Toll-like receptors and diabetes: a therapeutic perspective

Activation of Peroxisome Proliferator-Activated Receptor   (PPAR ) Suppresses Rho GTPases in Human Brain Microvascular Endothelial Cells and Inhibits Adhesion and Transendothelial Migration of HIV-1 Infected Monocytes

(2014) S. H. Ramirez et al.   JOURNAL OF IMMUNOLOGY

5-HT: The promiscuous and happy hormone!

(2011) Nicholas M Barnes   CURRENT OPINION IN PHARMACOLOGY

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals

(2011) Ling Zhao et al.   NUTRITION REVIEWS

Toll-like receptors as targets for immune disorders

(2011) Brian Keogh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The role of innate immune pathways in type 1 diabetes pathogenesis

(2011) Steven C Pino et al.   Current Opinion in Endocrinology Diabetes and Obesity

Free fatty acids in the presence of high glucose amplify monocyte inflammation via Toll-like receptors

(2010) Mohan R. Dasu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Nutrient Modification of the Innate Immune Response

(2010) Eric A. Schwartz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Differential Effects of Cream, Glucose, and Orange Juice on Inflammation, Endotoxin, and the Expression of Toll-Like Receptor-4 and Suppressor of Cytokine Signaling-3

(2010) R. Deopurkar et al.   DIABETES CARE

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Toll-like receptor 2 deficiency improves insulin sensitivity and hepatic insulin signalling in the mouse

(2010) L.-H. Kuo et al.   DIABETOLOGIA

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice

(2010) Mohan R Dasu et al.   LABORATORY INVESTIGATION

Association of Toll-Like Receptor Signaling and Reactive Oxygen Species: A Potential Therapeutic Target for Posttrauma Acute Lung Injury

(2010) Meng Xiang et al.   MEDIATORS OF INFLAMMATION

Functional Food Targeting the Regulation of Obesity-Induced Inflammatory Responses and Pathologies

(2010) Shizuka Hirai et al.   MEDIATORS OF INFLAMMATION

Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications

(2010) Sridevi Devaraj et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Regional Mucosa-Associated Microbiota Determine Physiological Expression of TLR2 and TLR4 in Murine Colon

(2010) Yunwei Wang et al.   PLoS One

Toll-Like Receptors and Diabetes

(2009) F. Susan Wong et al.   Annals of the New York Academy of Sciences

Activation of NF-κB by Palmitate in Endothelial Cells

(2009) Ezekiel Maloney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential Effect of Saturated and Unsaturated Free Fatty Acids on the Generation of Monocyte Adhesion and Chemotactic Factors by Adipocytes: Dissociation of Adipocyte Hypertrophy From Inflammation

(2009) C. Y. Han et al.   DIABETES

Increase in Plasma Endotoxin Concentrations and the Expression of Toll-Like Receptors and Suppressor of Cytokine Signaling-3 in Mononuclear Cells After a High-Fat, High-Carbohydrate Meal: Implications for insulin resistance

(2009) H. Ghanim et al.   DIABETES CARE

Pioglitazone Inhibits Toll-Like Receptor Expression and Activity in Human Monocytes and db/db Mice

(2009) Mohan R. Dasu et al.   ENDOCRINOLOGY

Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I

(2009) Marianne Böni-Schnetzler et al.   ENDOCRINOLOGY

Cyclooxygenase 2 Inhibition Exacerbates Palmitate-Induced Inflammation and Insulin Resistance in Skeletal Muscle Cells

(2009) Teresa Coll et al.   ENDOCRINOLOGY

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria

(2009) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidoglycan Enhances IL-6 Production in Human Synovial Fibroblasts via TLR2 Receptor, Focal Adhesion Kinase, Akt, and AP-1- Dependent Pathway

(2009) Y.-C. Chiu et al.   JOURNAL OF IMMUNOLOGY

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

PPARγ agonist, rosiglitazone, regulates angiotensin II-induced vascular inflammation through the TLR4-dependent signaling pathway

(2009) Yuanyuan Ji et al.   LABORATORY INVESTIGATION

Adding fuel to fire: microRNAs as a new class of mediators of inflammation

(2008) F J Sheedy et al.   ANNALS OF THE RHEUMATIC DISEASES

Candesartan inhibits Toll-like receptor expression and activity both in vitro and in vivo

(2008) Mohan R. Dasu et al.   ATHEROSCLEROSIS

High Glucose Induces Toll-Like Receptor Expression in Human Monocytes: Mechanism of Activation

(2008) M. R. Dasu et al.   DIABETES

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Inhibition of toll-like receptor 2 expression improves insulin sensitivity and signaling in muscle and white adipose tissue of mice fed a high-fat diet

(2008) Andréa M Caricilli et al.   JOURNAL OF ENDOCRINOLOGY

Diabetes and atherosclerosis: is there a role for hyperglycemia?

(2008) Alan Chait et al.   JOURNAL OF LIPID RESEARCH

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

Mechanisms of Disease: advanced glycation end-products and their receptor in inflammation and diabetes complications

(2008) Shi Fang Yan et al.   Nature clinical practice. Endocrinology & metabolism