Article
Immunology
Huanhuan Yan, Baochen Li, Rui Su, Chong Gao, Xiaofeng Li, Caihong Wang
Summary: This study compared immune cell abnormalities in antiphospholipid syndrome (APS) patients and healthy controls, and analyzed the correlation between antiphospholipid antibody titres and T cell subsets, as well as the correlation between cytokine profiles and clinical characteristics. The results showed that APS patients have immune disturbances, characterized by an increase in the Th17/Treg ratio and a decrease in Treg cell numbers. Additionally, primary APS patients had higher levels of peripheral blood lymphocytes compared to secondary APS patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Ru Ma, Hongling Su, Keping Jiao, Jian Liu
Summary: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, and chronic lung inflammation and immune system dysregulation are believed to contribute to its development. This review discusses the roles of Th17 cells and Treg cells in COPD, the imbalance of Th17/Treg ratio in inflammatory disorders, and recent advancements in immunomodulatory treatments targeting Th17/Treg cells in COPD.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuying Kou, Yujun Jiang, Shanshan Liu, Panpan Yang, Yupu Lu, Hongrui Liu, Minqi Li
Summary: This study aimed to investigate the role of Th17-Treg balance and Treg plasticity in periodontitis. The results showed that in patients with periodontitis, there was an imbalance between Th17 and Treg cells, with an increase in the number of Th17 cells and expression of related genes. The proportion of Treg cells in the blood and spleen was lower in the periodontitis group, and the expression of Foxp3 was downregulated while Rorc/IL-17A were increased in Treg cells. Immunofluorescence double staining demonstrated a significantly increased number of IL-17+Foxp3+ cells in periodontitis.
Review
Immunology
Jaehwan Kim, Ariana Moreno, James G. G. Krueger
Summary: Psoriasis vulgaris is a common inflammatory disease affecting 7.5 million adults in the US, with immunopathogenesis paradigms rapidly evolving due to advancements in technology. Single-cell RNA sequencing technology is now being applied to clinical trials of biologics to test the expansion of regulatory immune cell subsets involved in skin homeostasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Juliana Dias Lourenco, Juliana Tiyaki Ito, Milton de Arruda Martins, Iolanda de Fatima Lopes Calvo Tiberio, Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Summary: The imbalance between pro-inflammatory Th17 and anti-inflammatory Treg cells plays a crucial role in the development and progression of inflammation in COPD. Studies evaluating treatments targeting Th17/Treg cells have shown conflicting results, which vary based on lung compartments, COPD stages, or local and systemic markers. Careful examination of the data is necessary.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Xiao Zhou, Jingyi Yao, Jin Lin, Jingfeng Liu, Lei Dong, Meili Duan
Summary: A prospective observational study was conducted to analyze the predictive value of the Th17/Treg ratio for renal injury in sepsis patients. The study found that the Th17/Treg ratio was associated with sepsis-induced acute kidney injury and could be a potential predictive marker for this condition.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Yan Qin, Chong Gao, Jing Luo
Summary: The abnormal number and function of immune cells are the basis for various diseases. Recent studies have shown that the altered metabolic state of immune cells exists in autoimmune diseases and affects the occurrence and development of inflammation. This review summarizes the biology and function of Th17 and Treg cells in autoimmune diseases, with emphasis on the regulatory role of energy metabolism in the activation, differentiation, and physiological function of these cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Jianhui Wu, Bowen Ren, Daochao Wang, Hui Lin
Summary: This review discusses the role and mechanisms of regulatory T cells (Tregs) in skeletal muscle repair and regeneration, as well as new strategies for Treg immunotherapy in skeletal muscle diseases.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Yuzhi Lu, Ni Xia, Xiang Cheng
Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nicolas Krause, Joerg Mengwasser, Elpida Phithak, Francisca Beato, Marc Appis, Edgar Louis Milford, Johan Pratschke, Igor Sauer, Anja Kuehl, Arndt Vogel, Michael Goodyear, Linda Hammerich, Frank Tacke, Johanna Faith Haas, Tobias Mueller, Nalan Utku
Summary: IR1 cells are a subset of T regulatory cells that have immune suppressive functions and can inhibit proliferation in mixed lymphocyte reactions. They deliver regulatory signals by binding to their ligand, HLA-DR alpha 2, and have the potential to modulate immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qian Peng, Bingkun Zhao, Jie Lin, Haixia Liu, Rong Zhou, Dongmei Lan, Chao Yao, Shaohua Cong, Shen Tao, Yizhun Zhu, Raorao Wang, Shengcai Qi
Summary: The study found that SPRC can prevent the progression of periodontitis by inhibiting the ERK/CREB signaling pathway and regulating the Th17/Treg balance. This suggests that SPRC may be a novel therapeutic drug for periodontitis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Article
Medicine, Research & Experimental
Mingling Sun, Xiujuan Wang, Ning Zhang, Lei Wang, Xinyou Wang, Wenxia Fan, Qinzhi Li, Ying Liu, Mengting Song, Xinhong Guo
Summary: This study investigates the role of Tfr/Tfh cell imbalance in adult patients with primary ITP. The results show that the proportion of Tfr cells, FOXP3 mRNA, and IL-10 are decreased in pre-therapy ITP patients but increased after therapy. On the other hand, the proportion of Tfh cells, BCL-6 mRNA, and IL-21 are increased in pre-therapy ITP patients. These findings suggest that Tfr and Tfh cells may be involved in the pathogenesis of ITP.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Review
Immunology
Theodora Agalioti, Filippo Cortesi, Nicola Gagliani
Summary: The TH17 cell population at mucosal barriers is crucial for maintaining tissue homeostasis. Their adaptability and heterogeneity, determined by the environment, play a role in immune-mediated inflammatory diseases and cancer. Recent findings on the transcriptional and metabolic profiles of TH17 cells provide insights into their plasticity.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Letter
Immunology
Xinyu Zheng, Rui Su, Fangyuan Hu, Yue Liu, Xiaofeng Li, Chong Gao, Caihong Wang
Summary: This study showed that DM patients with EBV/CMV viremia have significantly decreased levels of Th17 and Treg cells, and low-dose IL-2 therapy can effectively elevate the levels of these cells, restoring the balance between Th17 and Treg proportions.
AUTOIMMUNITY REVIEWS
(2022)