Article
Dermatology
Xuefen Wu, Bingxia Ming, Tong Wu, Rongfen Gao, Peng Hu, Jungen Tang, Jixin Zhong, Fang Zheng, Lingli Dong
Summary: IL-33/ST2 axis plays a crucial role in the fibrotic disorder of SSc by promoting fibroblast activation, and IL-33/ST2 blockade could be a potential novel strategy to inhibit fibrosis progression in SSc patients.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Review
Immunology
Lanxuan Wei, David Abraham, Voon Ong
Summary: IL-17 is a pro-inflammatory cytokine that plays an important role in host defense. It activates transcription and stabilizes mRNAs through multiple pathways, mainly acting on stromal cells to promote the secretion of other immunomodulatory factors and support the growth and differentiation of immune cells. IL-17 has a dual role in immune reactions and inflammatory diseases, and it also plays a significant role in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
ChunYan Yuan
Summary: IL-33 is a cytokine that modulates inflammation and immune responses, primarily associated with the development of Th2 immunological responses. It has been shown to be elevated in various autoimmune disorders, suggesting a role in inducing autoimmunity and inflammatory damage. The IL-33/ST2 axis holds promising potential as a therapeutic target for autoimmune disease treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anca Cardoneanu, Alexandra Maria Burlui, Luana Andreea Macovei, Ioana Bratoiu, Patricia Richter, Elena Rezus
Summary: Systemic sclerosis (SS) is a chronic autoimmune disorder characterized by cutaneous and systemic clinical manifestations. Interleukin-6 (IL-6) plays a critical role in the development of vascular damage and fibrosis in SS. Tocilizumab, an anti-IL-6 therapy, shows promising results in improving skin and lung damage in SS patients.
Article
Multidisciplinary Sciences
Francesca Gatti, Sobuj Mia, Clara Hammarstrom, Nadine Frerker, Bjarte Fosby, Junbai Wang, Wojciech Pietka, Olav Sundnes, Johanna Hol, Monika Kasprzycka, Guttorm Haraldsen
Summary: IL-33 functions as a cytokine signaling molecule in fibrosis and also plays a role in affecting chromatin folding in the cell nucleus. Knockdown of IL-33 skews transcription profiles towards a myofibroblast phenotype in fibroblasts, leading to enhanced expression of fibrogenic genes and enrichment of gene sets involved in extracellular matrix formation and remodeling.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Antonio Giovanni Versace, Alessandra Bitto, Carmelo Ioppolo, Caterina Oriana Aragona, Daniela La Rosa, William Neal Roberts, Tommaso D'Angelo, Antonella Cinquegrani, Santa Cirmi, Natasha Irrera, Michele Navarra, Salvatore Corrao, Sebastiano Gangemi, Gianluca Bagnato
Summary: The study aimed to investigate the levels of IL-33 and IL-13 in patients with diffuse SSc and interstitial lung disease (SSc-ILD) compared to SSc patients without ILD and healthy controls. The results showed that both IL-13 and IL-33 levels were elevated in SSc patients and were significantly associated with each other. Additionally, higher levels of IL-33 and IL-13 were observed in SSc patients with reduced pulmonary function compared to those with normal lung function. This suggests that the IL-13/IL-33 axis may play a role in the development and severity of SSc-ILD.
FRONTIERS IN MEDICINE
(2022)
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Immunology
Eric Jou, Noe Rodriguez-Rodriguez, Andrew N. J. McKenzie
Summary: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and current immunotherapeutic interventions have limited effectiveness. Cytokines interleukin-25 (IL-25) and IL-33, expressed by barrier epithelial cells, play important roles in the intestinal immune responses and can influence tumorigenesis in CRC. IL-25 and IL-33 have different effects on different subtypes of CRC and can modulate various immune cell types and pathways, including angiogenesis, tumor stemness, invasion, and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Olga Gumkowska-Sroka, Kacper Kotyla, Ewa Mojs, Klaudia Palka, Przemyslaw Kotyla
Summary: Systemic sclerosis is a connective tissue disease with unknown origin and unpredictable course, exhibiting both cutaneous and internal organ manifestations. Despite the lack of understanding about its background and the absence of specific therapy, the focus of treatment is to preserve organ function. However, in modern times, insights from other fields of medicine may provide new possibilities for treating disease-related complications.
Article
Endocrinology & Metabolism
Qian Wang, Wenjing Ye, Fangfang Chen, Minrui Liang, Weiguo Wan, Wenyu Guo, Hejian Zou, Yu Xue
Summary: The study suggests that inhibiting the IL-6 transmitter signal with TJ301 may be a novel approach to treat systemic sclerosis (SSc).
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Immunology
Keshan Yang, Cheng Tian, Chengliang Zhang, Ming Xiang
Summary: This article summarizes the structure and function of IL-33, as well as its role in immune regulation, pulmonary fibrosis, and lung cancer. The dual regulation of IL-33 in lung cancer is highlighted, and potential treatment regimens, especially immunotherapies, based on its mechanism of action are proposed.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Gastroenterology & Hepatology
Akira Andoh, Atsushi Nishida
Summary: IL-33, IL-36, and IL-38 are members of the IL-1 cytokine family and their expression is increased in the inflamed mucosa of patients with inflammatory bowel disease (IBD). IL-33 and IL-36 have pro- and anti-inflammatory functions, while IL-38 acts as an anti-inflammatory cytokine by antagonizing the IL-36 receptor. IL-33 and IL-36 also play a crucial role in intestinal fibrosis, a characteristic manifestation of IBD.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Immunology
Shukur Wasman Smail, Shang Ziyad Abdulqadir, Zhikal Omar Khudhur, Sonia Elia Ishaq, Abdullah Faqiyazdin Ahmed, Mohammed B. Ghayour, Arash Abdolmaleki
Summary: This study investigated the neuroprotective effects of IL-33 in relieving sciatic nerve injury. The results showed that IL-33 at doses of 50 and 25 μg/kg can promote nerve regeneration and improve sensorimotor recovery, while exerting its effects through regulating the inflammatory microenvironment and inducing macrophage polarization towards the M2 phenotype.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Marco Calafiore, Ya-Yuan Fu, Paola Vinci, Viktor Arnhold, Winston Y. Chang, Suze A. Jansen, Anastasiya Egorova, Shuichiro Takashima, Jason Kuttiyara, Takahiro Ito, Jonathan Serody, Susumu Nakae, Heth Turnquist, Johan Van Es, Hans Clevers, Caroline A. Lindemans, Bruce R. Blazar, Alan M. Hanash
Summary: Intestinal stem cells produce IL-33 after radiation injury, which induces Paneth cells to produce EGF and promote regeneration of the intestinal epithelium.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Wanrong Shi, Huan Zhou, Xingyu Zhu, Jing Xie, Zhaohui Huang
Summary: This meta-analysis found that serum IL-33 levels were significantly higher in systemic sclerosis (SSc) patients compared to healthy controls, and early SSc patients had higher IL-33 levels compared to late SSc patients. However, no significant difference was observed between limited cutaneous SSc and diffuse cutaneous SSc.
IMMUNOLOGIC RESEARCH
(2023)
Article
Biology
Ruriko Kawanabe, Ayumi Yoshizaki, Kazuki M. Matsuda, Hirohito Kotani, Teruyoshi Hisamoto, Yuta Norimatsu, Ai Kuzumi, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Shinichi Sato
Summary: This study aimed to investigate the levels of CXCL1 in patients with systemic sclerosis (SSc) and its association with clinical features and disease activity. The results showed that serum CXCL1 levels were significantly elevated in SSc patients and were positively correlated with disease activity and extent of lesions.
Review
Biochemistry & Molecular Biology
Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Atsushi Enomoto, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki
Summary: Itching can have a negative impact on quality of life and worsen skin symptoms. Various factors, including histamine and other cytokines, can induce itching, with the degree of involvement varying among diseases and individuals. Antihistamines are commonly used and effective in treating itching. This review explores ligand-receptor dynamics, the role of G protein-coupled receptors, and considerations for antihistamine therapy and drug selection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Atsushi Enomoto, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki
Summary: This review explores the pathogenesis of Palmoplantar pustulosis (PPP) by examining its genetic background and molecular mechanisms, discusses the effectiveness of biological therapy, and explores its implications in relation to pathology, the IL-23-Th17 axis, and other autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Ai Kuzumi, Shunki Mitsuo, Tomomi Miyake, Shinichi Sato, Ayumi Yoshizaki
Article
Biochemistry & Molecular Biology
Teruyoshi Hisamoto, Hiraku Suga, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Summary: Atopic dermatitis is a common chronic skin disease characterized by Th2 inflammation. The cytokine TL1A has been found to play a role in chronic inflammatory diseases, but its role in atopic dermatitis is unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kazuki M. Matsuda, Hirohito Kotani, Kei Yamaguchi, Taishi Okumura, Eriko Fukuda, Masanori Kono, Teruyoshi Hisamoto, Ruriko Kawanabe, Yuta Norimatsu, Ai Kuzumi, Maiko Fukayama, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Tomohisa Okamura, Hirofumi Shoda, Keishi Fujio, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki
Summary: Cutaneous arteritis (CA) is a skin vasculitis that affects small to medium-sized arteries. The diagnosis relies on skin biopsy, which can be burdensome. The pathogenesis and treatment of CA are still unclear. In this study, anti-transcobalamin receptor (TCblR) antibodies were found in 24% of CA patients and were associated with skin-limited CA. These antibodies trigger interleukin-6 autocrine loop and induce periarterial inflammation. Methylcobalamin, a ligand of TCblR, can ameliorate inflammation caused by these antibodies. These findings suggest that anti-TCblR antibodies could be a diagnostic marker and a therapeutic target for CA.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Takemichi Fukasawa, Satoshi Toyama, Atsushi Enomoto, Asako Yoshizaki-Ogawa, Yuta Norimatsu, Shoko Tateishi, Hiroko Kanda, Kiyoshi Miyagawa, Shinichi Sato, Ayumi Yoshizaki
Summary: This study found that nailfold capillary abnormalities in patients with psoriasis may be a predictive factor for the development of psoriatic arthritis (PsA), and the degree of abnormality may be indicative of disease severity.
Article
Rheumatology
Bogdan Penev, Georgi Vasilev, Ekaterina Ivanova Todorova, Kalina Tumangelova-Yuzeir, Ekaterina Kurteva, Simeon Monov, Dobroslav Kyurkchiev
Summary: This cross-sectional study investigates the differences in clinical features, external risk factors, and immunological profiles between first-degree relatives of SLE patients, healthy individuals, and SLE patients. The study finds that first-degree relatives have higher titers of antinuclear autoantibodies, more specific staining immunofluorescent patterns, and more autoantibody specificities compared to healthy controls. Some clinical features are associated with higher ANA titers and specific antibodies.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Ayumi Yoshizaki, Shinichi Sato
Article
Rheumatology
Kazuki M. Matsuda, Ayumi Yoshizaki, Ai Kuzumi, Satoshi Toyama, Kentaro Awaji, Tomomi Miyake, Shinichi Sato
Summary: This study aims to summarize the current knowledge on the efficacy of IVIG against GI symptoms of SSc and identify future research directions. The results indicate that IVIG administration can lead to remarkable improvement in GI symptoms, including IPO, and previous reports also support its efficacy. However, further studies with objective and quantitative measures are needed to evaluate short-term outcomes.
Article
Dermatology
Ai Kuzumi, Satoshi Ebata, Takemichi Fukasawa, Kazuki M. Matsuda, Hirohito Kotani, Asako Yoshizaki-Ogawa, Shinichi Sato, Ayumi Yoshizaki
Summary: This cohort study found that long-term use of rituximab for systemic sclerosis improved skin and lung fibrosis, and a decrease in serum immunoglobulins was associated with better clinical response.
Article
Medicine, General & Internal
Mariko Hara, Rumi Ueha, Taku Sato, Takao Goto, Ayumi Yoshizaki, Hayakazu Sumida, Shinichi Sato, Tatsuya Yamasoba
Summary: Systemic sclerosis is often associated with dysphagia and esophageal dysmotility. This study evaluated the association between dysphagia and esophageal dysmotility in patients with systemic sclerosis and identified risk factors. The results showed that dysphagia was associated with autoantibody positivity and older age, while there were no identified risk factors for esophageal dysmotility. No correlation was found between dysphagia and esophageal dysmotility.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Takemichi Fukasawa, Atsushi Enomoto, Asako Yoshizaki-Ogawa, Shinichi Sato, Kiyoshi Miyagawa, Ayumi Yoshizaki
Summary: DNA is constantly damaged, and cells have evolved DNA damage response mechanisms to preserve genomic integrity. Kinases play a central role in this response by transmitting the DNA damage signal to various cellular processes. Recently, the role of STK38 in DNA damage signaling has emerged.
Article
Medicine, General & Internal
Yuta Norimatsu, Kazuki Mitsuru Matsuda, Kei Yamaguchi, Chihiro Ono, Taishi Okumura, Emi Kogo, Hirohito Kotani, Teruyoshi Hisamoto, Ai Kuzumi, Takemichi Fukasawa, Asako Yoshizaki-Ogawa, Naoki Goshima, Shinichi Sato, Ayumi Yoshizaki
Summary: This study developed a new method for detecting SSc and DM autoantibodies (A-cube) and examined its validity. The A-cube method showed comparable or higher sensitivity and specificity compared to existing testing methods, and could potentially lead to re-consideration of diagnosis in certain cases. The quality of the A-cube was ensured, and its usefulness for comprehensive analysis was demonstrated.
Article
Biochemistry & Molecular Biology
Kalina Tumangelova-Yuzeir, Krassimir Minkin, Ivan Angelov, Ekaterina Ivanova-Todorova, Ekaterina Kurteva, Georgi Vasilev, Jeliazko Arabadjiev, Petar Karazapryanov, Kaloyan Gabrovski, Lidia Zaharieva, Tsanislava Genova, Dobroslav Kyurkchiev
Summary: The development of glioblastoma multiforme (GBM) is hypothesized to start with the transformation of neural stem cells into cancer stem cells (CSC), and it has been found that mesenchymal stem cells (MSC) also play a role in the tumor stroma. MSCs may give rise to CSC and suppress immune cells. Photodynamic therapy can reduce neural transdifferentiation capacity in GB-MSCs.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
