A 6-month follow-up after constraint-induced movement therapy with and without transfer package for patients with hemiparesis after stroke: a pilot quasi-randomized controlled trial

Objective: To investigate the long-term effects of the 'transfer package' in constraint-induced movement therapy, which is an optional protocol to facilitate actual use of the trained affected arm in activities of daily living. Design: A pilot quasi-randomized controlled trial with a blinded single assessor with six-month follow-up. Setting: Hospitalized care at university hospital. Subjects: Twenty-one post-stroke patients were quasi-randomized to either a group with transfer package during constraint-induced movement therapy or a control group (without transfer package). Interventions: The transfer package group received 4.5 hours of intensive task training and 0.5 hours of transfer package whereas the control group received 5.0 hours of intensive task training per day during 10 consecutive weekdays. Main measures: Arm function was measured with Fugl-Meyer Assessment and Amount of Use score of Motor Activity Log. Results: Twenty-three patients were quasi-randomized, but data from two patients were missing from the long-term follow-up. Both groups showed increase in arm function postintervention. However, at six months' follow-up only the transfer package group showed consistent increase in arm function (with transfer package group versus control group; Fugl-Meyer Assessment, mean ( SD) from 48.6 +/- 7.8 (preintervention) to 55.7 +/- 4.5 (postintervention) and 59.0 +/- 3.6 (six months postintervention) versus from 49.1 +/- 5.5 to 52.8 +/- 6.0 and 53.3 +/- 4.9, P= 0.003; Amount of Use scale of Motor Activity Log, mean from 1.3 +/- 0.55 (preintervention) to 2.12 +/- 0.55 (postintervention) and 2.79 +/- 0.98 (six months postintervention) versus from 1.18 +/- 0.70 to 1.61 +/- 0.54 and 1.65 +/- 0.68, P= 0.002). Conclusions: Our results confirmed the long-term effects of the transfer package in constraint-induced movement therapy.