Review
Emergency Medicine
Beng Leong Lim, Wei Feng Lee, Wei Ming Ng, Wangmin Situ, Kee Vooi Loo, Carmen Jia, Wui Ling Chan
Summary: Transdermal GTN can reduce blood pressure in acute stroke, but does not alter clinical outcomes, even in ultra-early stroke (<= 6 h).
ACADEMIC EMERGENCY MEDICINE
(2022)
Article
Clinical Neurology
Lipeng Cai, Gary Rajah, Honglian Duan, Jie Gao, Zhe Cheng, Ruiqiang Xin, Shangqian Jiang, Peter Palmer, Xiaokun Geng, Yuchuan Ding
Summary: The study aims to evaluate the safety, feasibility, and preliminary efficacy of intravenous GTN in patients with AIS, as well as its potential neuroprotective effects. Early results will provide important parameters for future studies and shed light on the possible neuroprotective qualities of GTN in AIS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas J. Rieth, Dimitri Gruen, Georgios Zarogiannis, Steffen D. Kriechbaum, Sebastian Wolter, Manuel J. Richter, Khodr Tello, Ulrich Krueger, Veselin Mitrovic, Stephan Rosenkranz, Christian W. Hamm, Till Keller
Summary: This study aimed to explore the impact of sublingual glyceryl trinitrate (GTN) on transplant/ventricular assist device-free survival in HF patients with post-capillary PH. The results showed that improved pulmonary arterial elastance, pulmonary arterial compliance, and total pulmonary resistance after GTN administration were associated with survival. These parameters can be used as prognostic indicators.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Bianca N. Mason, Shayne N. Hassler, Kathryn DeFea, Scott Boitano, Josef Vagner, Theodore J. Price, Greg Dussor
Summary: Research has found that activation of PAR2 in the meninges can cause acute headache behavioral responses and increase sensitivity to glyceryl trinitrate (GTN) for migraines. However, control groups did not show this reaction. Therefore, this study suggests that PAR2 may be a novel therapeutic target for migraines.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Endocrinology & Metabolism
Alexia Sophie Pena, Jennifer Harrington, Sarah Kate Peters Black, Roger Gent, Craig Hirte, Jennifer J. Couper, Esko Wiltshire
Summary: Youth with obesity exhibit abnormal vascular function and lower levels of adiponectin during puberty, which do not deteriorate further. Better vascular function in healthy children is associated with lower BMI z-score and waist circumference.
HORMONE RESEARCH IN PAEDIATRICS
(2021)
Article
Biology
Julie Favre, Emilie Vessieres, Anne-Laure Guihot, Coralyne Proux, Linda Grimaud, Jordan Rivron, Manuela Cl Garcia, Lea Rethore, Rana Zahreddine, Morgane Davezac, Chanaelle Febrissy, Marine Adlanmerini, Laurent Loufrani, Vincent Procaccio, Jean-Michel Foidart, Gilles Flouriot, Francoise Lenfant, Coralie Fontaine, Jean-Francois Arnal, Daniel Henrion
Summary: The study found that endothelial membrane ER alpha promotes NO bioavailability through inhibition of oxidative stress, and thereby participates in the regulation of flow-mediated dilation (FMD).
Review
Peripheral Vascular Disease
J. Malik, L. Novakova, A. Valerianova, E. Chytilova, V Lejsek, Buryskova K. Salajova, L. Lambert, T. Grus, M. Porizka, P. Michalek
Summary: Wall shear stress plays a significant role in the development of atherosclerosis and its complications, especially in areas with chronically low oscillating wall shear stress such as outer bifurcation walls and inner walls of arches.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Caroline Bleakley, Aaron McCann, Vivienne McClenaghan, Paul Kevin Hamilton, Auleen Millar, Richard Pumb, Mark Harbinson, Gary Eugene McVeigh
CARDIOVASCULAR ULTRASOUND
(2015)
Editorial Material
Medical Laboratory Technology
Paul K. Hamilton, Giles E. Aldworth, Mike Smye, Margaret McDonnell, Grainne M. Connolly
CLINICAL CHEMISTRY
(2015)
Review
Peripheral Vascular Disease
Caroline Bleakley, Paul Kevin Hamilton, Richard Pumb, Mark Harbinson, Gary Eugene McVeigh
JOURNAL OF CLINICAL HYPERTENSION
(2015)
Article
Acoustics
Christina E. Agnew, Paul K. Hamilton, Aaron J. McCann, R. Canice McGivern, Gary E. McVeigh
ULTRASOUND IN MEDICINE AND BIOLOGY
(2015)
Review
Medicine, General & Internal
Michael Trimble, Paul Hamilton
Letter
Emergency Medicine
Paul K. Hamilton, Mark V. Roberts, Jonathan Dawson, Michael Trimble
EMERGENCY MEDICINE JOURNAL
(2016)
Letter
Emergency Medicine
Paul Hamilton, Jennifer Hamilton
JOURNAL OF EMERGENCY MEDICINE
(2017)
Article
Cardiac & Cardiovascular Systems
C. J. Lockhart, A. J. McCann, R. A. Pinnock, P. K. Hamilton, M. T. Harbinson, G. E. McVeigh
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2014)
Article
Anesthesiology
Emma Cunningham, Nicola Gallagher, Paul Hamilton, Leeann Bryce, David Beverland
Summary: The study found a prevalence rate of 21.7% for post-operative hyponatraemia in elective joint arthroplasty patients, with main risk factors including age, pre-operative sodium levels, and fasting glucose on day 1 post-surgery. Surprisingly, patients discharged with hyponatraemia did not show a higher rate of emergency department reattendance or readmission.
PERIOPERATIVE MEDICINE
(2021)
Article
Medical Laboratory Technology
Jonathan Macdonald, Emma Cunningham, Nicola Gallagher, Paul Hamilton, Roslyn Cassidy, Leeann Bryce, David Beverland
Summary: Post-operative hyponatraemia is common following joint replacement surgery and may indicate pre-operative vulnerability. However, it does not independently predict length of stay, re-attendance, or re-admission to hospital within 90 days. Further research is needed to develop a pre-operative approach to identify patients at risk of developing significant post-operative hyponatraemia.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Article
Medical Laboratory Technology
Eamon P. McCarron, Emma Murray, Gareth C. McKeeman, Stephen M. Coward, Paul Hamilton, Grainne Connolly, Brona Roberts
Summary: This study evaluated the interference of lipemia on sodium concentration measurement and found significant negative interference by endogenous lipemia. The study suggests that clinical laboratories should lower the cut-off value to ensure accurate reporting of sodium concentration.
ANNALS OF CLINICAL BIOCHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Alan Jones, Katherine Peers, Anthony S. Wierzbicki, Radha Ramachandran, Michael Mansfield, Charlotte Dawson, Antonio Ochoa-Ferraro, Handrean Soran, Fiona Jenkinson, Ian McDowell, Paul Downie, Paul Hamilton, Richard Jones
Summary: The VOL4002 study evaluated the efficacy and safety of volanesorsen in patients with familial chylomicronaemia syndrome (FCS). The results showed that volanesorsen can significantly reduce triglyceride levels and decrease the incidence of pancreatitis events in FCS patients. This study supports the effectiveness of volanesorsen in FCS patients and suggests that long-term use is safe.
Review
Medical Laboratory Technology
Aaron Vage, Eamon McCarron, Paul K. Hamilton
Summary: All humans experience acute psychological stress periodically, which can lead to physiological changes and activate various axes in the body. This review article examines the human response to acute stress and discusses how psychological stress can introduce variability in certain laboratory measurements. It highlights the role of biochemical markers, such as cortisol and growth hormone, in quantifying stress and its impact on human behavior.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medical Laboratory Technology
Dylan J. Mac Lochlainn, Paul K. Hamilton, M. Ivan Wiggam
JOURNAL OF APPLIED LABORATORY MEDICINE
(2020)
Meeting Abstract
Medicine, General & Internal
P. K. Hamilton, S. Hunter
IRISH JOURNAL OF MEDICAL SCIENCE
(2018)