Article
Biochemistry & Molecular Biology
Tarvi Teder, Stefanie Koenig, Rajkumar Singh, Bengt Samuelsson, Oliver Werz, Ulrike Garscha, Jesper Z. Haeggstrom
Summary: This study identified new drugs that can inhibit the expression of LTA(4)H and reduce the activity of 5-LOX in leukocytes, thus suppressing inflammatory responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Xingxia Wan, Huiling Wang, Baotang Shi, Yu Guo, Shi-Yu Liu, Xianwang Wang
Summary: In this study, a highly sensitive and specific method for detecting LTA(4)H activity using the ADMAB probe was developed. This method could be used for early diagnosis of cancer and biomedical research related to LTA(4)H.
Article
Biochemistry & Molecular Biology
Izumi Tsukayama, Yuki Kawakami, Asako Tamenobu, Keisuke Toda, Saya Maruoka, Yuki Nagasaki, Yoshiko Mori, Risa Sawazumi, Kensuke Okamoto, Keita Kanzaki, Hideyuki Ito, Yoshitaka Takahashi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto
Summary: In this study, it was found that malabaricone C, a component of nutmeg, strongly inhibited the activity of 5-lipoxygenase, an enzyme involved in leukotriene biosynthesis. Furthermore, malabaricone C was shown to ameliorate psoriasis-like skin inflammation by decreasing the level of leukotriene B4.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
R. Qin, H. Wang, A. Yan
Summary: In this study, 18 classification models and 6 QSAR models were built for LTA4H inhibitors, providing insights into the structural features of highly active inhibitors and guiding the design of new anti-inflammatory drugs. The best classification model achieved a prediction accuracy of 88.96% and MCC of 0.74, while the best QSAR model had coefficients of determination of 0.81 and 0.79 for training and test sets, respectively.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Simone Schierle, Steffen Brunst, Moritz Helmstaedter, Roland Ebert, Jan S. Kramer, Dieter Steinhilber, Ewgenij Proschak, Daniel Merk
Summary: Designed polypharmacology is an attractive strategy to increase therapeutic efficacy in multi-factorial diseases by targeting multiple involved targets with a single molecule. Activation of FXRa and inhibition of LTA4Hi show promise in counteracting NASH, and dual FXR/LTA4H modulators have been developed as pharmacological tools for further evaluation.
Article
Biochemistry & Molecular Biology
Miquel Canyelles-Nino, Angels Gonzalez-Lafont, Jose M. Lluch
Summary: LTA(4)H is an important enzyme that converts LTA(4) into LTB4, a potent chemotactic agent involved in inflammatory diseases. The enzyme acts through a unique mechanism, involving the attachment of a water molecule to the carbon backbone of LTA(4) several units away from the epoxide moiety. Molecular stacking and noncovalent interactions also play a crucial role in the reaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Xiaoxin Wu, Antonia RuJia Sun, Ross Crawford, Yin Xiao, Yanping Wang, Indira Prasadam, Xinzhan Mao
Summary: Chronic inflammation plays a crucial role in osteoarthritis (OA) pathology, but its impact on OA disease progression remains unclear. This study found that leukotriene B4 (LTB4) and its upstream enzyme, Leukotriene A(4) hydrolase (LTA(4)H), were highly expressed in OA cartilage. Inhibition of LTA(4)H showed therapeutic potential by suppressing cartilage degeneration and promoting regeneration, suggesting LTA(4)H as a potential therapeutic target for OA.
Article
Medicine, Research & Experimental
Armin Steffen, Stephanie Jeschke, Ryan J. Soose, Katrin Hasselbacher, Inke R. Koenig
Summary: Hypoglossal nerve stimulation is an effective treatment option for obstructive sleep apnea, and changing stimulation parameters may reduce voltage requirements while maintaining the same effect on tongue protrusion. However, this change does not affect the range of tolerated impulse steps between functional and subdiscomfort thresholds. Future technical appliances could help estimate functional thresholds at different electrode configurations for each patient by automatically measuring impedances.
Article
Clinical Neurology
Hannes Schacht, Inke Regina Koenig, Johannes Hensler, Peter Schramm, Jan Kuechler, Claudia Ditz, Alexander Neumann
Summary: MMA resembles a high heel shoe print on TOF-MRA images, with a shiny and thick appearance in DAVF patients. Cut-off values for signal intensity and diameter ratios can predict the presence of DAVF accurately.
CLINICAL NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Joanne Trinh, Theresa Luth, Susen Schaake, Bjorn-Hergen Laabs, Kathleen Schlueter, Joshua Lass, Jelena Pozojevic, Ronnie Tse, Inke Koenig, Roland Dominic Jamora, Raymond L. Rosales, Norbert Brueggemann, Gerard Saranza, Cid Czarina E. Diesta, Frank J. Kaiser, Christel Depienne, Christopher E. Pearson, Ana Westenberger, Christine Klein
Summary: By sequencing the genomes of XDP patients, researchers have discovered various mutations within the repetitive sequence SINE-VNTR-Alu(AGAGGG)(n), which may act as modifiers of disease expression in XDP.
Article
Clinical Neurology
Armin Steffen, Florian Joffrey Moritz, Inke R. Koenig, Maria Suurna, Norbert Brueggemann
Summary: This study examined the physiological effect of unilateral hypoglossal nerve stimulation on bilateral tongue motion and found no significant difference in EMG signals based on different factors such as electrode configurations, stimulation-cuff position, body-mass-index, and sleep apnea severity. The findings highlight the importance of considering individual anatomy during therapy titration for optimal response.
JOURNAL OF SLEEP RESEARCH
(2023)
Review
Immunology
Rochi Saurabh, Cesaire J. K. Fouodo, Inke R. R. Konig, Hauke Busch, Inken Wohlers
Summary: This paper reviews current publicly available GWAS and PGS data on autoimmune diseases, summarizes the diseases investigated and the respective studies conducted, and provides an overview of the genetic data and autoimmune disease patients in the UK Biobank. The study finds that only the more prevalent autoimmune diseases are covered by both GWAS and PGS catalogs in the UK Biobank.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Anja Bischof, Dominique Brandt, Samantha Schlossarek, Maren Vens, Dmitri Rozgonjuk, Jennifer Wernicke, Christopher Kannen, Klaus Woelfling, Michael Dreier, Harriet Salbach, Lara Basenach, Thomas Moessle, Denise Olbrich, Inke Koenig, Stefan Borgwardt, Christian Montag, Hans-Jurgen Rumpf
Summary: This study examines the effectiveness of a stepped care approach in reducing symptom severity for Internet Use Disorders (IUDs). The sample consists primarily of online recruited participants, with a focus on employees in companies with health insurance support. The stepped care approach includes app intervention, telephone counseling, and online therapy based on cognitive-behavioral therapy. Results will be analyzed using hierarchical testing procedures.
Article
Clinical Neurology
Joanne Trinh, Andrew A. Hicks, Inke R. Koenig, Sylvie Delcambre, Theresa Lueth, Susen Schaake, Kobi Wasner, Jenny Ghelfi, Max Borsche, Carles Vilarino-Gueell, Faycel Hentati, Elisabeth L. Germer, Peter Bauer, Masashi Takanashi, Vladimir Kostic, Anthony E. Lang, Norbert Brueggemann, Peter P. Pramstaller, Irene Pichler, Alex Rajput, Nobutaka Hattori, Matthew J. Farrer, Katja Lohmann, Hansi Weissensteiner, Patrick May, Christine Klein, Anne Gruenewald
Summary: Trinh et al. found that PINK1/PRKN mutations increase the risk of mitochondrial DNA variant accumulation in a dose- and disease-dependent manner. Monoallelic mutation carriers can be distinguished by the level of heteroplasmic mtDNA variants. Biallelic mutations in PINK1/PRKN lead to recessive Parkinson's disease.
Book Review
Mathematical & Computational Biology
Andreas Ziegler
BIOMETRICAL JOURNAL
(2023)
Letter
Genetics & Heredity
Hafiza Noor Ul Ayan, Pir Sheeraz Ali, Asad Aslam Korejo, Holger Thiele, Peter Nuernberg, Muhammad Tariq, Syed Zahid Jamal, Jeanette Erdmann, Ilyas Ahmad
Article
Cardiac & Cardiovascular Systems
Andreas Ziegler, Alper Oner, Gisela Quadflieg, Raphael O. Betschart, Alexandre Thiery, Hugo Babel, Henry G. Mwambi, Henriette Neumeyer, Steffen Mackschin, Sissy Hintz, Miriam Mann, Hermann Dittrich, Christian Schmidt
Summary: The main objective of this study was to analyze the cost-effectiveness of an integrated care concept (NICC) that combines telemonitoring with the support of a care center in addition to guideline therapy. The secondary aim was to compare health utility and quality of life between NICC and standard of care (SoC). The study found that NICC was associated with higher QoL and health utility compared to SoC.
Article
Computer Science, Information Systems
Giorgos Koliopanos, Francisco Ojeda, Andreas Ziegler
Summary: This work introduces a simple-to-use R package called "Mock Data Generation (modgo)" that can be used to simulate data from existing study data for continuous, ordinal categorical, and dichotomous variables. The core method combines rank inverse normal transformation with the calculation of a correlation matrix for all variables. modgo allows for flexibility in changing the correlation between variables, performing perturbation analysis, handling multicenter data, and changing inclusion/exclusion criteria.
METHODS OF INFORMATION IN MEDICINE
(2023)
Article
Oncology
David Krug, Detlef Imhoff, Alfred Haidenberger, Nicole Hessler, Jane Schaefer, Stefan Huttenlocher, Georgios Chatzikonstantinou, Christoph Fuerweger, Ulla Ramm, Inke R. Koenig, Felix Chun, Michael Staehler, Claus Roedel, Alexander Muacevic, Reinhard Vonthein, Juergen Dunst, Oliver Blanck
Summary: This study aimed to evaluate the efficacy and toxicity of robotic stereotactic body radiotherapy (SBRT) for patients with localized prostate cancer. The results showed that robotic SBRT had minimal toxicity and produced favorable short-term outcomes.
STRAHLENTHERAPIE UND ONKOLOGIE
(2023)
Article
Mathematical & Computational Biology
Francisco M. Ojeda, Max L. Jansen, Alexandre Thiery, Stefan Blankenberg, Christian Weimar, Matthias Schmid, Andreas Ziegler
Summary: Statistical prediction models are popular in applied research, but transferring the model to a different population poses a challenge. This study systematically evaluates various calibration approaches for two-class probability estimation. Logistic calibration and beta calibration consistently show the best results, with calibration on logit transformed probability estimates generally outperforming non-transformed estimates. Regression-based calibration approaches are recommended for validation studies.
STATISTICS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nicole Hessler, Andreas Ziegler
Summary: This study examined the differences in content and form of titles between original research articles published in major medical journals between 2011 and 2020. The analysis of 500 randomly chosen articles revealed that there were minimal mentions of results, quantitative information, declarative titles, dashes, or question marks in the titles across all journals. However, the use of subtitles and methods-related items increased over time, while the use of phrasal titles decreased. The study also found variations in the use of study names among the journals, with the Lancet having the highest usage. The findings highlight the importance for authors to carefully consider the titles of journal articles in their target journal before submission.
Article
Medicine, General & Internal
Inke R. Koenig, Mirja Mittermaier, Christian Sina, Matthias Raspe, Patrick Stais, Thomas Gamstaetter, Philipp Stachwitz, Sebastian Wolfrum, Jutta G. Richter, Martin Moeckel
Summary: This article presents methodological considerations for researching digital health applications (DiGA) and critically discusses current research practice using selected internal medicine DiGAs. It highlights the challenges in investigating DiGAs and the lack of health services research data supporting their benefits.
