Article
Medicine, General & Internal
James J. Son, Mariko Ishimori, James Mirocha, Michael H. Weisman, Lindsy J. Forbess
Summary: The study found a lower than expected positive predictive value of CCP 3.1 level in diagnosing rheumatoid arthritis (RA), but the likelihood of having an RA diagnosis increased with higher CCP levels.
Article
Immunology
Pureun Won, Youngkyun Kim, Hyerin Jung, Yeri Alice Rim, Dong Hyun Sohn, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju
Summary: The study demonstrated that monoclonal antibody 12G1 can directly detect citrullinated proteins in rheumatoid arthritis (RA) target tissue and sera, indicating its potential in arthritis induction. 12G1 may be useful for diagnosing RA, including seronegative RA, and could help to understand the pathophysiological role of citrullination in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Rheumatology
Jooyoung Cho, Jung Yoon Pyo, Ailyn Fadriquela, Young Uh, Jong-Han Lee
Summary: This study compared the analytical and clinical performances of four anti-CCP assays and found that they all showed good precision and linearity with similar sensitivity and specificity (88.0-97.2%). After adjusting the cutoff values, these assays are expected to show enhanced sensitivity and specificity.
CLINICAL RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Jiaxi Liu, Jinfang Gao, Zewen Wu, Liangyu Mi, Na Li, Yajing Wang, Xinyue Peng, Ke Xu, Fengping Wu, Liyun Zhang
Summary: ACPAs are autoantibodies commonly found in patients with RA, with most of the mechanisms of formation and bone destruction well-understood. Despite advances in clinical applications and targeted therapies related to ACPAs, the presence of different subtypes poses a limitation.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Chao-Yi Wu, Huang-Yu Yang, Shue-Fen Luo, Jenn-Haung Lai
Summary: RA is a chronic inflammatory disease involving synovial inflammation and articular destruction. RFs, ACPAs, and anti-CarP Abs have been identified as important autoantibodies in predicting and diagnosing RA, with potential implications for treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Kenia Chavez Ramos, Maria del Pilar Canizares Macias
Summary: Anti-cyclic citrullinated peptide IgG antibodies are specific biomarkers for rheumatoid arthritis, with the ability to be detected in early stages and being faster and more sensitive than commercial ELISA kits.
Article
Medicine, General & Internal
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: Limited data are available on test utilization and intraindividual changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-CCP) in Korean patients that visit local clinics and hospitals. This study retrospectively reviewed longitudinally measured RF and anti-CCP data in Korean patients and found qualitative changes in test results during follow-up in some patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Hiromitsu Yamazaki, Takanori Kuroiwa, Ken Shinmura, Masao Yukioka, Norikazu Murata
Summary: Among patients with other chronic arthritis diseases, psoriatic arthritis patients have a significantly higher prevalence rate of positive anti-CCP antibodies, while SAPHO and uSpA patients also show high positive rates. This study provides insights into the heterogeneity of SpA and its relevance for differential diagnosis with RA.
MODERN RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Weronika Kurowska, Iwona Slowinska, Zbigniew Krogulec, Piotr Syrowka, Wlodzimierz Maslinski
Summary: The presence of anti-citrullinated protein antibodies (ACPAs) in the bone marrow of rheumatoid arthritis (RA) patients is associated with increased osteoclast activation and bone resorption. Higher levels of IL-8 in bone marrow containing anti-CCP Abs may play a role in ACPA-induced bone resorption. Levels of TRAP5b, cathepsin K, CTX-I, and IL-8 are elevated in bone marrow compared to peripheral blood, indicating local generation of these molecules.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Xuan Tang, Zehao Liu, Zhihua Yang, Shengmei Xu, Maojie Wang, Xiumin Chen, Zehuai Wen, Runyue Huang
Summary: The use of Chinese medicine compound therapy in treating rheumatoid arthritis has been shown to effectively reduce serum levels of RF and anti-CCP, with potentially better clinical outcomes compared to Western medicine monotherapy. Active components in the Chinese medicine compound therapy may be responsible for its efficacy, warranting further investigation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Tan Wan Jiun, Haslina Taib, Wan Majdiah Wan Mohamad, Suharni Mohamad, Wan Syamimee Wan Ghazali
Summary: This study found no significant association between the bacterial load of Porphyromonas gingivalis (P. gingivalis), a primary periodontal pathogen, and the levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) and periodontitis. Despite the prevalence of periodontitis among RA patients, the bacterial load does not have an impact on the production of anti-CCP antibodies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chia Chen, Chung-Ming Huang, Ting-Yuan Liu, Ning Wu, Chia-Jung Chan, Peng-Yu Shih, Hsin-Han Chen, Shih-Yin Chen, Fuu-Jen Tsai
Summary: Rheumatoid arthritis is a systemic disease that causes non-infectious inflammation of the joints and surrounding tissues. It can lead to severe health problems, impact daily life, and even result in death. Diagnosis of RA is often based on the presence of blood serological markers, but about 20% of patients have negative results for these markers, making diagnosis difficult and delaying treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Lieve Van Hoovels, Bert Vander Cruyssen, Daniela Sieghart, Carolien Bonroy, Eszter Nagy, Rille Pullerits, Sasa Cucnik, Charlotte Dahle, Ingmar Heijnen, Luca Bernasconi, Farid Benkhadra, Laura Bogaert, Stefanie Van den Bremt, Ann Van Liedekerke, Geert Vanheule, Johan Robbrecht, Lucy Studholme, Claudine Wirth, Ruediger Mueller, Diego Kyburz, Christopher Sjowall, Alf Kastbom, Rok Jese, Boja Jovancevic, Emese Kiss, Peggy Jacques, Daniel Aletaha, Guenter Steiner, Patrick Verschueren, Xavier Bossuyt
Summary: This study aimed to refine the interpretation of RF and ACPA across commercial assays. By determining thresholds for antibody levels and assigning test result interval-specific LRs, clinical interpretation can be aligned for all RF and ACPA assays.
Review
Rheumatology
Anca Catrina, Akilan Krishnamurthy, Bence Rethi
Summary: ACPA may play a crucial role in the pathogenesis of RA, affecting the genetic and environmental risks in patients, leading to joint pain and bone loss. Research has shown that ACPAs can impact various cells, potentially triggering pathogenic pathways through multiple mechanisms.
Review
Pathology
Nicole Hartwig Trier, Gunnar Houen
Summary: The serological biomarker anti-citrullinated protein antibodies (ACPAs) are important for the diagnosis of rheumatoid arthritis (RA) and can improve our understanding of the disease etiology. This review provides an overview of ACPAs and highlights their diagnostic and etiological significance in RA.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)