期刊
CLINICAL SCIENCE
卷 118, 期 11-12, 页码 691-705出版社
PORTLAND PRESS LTD
DOI: 10.1042/CS20090549
关键词
fibrosis; hepatocellular carcinoma; ischaemia/reperfusion injury; non-alcoholic fatty liver disease (NAFLD); nuclear factor kappa B (NF-kappa B); regeneration
资金
- Medical Research Council
- Wellcome Trust
- Royal College of Surgeons of Edinburgh
NF-kappa B (nuclear factor kappa B) is a heterodimeric transcription factor that is constitutively expressed in all cell types and has a central role as a transcriptional regulator in response to cellular stress. In the present review, we discuss the role of NF-kappa B signalling in the maintenance of liver homoeostasis as well as in the pathogenesis of a wide variety of conditions affecting the liver, including viral hepatitis, steatohepatitis, cirrhosis and hepatocellular carcinoma. Much of the current knowledge of NF-kappa B signalling in the liver relates to the canonical pathway, the IKK [I kappa B (inhibitor of kappa B) kinase] complex and the RelA subunit. We explore the weaknesses of the experimental approaches to date and suggest that further work is needed to investigate in detail the discreet functions of each of the Rel subunits in liver physiology and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据