Article
Medicine, General & Internal
Leonardo De Luca, Francesca Cappadona, Pier Luigi Temporelli, Lucio Gonzini, Antonietta Ledda, Arturo Raisaro, Francesca Viazzi, Domenico Gabrielli, Furio Colivicchi, Michele Massimo Gulizia, Roberto Pontremoli
Summary: In patients with stable coronary artery disease (CAD), a reduction in estimated glomerular filtration rate (eGFR) is associated with an increased risk of all-cause mortality. Chronic kidney disease may limit treatment optimization.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Elisabet Van Loon, Wanqiu Zhang, Maarten Coemans, Maarten De Vos, Marie-Paule Emonds, Irina Scheffner, Wilfried Gwinner, Dirk Kuypers, Aleksandar Senev, Claire Tinel, Amaryllis H. Van Craenenbroeck, Bart De Moor, Maarten Naesens
Summary: A deep learning model was developed and validated to predict the patient-specific expected reference range of eGFR after kidney transplant, showing promising results in accurately forecasting individual trajectories within the first 3 months post-transplant.
Article
Transplantation
Pierre Delanaye, Emmanuelle Vidal-Petiot, Jonas Bjork, Natalie Ebert, Bjorn O. Eriksen, Laurence Dubourg, Anders Grubb, Magnus Hansson, Karin Littmann, Christophe Mariat, Toralf Melsom, Elke Schaeffner, Per-Ola Sundin, Arend Bokenkamp, Ulla B. Berg, Kajsa Asling-Monemi, Anna Akesson, Anders Larsson, Etienne Cavalier, R. Neil Dalton, Marie Courbebaisse, Lionel Couzi, Francois Gaillard, Cyril Garrouste, Lola Jacquemont, Nassim Kamar, Christophe Legendre, Lionel Rostaing, Thomas Stehle, Jean-Philippe Haymann, Luciano da Silva Selistre, Jorge P. Strogoff-de-Matos, Justine B. Bukabau, Ernest K. Sumaili, Eric Yayo, Dagui Monnet, Ulf Nyman, Hans Pottel, Martin Flamant
Summary: This study compared and validated the performance of the new Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPIAS) with the European Kidney Function Consortium (EKFC) and Lund-Malmo Revised (LMREV) equations in European and African cohorts. The results showed that the EKFC equation had the best performance in both European and African populations, while CKD-EPIAS had suboptimal performance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Nori J. L. Smeets, Joanna IntHout, Maurice J. P. van der Burgh, George J. Schwartz, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study establishes reference values for GFR in healthy, term-born neonates through an analysis of individual participant data (IPD). The study also optimizes the estimation of GFR using creatinine levels. The findings reveal a biphasic increase in GFR in neonates, with the largest increase occurring between days 1 and 5 after birth.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Lesley A. Inker, Nwamaka D. Eneanya, Josef Coresh, Hocine Tighiouart, Dan Wang, Yingying Sang, Deidra C. Crews, Alessandro Doria, Michelle M. Estrella, Marc Froissart, Morgan E. Grams, Tom Greene, Anders Grubb, Vilmundur Gudnason, Orlando M. Gutierrez, Roberto Kalil, Amy B. Karger, Michael Mauer, Gerjan Navis, Robert G. Nelson, Emilio D. Poggio, Roger Rodby, Peter Rossing, Andrew D. Rule, Elizabeth Selvin, Jesse C. Seegmiller, Michael G. Shlipak, Vicente E. Torres, Wei Yang, Shoshana H. Ballew, Sara J. Couture, Neil R. Powe, Andrew S. Levey
Summary: New equations for estimating GFR without considering race, using cystatin C and creatinine, reduce estimation errors between Black and non-Black participants. Compared to equations using creatinine alone, the new equations without race are more accurate and result in smaller differences between race groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Takaaki Koide, Shintaro Mandai, Reo Kitaoka, Hisazumi Matsuki, Motoko Chiga, Kouhei Yamamoto, Kotaro Yoshioka, Yohsuke Yagi, Soichiro Suzuki, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Soichiro Iimori, Shotaro Naito, Eisei Sohara, Tatemitsu Rai, Takanori Yokota, Shinichi Uchida
Summary: This study investigated the role of circulating small extracellular vesicles (sEVs) and their microRNAs (miRNAs) in vascular calcification in chronic kidney disease (CKD). It was found that sEVs accelerated calcification in vascular smooth muscle cells (VSMCs), and inhibiting sEV biogenesis/release could reduce calcification. The miRNA transcriptome of sEVs revealed a depletion of specific miRNAs in CKD patients, and transfection of VSMCs with these miRNAs mitigated calcification. The study also identified VEGFA as a convergent target of these miRNAs, and inhibiting VEGFA-VEGFR2 signaling could suppress calcification in VSMCs.
CIRCULATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Sehoon Park, Soojin Lee, Yaerim Kim, Yeonhee Lee, Min Woo Kang, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Summary: This study found that taller adult height is causally linked to worse kidney function in middle-aged to elderly individuals, independent of the effect of body mass index.
Article
Urology & Nephrology
Gregory L. Hundemer, Christine A. White, Patrick A. Norman, Greg A. Knoll, Navdeep Tangri, Manish M. Sood, Swapnil Hiremath, Kevin D. Burns, Christopher McCudden, Ayub Akbari
Summary: This study validated the 2021 race-free CKD-EPI eGFR equations among kidney transplant recipients, finding that they performed similarly to previous equations that included race correction terms. There was no significant difference in performance between the 2021 CKD-EPI eGFRcr and eGFRcr-cys equations in the kidney transplant population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Editorial Material
Urology & Nephrology
Bessie A. Young
Summary: Two studies suggest that cystatin-C-based equations can accurately estimate glomerular filtration rate regardless of race, addressing concerns about the incorrect use of race as a biological construct and its negative impact on health equity.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Yi-Ping Chang, Chen-Mao Liao, Li-Hsin Wang, Hsiu-Hua Hu, Chih-Ming Lin
Summary: This study followed 1042 chronic kidney disease patients with Stage 3-5 kidney disease and found that estimated glomerular filtration rate and urine protein to creatinine ratio had strong predictive abilities for disease progression. Additionally, differences in predictive variables were observed among patients at different stages of kidney disease, suggesting the potential for tailored prevention strategies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Minnie N. Dasgupta, Maria E. Montez-Rath, Seth A. Hollander, Scott M. Sutherland
Summary: This study found that AKI is common in children undergoing cardiac transplantation, particularly within 24 hours post-surgery, with 75% of patients developing AKI and 45% developing severe AKI. kGFR is moderately associated with identifying AKI risk, presenting a potential novel risk stratification technique.
PEDIATRIC RESEARCH
(2021)
Article
Geriatrics & Gerontology
Pei-Yu Kao, Hung-Chieh Yeh, Ying-Fang Hsia, Ya-Luan Hsiao, Jie-Sian Wang, David Ray Chang, Shih-Ni Chang, Hsiu-Yin Chiang, Chin-Chi Kuo
Summary: In this retrospective cohort study, different equation methods for predicting all-cause mortality were compared. The study found that the 24-hour U-CER-adjusted eGFR and 24-hour CrCl are viable options and can mitigate confounding biases. Only 24-hour CrCl exhibited a non-linear negative dose-response relationship. The findings of this study can guide clinical practice.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Peripheral Vascular Disease
Christine Y. Bakhoum, Matthew B. Matheson, Jason H. Greenberg, Susan L. Furth, Joachim H. Ix, Pranav S. Garimella
Summary: The study found no association between urine uromodulin levels and blood pressure in children with chronic kidney disease. Further research is needed to confirm this finding in healthy pediatric cohorts.
Article
Pathology
Rouvick M. Gama, Kathryn Griffiths, Royce P. Vincent, Adrien Michael Peters, Kate Bramham
Summary: Accurate diagnosis, classification, and risk stratification for chronic kidney disease (CKD) are important for early recognition and optimal care. Creatinine-based glomerular filtration rate (GFR), urinary albumin: creatinine ratio (UACR), and the kidney failure risk equation (KFRE) are important tools for achieving this, but understanding their limitations is crucial for optimal implementation.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Genetics & Heredity
Jadwiga Gazdzicka, Karolina Golabek, Dorota Hudy, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Wojciech Tynior, Marek Asman, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study investigated the association between selected single nucleotide polymorphisms (SNPs) of the FCN2 gene and chronic tonsillitis in the Polish population. The CT genotype of rs3124954 was significantly more frequent in chronic tonsillitis patients, while the CC genotype was less frequent. The A/G/T haplotype (rs17514136/rs3124953/rs3124954) was significantly more common in chronic tonsillitis patients. The CT genotype of rs3124954 was associated with a higher risk of chronic tonsillitis, while the CC genotype decreased this risk.
Review
Endocrinology & Metabolism
Martyna Fronczek, Tadeusz Osadnik, Maciej Banach
Summary: The purpose of this study was to review recent publications and examine the relationship between genetic variants in the vitamin D receptor (VDR) gene and type 2 diabetes, metabolic syndrome, overweight, and obesity. Recent studies have focused on genetic variants in both coding and noncoding regions of the VDR gene, which may affect VDR expression or functionality. However, the data collected in recent months still do not provide a clear answer regarding the direct impact of VDR genetic variants on these metabolic disorders.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
(2023)
Article
Biochemistry & Molecular Biology
Karolina Golabek, Dorota Hudy, Agata Swietek, Jadwiga Gazdzicka, Natalia Dabrowska, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study analyzed the expression of E2F2 gene and protein, as well as the miRNAs candidate targets (miR-125b-5p, miR-155-3p, and miR-214-5p) in oral squamous cell carcinoma (OSCC) tumor and margin samples. The results showed that E2F2 gene is not the target for analyzed miRNAs in OSCC, while miR-155-3p and miR-125b-5p may play roles in the pathogenesis of OSCC. Additionally, miRNAs expression in response to tobacco smoke and HPV status showed differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jakub Wnuk, Joanna Katarzyna Strzelczyk, Iwona Gisterek
Summary: Pancreatic cancer is the seventh leading cause of cancer-related deaths, and the number of deaths is expected to rise. Early diagnosis is crucial for improving treatment outcomes. MicroRNAs are found to be useful biomarkers in the diagnosis and prognosis of pancreatic ductal adenocarcinoma. This review evaluates the clinical value of circulating miRNAs in the screening, diagnosis, prognosis, and monitoring of pancreatic ductal adenocarcinoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Alicja Nowowiejska-Wiewiora, Krystian Wita, Zofia Medrala, Lidia Tomkiewicz-Pajak, Kamil Bujak, Katarzyna Mizia-Stec, Piotr Brzychczy, Mariusz Gasior, Zbigniew Gasior, Aleksandra Kulbat, Zbigniew Kalarus, Wojciech Wojakowski, Przemyslaw Trzeciak, Adam Witkowski, Maciej Banach, JaceK Legutko
Summary: This study aimed to assess the management of dyslipidemia and achievement of treatment goals in AMI patients participating in the MACAMIS program. The results showed that participation in the program may improve the quality of dyslipidemia management in AMI patients, but only one-fifth of patients achieved the treatment goal for LDL-C.
KARDIOLOGIA POLSKA
(2023)
Article
Cardiac & Cardiovascular Systems
Karol Kazirod-Wolski, Janusz Sielski, Mariusz Gasior, Kamil Bujak, Michal Hawranek, Lukasz Pyka, Marek Gierlotka, Tomasz Pawlowski, Zbigniew Siudak
Summary: This study aimed to evaluate the frequency of IVUS and FFR use in patients with ACS in Poland and their impact on short-and long-term survival. The study included 103849 patients enrolled in the Polish Registry of Acute Coronary Syndromes. The use of FFR and IVUS has increased in recent years, and the FFR and/or IVUS group showed lower in-hospital mortality and no differences in other complications compared to patients who did not undergo these procedures.
KARDIOLOGIA POLSKA
(2023)
Article
Cardiac & Cardiovascular Systems
Kamila Osadnik, Tadeusz Osadnik, Marek Gierlotka, Adam Windak, Tomasz Tomasik, Miroslaw Mastej, Agnieszka Kuras, Kacper Jozwiak, Peter E. Penson, Gregory Y. H. Lip, Dimitri P. Mikhailidis, Peter P. Toth, Alberico L. Catapano, Kausik K. Ray, George Howard, Maciej Tomaszewski, Fadi J. Charchar, Naveed Sattar, Bryan Williams, Thomas M. MacDonald, Maciej Banach, Jacek Jozwiak
Summary: This study examined the association between metabolic syndrome (MetS) and long-term all-cause mortality. The findings showed that MetS was associated with increased mortality risk in both obese and non-obese individuals. The concept of metabolically healthy obesity should be reconsidered, and maintaining normal body weight is important for overall health.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Joanna Katarzyna Strzelczyk, Agata Swietek, Dorota Hudy, Karolina Golabek, Jadwiga Gazdzicka, Katarzyna Miskiewicz-Orczyk, Wojciech Scierski, Janusz Strzelczyk, Maciej Misiolek
Summary: Recent studies have found that viral and bacterial factors, including HSV-1 and H. pylori, may be associated with diseases such as chronic tonsillitis and cancers like head and neck squamous cell carcinoma (HNSCC). By using PCR after DNA isolation, the prevalence of HSV-1/2 and H. pylori was assessed in patients with HNSCC, chronic tonsillitis, and healthy individuals. HSV-1 and H. pylori were found most frequently in the control group.
Article
Biochemistry & Molecular Biology
Jolanta Malinowska-Borowska, Malgorzata Piecuch, Patryk Szlacheta, Aleksandra Kulik, Jacek Niedziela, Jolanta Urszula Nowak, Lukasz Pyka, Mariusz Gasior, Piotr Rozentryt
Summary: Low spot urinary creatinine concentration (SUCR) has been linked to poor prognosis in heart failure (HF) patients. However, its correlation with body composition markers and volume overload markers has not been studied before. This study aimed to determine the prognostic value of SUCR after adjusting for body composition and volume overload markers in HF patients.
Article
Cardiac & Cardiovascular Systems
Joanna Lewek, Jacek Niedziela, Piotr Desperak, Krzysztof Dyrbus, Tadeusz Osadnik, Piotr Jankowski, Adam Witkowski, Agata Bielecka-Dabrowa, Dariusz Dudek, Marek Gierlotka, Mariusz Gasior, Maciej Banach
Summary: Compared to statin monotherapy, upfront combination therapy of statin and ezetimibe significantly reduces all-cause mortality in patients with acute coronary syndromes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Janusz Strzelczyk, Monika Wojcik-Giertuga, Joanna Katarzyna Strzelczyk, Alicja Prawdzic Senkowska, Krzysztof Biernacki, Beata Kos-Kudla
Summary: This study aimed to evaluate bone metabolism based on selected markers (OST, OPG, and IGFBP-3) in patients with neuroendocrine tumors (NETs) and the control group. The results showed significantly higher levels of OST and OPG in the study group compared to the control group. These markers were found to be correlated with clinical stage, chromogranin A, and other indicators of NETs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jolanta Malinowska-Borowska, Marta Buczkowska, Sylwia Duda, Apolonia Stefaniak, Jacek Niedziela, Jolanta Urszula Nowak, Jadwiga Nessler, Karol Adam Kaminski, Mariusz Gasior, Piotr Rozentryt
Summary: Heart failure is a highly heterogeneous syndrome, and the heterogeneity of skeletal muscle quantity and function may have an impact on patient's phenotype. In this study, clinical characteristics of different phenotypes defined by a combination of skeletal muscle mass and urinary creatinine levels were compared. The phenotype with low skeletal muscle mass and low urinary creatinine levels was associated with the highest mortality, and this risk was not captured by the MAGGIC score. Measurement of urinary creatinine can serve as a potentially useful biomarker to phenotype heart failure patients independently of their skeletal muscle status.
Article
Biochemistry & Molecular Biology
Agata Swietek, Karolina Golabek, Dorota Hudy, Jadwiga Gazdzicka, Krzysztof Biernacki, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study evaluated the concentrations of E2F2, MDM2, and p16 in oral squamous cell carcinoma tumour and margin samples and their association with sociodemographic and clinicopathological characteristics of patients. The results showed that E2F2 concentrations were lower in N0 patients compared to N1 patients in tumour samples, and HPV-negative patients had higher E2F2 protein concentrations. In addition, p16 levels were lower in alcohol drinkers in margin samples, and similar observations were found in concurrent drinkers and smokers.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Medicine, General & Internal
Jacek Bil, Adam Kern, Kamil Bujak, Marek Gierlotka, Jacek Legutko, Mariusz Gasior, Wojciech Wanha, Leszek Gromadzinski, Robert J. Gil
Summary: This study compared the characteristics and 12-month clinical outcomes of patients with MINOCA treated before and during the COVID-19 pandemic. The rate of MINOCA was lower in 2020 and in-hospital stroke rates were higher during the pandemic. Further evaluation is needed to assess the association between worse clinical outcomes of MINOCA patients treated during the pandemic and the increased risk for thromboembolic complications of SARS-CoV-2 infection.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Medicine, General & Internal
Patryk Szlacheta, Jolanta Malinowska-Borowska, Jolanta U. Nowak, Marta Buczkowska, Aleksandra Kulik, Alina Mroczek, Sylwia Duda, Weronika Ostrega, Jacek T. Niedziela, Michal Skrzypek, Mariusz Gasior, Piotr Rozentryt
Summary: This study assessed the prognostic value of red cell distribution width (RDW) in chronic heart failure with reduced ejection fraction (HFrEF), and found that RDW has a strong independent prognostic power regardless of the risk assessed by MAGGIC-HF or SHFSM score.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)