Article
Medicine, General & Internal
Ameenathul M. M. Fawzy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study investigated the association between atrial fibrillation (AF) and ventricular arrhythmias (VAs) and sudden death in hospitalized patients in France. The results showed that AF patients had significantly higher incidence and risk of VAs and cardiac arrest compared to non-AF patients. This association remained significant after adjusting for confounders, indicating a clear association between AF and VAs and sudden death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Philippe Chevalier, Adrien Moreau, Francis Bessiere, Sylvain Richard, Mohamed Chahine, Gilles Millat, Elodie Morel, Franck Paganelli, Nathalie Lesavre, Leslie Placide, Francois Montestruc, Benedicte Ankou, Rosa Donate Puertas, Babken Asatryan, Antoine Deliniere
Summary: The presence of GJA1 gene variants increases the risk of ventricular fibrillation (VF) in ST-elevation myocardial infarction (STEMI) patients. Beta-blocker intake, atrial fibrillation, and left ventricular ejection fraction >50% decrease the risk of primary VF (PVF). Three novel GJA1 variants were identified, and in vitro studies showed that these variants cause changes in Cx43 localization and cellular communication.
Article
Cardiac & Cardiovascular Systems
Richard T. Carrick, Anneline S. J. M. te Riele, Alessio Gasperetti, Laurens Bosman, Steven A. Muller, Catherine Pendleton, Crystal Tichnell, Brittney Murray, Sing-Chien Yap, Maarten P. van den Berg, Arthur Wilde, Katja Zeppenfeld, Allison Hays, Stefan L. Zimmerman, Harikrishna Tandri, Julia Cadrin-Tourigny, Peter van Tintelen, Hugh Calkins, Cynthia A. James, Katherine C. Wu
Summary: Risk factors for VA in ARVC are dynamic and overall risk for incident sustained VA decreases during follow-up. Up-to-date risk factor assessment improves VA risk stratification.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Aleksandra Lizewska-Springer, Grzegorz Slawinski, Ewa Lewicka
Summary: The article provides a narrative review on electrophysiological abnormalities and ventricular arrhythmias in patients with cardiac amyloidosis, as well as the role of implantable cardioverter-defibrillator (ICD) in terms of survival benefit for this group of patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Rodrigue Garcia, Eloi Marijon, Nicole Karam, Kumar Narayanan, Frederic Anselme, Olivier Cesari, Laure Champ-Rigot, Vladimir Manenti, Raphael Martins, Etienne Puymirat, Jean Ferrieres, Francois Schiele, Tabassome Simon, Nicolas Danchin
Summary: The incidence and mortality of ventricular fibrillation (VF) among patients hospitalized for acute myocardial infarction (AMI) have significantly decreased over the past 20 years. However, VF remains associated with a 10-fold increased relative risk of in-hospital mortality, without affecting post-discharge mortality. These findings highlight the need for interventions during hospitalization to further reduce mortality in VF patients.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Khaled Q. A. Abdullah, Jana Roedler, Juergen vom Dahl, Istvan Szendey, Dimitrios Dimitroulis, Lars Eckardt, Albert Topf, Bernhard Ohnewein, Lorenz Fritsch, Fabian Foettinger, Mathias C. Brandt, Bernhard Wernly, Lukas J. Motloch, Robert Larbig
Summary: In this study, 109 consecutive patients who survived sudden cardiac death and required hemodynamic support from an Impella assist device were analyzed. Despite high hospital mortality and frequent cardiac arrhythmias during Impella treatment, these arrhythmias did not predict patient survival. The hemodynamic support from the pump appeared to counteract the adverse effects of these events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ibrahim El-Battrawy, Katharina Koepsel, David Tenbrink, Boldizsar Kovacs, Tobias C. Dreher, Christian Blockhaus, Michael Gotzmann, Norbert Klein, Thomas Kuntz, Dong-In Shin, Hendrik Lapp, Stephanie Rosenkaimer, Mohammad Abumayyaleh, Nazha Hamdani, Ardan Muammer Saguner, Jacqueline Kowitz, Julia W. Erath, Firat Duru, Andreas Muegge, Ibrahim Akin, Assem Aweimer, Thomas Beiert
Summary: This study shows that the use of wearable cardioverter-defibrillator (WCD) may be beneficial for the treatment of patients with myocarditis. Prior ventricular arrhythmia may be a better predictor of risk than a reduced left ventricular ejection fraction <35% in this population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Eric J. Hall, Soumojit Pal, Michael S. Glennon, Puneeth Shridhar, Sidney L. Satterfield, Beth Weber, Qinkun Zhang, Guy Salama, Hind Lal, Jason R. Becker
Summary: Cardiac natriuretic peptides play a crucial role in regulating cardiovascular physiology. Deficiency in either atrial natriuretic peptide (ANP) or B-type natriuretic peptide (BNP) can cause adverse effects on the structure and function of the heart. This study shows that ANP and BNP exert non-redundant functions in maintaining myocardial cGMP levels, which in turn regulate the activity of cardiomyocyte p38 mitogen-activated protein kinase (p38 MAPK) and cAMP response element-binding protein (CREB). Deficiency in cardiac natriuretic peptides increases the risk of stress-induced ventricular arrhythmias.
CARDIOVASCULAR RESEARCH
(2022)
Article
Health Care Sciences & Services
Henrik Eckert, Ibrahim El-Battrawy, Michael Veith, Gretje Roterberg, Jacqueline Kowitz, Siegfried Lang, Xiaobo Zhou, Ibrahim Akin, Andreas Muegge, Assem Aweimer
Summary: This study compared the complications of transvenous and subcutaneous implantable cardioverter-defibrillators (ICDs). The results showed that subcutaneous ICDs (S-ICDs) have certain advantages over transvenous ICDs (T-ICDs) in terms of lead-related complications. However, S-ICDs still have issues with inappropriate shocks and other ICD-related complications. Therefore, a case-by-case decision is recommended, but the continuous improvement of S-ICDs may make them an overall advantageous therapy option in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Teresa Oliveras, Iolanda Lazaro, Ferran Rueda, German Cediel, Deepak L. Bhatt, Montserrat Fito, Francisco Madrid-Gambin, Oscar J. Pozo, William S. Harris, Cosme Garcia-Garcia, Aleix Sala-Vila, Antoni Bayes-Genis
Summary: This study found that levels of linoleic acid (LA) in serum phospholipids are associated with susceptibility to primary ventricular fibrillation (PVF). PVF patients had lower levels of LA. Each one standard deviation increase in the proportion of LA was associated with a 42% lower prevalence of PVF.
SCIENTIFIC REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Francis Bessiere, Victor Waldmann, Nicolas Combes, Olivier Metton, Nabil Dib, Blandine Mondesert, Edward O'Leary, Elizabeth De Witt, Chrystalle Katte Carreon, Stephen P. Sanders, Jeremy P. Moore, John Triedman, Paul Khairy
Summary: Patients with congenital heart disease have a higher risk for ventricular arrhythmias, which can be divided into those with discrete mechanisms and those with more diffuse substrates. This review focuses on patients with tetralogy of Fallot and related variants who have reentrant monomorphic ventricular tachycardia. Programmed ventricular stimulation is useful for risk stratification, and catheter ablation may be an alternative for selected patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Eduardo Arana-Rueda, Beatriz Jauregui, Manuel Frutos-Lopez, Juan Acosta, Juan Antonio Sanchez-Brotons, Lorena Garcia-Riesco, Ana Campos-Pareja, Carmen Nieto, Alonso Pedrote
Summary: The study analyzed the impact of sex on the benefit of ICD implantation for sudden death prevention. Clinical characteristics at the time of ICD implantation differed between sexes, but after adjustment, both men and women equally benefited from ICD, with heart failure being the main cause of mortality for both genders.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Health Care Sciences & Services
Tobias Schupp, Jonas Rusnak, Kathrin Weidner, Thomas Bertsch, Kambis Mashayekhi, Peter Tajti, Ibrahim Akin, Michael Behnes
Summary: Limited data is available regarding the outcome of patients with different types of ventricular tachyarrhythmias. This study aimed to assess the prognostic impact of different types of ventricular tachyarrhythmias stratified by underlying cardiac disease. VF was associated with worse long-term prognosis compared to s-VT in IHD patients, while the risk of all-cause mortality did not differ significantly between VF and s-VT patients in those with AMI, NICM, and patients considered at lower risk for ventricular tachyarrhythmias.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Paloma Jorda, Laurens P. Bosman, Alessio Gasperetti, Andrea Mazzanti, Jean-Baptiste Gourraud, Brianna Davies, Tanja Charlotte Frederiksen, Zoraida Moreno Weidmann, Andrea Di Marco, Jason D. Roberts, Ciorsti MacIntyre, Colette Seifer, Antoine Deliniere, Wael Alqarawi, Deni Kukavica, Damien Minois, Alessandro Trancuccio, Marine Arnaud, Mattia Targetti, Annamaria Martino, Giada Oliviero, Daniel C. Pipilas, Corrado Carbucicchio, Paolo Compagnucci, Antonio Dello Russo, Iacopo Olivotto, Leonardo Calo, Steven A. Lubitz, Michael J. Cutler, Philippe Chevalier, Elena Arbelo, Silvia Giuliana Priori, Jeffrey S. Healey, Hugh Calkins, Michela Casella, Henrik Kjaerulf Jensen, Claudio Tondo, Rafik Tadros, Cynthia A. James, Andrew D. Krahn, Julia Cadrin-Tourigny
Summary: This study validated a 5-year risk prediction model for ARVC patients, demonstrating its superior performance in guiding ICD implantation decisions compared to other published guidelines and consensus statements. The findings support the use of this model for shared decision making in the primary prevention of SCD in ARVC patients.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Carsten Israel, Ingo Staudacher, Christophe Leclercq, Giovanni Luca Botto, Daniel Scherr, Andreas Fach, Firat Duru, Maura M. Zylla, Hugo A. Katus, Dierk Thomas
Summary: Sudden cardiac death (SCD) is the leading cause of cardiovascular death in industrialized nations. Patients with cardiomyopathy are at higher risk of SCD and may benefit from an implantable cardioverter-defibrillator (ICD). The wearable cardioverter-defibrillator (WCD) provides a non-invasive, temporary therapy that may offer advantages over early ICD implantation. However, patient compliance and education play a crucial role in preventing SCD.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tamas Szili-Torok, Jens Rump, Torsten Luther, Sing-Chien Yap
Summary: This study utilized a biplane cine-fluoroscopy method to investigate lead curvature, suggesting that lead curvatures can be accurately computed and implemented to enhance lead design and testing.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Medicine, General & Internal
Wern Yew Ding, Tatjana S. Potpara, Carina Blomstrom-Lundqvist, Giuseppe Boriani, Francisco Marin, Laurent Fauchier, Gregory Y. H. Lip
Summary: The study examined the impact of renal impairment on patients with AF and found that impaired renal function was associated with a higher incidence of adverse events. Even in patients with indications for anticoagulants, severe renal impairment was linked to a reduction in prescription of these agents.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Liesbeth Timmers, P. Vervaet, P. Goethals, J. De Pooter, F. Vanheuverswyn, E. Van de Velde, M. De Pauw, L. Jordaens
Summary: After catheter ablation for ventricular extrasystoles in patients with structurally normal hearts, palpitations become less frequent, syncope becomes rare, and quality of life significantly improves from all perspectives.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan Roest, Olivier C. Manintveld, Marit A. E. Kolff, Ferdi Akca, Jesse F. Veenis, Alina A. Constantinescu, Jasper J. Brugts, Ozcan Birim, Lennie M. van Osch-Gevers, Tamas Szili-Torok, Kadir Caliskan
Summary: The need for permanent pacemakers after heart transplantation is increasing, and donor age, ischemic time, and pre-transplant amiodarone use are risk factors for early pacemaker implantation. Donor age and cardiac allograft vasculopathy (CAV) are risk factors for late pacemaker implantation. Late pacemaker implantation has a negative impact on survival, possibly indicating underlying progressive cardiac disease.
Article
Cardiac & Cardiovascular Systems
Amira Assaf, Dominic A. M. J. Theuns, Rafi Sakhi, Rohit E. Bhagwandien, Tamas Szili-Torok, Sing-Chien Yap
Summary: This study evaluated the performance of the atrial fibrillation (AF) detection algorithm of BioMonitor III (BM3) in patients before and after catheter ablation of AF. The results showed that BM3 accurately detected AF burden and had a high correlation with the results obtained from Holter monitoring.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2022)
Article
Medicine, General & Internal
Vincenzo L. Malavasi, Marco Vitolo, Marco Proietti, Igor Diemberger, Laurent Fauchier, Francisco Marin, Michael Nabauer, Tatjana S. Potpara, Gheorghe-Andrei Dan, Zbigniew Kalarus, Luigi Tavazzi, Aldo Pietro Maggioni, Deirdre A. Lane, Gregory Y. H. Lip, Giuseppe Boriani
Summary: This study evaluated the outcomes of European atrial fibrillation (AF) patients with active or prior malignancy. The results showed that active malignancy was independently associated with all-cause death, MACE, and bleeding events. However, the use of oral anticoagulants was not significantly associated with higher risks of all-cause death or bleeding in patients with active malignancies.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Robbert Ramak, Felicia Lipartiti, Joerelle Mojica, Cinzia Monaco, Antonio Bisignani, Ivan Eltsov, Antonio Sorgente, Lucio Capulzini, Gaetano Paparella, Bernard Deruyter, Saverio Iacopino, Andreea Iulia Motoc, Maria Luiza Luchian, Thiago Guimaraes Osorio, Ingrid Overeinder, Gezim Bala, Alexandre Almorad, Erwin Stroker, Juan Sieira, Luc Jordaens, Pedro Brugada, Carlo de Asmundis, Gian-Battista Chierchia
Summary: This study evaluated the impact of DiamondTemp (DT) technology on ablation efficiency during atrial flutter (AFL). The results showed that the use of the DT catheter for RF ablation resulted in a significant reduction in the duration of RF applications, procedure time, and fluoroscopy time compared to the use of the 8-mm tip catheter.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Antonio Bisignani, Luigi Pannone, Vincenzo Miraglia, Juan Sieira, Saverio Iacopino, Gezim Bala, Erwin Stroker, Ingrid Overeinder, Alexandre Almorad, Anais Gauthey, Cinzia Monaco, Gaetano Paparella, Thiago Guimaraes Osorio, Antonio Sorgente, Luc Jordaens, Pedro Brugada, Gian-Battista Chierchia, Carlo de Asmundis
Summary: This study evaluated the feasibility and safety of a new cryoballoon ablation system in achieving pulmonary vein isolation (PVI) and left atrial posterior wall isolation (LAPWI). The results showed that the novel system was comparable to the established system in terms of efficacy and safety.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anna M. E. Noten, Nawin L. Ramdat Misier, Janneke A. E. Kammeraad, Sip Wijchers, Ingrid M. Van Beynum, Michiel Dalinghaus, Thomas B. Krasemann, Sing-Chien Yap, Natasja M. S. de Groot, Tamas Szili-Torok
Summary: This study compared procedural and long-term outcomes of remote magnetic navigation (RMN)-guided and manual (MAN)-guided ventricular arrhythmias (VA) ablation in children. The study found that RMN resulted in lower recurrence rates and reduced fluoroscopy exposure compared to MAN.
PEDIATRIC CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
David E. Haines, Melissa H. Kong, Peter Ruppersberg, Philip Haeusser, Boaz Avitall, Tamas Szili Torok, Atul Verma
Summary: Ablation strategies are still unclear for persistent atrial fibrillation patients who experience recurrence despite intact pulmonary vein isolation. Advanced mapping techniques that can identify extra-pulmonary vein sources of atrial fibrillation are increasingly necessary as the ability to perform durable pulmonary vein isolation improves. Electrographic flow mapping provides a novel method for mapping atrial fibrillation by reconstructing organized wavefront propagation within chaotic electrical conduction. This paper explains the technical and mathematical foundations of electrographic flow mapping and demonstrates its clinical applications.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stefan G. Spitzer, John M. Miller, Philipp Sommer, Tamas Szili-Torok, Vivek Y. Reddy, Georg Noelker, Chris Williams, Anne Sarver, David J. Wilber
Summary: The REDO-FIRM study evaluated the safety and effectiveness of conventional and FIRM-guided ablation in patients with recurrent atrial fibrillation. The study found that while FIRM-guided ablation did not provide additional efficacy, it was equally safe.
Article
Cardiac & Cardiovascular Systems
Rita B. Gagyi, Anna M. E. Noten, Krista Lesina, Bakhtawar K. Mahmoodi, Sing-Chien Yap, Mark G. Hoogendijk, Sip Wijchers, Rohit E. Bhagwandien, Tamas Szili-Torok
Summary: The novel dipole charge density-based high-resolution mapping technique (AcQMap) has been proven to have significant value in treating brief episodes of atrial tachycardia and premature atrial contractions (PACs), with high accuracy and success rates.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Review
Engineering, Biomedical
Amira Assaf, Dominic A. M. J. Theuns, Michelle Michels, Jolien Roos-Hesselink, Tamas Szili-Torok, Sing-Chien Yap
Summary: The 2018 ESC Syncope guidelines expanded the indications for an insertable cardiac monitor (ICM) to include patients with unexplained syncope and primary cardiomyopathy or inheritable arrhythmogenic disorders. This review article discusses the clinical evidence for using an ICM for risk stratification in different patient populations, including various cardiac conditions. The experts suggest that while there is limited data on the usefulness of ICMs in these populations, most studies demonstrate its early detection of clinically relevant arrhythmias. However, the impact of ICMs on prognosis is difficult to demonstrate in populations with rare diseases.
EXPERT REVIEW OF MEDICAL DEVICES
(2023)
Article
Cardiac & Cardiovascular Systems
Rita B. Gagyi, Rohit E. Bhagwandien, Sing-Chien Yap, Mark Hoogendijk, Sip Wijchers, Tamas Szili-Torok
Summary: This study compared the efficacy of electrographic flow (EGF) guided ablation with empiric ablation in the treatment of persistent atrial fibrillation. The results showed that EGF-guided ablation led to fewer AF recurrences at 12 months. Despite longer procedure times, it was safe and offered a more targeted, patient-specific ablation strategy for this complex group of patients.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wern Yew Ding, Marco Proietti, Giuseppe Boriani, Laurent Fauchier, Carina Blomstrom-Lundqvist, Francisco Marin, Tatjana S. Potpara, Gregory Y. H. Lip
Summary: The 4S-AF classification scheme, consisting of four domains, including stroke risk, symptom severity, AF burden, and substrate, improves mortality rates in AF patients through treatment decisions. Implementing this scheme is feasible and associated with a significant decrease in all-cause mortality.