Article
Cardiac & Cardiovascular Systems
Jose Maria Medina-Gil, Ana Perez-Garcia, Pedro Saavedra-Santana, Asuncion Diaz-Carrasco, Efren Martinez-Quintana, Fayna Rodriguez-Gonzalez, Cristina M. Ramirez, Marta Riano, Paloma Garay-Sanchez, Antonio Tugores
Summary: This study aimed to determine whether genetic variants affecting the activity of CCL2 and CCL7 were associated with cardiovascular disease. The research found that a variant in the CCL7 gene transcript was associated with decreased cardiovascular risk, potentially playing a meaningful role in the development of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Oana P. Zaharia, Stefanie Lanzinger, Joachim Rosenbauer, Wolfram Karges, Karsten Muessig, Sebastian M. Meyhoefer, Volker Burkart, Michael Hummel, Dirk Raddatz, Michael Roden, Julia Szendroedi, Reinhard W. Holl
Summary: By comparing two differently designed German cohorts, this study assessed the prevalence of cardiovascular risk factors and diabetes-related complications in recent-onset adult type 1 diabetes. Diabetic nephropathy and retinopathy are the most frequent complications in type 1 diabetes, affecting up to every 10th patient within the first year after diagnosis, underlining the need for more stringent risk factor management already at the time of diagnosis of type 1 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Raza Abbas Syed, Matthew G. Davey, Vinitha Richard, Nicola Miller, Michael J. Kerin
Summary: Contemporary breast cancer management includes personalized treatment approaches and focuses on miRNAs as potential biomarkers for predicting treatment-related cardiovascular toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Akshaya Srikanth Bhagavathula, Abdullah Shehab, Anhar Ullah, Jamal Rahmani
Summary: Cardiovascular disease (CVD) poses a growing threat to the Middle Eastern population, with a prevalence of 10.1% according to a systematic review and meta-analysis conducted on literature from 2012 to 2018. The region also shows high rates of dyslipidaemia, hypertension, and diabetes, highlighting the need for multifaceted interventions for primary prevention.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Review
Urology & Nephrology
Anne M. Kouri, Michelle N. Rheault
Summary: Cardiovascular disease is a significant cause of morbidity and mortality in children with chronic kidney disease (CKD), with multifactorial causes. Recent studies have shown high prevalence and risk factors for CVD in this population, emphasizing the need for research on cardiovascular outcomes in children.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2021)
Review
Obstetrics & Gynecology
Mercedes Millan-de-Meer, Manuel Luque-Ramirez, Lia Nattero-Chavez, Hector F. Escobar-Morreale
Summary: This study is a systematic review and meta-analysis on the consequences of PCOS during the late reproductive years and after menopause. The study found that women with PCOS in peri- and postmenopause presented increased levels of testosterone and androgens, as well as decreased levels of sex hormone-binding globulin. They also had higher measures of obesity, insulin resistance, and risk for diabetes and hypertension. Furthermore, they had lower levels of HDL cholesterol and higher levels of triglycerides. Although myocardial infarction and stroke were more prevalent in women with PCOS, the prevalence of cardiovascular disease, coronary artery disease, breast cancer, and age at menopause were similar between patients and controls. The study highlights the persistence of hyperandrogenism and the importance of addressing the comorbidity of weight excess in women with PCOS.
HUMAN REPRODUCTION UPDATE
(2023)
Review
Cardiac & Cardiovascular Systems
Sylwester Rogula, Bartosz Pomirski, Norbert Czyzak, Ceren Eyileten, Marek Postula, Lukasz Szarpak, Krzysztof J. Filipiak, Marcin Kurzyna, Milosz Jaguszewski, Tomasz Mazurek, Marcin Grabowski, Aleksandra Gasecka
Summary: Pulmonary arterial hypertension (PAH) presents challenges in diagnosis and treatment, including differentiating etiologies, determining severity, and unpredictable treatment outcomes. MicroRNAs (miRNAs) show promise as novel biomarkers and therapeutic targets in PAH.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hanan Amadid, Pernille F. Ronn, Maria B. N. Dunbar, Jakob S. Knudsen, Bendix Carstensen, Frederik Persson, Marit E. Jorgensen
Summary: The use of lipid-lowering drugs (LLDs) among type 2 diabetes patients in Denmark has decreased since 2012, with only 55% using LLDs in 2017. Levels of total cholesterol and LDL-C have decreased, while triglycerides have increased from 2010 to 2017. LLD users had lower LDL-C levels and a higher rate of achieving LDL-C goals compared to non-users.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jie Wang, Qi Sun, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: This study found that elevated remnant cholesterol is associated with a higher risk of hypertension in the Chinese population, especially among individuals with diabetes. However, with ideal management of remnant cholesterol, glucose, and other cardiovascular risk factors, the risk of hypertension can be minimized for diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Andriani Vazeou, Sascha R. Tittel, Olga Kordonouri, Niels H. Birkebaek, Violeta Iotova, Barbara Piccini, Sebastian Seget, Pravesh Kumar Guness, David M. Maahs, George S. Stergiou
Summary: The prevalence of modifiable cardiovascular risk factors is higher in children and adolescents with type 1 diabetes who have elevated blood pressure/hypertension than in those with normal blood pressure, suggesting the need for early detection and intervention to prevent future morbidity and mortality.
DIABETES OBESITY & METABOLISM
(2022)
Review
Cell Biology
Mirolyuba Ilieva, Riccardo Panella, Shizuka Uchida
Summary: Although rare, cardiac tumor formation shares similarities in terms of pathogenesis with cancers and cardiovascular diseases, including angiogenesis, immune responses, and fibrosis. This has led to the emergence of the field of cardio-oncology. This review explores the similarities between cancer and cardiovascular disease from the perspective of microRNAs (miRNAs). In particular, it examines a specific set of miRNAs that act as both oncomiRs (miRNAs in cancer) and myomiRs (muscle-related miRNAs), as well as different categories of miRNAs related to similar pathogenesis.
Review
Pharmacology & Pharmacy
Vijayvardhan Kamalumpundi, Elham Shams, Cally Tucker, Linhai Cheng, Joshua Peterson, Sanmati Thangavel, Oloigbe Ofori, Marcelo Correia
Summary: Type 2 diabetes often overlaps with hypertension due to genetic, physiological, and environmental factors. There are several metabolic abnormalities that contribute to the coexistence. While diet and exercise are early treatment options, long-term strategies are needed. Novel medications can prevent long-term complications. Understanding the common causes and consequences allows for proactive prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Bielska, Magdalena Niemira, Adam Kretowski
Summary: Type 2 diabetes and its complications pose a serious threat to patients' life and health worldwide, especially vascular complications. MicroRNAs are considered potential biomarkers for detecting diabetes-related complications and may facilitate the development of more effective therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Chengshun Li, Dongxu Wang, Ziping Jiang, Yongjian Gao, Liqun Sun, Rong Li, Minqi Chen, Chao Lin, Dianfeng Liu
Summary: More than 10% of the world's population already suffers from diabetes mellitus (DM) to varying degrees, which can lead to cardiovascular disease (CVD) and become the leading cause of death in diabetes patients. Non-coding RNAs (ncRNAs) have been found to play an important role in DM and CVD, and aberrant ncRNAs may serve as potential biomarkers for diagnosis. Regulation of ncRNA expression levels may also be a key mechanism in future DM treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sung-Bum Lee, Ja-Eun Choi, Byoungjin Park, Mi-Yeon Cha, Kyung-Won Hong, Dong-Hyuk Jung
Summary: This study investigated the interactions of genetic variants and nutrient intake on cardiovascular disease, revealing that specific polymorphisms associated with dyslipidaemia and nutrients intake can influence cardio-cerebrovascular disease risk. The findings suggest the importance of genetic factors in dietary guidelines for the prevention and management of cardiovascular disease.