Article
Cardiac & Cardiovascular Systems
Julien Grynblat, Sophie-Guiti Malekzadeh-Milani, Mathilde Meot, Frederic Perros, Isabelle Szezepanski, Stephane Morisset, Caroline Ovaert, Caroline Bonnet, Pascale Maragnes, Julien Ranchoup, Marc Humbert, I. David Montani, Marilyne Levy, Damien Bonnet
Summary: This study aims to define the goals of repeated right heart catheterization (RHC) and evaluate the correlation between noninvasive criteria and hemodynamic parameters. The results showed that pulmonary vascular resistance index, pulmonary artery compliance index, and right atrial pressure were associated with adverse outcomes in pediatric pulmonary arterial hypertension. Noninvasive criteria accurately predicted the evolution of hemodynamic parameters, but some patients still had at least one at-risk hemodynamic parameter at second RHC.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Zhuoyuan Xu, Hongsheng Zhang, Alexandra Arvanitaki, Chen Zhang, Qiangqiang Li, Bradley B. Keller, Hong Gu
Summary: This retrospective study analyzed 591 diagnostic RHC procedures in pediatric PAH patients and found that most patients had low-risk outcomes, with approximately 3% experiencing a pulmonary hypertensive crisis. Therefore, it is recommended to perform RHC procedures in experienced pediatric cardiology centers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shang Wang, Zi-Yan Guo, Xing-Xing Sun, Ping Yuan, Qin-Hua Zhao, Wen-Hui Wu, Hong-Ling Qiu, Ci-Jun Luo, Su-Gang Gong, Hui-Ting Li, Rui Zhang, Jing He, Lan Wang, Jin-Ming Liu, Jian Guo, Rong Jiang
Summary: The study explored the differences in exercise-induced venous-to-systemic shunt (EIS) in patients with IPAH and CTEPH. It was found that in IPAH patients, those with EIS had a better prognosis, with VO2/VE being an independent factor influencing EIS occurrence.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Birger Tielemans, Leanda Stoian, Allard Wagenaar, Mathias Leys, Catharina Belge, Marion Delcroix, Rozenn Quarck
Summary: Pulmonary arterial hypertension affects the pulmonary endothelium, and despite available treatments, the mortality rate remains high. A new technique allows harvesting and culturing patients' pulmonary arterial endothelial cells, maintaining their endothelial phenotype. This study highlights the potential for personalized precision medicine for patients with rare pulmonary vascular diseases.
Article
Cardiac & Cardiovascular Systems
Franz P. Rischard, Roberto J. Bernardo, Rebecca R. Vanderpool, Deborah H. Kwon, Tushar Acharya, Margaret M. Park, Austin Katrynuik, Michael Insel, Saad Kubba, Roberto Badagliacca, A. Brett Larive, Robert Naeije, Joe G. N. Garcia, Gerald J. Beck, Serpil C. Erzurum, Robert P. Frantz, Paul M. Hassoun, Anna R. Hemnes, Nicholas S. Hill, Evelyn M. Horn, Jane A. Leopold, Erika B. Rosenzweig, W. H. Wilson Tang, Jennifer D. Wilcox
Summary: The aim of this study is to assess the clinical relevance of a proposed definition for RV functional recovery (RVFnRec). A decrease in RV end-diastolic volume of -15 mL and an increase in compliance had the best predictive value for RVFnRec. RVFnRec is associated with improvements in exercise capacity and clinical worsening.
CIRCULATION-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Xin Li, Yi Zhang, Qin Luo, Qing Zhao, Qixian Zeng, Tao Yang, Qi Jin, Lu Yan, Anqi Duan, Jiaran Liu, Chenhong An, Xiuping Ma, Changming Xiong, Zhihui Zhao, Zhihong Liu
Summary: A baseline DLCO < 70% and Delta DLCO > 6% can independently predict unfavorable responses to BPA. Dynamic measurement of DLCO facilitates the identification of patients who might have unsatisfactory hemodynamic results after BPA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Carolina M. S. Messina, Eloara V. M. Ferreira, Inderjit Singh, Angelo X. C. Fonseca, Roberta P. Ramos, Luiz E. Nery, David M. Systrom, Rudolf K. F. Oliveira, Jaquelina S. Ota-Arakaki
Summary: The study revealed that peak RV stroke work index and Delta PA compliance significantly influence pVO2 in patients with idiopathic pulmonary arterial hypertension, highlighting the crucial role of hemodynamic coupling to exercise capacity in IPAH.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Critical Care Medicine
Francois Haddad, Kevin Contrepois, Myriam Amsallem, Andre Y. Denault, Roberto J. Bernardo, Alokkumar Jha, Shalina Taylor, Jennifer Arthur Ataam, Olaf Mercier, Tatiana Kuznetsova, Anton Vonk Noordegraaf, Roham T. Zamanian, Andrew J. Sweatt
Summary: This study found that NT-proBNP plays a central role in the clinical network of PAH, closely related to 6MWD. Connectivity analysis provides explainability for feature selection and combination. The prognostic model established showed high predictive ability.
Article
Cardiac & Cardiovascular Systems
Lucas R. Celant, Jeroen N. Wessels, Azar Kianzad, J. Tim Marcus, Lilian J. Meijboom, Harm Jan Bogaard, Frances S. de Man, Anton Vonk Noordegraaf
Summary: This study aimed to investigate the relationship between reaching or maintaining a 45% threshold of right ventricular ejection fraction (RVEF) and treatment response, long-term functional stability, and prognosis in patients with pulmonary arterial hypertension (PAH). The findings demonstrated that patients who reached or maintained the 45% RVEF threshold had favorable prognosis and long-term stable RV function.
Review
Physiology
Michael H. Lee, Thais C. F. Menezes, Julie A. Reisz, Eloara V. M. Ferreira, Brian B. Graham, Rudolf K. F. Oliveira
Summary: Pulmonary arterial hypertension is an incurable disease characterized by dysregulated metabolism at the cellular level in the pulmonary vasculature and impaired exercise oxygen consumption. The precise interactions between altered pulmonary vascular metabolism and abnormal exercise physiology are relatively unknown.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Weichun Wu, Bingyang Liu, Min Huang, David H. Hsi, LiLi Niu, Yue Tian, Jingru Lin, Jiangtao Wang, Shuai Yang, Hongquan Lu, Changming Xiong, Zhenhui Zhu, Hao Wang
Summary: The 4D auto-RVQ technology shows potential in estimating right ventricular function and some hemodynamic changes in pulmonary hypertension patients with high image quality, while further large-scale studies are needed to evaluate RV function in patients with average image quality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Giulia Manguso, Anthony Vignone, Manuela Merli, Cristiano Miotti, Annalisa Caputo, Carmine Dario Vizza, Roberto Badagliacca
Summary: Liver cirrhosis is the fourth leading cause of death in Europe, with a high mortality rate and the need for liver transplantation. Transjugular intrahepatic portosystemic shunt (TIPS) is a common treatment strategy to reverse portal hypertension in these patients. However, the coexistence of pulmonary hypertension or heart failure is considered a contraindication to TIPS, but the definition of heart failure has not been clearly specified. There is limited and controversial data regarding the development of heart failure and pulmonary hypertension after TIPS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Gabor Kovacs, Alexander Avian, Gerhard Bachmaier, Natascha Troester, Adrienn Tornyos, Philipp Douschan, Vasile Foris, Teresa Sassmann, Katarina Zeder, Joerg Lindenmann, Luka Brcic, Michael Fuchsjaeger, Alvar Agusti, Horst Olschewski
Summary: By combining echocardiography, NT-proBNP level, and PA to Ao diameter ratio, severe PH in patients with COPD can be predicted with high sensitivity and specificity. The contribution of severe airflow limitation and severe PH to impaired survival is comparable.
Article
Cardiac & Cardiovascular Systems
Ze Ming Goh, Nithin Balasubramanian, Samer Alabed, Krit Dwivedi, Yousef Shahin, Alexander M. K. Rothman, Pankaj Garg, Allan Lawrie, David Capener, A. A. Roger Thompson, Faisal Alandejani, Jim M. Wild, Christopher S. Johns, Robert A. Lewis, Rebecca Gosling, Michael Sharkey, Robin Condliffe, David G. Kiely, Andrew J. Swift
Summary: This study investigated the prognostic value of patterns of right ventricular adaptation in patients with pulmonary arterial hypertension (PAH) using cardiac magnetic resonance imaging. The results showed that patients in different volume/mass groups had different survival outcomes, with those in the high-volume-low-mass group having a higher risk of treatment failure.
Article
Cardiac & Cardiovascular Systems
Claudia Baratto, Sergio Caravita, Celine Dewachter, Andrea Faini, Giovanni Battista Perego, Antoine Bondue, Michele Senni, Denisa Muraru, Luigi P. Badano, Gianfranco Parati, Jean-Luc Vachie
Summary: This study aimed to define the differences in right heart adaptation during exercise between a normal population and patients with pulmonary arterial hypertension (PAH), as well as identify factors associated with right heart maladaptation. The results showed that patients with PAH and heart failure with preserved ejection fraction (PH-HFpEF) had different rates of right atrial pressure (RAP) increase during exercise, with PH-HFpEF patients showing a steeper increase. Age, rate of increase in stressed blood volume during exercise, severe tricuspid regurgitation, and right atrial dilation were factors associated with RAP/CO slope.
JOURNAL OF CARDIAC FAILURE
(2023)