Article
Multidisciplinary Sciences
Sahar Gelfman, Arden Moscati, Santiago Mendez Huergo, Rujin Wang, Veera Rajagopal, Neelroop Parikshak, Vijay Kumar Pounraja, Esteban Chen, Michelle Leblanc, Ralph Hazlewood, Jan Freudenberg, Blerta Cooper, Ann J. Ligocki, Charles G. Miller, Tave Van Zyl, Jonathan Weyne, Carmelo Romano, Botir Sagdullaev, Olle Melander, Aris Baras, Eli A. Stahl, Giovanni Coppola
Summary: In this study, the authors performed genome-wide association analysis and whole-exome analysis to uncover the underlying genetics of HLA-B*27 positive and negative forms of anterior uveitis (AU).
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Jin-Xian Huang, Yung-Heng Lee, James Cheng-Chung Wei
Summary: Ankylosing spondylitis (AS) is associated with increased risk of cardiovascular disease (CVD), and tumor necrosis factor inhibitors (TNFi) may be effective in treating this risk. However, the impact of TNFi on lipid changes and atherosclerosis is still controversial.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Kathy Ming Feng, Wu-Chien Chien, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis could be a predictor of ACS in patients with AS. Both anterior uveitis and posterior segment involvement were associated with an increased risk of ACS in AS patients. Age, diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, asthma, and systemic steroids were significant risk factors for ACS. The all-cause mortality was higher in the uveitis group compared to the non-uveitis group.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yi-Fen Lai, Ting-Yi Lin, Wu-Chien Chien, Chien-An Sun, Chi-Hsiang Chung, Yi-Hao Chen, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that patients with AS who have uveitis are at a significantly higher risk of developing acute myocardial infarction (AMI) compared to those without uveitis. Regardless of gender or age group, patients with uveitis in the AS population have an increased risk for AMI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Jean W. Liew, John D. Reveille, Maria Castillo, Henna Sawhney, Benjamin S. Naovarat, Susan R. Heckbert, Lianne S. Gensler
Summary: This study compared the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in axial spondyloarthritis (axSpA) patients with the general US population and found no significant difference in the prevalence of high ASCVD risk scores. Future research should focus on improving cardiovascular risk prediction in axSpA patients to potentially explain these results.
JOURNAL OF RHEUMATOLOGY
(2021)
Editorial Material
Rheumatology
Juergen Braun, Robert B. M. Landewe
Summary: Three monoclonal antibodies targeting interleukin-23 have been approved for psoriasis treatment, with two also approved for psoriatic arthritis. However, they have shown to be ineffective in axial spondyloarthritis and may be due to generic effects rather than specific inflammation.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Helena Forsblad-d'Elia, Lucy Law, Karin Bengtsson, Johan Smeds, Maria Ketonen, Bjorn Sundstrom, Lotta Ljung, Mats Geijer, Stefan Soderberg, Per Lindqvist
Summary: The research examined biomechanical properties of the common carotid artery in patients with ankylosing spondylitis (AS), finding that strain and stiffness were associated with factors like age, disease characteristics, and traditional risk factors for cardiovascular disease. Strain showed associations with AS-related factors and age, whereas stiffness was only associated with age, indicating different pathogenic vascular processes.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Jean W. Liew, S. Reza Jafarzadeh, Maureen Dubreuil, Susan R. Heckbert, Stephen J. Mooney, Matthew A. Brown, Mariko L. Ishimori, John D. Reveille, Michael M. Ward, Michael H. Weisman, Lianne S. Gensler
Summary: This study found no significant association between TNFi use and incident hypertension in a longitudinal cohort of patients with ankylosing spondylitis.
JOURNAL OF RHEUMATOLOGY
(2022)
Review
Medicine, General & Internal
Eric Toussirot
Summary: Patients with axial spondyloarthritis (axSpA) have an increased cardiovascular risk, which may be attributed to various factors including traditional risk factors, inflammation, and medication use. More research is needed, especially in patients with non-radiographic form of axSpA, to assess cardiovascular comorbidities.
FRONTIERS IN MEDICINE
(2021)
Article
Rheumatology
Samantha S. R. Crossfield, Helena Marzo-Ortega, Sarah R. Kingsbury, Mar Pujades-Rodriguez, Philip G. Conaghan
Summary: This study found that the incidence of ankylosing spondylitis decreased between 1998 and 2007, then increased from 2007 to 2017. The rising prevalence may indicate improved patient survival. However, there is a persisting delay in rheumatology referral and diagnosis, particularly in women.
Article
Immunology
Ta-hsin Tsung, Ke-Hao Huang, Wu-Chien Chien, Yi-Hao Chen, I-Chuan Yen, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis is a risk factor for stroke development in patients with AS, and both anterior uveitis and posterior segment involvement increase the risk of stroke.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Anna Sodergren, Johan Askling, Karin Bengtsson, Helena Forsblad-d'Elia, Tomas Jernberg, Ulf Lindstrom, Lotta Ljung, Angla Mantel, Lennart T. H. Jacobsson
Summary: Patients with ankylosing spondylitis (AS) have a higher burden of comorbidities at admission for a first acute myocardial infarction (AMI), and are less likely to be prescribed lipid-lowering drugs and non-aspirin antiplatelet therapy at discharge. Despite an increased overall mortality during days 31-365, there is no elevation in mortality due to cardiovascular-related causes among patients with AS.
CLINICAL RHEUMATOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yan Zhong, Yingwen Chen, Xinyue Zhang, Wenjun Cai, Changwei Zhao, Wenhai Zhao
Summary: This Mendelian randomization study found no evidence to support a causal relationship between ankylosing spondylitis and cardiovascular disease. Further research is needed to confirm this association.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Milad Baniaamam, Sjoerd C. Heslinga, Laura Boekel, Thelma C. Konings, M. Louis Handoko, Otto Kamp, Vokko P. van Halm, Irene E. van der Horst-Bruinsma, Mike T. Nurmohamed
Summary: The study revealed that the prevalence of diastolic left ventricular dysfunction and conduction disorders in elderly ankylosing spondylitis patients was similar to controls and not clinically relevant. However, ankylosing spondylitis patients had up to five times increased odds of developing aortic valve regurgitation compared to controls.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dermatology
Alina I. Marusina, Antonio Ji-Xu, Stephanie T. Le, Atrin Toussi, Lam C. Tsoi, Qinyuan Li, Guillaume Luxardi, Jordan Nava, Lauren Downing, Annie R. Leal, Nikolay Y. Kuzminykh, Olga Kruglinskaya, Marie-Charlotte Bruggen, Iannis E. Adamopoulos, Alexander A. Merleev, Johann E. Gudjonsson, Emanual Maverakis
Summary: ERAP1, ERAP2, and LNPEP, which are aminopeptidases, play a role in autoimmune diseases. The expression of ERAP2 is increased while ERAP1 is decreased in psoriasis patients with autoimmune-linked variants of ERAP. Different layers of skin cells show different expression patterns of aminopeptidases, and in psoriasis, basal keratinocytes also express CCL2 and IL-15. In addition, ERAP2-high skin fibroblasts also express more CXCL14.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)