Recent advances in pre-clinical mouse models of COPD

Role of CXCL13 in Cigarette Smoke–induced Lymphoid Follicle Formation and Chronic Obstructive Pulmonary Disease

(2013) Ken R. Bracke et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Toll-like Receptor 3 Stimulation Causes Corticosteroid-Refractory Airway Neutrophilia and Hyperresponsiveness in Mice

(2013) Genki Kimura et al.   CHEST

A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

(2013) Emma L. Beckett et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Detection of Lung Dysfunction Using Ventilation and Perfusion SPECT in a Mouse Model of Chronic Cigarette Smoke Exposure

(2013) B. N. Jobse et al.   JOURNAL OF NUCLEAR MEDICINE

New anti-inflammatory targets for chronic obstructive pulmonary disease

(2013) Peter J. Barnes   NATURE REVIEWS DRUG DISCOVERY

Cigarette Smoke Induced Airway Inflammation Is Independent of NF-κB Signalling

(2013) Joseph M. D. Rastrick et al.   PLoS One

Cardiac-Specific Overexpression of Metallothionein Rescues against Cigarette Smoking Exposure-Induced Myocardial Contractile and Mitochondrial Damage

(2013) Nan Hu et al.   PLoS One

Safety and tolerability of the inhaled phosphodiesterase 4 inhibitor GSK256066 in moderate COPD

(2013) Henrik Watz et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Glutathione peroxidase-1 as a novel therapeutic target for COPD

(2013) Ross Vlahos et al.   REDOX REPORT

Second hand smoke and COPD: lessons from animal studies

(2013) Monica P. Goldklang et al.   Frontiers in Physiology

Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle

(2012) Vladimir T. Basic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Long-term nose-only cigarette smoke exposure induces emphysema and mild skeletal muscle dysfunction in mice

(2012) M. Rinaldi et al.   Disease Models & Mechanisms

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Late Intervention with a Myeloperoxidase Inhibitor Stops Progression of Experimental Chronic Obstructive Pulmonary Disease

(2011) Andrew Churg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interleukin-6 Promotes Pulmonary Emphysema Associated with Apoptosis in Mice

(2011) Saleela M. Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pharmacological antioxidant strategies as therapeutic interventions for COPD

(2011) Irfan Rahman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Matrix metalloproteinases in COPD

(2011) A. Churg et al.   EUROPEAN RESPIRATORY JOURNAL

Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients

(2011) Deepti Malhotra et al.   JOURNAL OF CLINICAL INVESTIGATION

Angiotensin receptor blockade attenuates cigarette smoke–induced lung injury and rescues lung architecture in mice

(2011) Megan Podowski et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Characterization of GSK256066, a High-Affinity Inhaled Phosphodiesterase 4 Inhibitor

(2011) A. T. Nials et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

P2X7 Receptor and Caspase 1 Activation Are Central to Airway Inflammation Observed after Exposure to Tobacco Smoke

(2011) Suffwan Eltom et al.   PLoS One

AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD

(2011) Piotr Kuna et al.   RESPIRATORY MEDICINE

Suppressing production of reactive oxygen species (ROS) for influenza A virus therapy

(2011) Ross Vlahos et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of Nox2 Oxidase Activity Ameliorates Influenza A Virus-Induced Lung Inflammation

(2011) Ross Vlahos et al.   PLoS Pathogens

Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice

(2010) M. A. Hassan Talukder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Glutathione peroxidase-1 protects against cigarette smoke-induced lung inflammation in mice

(2010) Chi Duong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cigarette Smoke–induced Oxidative Stress

(2010) Esther Barreiro et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

(2010) Ross Vlahos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Statin Reverses Smoke-induced Pulmonary Hypertension and Prevents Emphysema but Not Airway Remodeling

(2010) Joanne L. Wright et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Carbonylation Caused by Cigarette Smoke Extract Is Associated with Defective Macrophage Immunity

(2010) Steven Bozinovski et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs

(2010) John A Marwick et al.   Journal of Inflammation-London

Moving towards a new generation of animal models for asthma and COPD with improved clinical relevance

(2010) Christopher S. Stevenson et al.   PHARMACOLOGY & THERAPEUTICS

Treating Viral Exacerbations of Chronic Obstructive Pulmonary Disease: Insights from a Mouse Model of Cigarette Smoke and H1N1 Influenza Infection

(2010) Carla M. T. Bauer et al.   PLoS One

Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM

(2010) H. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Animal models of cigarette smoke-induced chronic obstructive pulmonary disease

(2010) Joanne L Wright et al.   Expert Review of Respiratory Medicine

Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

(2009) John A. Marwick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of animal models in the pharmacological evaluation of emerging anti-inflammatory agents for the treatment of COPD

(2009) J Craig Fox et al.   CURRENT OPINION IN PHARMACOLOGY

A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD

(2009) J. Vestbo et al.   EUROPEAN RESPIRATORY JOURNAL

Systemic manifestations and comorbidities of COPD

(2009) P. J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

TNF-α-mediated reduction in PGC-1α may impair skeletal muscle function after cigarette smoke exposure

(2009) Kechun Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Animal models of chronic obstructive pulmonary disease

(2008) Joanne L. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanisms of cigarette smoke-induced COPD: insights from animal models

(2008) Andrew Churg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Superoxide Dismutase 3 Polymorphism Associated with Reduced Lung Function in Two Large Populations

(2008) Morten Dahl et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extrapulmonary Manifestations of Chronic Obstructive Pulmonary Disease in a Mouse Model of Chronic Cigarette Smoke Exposure

(2008) Harry R. Gosker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Comparison of Cigarette Smoke-Induced Acute Inflammation in Multiple Strains of Mice and the Effect of a Matrix Metalloproteinase Inhibitor on These Responses

(2008) A. Morris et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

(2008) T. E. Sussan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical animal models of asthma and chronic obstructive pulmonary disease

(2008) Christopher S Stevenson et al.   Expert Review of Respiratory Medicine