Article
Immunology
Sushmita Chakraborty, Ranjan Gupta, Katharina F. Kubatzky, Santanu Kar, Franziska Kraus, M. Margarida Souto-Carneiro, Hanns-Martin Lorenz, Pankaj Kumar, Vijay Kumar, Dipendra Kumar Mitra
Summary: In patients with rheumatoid arthritis, regulatory T cells in the synovial fluid are impaired in their function. Blocking the action of IL-9 can restore the function of regulatory T cells and reduce the production of inflammatory T cells.
CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Jia Wang, Sheng-Xiao Zhang, Jia-Song Chang, Ting Cheng, Xiao-Jing Jiang, Qin-Yi Su, Jia-Qi Zhang, Jing Luo, Xiao-Feng Li
Summary: This study investigated the status of CD4(+) Tregs and the effects of low-dose IL-2 therapy in patients with refractory rheumatoid arthritis (RA). The results showed that a decrease in the absolute number of CD4 Tregs, rather than an increase in Th17 cells, contributed to an imbalance and high disease activity. Low-dose IL-2 selectively increased CD4 Tregs and rebalanced the ratio of Th17 and CD4 Tregs, leading to symptom remission without side effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dao X. Nguyen, Helen M. Baldwin, Amara N. Ezeonyeji, Mohammed Rohan Butt, Michael R. Ehrenstein
Summary: The study revealed that patients with PsA have an increased Th17:Treg ratio, which can be reversed by anti-TNF therapy. Treg from patients treated with different therapies showed contrasting effects on regulating effector T-cell migration, with TNF blockade boosting Treg suppression of migration.
Article
Medicine, Research & Experimental
Jin-Sil Park, Donghyun Lee, SeungCheon Yang, Ha Yeon Jeong, Hyun Sik Na, Keun-Hyung Cho, JeongWon Choi, Heebeom Koo, Mi-La Cho, Sung-Hwan Park
Summary: MTX-loaded NPs can alleviate severity and destruction of joints in collagen-induced arthritis (CIA) mice, reduce inflammatory cytokine levels, increase the number of regulatory cells, and have therapeutic potential for RA.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Konstantin Kotschenreuther, Shuaifeng Yan, David M. Kofler
Summary: Regulatory T (T-reg) cells are crucial in the pathogenesis of rheumatoid arthritis (RA), contributing to immune homeostasis and tissue migration.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiaoya Li, Huihui Xu, Jing Huang, Dan Luo, Shuang Lv, Xiangchen Lu, Cheng Xiao
Summary: Regulatory T cells (Tregs) play a crucial role in promoting immune tolerance and maintaining immune system homeostasis. Dysfunction of Tregs is closely linked to rheumatoid arthritis (RA), and research on Tregs in RA has made significant progress in both basic and clinical aspects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Patricia Ramos-Ramirez, Carina Malmhall, Omar Tliba, Madeleine Radinger, Apostolos Bossios
Summary: Adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios(-) Tregs, and the effect was amplified by T2 inflammation in Helios(+) Tregs. This suggests a potential role of adiponectin in regulating Treg function in human inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Maha Fahad Alenazy, Fatemeh Saheb Sharif-Askari, Mohammed A. Omair, Mohammad S. El-Wetidy, Maha A. Omair, Hussam Mitwalli, Saleh Al-Muhsen, Abeer Al-Masri, Qutayba Hamid, Rabih Halwani
Summary: Abatacept treatment significantly enhances the levels of IL-35(+) IL-10(+) Bregs in RA patients, contributing to achieving remission in some patients and also increasing Tregs.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Tsuyoshi Nakayama, Motoki Yoshimura, Kazuhiko Higashioka, Kohta Miyawaki, Yuri Ota, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Nobuyuki Ono, Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: The efficacy of B-cell depletion therapy in rheumatoid arthritis highlights the antibody-independent effector functions of B cells. Studies have shown that Th1 cells can promote the generation of CXCL9/10-producing T-bet+ B cells in RA, suggesting a potential novel target for therapy.
CELLULAR IMMUNOLOGY
(2021)
Article
Biology
Meenu Kalkal, Rubika Chauhan, Reva Sharan Thakur, Mrinalini Tiwari, Veena Pande, Jyoti Das
Summary: Regulatory B cells play a crucial role in immune protection during infection with malaria parasites by controlling inflammation and inhibiting parasite growth. Adoptive transfer of these cells can slow down parasite growth and enhance survival in infected animals.
Article
Biology
Daniil Shevyrev, Valeriy Tereshchenko, Elena Blinova, Nadezda Knauer, Ekaterina Pashkina, Alexey Sizikov, Vladimir Kozlov
Summary: The study revealed that the proliferation of Treg cells in patients with rheumatoid arthritis under HP cytokine stimulation is lower compared to healthy individuals, and the suppressive activity decreases, which may lead to the proliferation of self-reactive T cell clones.
Article
Immunology
Jingjing Qi, Jiaqing Liu, Xiangge Zhao, Huina Huang, Yawei Tang, Xia Li
Summary: Our study found that IL-27 can promote B cell dysfunction in rheumatoid arthritis by activating the mTOR signaling pathway. The study aimed to explore the effects of IL-27 on B cell metabolism and clarify the mechanisms by which IL-27 enhances glycolysis to induce B cell hyperactivation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Jin Kyeong Choi, Charles E. Egwuagu
Summary: B lymphocytes play a central role in host immunity by orchestrating humoral immune responses and producing neutralizing antibodies. Recent recognition shows that B cells also help maintain peripheral tolerance and suppress autoimmune diseases, with rare populations of regulatory B cells producing anti-inflammatory cytokines. The newly discovered i35-Bregs can suppress autoimmune diseases by inducing infectious tolerance in conventional B cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)