Article
Cardiac & Cardiovascular Systems
Yudai Fujimoto, Daichi Maeda, Nobuyuki Kagiyama, Tsutomu Sunayama, Taishi Dotare, Kentaro Jujo, Kazuya Saito, Kentaro Kamiya, Hiroshi Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Hiroshi Wada, Masaru Hiki, Takatoshi Kasai, Hirofumi Nagamatsu, Tetsuya Ozawa, Katsuya Izawa, Shuhei Yamamoto, Naoki Aizawa, Kazuki Wakaume, Kazuhiro Oka, Shin-ichi Momomura, Yuya Matsue
Summary: This study examined the relationship between sar-copenia and cachexia in older patients with heart failure, and found that there is an overlap between these two conditions and they have prognostic implications. This study is of great importance for understanding the relevant diseases in patients with heart failure.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ikuko Okuni, Yuta Otsubo, Satoru Ebihara
Summary: Cancer is a leading cause of death globally, but survival rates have improved significantly. Taste and smell disorders may contribute to swallowing difficulties in cancer patients, necessitating a multifaceted approach from the medical care team due to the complexity of factors involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Antia Fernandez-Pombo, Gemma Rodriguez-Carnero, Ana I. Castro, Ana Canton-Blanco, Luisa M. Seoane, Felipe F. Casanueva, Ana B. Crujeiras, Miguel A. Martinez-Olmos
Summary: Chronic heart failure often leads to involuntary weight loss and muscle wasting, necessitating careful nutritional evaluation and treatment to prevent or improve cardiac cachexia and sarcopenia, as well as improve the course of the disease.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Masaaki Konishi, Eiichi Akiyama, Yasushi Matsuzawa, Ryosuke Sato, Shinnosuke Kikuchi, Hidefumi Nakahashi, Nobuhiko Maejima, Noriaki Iwahashi, Masami Kosuge, Toshiaki Ebina, Kiyoshi Hibi, Toshihiro Misumi, Stephan von Haehling, Stefan D. Anker, Kouichi Tamura, Kazuo Kimura
Summary: The study found that more than half of heart failure patients had reduced muscle mass, and lower values of both muscle and fat mass were associated with higher mortality in heart failure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Geriatrics & Gerontology
Katsuhiko Ohori, Toshiyuki Yano, Satoshi Katano, Ryohei Nagaoka, Ryo Numazawa, Kotaro Yamano, Yusuke Fujisawa, Hidemichi Kouzu, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Wataru Ohwada, Masato Furuhashi
Summary: This study examined whether self-reported weight loss improves the accuracy of predicting mortality caused by sarcopenia in heart failure patients. The results showed that sarcopenia and self-reported weight loss coexisted in 32% of patients. The coexistence of sarcopenia and self-reported weight loss was found to be a powerful predictor of mortality in heart failure patients, and its inclusion significantly improved the accuracy of the prediction model.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Amanda R. Vest, Joronia Chery, Laura Telfer, Matthew Lawrence, Michael S. Kiernan, Gregory Couper, Edward Saltzman, Didjana Celkupa, Masashi Kawaborie, William W. Wong, Alex Coston
Summary: There were significant gains in skeletal muscle mass among LVAD recipients with advanced systolic heart failure during the first 6 months of LVAD support.
CIRCULATION-HEART FAILURE
(2022)
Review
Cardiac & Cardiovascular Systems
Ruting Wang, Jiahao Duan, Wei Liu, Kai Huang, Zijun Chen, Chun Yang, Ling Yang
Summary: There is an association between heart failure and depression, with depression increasing the incidence of heart failure. Hospitalization and mortality rates are higher in heart failure patients with comorbid depression. Sarcopenia is also linked to heart failure and depression.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Alessia Lena, Sara Hadzibegovic, Stephan von Haehling, Jochen Springer, Andrew J. Stewart Coats, Markus S. Anker
Summary: Wasting disorders in chronic disease, such as cachexia and sarcopenia, share similar symptoms due to impairments in inflammatory responses, neurohormonal activity, and metabolic systems, leading to tissue depletion and reduced quality of life. While therapeutic strategies have shown promise, there is no guideline-recommended pharmacotherapy available for these disorders. Further research is needed to better understand and treat wasting disorders.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2021)
Review
Biochemistry & Molecular Biology
Rodrigo Haber Mellen, Otavio Simoes Girotto, Eduarda Boni Marques, Lucas Fornari Laurindo, Paulo Cesar Grippa, Claudemir Gregorio Mendes, Lorena Natalino Haber Garcia, Marcelo Dib Bechara, Sandra Maria Barbalho, Renata Vargas Sinatora, Jesselina Francisco dos Santos Haber, Uri Adrian P. Flato, Patricia Cincotto dos Santos Bueno, Claudia Rucco Penteado Detregiachi, Karina Quesada
Summary: Sarcopenia, caused by factors like aging, diet, inactivity, or other diseases, is associated with muscle loss and increased health risks. This systematic review examines the effects of nutrition and drugs on sarcopenic patients to improve their health and quality of life. Lifestyle interventions have significant effects on sarcopenia treatment, while supplements like creatine, leucine, branched-chain amino acids, omega 3, and vitamin D can also be beneficial. Medications such as Metformin, GLP-1, losartan, statin, growth hormone, and dipeptidyl peptidase 4 inhibitors have controversial results but can potentially alter metabolic parameters and protect against cardiovascular diseases in sarcopenic patients.
Article
Medicine, General & Internal
Grzegorz Sobieszek, Tomasz Powrozek, Aneta Skwarek-Dziekanowska, Teresa Malecka-Massalska
Summary: The TT genotype of TNFRSF1A is associated with a higher risk of cachexia in CHF patients, characterized by weight loss and muscle wasting. Patients with the TT genotype have lower albumin concentration, poorer cardiac function parameters, and higher risk for cachexia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jong Min Park, Young Min Han, Ho Jae Lee, Yong Jin Park, Ki Baik Hahm
Summary: Nicotinamide riboside (NR) intake can ameliorate cancer cachexia by inhibiting cachexic factors, muscle-specific ubiquitin-proteasome ligases, and adipose triglyceride lipase, while increasing crucial enzymes in NAD(+) biosynthesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hidemichi Kouzu, Satoshi Katano, Toshiyuki Yano, Katsuhiko Ohori, Ryohei Nagaoka, Takuya Inoue, Yuhei Takamura, Tomoyuki Ishigo, Ayako Watanabe, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Wataru Ohwada, Tetsuji Miura
Summary: The study retrospectively examined 301 patients with HF, finding that high concentrations of 3-methylhistidine and low concentrations of beta-alanine and valine were associated with adverse events. Plasma amino acid profiling improves risk stratification for HF patients.
Article
Cardiac & Cardiovascular Systems
Hidemichi Kouzu, Satoshi Katano, Toshiyuki Yano, Katsuhiko Ohori, Ryohei Nagaoka, Takuya Inoue, Yuhei Takamura, Tomoyuki Ishigo, Ayako Watanabe, Masayuki Koyama, Nobutaka Nagano, Takefumi Fujito, Ryo Nishikawa, Wataru Ohwada, Tetsuji Miura
Summary: This study suggests that plasma amino acid profiling can improve the prediction of clinical outcomes in HF patients, with high 3-methylhistidine and low beta-alanine concentrations independently associated with adverse events.
Article
Cardiac & Cardiovascular Systems
Ke Ma, Jie Yang, Yihui Shao, Ping Li, Hongchang Guo, Jianing Wu, Yi Zhu, Hui Zhang, Xu Zhang, Jie Du, Yulin Li
Summary: An accurate prediction model based on arachidonic acid metabolites was developed to predict mortality in patients with acute decompensated heart failure. The model showed high accuracy in predicting death in validation cohort and provided incremental information beyond existing clinical scores. In a murine model, inhibiting soluble epoxide hydrolase was shown to be a potential therapeutic target for treating heart failure.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Chiara Della Peruta, Biliana Lozanoska-Ochser, Alessandra Renzini, Viviana Moresi, Carles Sanchez Riera, Marina Bouche, Dario Coletti
Summary: Thanks to precision medicine, personalized treatments based on sex have emerged in recent years. Male and female skeletal muscles have significant differences, which impacts diagnosis and therapy. Men have more muscle and exhibit different inflammation responses, leading to different treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)