Review
Medicine, General & Internal
Hemil Dario Rosales, Henry Garcia Guevara, Stefania Requejo, Maria Dianella Jensen, Julio Acero, Sergio Olate
Summary: This study analyzed medication-related osteonecrosis of the jaw (MRONJ) in children and young patients, and its relation with oral surgery. The study found a low presence of MRONJ in children and young patients treated with antiresorptive drugs. Data collection was weak, and details of therapy were not clear in most of the included articles.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Vanessa Costa de Sousa, Fatima Regina Nunes Sousa, Raquel Felipe Vasconcelos, Conceicao S. Martins, Amanda Pimentel Lopes, Nicholas Militao, Delane Viana, Karuza Alves, Renata Leitao, Gerly A. C. Brito, Virginia Girao, Paula Goes
Summary: Atorvastatin has a positive effect on bisphosphonate-induced osteonecrosis of the jaw in rats. It improves mucosal healing, increases viable osteocytes, reduces cell apoptosis, and decreases bone sequestration. It also modulates inflammation and improves bone vitality, metabolism, and structure.
Review
Biochemistry & Molecular Biology
Minerva Codruta Badescu, Elena Rezus, Manuela Ciocoiu, Oana Viola Badulescu, Lacramioara Ionela Butnariu, Diana Popescu, Ioana Bratoiu, Ciprian Rezus
Summary: Osteonecrosis of the jaws (ONJ) is often caused by local infection or trauma, radiotherapy, and drugs that affect the blood supply or bone turnover. However, our research highlights the significance of hereditary thrombophilia and/or hypofibrinolysis states in ONJ. We discovered that these prothrombotic abnormalities are common in patients with refractory ONJ. Moreover, acquired prothrombotic abnormalities can enhance the negative effects of hereditary abnormalities on the bone. Therefore, personalized therapeutic approaches targeting modifiable risk factors are recommended for better patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Filip Michalak, Sylwia Hnitecka, Marzena Dominiak, Kinga Grzech-Lesniak
Summary: Medications that inhibit bone resorption are commonly prescribed by orthopedists, hematologists, or oncologists, with dental professionals often overlooking their impact on oral health. While primarily affecting older individuals due to oncological issues or postmenopausal consequences, anyone can be at risk. Careful interviews and analysis of patient history and disease should always be conducted before taking any action with these medications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Siyue Mao, Jun Dong, Yiqi Wang, Chao Zhang, Annan Dong, Jingxian Shen
Summary: FDCS is a rare malignancy that can originate from lymph nodes or extranodal sites, typically presenting as solitary, well-circumscribed tumors. Extranodal lesions tend to be larger, with internal necrosis and calcifications, and are more likely to have regional lymphadenopathy and distant metastases. Hypervascularity and progressive enhancement are common features seen in the majority of tumors.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hirotaka Muraoka, Kotaro Ito, Naohisa Hirahara, Shunya Okada, Takumi Kondo, Takashi Kaneda
Summary: The study found that ADC values of bone marrow affected by MRONJ are significantly different among controls and stages 0 to 3, and ADC values may be useful for distinguishing normal from MRONJ stage 0.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Review
Medicine, General & Internal
Mario Dioguardi, Francesca Spirito, Mario Alovisi, Riccardo Aiuto, Daniele Garcovich, Vito Crincoli, Andrea Ballini, Giorgia Apollonia Caloro, Lorenzo Lo Muzio
Summary: Antiresorption drugs like bisphosphonates and monoclonal antibodies are used in the treatment of osteoporosis and other bone-related diseases. These drugs have been associated with cases of osteonecrosis of the jaws (MRONJ). Risk factors include extraction procedures in oral surgery, particularly in the mandible and maxilla. A systematic review and meta-analysis was conducted to determine if there is a greater risk of MRONJ in male or female subjects and to assess the involvement of osteonecrosis in different extraction sites. After analyzing 24 studies, the results showed a trend of higher risk in males and in the posterior mandibular sector, but further studies are needed to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Sung Hyun Yu, Yu Mi Jeong, Sheen-Woo Lee
Summary: This study aimed to explore the role of MRI findings in the diagnosis of Kummell's disease (KD), with prevertebral soft-tissue changes and intraosseous cavity being associated with KD. The combined findings of prevertebral soft-tissue changes and intraosseous cavity can aid in the diagnosis of KD.
Article
Dentistry, Oral Surgery & Medicine
Ling-Ying Wei, Sang-Heng Kok, Yen-Ching Lee, Wei-Yih Chiu, Jai-Jen Wang, Shih-Jung Cheng, Hao-Hueng Chang, Jang-Jaer Lee
Summary: This study aimed to investigate the prognosis of medication-related osteonecrosis of the jaws (MRONJ) in prostate cancer patients who received different types of antiresorptive agents for bone metastasis. The results showed that patients treated with denosumab as the antiresorptive agent, with higher pretreatment levels of CTX and without anemia, had a better treatment outcome for MRONJ.
Article
Medicine, General & Internal
Gianluca Colapinto, Funda Goker, Riccardo Nocini, Massimo Albanese, Pier Francesco Nocini, Salvatore Sembronio, Francesca Argenta, Massimo Robiony, Massimo Del Fabbro
Summary: The aim of this randomized study was to evaluate the effect of pentoxifylline and tocopherol in patients that had developed MRONJ after tooth extractions. The study showed that patients who received pharmacological treatment had better mucosal healing after 1 month and clinical and radiographic healing of the bone lesion after 6 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Dentistry, Oral Surgery & Medicine
Caterina Bensi, Francesco Giovacchini, Giuseppe Lomurno, Stefano Eramo, Giancarlo Barraco, Antonio Tullio
Summary: This systematic review aimed to describe the quality of life and oral health-related quality of life of patients affected by medication-related osteonecrosis of the jaw. Surgical treatment of the osteonecrosis was found to improve the quality of life of these patients. The study suggested a negative influence of osteonecrosis of the jaw on the quality of life and oral health-related quality of life among oncologic and osteoporotic patients.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zafeiroula Yfanti, Sotirios Tetradis, Nikolaos G. Nikitakis, Konstantina Eleni Alexiou, Nikolaos Makris, Christos Angelopoulos, Kostas Tsiklakis
Summary: The purpose of this study was to assess the CBCT scans of patients with MRONJ, ORN, OM, and JM, evaluate radiologic findings, identify parameters that distinguish these conditions, and introduce a new modified radiographic index (CRIm) to aid in diagnosis. A total of 335 CBCT scans met the inclusion criteria and were blindly assessed by two observers. The CRIm index evaluates various radiologic features and shows significant differences between different conditions. Extensive lytic changes were the most common finding, particularly in ORN. The new CRIm index appears to improve the objectivity of diagnosing these conditions.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Karim Amrane, Romain Le Pennec, Valentin Tissot, Ulrike Schick, Ronan Abgral
Summary: This case report highlights a situation where uptake of F-18-choline in a 73-year-old man with biochemical failure prostate cancer after radical prostatectomy suggested potential bone metastasis in the skull base, which was later confirmed to be a vestibular schwannoma. It emphasizes the diagnostic challenge of schwannoma in F-18-choline PET/CT and suggests the radiolabeled tracer as a promising tool for characterizing brain tumors due to its higher signal-to-background ratio compared to F-18-FDG.
CLINICAL NUCLEAR MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Mariko Nakayama, Shotaro Naganawa, Michelle Ouyang, Karra A. Jones, John Kim, Aristides A. Capizzano, Toshio Moritani
Summary: This article reviews the clinical and radiologic findings of tumefactive demyelination to aid in its identification on imaging. Integration of clinical and radiologic findings is important to differentiate tumefactive demyelinating lesions from other similar lesions on imaging. Further research on the immunopathogenesis of tumefactive demyelination and associated conditions will clarify their relationship.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
