Article
Pharmacology & Pharmacy
Evangelia Balla, Alexandra Zamboulis, Panagiotis Klonos, Apostolos Kyritsis, Panagiotis Barmpalexis, Dimitrios N. Bikiaris
Summary: Novel interpenetrated networks (IPNs) of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide) (SBMA) and poly(vinyl alcohol) (PVA) were prepared for ocular coadministration of timolol maleate (TIM) and dorzolamide hydrochloride (DORZ), both widely used for glaucoma treatment. The IPNs showed significant hydrophilicity and antimicrobial properties, making them suitable for ocular applications. The drug-loaded IPNs exhibited sustained release patterns primarily controlled by diffusion, and were safe for ophthalmic use.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Veterinary Sciences
Mizuki Kita, Kazutaka Kanai, Hiroki Mitsuhashi, Tomoki Noguchi, Noriaki Nagai, Mizuki Yamaguchi, Yuya Otaka, Rina Kudo, Yohei Yamashita, Kazuki Tajima
Summary: The study demonstrated that magnesium hydroxide nanoparticles (nMH) can improve the ocular hypotensive effect of timolol maleate (TM) without enhancing its side effects. The fixed combination of nMH-TM may be more effective for lowering intraocular pressure in dogs compared to TM alone.
VETERINARY SCIENCES
(2021)
Article
Chemistry, Medicinal
Sang-Woo Park, Jiwoong Lee, Michael S. Kook
Summary: This study compared the efficacy, patient-reported satisfaction, and safety of preservative-free tafluprost, dorzolamide/timolol, and preservative-containing latanoprost in Korean glaucoma patients with ocular surface disease. The results showed that preservative-free tafluprost and dorzolamide/timolol significantly improved the OSD Index scores and patient-reported satisfaction compared to preservative-containing latanoprost.
Article
Biotechnology & Applied Microbiology
Yahui Wei, Yu Cai, Chenying Bao, Yanfei Zhu, Yingzi Pan
Summary: This study aims to analyze the effects of dynamic corneal response parameters (DCRs) on visual field (VF) progression in normal-tension glaucoma (NTG) and hypertension glaucoma (HTG). The results show that the first applanation deflection area (A1Area) is an independent risk factor for VF progression in NTG, while DCRs in HTG are not related to VF progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Ioannis I. Andreadis, Christina Karavasili, Angelos Thomas, Anastasia Komnenou, Manolis Tzimtzimis, Dimitrios Tzetzis, Dimitrios Andreadis, Nikolaos Bouropoulos, Dimitrios G. Fatouros
Summary: Intraocular pressure reduction regimens for glaucoma often involve eye drops, which have limitations such as short residence time and reduced patient compliance. In situ gelling nanofiber films were developed for ocular delivery of timolol maleate, showing sustained IOP-lowering effects and improved drug release compared to conventional eye drops.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biology
Jan Lestak, Martin Fus, Marain Rybar, Antonin Benda
Summary: The aim of this study was to compare the values of vessel density (VD) and perfusion parameters in the ophthalmic artery (OA) and central retinal artery (CRA) between hypertensive glaucoma (HTG) and normotensive glaucoma (NTG) patients. The results showed no differences in visual field (VF), VD, PSV-OA, and EDV-CRA between the two groups. However, statistically significant differences were observed in PSV of CRA, EDV of OA, and resistance index (RI) of both CRA and OA.
Review
Medicine, Research & Experimental
Anastasios G. Konstas, Leopold Schmetterer, Andreas Katsanos, Cindy M. L. Hutnik, Gabor Hollo, Luciano Quaranta, Miguel A. Teus, Hannu Uusitalo, Norbert Pfeiffer, L. Jay Katz
Summary: This review discusses the clinical attributes of preserved dorzolamide/timolol fixed combination (DTFC) and the potential of preservative-free (PF) DTFC based on published evidence and clinical experience. DTFC is the first FDA-approved intraocular pressure-lowering fixed combination and remains widely used globally. The pharmacological properties of DTFC are reflective of its constituents, dorzolamide and timolol, and studies have shown its efficacy in lowering IOP. PF DTFC has been shown to be at least as effective as preserved DTFC, providing clinical benefits for glaucoma patients with ocular surface disease. Further research is needed to explore the full potential of both preserved and PF DTFC.
ADVANCES IN THERAPY
(2021)
Article
Polymer Science
Denitsa Nikolova, Konstans Ruseva, Christo Tzachev, Lachezar Christov, Elena Vassileva
Summary: Polysulfobetaine methacrylate (PSB) based vehicles with different structures were synthesized and investigated for ocular drug delivery systems. The relationship between the structure of PSB vehicles and the release profiles of timolol maleate (TM) was revealed.
POLYMER INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Maryam Sadat Hosseini, Mojdeh Mohseni, Masood Naseripour, Mehdi Mirzaei, Kowsar Bagherzadeh, Sayyed Amirpooya Alemezadeh, Bita Mehravi
Summary: In this study, contact lenses with surface modification and nanoparticles were used for long-term drug delivery and better patient compatibility. Timolol-maleate was loaded into polymeric nanoparticles made of chitosan conjugate with lauric acid and sodium alginate. The best surface modification of the lenses was achieved with 5% albumin concentration and 150 s exposure time, resulting in the highest increase in hydrophilicity. The drug release from nanoparticles lasted for 3 days and extended to 6 days after dispersion in the modified lens matrix. This study presents a novel drug delivery system for glaucoma treatment.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Ophthalmology
Pratheeba D. Nivean, Murali Ariga, M. R. Chithra, Pooja Gohil, Sandhya Das, Gogtay Jaideep
Summary: This study aimed to evaluate the efficacy of 2% dorzolamide eye drops in improving retrobulbar blood flow in Indian patients with OAG. The study found that dorzolamide significantly increased ocular perfusion pressure and end diastolic velocity in major ophthalmic arteries, and significantly reduced intraocular pressure in OAG patients after 12 weeks of treatment. No adverse events were reported.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Kyung Euy Hong, Seong Ah Kim, Da-Young Shin, Chan Kee Park, Hae-Young Lopilly Park
Summary: The purpose of this study was to investigate the ocular and hemodynamic factors contributing to the central visual function in glaucoma patients with myopia. The results showed that there were significant differences in the deep layer vascular density of the peripapillary and macular areas between mild and moderate-to-severe myopia. Structural parameters, especially the ratio of peripapillary atrophy to disc area, were significantly correlated with peripapillary vascular density in myopic eyes. Lower SDNN value, lower deep vascular density of the macular area, and greater fluctuation of deep vascular density in the peripapillary area were associated with the presence of central scotoma in patients with glaucoma with myopia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Eunoo Bak, Young Kook Kim, Ahnul Ha, Young Soo Han, Jin-Soo Kim, Jinho Lee, Yong Woo Kim, Sung Uk Baek, Jin Wook Jeoung, Ki Ho Park
Summary: In patients with moderate-stage primary open-angle glaucoma, differences in intereye visual field defect (VFD) asymmetry were associated with varying rates of progression, with unilateral VFD eyes showing the fastest progression. Greater intereye MD asymmetry index and intereye hemifield visual-sensitivity asymmetry index were significant risk factors for glaucoma progression.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Tao Wang, Yunran Zhang, Meiling Chi, Chen Zhao, Linlin Cao, Chutong Tian, K. Kamei, Ying Zheng, Qikun Jiang
Summary: Currently, the commercial fixed combination therapy for glaucoma has various problems, while the once-daily fixed-combination timolol-netarsudil-latanoprost ophthalmic solution (FC-TNL) offers great efficacy and patient compliance. By using a homologous salt engineering strategy and studying the drug morphology, the prepared FC-TNL demonstrated good stability, no influence on intraocular penetration, and potent effects on lowering intraocular pressure and protecting retinal ganglion cells.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Medicinal
Hui-Ping Duan, Rong Liu
Summary: By retrospectively analyzing the clinical data of patients with open-angle glaucoma, it was found that nimodipine combined with latanoprost treatment can significantly improve the condition and have a positive impact on ocular hemodynamics and visual field defects. It has fewer adverse reactions and higher safety.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Ophthalmology
Alice Chandra Verticchio Vercellin, Alon Harris, Francesco Oddone, Brent Siesky, George Eckert, Aditya Belamkar, Gal Antman, Fani Segev
Summary: In patients with OAG, lower baseline retinal capillary perfusion in the superior retina is significantly associated with long-term structural progression.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)