Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Kamila Nurbaeva, Ivan Ptashnik, Anna Kudriaeva, Alexey Belogurov Jr, Aleksandr Lila, Evgeny Nasonov
Summary: This study aimed to assess the role of neutrophil extracellular traps (NETs) markers, MPO-DNA complex and nucleosomes, in the diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The study found that levels of MPO-DNA complex were higher in SLE patients and associated with SLE activity and lupus glomerulonephritis. Lower levels of nucleosomes were observed in SLE patients and associated with SLE activity and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Ch Lopez-Pedrera, A. M. Patino-Trives, T. Cerdo, R. Ortega-Castro, I. Sanchez-Pareja, A. Ibanez-Costa, L. Munoz-Barrera, M. C. Abalos-Aguilera, D. Ruiz-Vilchez, P. Segui Azpilcueta, M. Espinosa, N. Barbarroja, A. Escudero-Contreras, J. P. Castano, R. Luque, R. Ortega, M. A. Aguirre, C. Perez-Sanchez
Summary: This study characterized the splicing machinery (SM) of leukocytes from patients with primary antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE), and antiphospholipid syndrome with lupus (APS + SLE), and assessed its clinical involvement. The results showed that leukocytes from APS, SLE, and APS + SLE patients displayed significant and specific alterations in SM-components (SMC), which were associated with clinical features. This study identified a specific alteration of SMC in leukocytes from APS, SLE, and APS + SLE patients, which may be responsible for the development of distinctive clinical profiles.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Medicine, General & Internal
Nuria Banos, Aleida Castellanos, Giuseppe Barilaro, Francesc Figueras, Gema Lledo, Marta Santana, Gerard Espinosa
Summary: A prospective study was conducted on pregnant women with SLE, antiphospholipid syndrome, or non-criteria obstetric antiphospholipid syndrome to develop a predictive tool for adverse pregnancy outcomes. Baseline characteristics and certain biomarkers were found to be predictive of adverse outcomes, highlighting the need for better biomarkers for pregnant women with autoimmune diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Merlijn Wind, Maike Hendriks, Bernadette T. J. van Brussel, Jeroen Eikenboom, Cornelia F. Allaart, Hildo J. Lamb, Hans-Marc J. Siebelink, Maarten K. Ninaber, Nan van Geloven, Jan M. M. van Lith, Tom W. J. Huizinga, Ton J. Rabelink, Marieke Sueters, Y. K. Onno Teng
Summary: Patients with SLE/APS benefit from multidisciplinary clinical pathway and pre-pregnancy counseling, leading to a reduced risk of SLE flares during pregnancy. However, there was no significant impact on maternal and fetal pregnancy complications.
LUPUS SCIENCE & MEDICINE
(2021)
Review
Medicine, General & Internal
Zhengyan Hu, Rui Gao, Wanrong Huang, Huiqing Wang, Lang Qin
Summary: The additional use of HCQ may decrease the risk of high lupus activity during pregnancy and the incidence of preeclampsia for SLE patients, but it does not reduce the risk of preeclampsia for APS/aPLs patients or intrauterine growth restriction for SLE and/or APS/aPLs patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Duarte Andre Ferreira, Filipa Taborda, Teresa Mendonca, Fatima Farinha
Summary: Pregnancy and lactation-associated osteoporosis is a rare disease that is often seen in late pregnancy or early postpartum, and it is characterized by multiple vertebral fractures. Early diagnosis, cessation of breastfeeding, and targeted therapy are crucial for symptom control, improving the quality of life, and preventing future fractures.
Review
Ophthalmology
Iris Lee, Lisa Zickuhr, Lynn Hassman
Summary: Ocular manifestations of SLE are linked with systemic symptoms, emphasizing the importance of collaboration between ophthalmologists and rheumatologists. Research utilizing both clinical and molecular techniques is crucial in advancing our understanding and treatment of SLE.
CURRENT OPINION IN OPHTHALMOLOGY
(2021)
Article
Rheumatology
Antonio Braga, Tania Barros, Raquel Faria, Antonio Marinho, Graziela Carvalheira, Guilherme Rocha, Fatima Farinha, Esmeralda Neves, Carlos Vasconcelos, Jorge Braga
Summary: This study found that pregnancy in SLE patients is associated with an increased incidence of adverse obstetric outcomes. Good disease control before pregnancy and adequate treatment, especially with HCQ, is crucial to achieving the best obstetric results.
Article
Rheumatology
Jozelio Freire de Carvalho, Felipe Freire Silva, Yehuda Shoenfeld
Summary: This article describes a rare case of a young patient with cAPS who later developed SLE. Treatment included methylprednisolone, heparin, and immunoglobulin, leading to a good outcome and discharge from the hospital. The patient was later diagnosed with SLE and successfully treated with prednisone, azathioprine, and hydroxychloroquine, currently managing symptoms well with these medications.
Article
Pediatrics
Lingjuan Liu, Liqun Liu, Lu Zhang, Peng Huang, Xiqiang Dang, Lanjun Shuai, Xingfang Li, Yongzhen Li, Dingan Mao, Xiaochuan Wu, Yan Cao
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease with complex clinical features. SLE patients are at significantly increased risk of thrombotic events. Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by recurrent thrombosis and pregnancy-related complications. This paper reports a school-age patient diagnosed with SLE coexisting with APS, which started with renal contusion and later developed into pulmonary embolism.
FRONTIERS IN PEDIATRICS
(2023)
Article
Rheumatology
Mette Gohr, Iris Marie Jakobsen, Rikke Bek Helmig, Kristian Stengaard-Pedersen, Trine Bay Laurberg, Anne Troldborg
Summary: Pregnant SLE patients require close monitoring and continued treatment during pregnancy to reduce the risk of adverse pregnancy outcomes, although the risk remains high.
Article
Rheumatology
Abir Mokbel, Doaa H. S. Attia, Hania S. Zayed, Nahlaa Eesa Naeem, Geilan Mahmoud, Rafat Riad, Soumaya Abou Elewa, Mohamed Youssef, Hisham Haggag, Sally S. Mohamed
Summary: This study aims to describe the pregnancy outcomes of SLE patients and identify predictors of adverse maternal and fetal outcomes. The study included 201 singleton pregnancies of 123 women with SLE. The study found that pregnancy planning, disease flares, and secondary antiphospholipid syndrome were predictors of adverse pregnancy outcomes.
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Fariza Cheldieva, Maria Cherkasova, Alexander Lila, Evgeny Nasonov
Summary: This study investigates the role of IgA antibodies to cardiolipin (aCL) and IgA antibodies to beta-2 glycoprotein 1 (anti-beta(2)-GP1) in the development of vascular complications in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The results show that the levels of IgA aCL and IgA anti-beta(2)-GP1 are significantly higher in APS patients compared to SLE patients and the control group. These antibodies are closely associated with thrombosis in APS, demonstrating high specificity but low sensitivity for the diagnosis of APS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ryo Hisada, Tatsuya Atsumi
Summary: Despite advances in treatment, thrombosis remains the leading cause of death in SLE. aPL are the main triggers of thrombosis in SLE patients, with a frequency of approximately 30-40%. Lupus anticoagulant, anticardiolipin, anti-beta 2-glycoprotein I antibodies, and non-criteria aPL are risk factors for thrombosis in SLE. Multiple positivity for aPL and calculated scores can predict the risk of thrombosis. Treatment with anticoagulants and/or low-dose aspirin may be appropriate for aPL-positive SLE patients.
Article
Rheumatology
Aardra Rajendran, Amanda M. Eudy, Stephen J. Balevic, Megan E. B. Clowse
Summary: This study explores the association between pregnancy planning, recommended behaviors, and pregnancy outcomes in women with lupus. Results show that not-planned pregnancies are associated with poorer outcomes, particularly in women who are ambivalent about pregnancy. Effective pregnancy planning and contraception guidance may decrease the risk for maternal-fetal morbidity and mortality in this high-risk population.