after proximal tubule injury. Findings showed increased uptake of CdMT complex and 24p3R expression in the distal tubules after proximal tubule injury, potentially compensating for protein losses associated with AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Andrew M. Hall, Sophie de Seigneux
Summary: Damage to the proximal tubule is the most common cause of acute kidney injury in humans. Current diagnostic and treatment options are limited, and a deeper understanding of pathogenic mechanisms at a cellular level is needed. Recent studies have shown significant changes in proximal tubule metabolism during acute kidney injury, highlighting potential targets for intervention. This article emphasizes the current state of the field and highlights three emerging areas worthy of attention: axial heterogeneity in determining baseline susceptibility, insult specific pathogenic mechanisms, and the link between tubular metabolism and whole-body homeostasis.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Enayatollah Seydi, Marjan Rahemi, Hadi Esmaily, Abdollah Arjmand, Jalal Pourahmad
Summary: Transplanting healthy mitochondria can reduce the cytotoxicity, ROS production, MMP collapse, lysosomal damage, GSSG levels, and caspase-3 activity caused by FAV in RPTCs, while increasing ATP level, GSH content, Bcl-2 content, and GSH/GSSG ratio.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Cell Biology
Min Chen, Xiangchen Gu
Summary: Endocytosis plays a crucial role in kidney diseases, particularly in renal fibrosis, and is affected by other diseases and factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Infectious Diseases
Jihyun Yang, Yoon Sook Ko, Hee Young Lee, Yina Fang, Se Won Oh, Myung-Gyu Kim, Won Yong Cho, Sang-Kyung Jo
Summary: Piperacillin/tazobactam (PT) is commonly used in intensive care for critically ill patients, but the mechanisms of its nephrotoxicity are unclear. This study demonstrated that PT directly induces oxidative stress and mitochondrial damage in renal tubular cells, suggesting a direct nephrotoxic effect.
Article
Urology & Nephrology
Johanna E. Emmens, Martin H. de Borst, Eva M. Boorsma, Kevin Damman, Gerjan Navis, Dirk J. van Veldhuisen, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Gerasimos Filippatos, Marco Metra, Nilesh J. Samani, Piotr Ponikowski, Leong L. Ng, Adriaan A. Voors, Jozine M. ter Maaten
Summary: By studying 2085 patients with heart failure, we found that proximal tubular function is frequently reduced in these patients, and this reduction is associated with an increased risk of plasma NGAL doubling and worse clinical outcomes, independent of glomerular function. In addition, inhibition of SGLT2 by empagliflozin and improvement of TmP/GFR may have a positive effect in patients with heart failure.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Medicine, General & Internal
Robert J. Unwin
Summary: Toxic nephropathy, a growing concern, is often caused by new drugs and polypharmacy. Patients' lack of knowledge about their medications and the prevalence of unapproved drugs contribute to the problem. Early detection, drug withdrawal, and supportive care are crucial for effective treatment.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Samuel Shin, Eugenia Awuah Boadi, Bidhan C. Bandyopadhyay
Summary: This study found that the reduced activities of HCO3-, PO43-, and C2O42- transporters in PT cells of TRPC3(-/-) mice may contribute to the formation of CaP crystals.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lawrence H. Lash
Summary: Previous studies have shown that overexpression of transporters can reduce cellular susceptibility to chemicals. However, this study found that overexpression of the mitochondrial 2-oxoglutarate carrier (OGC) increased cellular injury from the antineoplastic drug cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew Hoofnagle, Jing Chen, Derek Colaizzo, Mirela Dobre, Katherine T. Mills, Anna C. Porter, Sylvia E. Rosas, Mark J. Sarnak, Stephen Seliger, James Sondheimer, Manjula Kurella Tamura, Kristine Yaffe, Bryan Kestenbaum
Summary: Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. However, serum concentrations of the solutes were not associated with cognitive decline. Further research is needed to determine the specific domains of cognition affected by decreased secretory clearance and the underlying mechanisms of these associations.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qing-Lin Ye, Da-Ming Wang, Xin Wang, Zhi-Qiang Zhang, Qi-Xing Tian, Shi-Yao Feng, Zhi-Hui Zhang, De-Xin Yu, De-Mao Ding, Dong-Dong Xie
Summary: The study found that the levels of Sirt1 expression are closely related to CaOx kidney stone formation, with downregulation of Sirt1 leading to increased cell injury and crystal deposition. Increasing Sirt1 expression in vitro or administering resveratrol in vivo can alleviate cell damage and reduce crystal deposition.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Biochemistry & Molecular Biology
Lawrence H. Lash
Summary: Mitochondria in renal proximal tubular cells play various key roles, including ATP synthesis, regulation of redox status, initiation of mitophagy and apoptosis. The membrane transport mechanisms of glutathione and its derivatives across the mitochondrial inner membrane are critical for these functions and may serve as targets for therapeutic approaches. Detecting specific components released by renal mitochondria into urine or extracellular medium could serve as indicators of exposure to nephrotoxicants before irreversible renal injury occurs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Ahmet Guzel, Sedat Yunusoglu, Mustafa Calapoglu, Ibrahim Aydin Candan, Ibrahim Onaran, Meral Oncu, Osman Ergun, Taylan Oksay
Summary: This study investigated the protective effect of quercetin in hyperoxaluria-induced nephrolithiasis. The results showed that quercetin reduced oxidative stress and inflammation indicators in renal tissues, suggesting its potential as a therapeutic agent for decreasing oxalate stone formation.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, Research & Experimental
Eugenia Awuah Boadi, Samuel Shin, Bidhan C. Bandyopadhyay
Summary: The study demonstrates that vascular calcification can result in renal tubular cell damage, while tannic acid (TA) has a protective role in preventing such pathological consequences.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Jennifer Eymael, Martijn van den Broek, Laura Miesen, Valerie Villacorta Monge, Bartholomeus T. van den Berge, Fieke Mooren, Vicky Luna Velez, Jelmer Dijkstra, Meyke Hermsen, Peter Bandi, Michiel Vermeulen, Saskia de Wildt, Brigith Willemsen, Sandrine Florquin, Roy Wetzels, Eric Steenbergen, Rafael Kramann, Marcus Moeller, Michiel F. Schreuder, Jack Fm Wetzels, Johan van der Vlag, Jitske Jansen, Bart Smeets
Summary: Scattered tubular cells (STCs) in the proximal tubule increase in number after acute kidney injury. STCs are preferentially located within the inner bends of the tubule and their number increases with age. STCs represent a transient state of dedifferentiated proximal tubule epithelial cells (PTECs) showing metabolic shift towards glycolysis, facilitating cellular survival after kidney injury.
JOURNAL OF PATHOLOGY
(2023)