Review
Medicine, General & Internal
Ambreen Amir Ali Gowani, Gail Low, Colleen Norris, Matthias Hoben
Summary: This study aims to critically appraise, summarise, and compare the available evidence on the factor structure and internal consistency reliability (ICR) of the Minnesota Living with Heart Failure Questionnaire (MLHFQ).
Article
Multidisciplinary Sciences
Anne Grauer, Talea Cornelius, Marwah Abdalla, Nathalie Moise, Ian M. Kronish, Siqin Ye
Summary: This retrospective observational study using electronic health records data found that telemedicine visits did not significantly reduce 30-day hospital readmission rates compared to in-person visits. These findings suggest that telemedicine visits are a safe and viable alternative for post-hospitalization follow-up care.
Article
Cardiac & Cardiovascular Systems
Maria Pilar Lopez-Diez, Aitor Alquezar-Arbe, Javier Jacob, Pere Llorens, Lluis Llauger, Pablo Herrero, Victor Gil, Julio Nunez, Francisco Javier Martin-Sanchez, Oscar Miro
Summary: This study investigated whether the existence of heart failure units (HFU) and link nurse units (LNU) in the hospital improve short-term outcomes of acute heart failure (AHF) episodes. The results showed that the complete development of these follow-up units was not associated with 30-day mortality but was associated with less prolonged hospitalization and fewer post-discharge adverse events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Kartik S. Telukuntla, Chetan P. Huded, Mingyuan Shao, Tim Sobol, Mouin Abdallah, Kathleen Kravitz, Michael Hulseman, Benico Barzilai, Randall C. Starling, Lars G. Svensson, Steven E. Nissen, Umesh N. Khot
Summary: An EMR-based appointment order for follow-up appointment scheduling was associated with increased cardiovascular medicine follow-up, but was not associated with an observed reduction in 30-day readmission rates.
NPJ DIGITAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Christoffer R. Vissing, Kiri Espersen, Helen L. Mills, Emil D. Bartels, Rebecca Jurlander, Sofie Skriver, Jonas Ghouse, Jens J. Thune, Anna Axelsson Raja, Alex H. Christensen, Henning Bundgaard
Summary: This study investigated the prevalence, incidence, and predictors of familial dilated cardiomyopathy (FDC) in relatives participating in family screening. The results showed that 22% of relatives were diagnosed with FDC at baseline, and genetic sequencing identified the etiology in 37% of families screened. During follow-up, 2.0% developed FDC per person-year. Baseline screening helped identify relatives at low risk of developing FDC, reducing the need for follow-up.
JACC-HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Yanbo Zhu, Jianni Cong, Lin Lin, Jinhang Du, Liqun Long, Yuan He, Jiaju Ren
Summary: The study aimed to estimate the minimum clinically important differences (MCIDs) in the Minnesota Living with Heart Failure questionnaire (MLHFQ) for heart failure patients treated with integrated Chinese and Western medicine in order to assist doctors and patients in assessing intervention effectiveness. MCIDs were estimated using anchor-based and distribution-based approaches, and different MCIDs were obtained for different dimensions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Lukasz Wolowiec, Joanna Banach, Jacek Budzynski, Anna Wolowiec, Mariusz Kozakiewicz, Maciej Bielinski, Albert Jasniak, Agata Olejarczyk, Grzegorz Grzesk
Summary: The study aimed to assess the prognostic value of plasma catestatin concentration in patients with heart failure with reduced ejection fraction (HFrEF) in predicting unplanned hospitalization and all-cause death at a 2-year follow-up. The study included 122 hospitalized Caucasian patients in NYHA classes II to IV. Patients who died during the follow-up period had higher levels of CST, NT-proBNP, troponin T, creatinine, and glucose, and lower TAPSE, hemoglobin concentration, hematocrit, and platelet count compared to survivors. Plasma catestatin concentration was positively associated with NYHA class and blood NT-proBNP concentration. Higher plasma catestatin concentration increased the risk of all-cause death by more than five times. Plasma CST concentration is a valuable prognostic parameter in predicting death from all causes and unplanned hospitalization in patients with HFrEF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Maria F. Paton, John Gierula, Judith E. Lowry, David A. Cairns, Kieran Bose Rosling, Charlotte A. Cole, Melanie McGinlay, Sam Straw, Rowena Byrom, Richard M. Cubbon, Mark T. Kearney, Klaus K. Witte
Summary: The study aimed to compare personalized pacemaker reprogramming with usual care on echocardiographic and patient-oriented outcomes. Results showed that personalized programming reduced RV pacing, improved LV function and size, and extended battery longevity, with no impact on quality of life.
Article
Cardiac & Cardiovascular Systems
Georg M. Wieselthaler, Liviu Klein, Anson W. Cheung, Matthew R. Danter, Martin Strueber, Claudius Mahr, Nahush A. Mokadam, Simon Maltais, Edwin C. McGee
Summary: The two-year follow-up of the LATERAL trial demonstrated a favorable morbidity profile in HVAD system-supported patients, with higher AE rates occurring within the first 30 days postimplant but significantly reduced overall AE rates after 6 months. Importantly, the 2-year freedom from disabling stroke was 95%. These findings further support the improving AE profile in long-term HVAD-supported patients.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Ryuichi Matsukawa, Seigo Masuda, Hirohide Matsuura, Hiroka Nakashima, Hiroshi Ikuta, Kousuke Okabe, Arihide Okahara, Shunsuke Kawai, Masaki Tokutome, Tomoyuki Tobushi, Yasushi Mukai
Summary: The study suggests that early outpatient follow-up after discharge in patients with congestive heart failure may improve long-term prognosis by reducing readmission rates and composite adverse outcomes. These positive outcomes appear to not be solely dependent on medication adjustments but on early modification of patient factors post-discharge.
Article
Medicine, General & Internal
Giulia Elena Mandoli, Maria Barilli, Davide Soviero, Nicolo Ghionzoli, Federico Landra, Massimo Maccherini, Sonia Bernazzali, Benedetta Maria Natali, Marta Focardi, Luna Cavigli, Flavio D'Ascenzi, Maria Concetta Pastore, Carlotta Sciaccaluga, Tonino Bombardini, Serafina Valente, Matteo Cameli
Summary: In this study, the outcomes of recipients who received marginal donor hearts selected by dipyridamole stress echocardiography were compared to those who received acceptable donor hearts. The results showed that transplanting marginal donor hearts through a non-invasive bedside technique can alleviate the shortage of organs without affecting survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Manuel Mendez-Bailon, Noel Lorenzo-Villalba, Alvaro Gonzalez-Franco, Luis Manzano, Jesus Casado-Cerrada, Jose M. Cerqueiro, Jose Perez-Silvestre, Jose Carlos Arevalo-Lorido, Alicia Conde-Martel, Meliton Francisco Davila-Ramos, Margarita Carrera-Izquierdo, Emmanuel Andres, Manuel Montero-Perez-Barquero
Summary: The UMIPIC program, which focuses on holistic and ongoing care, effectively reduces both hospital admissions and mortality rates for HF and CRS patients after a one-year follow-up period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Sophie Margaretha Eschlboeck, Philipp Rellecke, Hannan Dalyanoglu, Igor Tudorache, Udo Boeken, Payam Akhyari, Alexander Albert, Artur Lichtenberg, Hug Aubin
Summary: ECLS therapy for refractory circulatory failure patients who survive the first 30 days shows favorable outcomes in subsequent survival and functional recovery, indicating the potential for patient recovery even after long periods of mechanical support.
Article
Medicine, General & Internal
Giuseppe Dattilo, Giulia Laterra, Roberto Licordari, Francesca Parisi, Lorenzo Pistelli, Luigi Colarusso, Luca Zappia, Vittoria Vaccaro, Elisabetta Demurtas, Marta Allegra, Pasquale Crea, Gianluca Di Bella, Salvatore Santo Signorelli, Nadia Aspromonte, Egidio Imbalzano, Michele Correale
Summary: This study evaluated the effects of Sacubitril/Valsartan treatment in patients with HFrEF for a period of 5 years. The results showed that the treatment not only improved patient outcomes after 1 year, but continued to show significant improvements at 5 years, with profound clinical implications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Theo Pezel, Thierry Unterseeh, Philippe Garot, Thomas Hovasse, Francesca Sanguineti, Solenn Toupin, Stephane Morisset, Stephane Champagne, Jerome Garot
Summary: This study evaluated the long-term prognostic value of stress cardiovascular magnetic resonance (CMR) for coronary revascularization, finding that CMR-related revascularization was associated with a lower incidence of death, especially in patients with severe inducible ischemia.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Hematology
Stephan Binneboessel, Raphael Romano Bruno, Bernhard Wernly, Maryna Masyuk, Hans Flaatten, Jesper Fjolner, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Wojciech Szczeklik, Susannah Leaver, Dylan W. De Lange, Bertrand Guidet, Christian Jung
Summary: This study investigated the impact of cytokine absorption on mortality in elderly critically ill patients with COVID-19 and renal failure admitted to intensive care units. The results showed that short-term mortality rates were higher in patients treated with cytokine absorption, but mortality was associated with disease severity rather than cytokine absorption in a multivariate analysis.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Critical Care Medicine
Christian Jung, Bertrand Guidet, Hans Flaatten
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Robert Uzel, Richard Rezar, Raphael Romano Bruno, Sarah Wernly, Christian Jung, Georg Delle Karth, Christian Datz, Friedrich Hoppichler, Bernhard Wernly
Summary: Frailty was evaluated as a predictor of outcome in patients with moderate to severe secondary mitral regurgitation. The study found that frailty was associated with a higher risk of adverse outcomes and outperformed EuroSCORE2 in predicting the combined endpoint. Therefore, routine assessment of frailty should be carried out in patients with heart failure to guide clinical decision making.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Medicine, General & Internal
Richard Rezar, Behrooz Mamandipoor, Clemens Seelmaier, Christian Jung, Michael Lichtenauer, Uta C. C. Hoppe, Reinhard Kaufmann, Venet Osmani, Bernhard Wernly
Summary: Severe hyperlactatemia (>10mmol/L) or impaired lactate metabolism are associated with increased mortality. A study analyzed the maximum lactate concentration on day 1 of 10,724 septic patients and categorized them into three groups based on lactate levels. Findings showed that severe hyperlactatemia was linked to high mortality rates, especially if it persists beyond 24 hours. The results suggest that severe hyperlactatemia, along with clinical parameters, could be used to determine treatment limits.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Medicine, General & Internal
Christoph Sponholz, Oliver Sommerfeld, Caroline Moehl, Thomas Lehmann, Marcus Franz, Michael Bauer, Torsten Doenst, Gloria Faerber, Mahmoud Diab
Summary: A retrospective study evaluated the use of intraoperative cell salvage with autologous blood retransfusion in patients with infective endocarditis. The findings suggest that intraoperative cell salvage can reduce perioperative transfusion requirement without affecting inflammatory markers and organ function. The restriction of intraoperative cell salvage in this surgery should be re-evaluated.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Dragos Andrei Duse, Michael Groene, Nicolas Kramser, Matthias Ortkemper, Christine Quast, Fabian Voss, Nadia Heramvand, Karel Kostev, Malte Kelm, Patrick Horn, Christian Jung, Ralf Erkens
Summary: This study analyzed the initial serum phosphate levels of 488 patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest (CA), and found that phosphate levels higher than 2.7 mmol/L were associated with higher mortality and neurological impairment. These results suggest that phosphate determination may improve the preciseness of overall and neurological prognostication in patients after cardiopulmonary resuscitation (CPR) following ROSC.
Article
Cardiac & Cardiovascular Systems
Verena Veulemans, Nihal Wilde, Hendrik Wienemann, Rik Adrichem, Thijmen W. Hokken, Baravan Al-Kassou, Jasmin Shamekhi, Victor Mauri, Oliver Maier, Christian Jung, Patrick Horn, Matti Adam, Georg Nickenig, Stephan Baldus, Nicolas M. Van Mieghem, Malte Kelm, Alexander Sedaghat, Tobias Zeus
Summary: This study evaluated the impact of different TAVI-guidewires on procedural success and outcomes during transcatheter aortic valve implantation (TAVI). The use of the Lunderquist(TM) guidewire was associated with a higher final implantation depth, but had no significant impact on outcomes such as conduction disturbances and pacemaker need within 30 days.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Infectious Diseases
Andreas Kokoefer, Behrooz Mamandipoor, Maria Flamm, Richard Rezar, Sarah Wernly, Christian Datz, Christian Jung, Venet Osmani, Bernhard Wernly, Raphael Romano Bruno
Summary: This study examined the impact of ethnic background on the management and outcome of sepsis and septic shock. The findings showed that there were no significant differences in treatment and mortality rates among different ethnic groups.
BMC INFECTIOUS DISEASES
(2023)
Article
Hematology
Lilyana Georgieva, Fabian Nienhaus, Sebastian M. Haberkorn, Ralf Erkens, Amin Polzin, Patricia Wischmann, Rojda Ipek, Kian Marjani, Aikaterini Christidi, Michael Roden, Christian Jung, Florian Boenner, Malte Kelm, Stefan Perings, Mareike Gastl
Summary: Early after ST-segment elevation myocardial infarction (STEMI), LV function analysis may be affected by initial LV reshaping and hypokinesia, as well as concomitant microvascular dysfunction. This study compared left ventricular ejection fraction (LVEF) and stroke volume (SV) using different imaging modalities in the early stages of STEMI. The results showed that 2D analysis methods of LVEF yielded consistent results using cineventriculography (CVG), 2-dimensional echocardiography (2DE), and 2D cardiovascular magnetic resonance (CMR) within 24 hours and 5 days after STEMI. SV measurements differed significantly between imaging techniques due to variations in volumetric measurements.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Infectious Diseases
Timo Mayerhoefer, Sebastian Klein, Bernhard Wernly, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjolner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Antonio Artigas, Peter Vernon van Heerden, Bernardo Bollen Pinto, Joerg C. Schefold, Rui Moreno, Maurizio Cecconi, Wojciech Szczeklik, Christian Jung, Michael Joannidis
Summary: This study investigated the impact of diabetes mellitus on 90-day mortality in a high-risk cohort of critically ill patients over 70 years of age. The study found that patients with diabetes had a significantly higher 90-day mortality rate compared to those without diabetes. This suggests that diabetes is a relevant risk factor for COVID-19 in old critically ill patients.
Letter
Critical Care Medicine
Niklas Rodemund, Bernhard Wernly, Christian Jung, Crispiana Cozowicz, Andreas Kokoefer
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Dragos Andrei Duse, Fabian Voss, Laura Heyng, Georg Wolff, Christine Quast, Daniel Scheiber, Patrick Horn, Malte Kelm, Ralf Westenfeld, Christian Jung, Ralf Erkens
Summary: This study found that phosphate and lactate levels are associated with the benefits of mechanical circulatory support (MCS) in patients with out-of-hospital cardiac arrest (OHCA) and return of spontaneous circulation (ROSC). MCS therapy was found to reduce 30-day mortality in patients with initial phosphate levels above 2.2 mmol/L. Both lactate and phosphate levels showed comparable predictive ability for overall survival.
Article
Emergency Medicine
Janina Dziegielewski, Falko C. Schulte, Christian Jung, Georg Wolff, Oliver Hannappel, Philipp Kuempers, Michael Bernhard, Mark Michael
Summary: This retrospective study analyzed the epidemiology, management, and outcome of critically ill non-traumatic patients admitted to the emergency department (ED). It found that further development of structured care algorithms for these patients is needed.
BMC EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert Uzel, Raphael R. Bruno, Christian Jung, Christian Lang, Hannes Hoi, Martin Gruenbart, Christian Datz, Friedrich Hoppichler, Bernhard Wernly
Summary: This study evaluated the impact of ACE inhibitors and angiotensin receptor blockers (ACE-I/ARB) on elderly patients with moderate-to-severe mitral regurgitation (MR) and mildly reduced to preserved ejection fraction. The results showed that patients treated with ACEI/ARB had a lower risk for the combined endpoint of death and heart failure-related readmission, even after adjustment for risk scores and frailty. Therefore, ACE-I/ARB might be a valuable therapeutic option for conservatively treated patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Letter
Critical Care Medicine
Bernhard Wernly, Hans Flaatten, Susannah Leaver, Bertrand Guidet, Christian Jung
