Article
Cardiac & Cardiovascular Systems
Erica G. Soltero, Anna N. Solovey, Robert P. Hebbel, Elise F. Palzer, Justin R. Ryder, Gabriel Q. Shaibi, Micah Olson, Claudia K. Fox, Kyle D. Rudser, Donald R. Dengel, Nicholas G. Evanoff, Aaron S. Kelly
Summary: The study revealed that there was no difference in CEC number among different BMI categories, but youth with severe obesity had higher CEC activation levels. Higher CEC number was associated with greater body fat percentage and higher systolic blood pressure percentile, while higher degree of CEC activation was associated with greater visceral adipose tissue and non-high-density lipoprotein cholesterol.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Athanasia Tragomalou, George Paltoglou, Maria Manou, Ioannis V. Kostopoulos, Sofia Loukopoulou, Maria Binou, Ourania E. Tsitsilonis, Flora Bacopoulou, Penio Kassari, Marina Papadopoulou, George Mastorakos, Evangelia Charmandari
Summary: Obesity in adolescence is linked to cardiovascular disease. Non-traditional risk factors can be used as biomarkers to predict future CVD. Lifestyle intervention programs can improve these risk factors.
Article
Endocrinology & Metabolism
Jason Phowira, Sherin Bakhashab, Anuradha Doddaballapur, Jolanta U. Weaver
Summary: This study aimed to investigate the changes in endothelial function and circulating endothelial progenitor cells (cEPCs) and circulating angiogenic cells (CACs) counts in SCT patients, as well as the effect of T3 on proangiogenic cell (PAC) function in healthy individuals. The results showed that SCT patients had lower cEPC count and flow-mediated dilation (FMD), indicating increased cardiovascular risk. Furthermore, in vitro studies revealed that T3 increased early apoptosis and reduced endothelial nitric oxide synthase (eNOS) expression in PACs.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jieun Lee, Hal Sternberg, Paola A. Bignone, James Murai, Nafees N. Malik, Michael D. West, Dana Larocca
Summary: This study presents a panel of clonal embryonic endothelial progenitor cell lines derived from human embryonic stem cells. These cell lines exhibit characteristics of endothelial cells and show strong transcriptomic similarity to adult endothelial primary cell lines. The cells have demonstrated scalability and stable angiogenic properties, making them a potential source for therapeutic cells in cardiovascular disease treatment.
Article
Nutrition & Dietetics
Mariana Migliavacca Madalosso, Nina Nayara Ferreira Martins, Brenda Massochin Medeiros, Luana Lara Rocha, Larissa Loures Mendes, Beatriz D. Schaan, Felipe Vogt Cureau
Summary: This study evaluated the association between consumption of ultra-processed foods (UPF) and cardiometabolic risk factors in Brazilian adolescents. The findings showed that high UPF consumption was associated with high LDL-c and low HDL-c levels, but not with other cardiometabolic risk factors.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Maria-Jose Castro, Jose-Maria Jimenez, Maria Lopez, Maria-Jose Cao, Manuel Duran, Irene Albertos, Sara Garcia, Jaime Ruiz-Tovar
Summary: The study showed that the relationship between breast volume and body mass index can be used as a predictor of cardiovascular risk in premenopausal women who are overweight and mildly obese.
Article
Biochemistry & Molecular Biology
Lars Brodowski, Bianca Schroeder-Heurich, Sandra von Hardenberg, Katja Richter, Constantin S. von Kaisenberg, Oliver Dittrich-Breiholz, Nadia Meyer, Thilo Doerk, Frauke von Versen-Hoeynck
Summary: Preeclampsia is associated with increased cardiovascular morbidity in mothers and offspring, with endothelial progenitor cell (EPC) abnormalities potentially playing a role. This study found different levels of miRNAs in EPC derived from preeclampsia and healthy controls, suggesting a potential role of miRNA modifications in preeclampsia-related complications. Understanding these epigenetic mechanisms in EPC may lead to new therapeutic strategies in managing preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Xiaohong Li, Petra Haberzettl, Daniel J. Conklin, Aruni Bhatnagar, Eric C. Rouchka, Mei Zhang, Timothy E. O'Toole
Summary: Exposure to PM2.5 air pollution has been linked to quantitative deficits of circulating endothelial progenitor cells (EPCs) in humans and mice, indicating potential cardiovascular dysfunction. Transcriptomic analysis of cells isolated from exposed mice revealed PM2.5-induced changes in gene expression that may contribute to EPC dysfunction, highlighting the adverse cardiovascular outcomes of air pollution exposure.
Review
Cell Biology
Maria Cristina Vinci, Ermes Carulli, Erica Rurali, Raffaella Rinaldi, Giulia Damiano, Angela Raucci, Giulio Pompilio, Stefano Genovese
Summary: Endothelial progenitor cells (EPCs) have been the subject of extensive research and clinical expectations, but their current status and potential in regenerative medicine remain uncertain. This review explores the past and recent literature on this diverse and intriguing cell population, taking the reader on a chronological journey from their initial discovery to subsequent efforts in understanding their biology and their recent applications in cardiovascular disease and regenerative medicine.
Article
Cell Biology
Davide Medica, Rossana Franzin, Alessandra Stasi, Giuseppe Castellano, Massimiliano Migliori, Vincenzo Panichi, Federico Figliolini, Loreto Gesualdo, Giovanni Camussi, Vincenzo Cantaluppi
Summary: The study demonstrates the protective effect of EPC-derived EVs on glomerular endothelial cells and podocytes, showing reductions in apoptosis, antioxidative actions, prevention of leukocyte adhesion, and maintenance of cell function. Additionally, EVs can protect damaged glomerular cells by transferring RNA, suggesting their potential therapeutic role in drug-resistant glomerulonephritis.
Article
Biochemistry & Molecular Biology
Nadia Meyer, Lars Brodowski, Constantin von Kaisenberg, Bianca Schroeder-Heurich, Frauke Von Versen-Hoeynck
Summary: This study investigated the effects of CsA and Tac on endothelial colony-forming cells (ECFCs), finding that these immunosuppressants not only impair vascular repair and angiogenesis, but also trigger an inflammatory cascade and increase cardiovascular risk in transplant patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Nana Yang, Shiyu Sun, Guangqing Duan, Kaixuan Lv, Chen Liang, Linlin Zhang, Jielun Yu, Yaohui Tang, Guohua Lu
Summary: Depression is a major psychological disease that increases the risk of cardiovascular disease, especially acute coronary syndrome. The decrease in the number of endothelial progenitor cells is closely related to depression development. EPCs might serve as a new target for evaluating the severity of depression and its complications.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Subin Jang, Elise F. Palzer, Kyle D. Rudser, Claudia K. Fox, Robert P. Hebbel, Donald R. Dengel, Liming Milbauer, Aaron S. Kelly, Justin R. Ryder
Summary: Levels of microparticles, EMPs, and activated EMPs were positively associated with adiposity and poor subclinical CVD risk in a pediatric population.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Biochemistry & Molecular Biology
Klara Komici, Angelica Perna, Germano Guerra
Summary: Frailty is a clinical condition characterized by a decline in biological reserves, physiological mechanism failure, and vulnerability to stressors. This review focuses on the role of endothelial progenitor cells (EPCs) in frailty, highlighting their impaired function, number, and survival in the elderly. It also discusses the modification of EPCs in age-related diseases such as atherosclerosis, hypertension, and diabetes mellitus. The review concludes by exploring interventions that may restore EPCs expression and function in frail individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Miriam Peracaula, Daniela Torres, Paula Poyatos, Neus Luque, Eric Rojas, Anton Obrador, Ramon Orriols, Olga Tura-Ceide
Summary: Obstructive sleep apnea (OSA) is a respiratory condition characterized by repeated pauses in breathing during sleep due to upper airway obstruction. OSA is associated with endothelial dysfunction and an increased risk of cardiovascular diseases such as hypertension. This review explores the relationship between OSA and endothelial dysfunction, discusses the available treatments and their limitations, and provides insights into future research directions.
Article
Hematology
Stephan Binneboessel, Raphael Romano Bruno, Bernhard Wernly, Maryna Masyuk, Hans Flaatten, Jesper Fjolner, Georg Wolff, Malte Kelm, Michael Beil, Sigal Sviri, Wojciech Szczeklik, Susannah Leaver, Dylan W. De Lange, Bertrand Guidet, Christian Jung
Summary: This study investigated the impact of cytokine absorption on mortality in elderly critically ill patients with COVID-19 and renal failure admitted to intensive care units. The results showed that short-term mortality rates were higher in patients treated with cytokine absorption, but mortality was associated with disease severity rather than cytokine absorption in a multivariate analysis.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Critical Care Medicine
Christian Jung, Bertrand Guidet, Hans Flaatten
INTENSIVE CARE MEDICINE
(2023)
Article
Medical Informatics
Michael Beil, P. Vernon van Heerden, Dylan W. de Lange, Wojciech Szczeklik, Susannah Leaver, Bertrand Guidet, Hans Flaatten, Christian Jung, Sigal Sviri, Leo Joskowicz
Summary: This study used the framework of information theory to evaluate the uncertainty in decision-making about life-sustaining treatment (LST) in the intensive care unit (ICU). The results showed that information about the severity of the acute illness was the most important, while age, gender, and geriatric characteristics contributed to a lesser degree. This suggests that there is still a gap in fully understanding decision-making about LST and further research is needed.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Article
Hematology
Stephan Binneboessel, Maryna Masyuk, Kerstin Piayda, Raphael Romano Bruno, Bernhard Wernly, Peter Jirak, Georg Wolff, Norbert Gerdes, Philipp Heinrich Baldia, Malte Kelm, Fabian Nienhaus, Alexander Lang, Holger Winkels, Gerd Geerling, Rainer Guthoff, Sema Kaya, Gerald Flossmann, Thomas Riemer, Michael Baertschi, Christian Jung
Summary: This study aims to investigate the effect of weightlessness on retinal microcirculation and explore its relationship with the development of SANS.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Medicine, General & Internal
Robert Uzel, Richard Rezar, Raphael Romano Bruno, Sarah Wernly, Christian Jung, Georg Delle Karth, Christian Datz, Friedrich Hoppichler, Bernhard Wernly
Summary: Frailty was evaluated as a predictor of outcome in patients with moderate to severe secondary mitral regurgitation. The study found that frailty was associated with a higher risk of adverse outcomes and outperformed EuroSCORE2 in predicting the combined endpoint. Therefore, routine assessment of frailty should be carried out in patients with heart failure to guide clinical decision making.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Medicine, General & Internal
Richard Rezar, Behrooz Mamandipoor, Clemens Seelmaier, Christian Jung, Michael Lichtenauer, Uta C. C. Hoppe, Reinhard Kaufmann, Venet Osmani, Bernhard Wernly
Summary: Severe hyperlactatemia (>10mmol/L) or impaired lactate metabolism are associated with increased mortality. A study analyzed the maximum lactate concentration on day 1 of 10,724 septic patients and categorized them into three groups based on lactate levels. Findings showed that severe hyperlactatemia was linked to high mortality rates, especially if it persists beyond 24 hours. The results suggest that severe hyperlactatemia, along with clinical parameters, could be used to determine treatment limits.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Medicine, General & Internal
Dragos Andrei Duse, Michael Groene, Nicolas Kramser, Matthias Ortkemper, Christine Quast, Fabian Voss, Nadia Heramvand, Karel Kostev, Malte Kelm, Patrick Horn, Christian Jung, Ralf Erkens
Summary: This study analyzed the initial serum phosphate levels of 488 patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest (CA), and found that phosphate levels higher than 2.7 mmol/L were associated with higher mortality and neurological impairment. These results suggest that phosphate determination may improve the preciseness of overall and neurological prognostication in patients after cardiopulmonary resuscitation (CPR) following ROSC.
Article
Cardiac & Cardiovascular Systems
Verena Veulemans, Nihal Wilde, Hendrik Wienemann, Rik Adrichem, Thijmen W. Hokken, Baravan Al-Kassou, Jasmin Shamekhi, Victor Mauri, Oliver Maier, Christian Jung, Patrick Horn, Matti Adam, Georg Nickenig, Stephan Baldus, Nicolas M. Van Mieghem, Malte Kelm, Alexander Sedaghat, Tobias Zeus
Summary: This study evaluated the impact of different TAVI-guidewires on procedural success and outcomes during transcatheter aortic valve implantation (TAVI). The use of the Lunderquist(TM) guidewire was associated with a higher final implantation depth, but had no significant impact on outcomes such as conduction disturbances and pacemaker need within 30 days.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Infectious Diseases
Andreas Kokoefer, Behrooz Mamandipoor, Maria Flamm, Richard Rezar, Sarah Wernly, Christian Datz, Christian Jung, Venet Osmani, Bernhard Wernly, Raphael Romano Bruno
Summary: This study examined the impact of ethnic background on the management and outcome of sepsis and septic shock. The findings showed that there were no significant differences in treatment and mortality rates among different ethnic groups.
BMC INFECTIOUS DISEASES
(2023)
Article
Hematology
Lilyana Georgieva, Fabian Nienhaus, Sebastian M. Haberkorn, Ralf Erkens, Amin Polzin, Patricia Wischmann, Rojda Ipek, Kian Marjani, Aikaterini Christidi, Michael Roden, Christian Jung, Florian Boenner, Malte Kelm, Stefan Perings, Mareike Gastl
Summary: Early after ST-segment elevation myocardial infarction (STEMI), LV function analysis may be affected by initial LV reshaping and hypokinesia, as well as concomitant microvascular dysfunction. This study compared left ventricular ejection fraction (LVEF) and stroke volume (SV) using different imaging modalities in the early stages of STEMI. The results showed that 2D analysis methods of LVEF yielded consistent results using cineventriculography (CVG), 2-dimensional echocardiography (2DE), and 2D cardiovascular magnetic resonance (CMR) within 24 hours and 5 days after STEMI. SV measurements differed significantly between imaging techniques due to variations in volumetric measurements.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Infectious Diseases
Timo Mayerhoefer, Sebastian Klein, Bernhard Wernly, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjolner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Antonio Artigas, Peter Vernon van Heerden, Bernardo Bollen Pinto, Joerg C. Schefold, Rui Moreno, Maurizio Cecconi, Wojciech Szczeklik, Christian Jung, Michael Joannidis
Summary: This study investigated the impact of diabetes mellitus on 90-day mortality in a high-risk cohort of critically ill patients over 70 years of age. The study found that patients with diabetes had a significantly higher 90-day mortality rate compared to those without diabetes. This suggests that diabetes is a relevant risk factor for COVID-19 in old critically ill patients.
Letter
Critical Care Medicine
Niklas Rodemund, Bernhard Wernly, Christian Jung, Crispiana Cozowicz, Andreas Kokoefer
INTENSIVE CARE MEDICINE
(2023)
Article
Emergency Medicine
Janina Dziegielewski, Falko C. Schulte, Christian Jung, Georg Wolff, Oliver Hannappel, Philipp Kuempers, Michael Bernhard, Mark Michael
Summary: This retrospective study analyzed the epidemiology, management, and outcome of critically ill non-traumatic patients admitted to the emergency department (ED). It found that further development of structured care algorithms for these patients is needed.
BMC EMERGENCY MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Robert Uzel, Raphael R. Bruno, Christian Jung, Christian Lang, Hannes Hoi, Martin Gruenbart, Christian Datz, Friedrich Hoppichler, Bernhard Wernly
Summary: This study evaluated the impact of ACE inhibitors and angiotensin receptor blockers (ACE-I/ARB) on elderly patients with moderate-to-severe mitral regurgitation (MR) and mildly reduced to preserved ejection fraction. The results showed that patients treated with ACEI/ARB had a lower risk for the combined endpoint of death and heart failure-related readmission, even after adjustment for risk scores and frailty. Therefore, ACE-I/ARB might be a valuable therapeutic option for conservatively treated patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Letter
Critical Care Medicine
Bernhard Wernly, Hans Flaatten, Susannah Leaver, Bertrand Guidet, Christian Jung
