Article
Medicine, General & Internal
Goksel Guz, Serdar Demirgan
Summary: This study aimed to investigate the effect of endothelial dysfunction assessed using flow-mediated dilatation (FMD) on the prognosis and mortality rate of Covid-19 patients. The results showed that FMD% values were significantly lower in Covid-19 ICU patients compared to those in patients followed up in the ward, as well as in patients who died compared to those who were discharged alive. There were moderate negative correlations between FMD% and peak values of D-dimer, troponin, ferritin, lactate dehydrogenase, and white blood cell count. Lower FMD% was associated with higher lung involvement. The optimal cutoff point for predicting mortality using FMD was found to be 3.135%.
Article
Multidisciplinary Sciences
Joao Luis Maroco, Marco Pinto, Helena Santa-Clara, Bo Fernhall, Xavier Melo
Summary: This study aimed to evaluate the repeatability of FMS and FMD methods in measuring brachial artery endothelial function. The results showed that FMS had poor repeatability, while FMD demonstrated moderate-to-good repeatability, with scaling FMD improving its repeatability.
Article
Clinical Neurology
Seong-Joon Lee, Jin Soo Lee, Min Kim, So Young Park, Ji Hyun Park, Bumhee Park, Woo Sang Jung, Jin Wook Choi, Ji Man Hong
Summary: This study investigated the effects of endothelial function and arterial stiffness on CCAD using FMD and PWV measurements. The results showed that preserved endothelial function was associated with spontaneous arterial healing, while higher arterial stiffness was associated with ischemic presentation.
FRONTIERS IN NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Joao Luis Maroco, Tiago Silvestre, Ines Arrais, Marco Pinto, Helena Santa-Clara, Bo Fernhall, Xavier Melo
Summary: Flow-mediated slowing (FMS) is a non-invasive measure of endothelial function measured through reactive hyperemia-induced changes in pulse wave velocity (PWV). Inter- and intra-rater repeatability of ultrasound-based changes in local PWV (FMS) and diameter (FMD) were assessed. The results showed that both FMS and FMD exhibited good inter-rater repeatability, while the intra-rater repeatability of FMD was better than FMS. Ultrasound-based local measurements of PWV deceleration reactive hyperemia were found to be repeatable among the raters.
Article
Biology
Cedric H. G. Neutel, Anne-Sophie Weyns, Arthur Leloup, Sofie De Moudt, Pieter-Jan Guns, Paul Fransen
Summary: This study investigated the effects of physical activity on cardiovascular function in mice and found that vascular smooth muscle cells in the aorta have the ability to de-stiffen or relax after periods of high cyclic stretch. These findings have implications for the therapeutic potential of physical activity in cardiovascular disease.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mandi Luo, Dan Yan, Xiaolu Liang, Yi Huang, Pengcheng Luo, Zhen Yang, Yucong Zhang, Ting Xu, Shangbang Gao, Le Zhang, Yiwu Zhou, Qing Shi, Cuntai Zhang, Lei Ruan
Summary: Arterial stiffness is the basis for cardiovascular diseases and its early detection and intervention are crucial for improving global burden of CVD. In this study, the researchers used quantitative proteomics to analyze plasma samples and found that fibulin-1 was significantly upregulated in individuals with high arterial stiffness, and it was positively correlated with arterial stiffness.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Health Care Sciences & Services
Hyun-Bae Kim, Myong-Won Seo, Hyun Chul Jung
Summary: This study investigated the effects of different types of exercise on vascular function and vascular endothelial growth factor in older women. The results showed that aerobic exercise had greater benefits for vascular function, while resistance exercise increased vascular endothelial growth factor.
Article
Medicine, General & Internal
Charlotte Loessner, Anna Multhaup, Thomas Lehmann, Ekkehard Schleussner, Tanja Groten
Summary: The evaluation of endothelial function during pregnancy is becoming increasingly important, as impaired adaptation in early pregnancy is associated with an increased risk of preeclampsia and fetal growth restriction. To standardize risk assessment and incorporate vascular function evaluation into routine pregnancy care, a suitable, accurate, and easy-to-use method is needed. Flow-mediated dilatation (FMD) of the brachial artery assessed by ultrasound is considered the gold standard for measuring vascular endothelial function. However, the challenges of FMD measurement have hindered its introduction into clinical practice. The VICORDER(R) device allows for automated determination of flow-mediated slowing (FMS), but its equivalence to FMD has not been proven in pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Peripheral Vascular Disease
Tshegofatso H. Motau, Gavin R. Norton, Keneilwe N. Mmopi, Hamza Bello, Vernice R. Peterson, Carlos Libhaber, Eitzaz Sadiq, Ravi Naran, Daniel Da Silva Fernandes, Mohlabani Masiu, Nonhlanhla Mthembu, Monica Gomes, Taalib Monareng, Talib Abdool-Carrim, Martin Veller, Ismail Cassimjee, Ferande Peters, Girish Modi, Pinhas Sareli, Angela J. Woodiwiss
Summary: The impact of aortic stiffness on arterial damage is influenced by both central arterial pulsatile load (proximal aortic Zc and hence P-QxZc) and full aortic length indexed by PWV. Additionally, neither PWV nor brachial PP may fully account for all damage mediated by increases in aortic stiffness.
JOURNAL OF HYPERTENSION
(2021)
Article
Health Care Sciences & Services
Kyi Mar Wai, Sawada Kaori, Ken Itoh, Okuyama Shinya, Yuka Uchikawa, Sakura Hayashi, Akiko Shiraki, Koichi Murashita, Shigeyuki Nakaji, Kazushige Ihara
Summary: Telomere length is inversely associated with arterial stiffness as reflected by baPWV, suggesting that shorter telomeres may increase the risk of developing cardiovascular diseases. Individuals with longer telomeres may have a lower risk of arterial stiffness and related cardiovascular risks.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Marianne Riou, Walid Oulehri, Cedric Momas, Olivier Rouyer, Fabienne Lebourg, Alain Meyer, Irina Enache, Cristina Pistea, Anne Charloux, Christophe Marcot, Frederic de Blay, Olivier Collange, Michel Mertes, Emmanuel Andres, Samy Talha, Bernard Geny
Summary: The coronavirus disease 2019 (COVID-19) pandemic has caused over two million deaths worldwide, with evidence suggesting vascular endothelial dysfunction plays a critical role. However, impaired brachial artery flow-mediated dilatation (FMD) in COVID-19 patients three months after infection does not appear to be associated with disease severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jun Fan, Shirley Wang, Kai Chen, Zhongjie Sun
Summary: This study found that aging and arterial stiffness can be caused by Klotho deficiency leading to immune dysfunction and decreased arterial elasticity. AAV-SKL can alleviate arterial stiffness in aging mice by restoring B-cell populations and serum IgG levels.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Physiology
Fabian Tomschi, Hannah Ottmann, Wilhelm Bloch, Marijke Grau, Hans-Georg Predel
Summary: The study found no difference between athletes and controls in any parameter measured. Women exhibited lower brachial and central BP as well as AS values compared to men. Pulse wave velocity was positively correlated with age. Evaluation based on different sport categories showed that endurance athletes had lower BP and PWV compared to other athletes.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zheng-Wei Chen, Chien-Ting Pan, Cheng-Hsuan Tsai, Yi-Yao Chang, Chin-Chen Chang, Bo-Ching Lee, Yu-Wei Chiu, Wei-Chieh Huang, Yu-Li Lin, Vin-Cent Wu, Chi-Sheng Hung, Che-Wei Liao, Yen-Hung Lin
Summary: In this study involving 1006 PA patients and 983 EH patients, it was found that haPWV is more sensitive than baPWV in detecting aldosterone-induced arterial stiffness. Results indicated that PA patients had significantly higher baPWV compared to EH patients.
Article
Pharmacology & Pharmacy
Ping Wang, Guihua Liao, Xi Wu, Rentao Yu, Jun Ma
Summary: Brachial-ankle pulse wave velocity (baPWV) is a clinical indicator of aortic stiffness and a risk predictor of cardiovascular disease. In this study, we examined the correlation of baPWV with body fat-related indicators and assessed whether baPWV can predict these indicators.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2023)
Article
Urology & Nephrology
Didier Collard, Peter M. van Brussel, Lennart van de Velde, Gilbert W. M. Wijntjens, Berend E. Westerhof, John M. Karemaker, Jan J. Piek, Jim A. Reekers, Liffert Vogt, Robbert J. de Winter, Bert-Jan H. van den Born
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Neurosciences
John M. Karemaker
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Cardiac & Cardiovascular Systems
Hein J. Verberne, Marieke T. Blom, Abdenasser Bardai, John M. Karemaker, Hanno L. Tan
Summary: A recently discovered sudden cardiac arrest (SCA) syndrome is associated with a high-risk haplotype containing the DPP6 gene. This study found that carriers of the risk haplotype have functional changes in both the heart and autonomic nervous system, which may contribute to ventricular fibrillation (VF). These findings suggest that the primary abnormalities in SCA syndrome may reside in both the heart and the autonomic nervous system.
Letter
Critical Care Medicine
Harm J. Scholten, Michael I. Meesters, Leon J. Montenij, Erik H. M. Korsten, R. Arthur Bouwman
INTENSIVE CARE MEDICINE
(2022)
Article
Acoustics
Fredericus H. J. Van Loon, Harm J. Scholten, Hendrikus H. M. Korsten, Angelique T. M. Dierick-van Daele, Arthur R. A. Bouwman
Summary: Competency in US-guided peripheral intravenous cannulation can be gained through experience and a fixed educational curriculum. The study found that with increased number of procedures performed, the success rate of first attempt cannulation also increased.
MEDICAL ULTRASONOGRAPHY
(2022)
Article
Gastroenterology & Hepatology
Stijn H. J. Ketelaers, Lieke Dhondt, Nikki van Ham, Ansgar S. Harms, Harm J. Scholten, Grard A. P. Nieuwenhuijzen, Harm J. T. Rutten, Jacobus W. A. Burger, Johanne G. Bloemen, F. Jeroen Vogelaar
Summary: This study evaluated the outcomes of continuous wound infusion (CWI) after colorectal cancer surgery within an enhanced recovery protocol. The results showed that CWI could reduce the consumption of opioids after surgery, while maintaining adequate pain control and enhanced recovery, which is particularly valuable for older patients.
COLORECTAL DISEASE
(2022)
Article
Critical Care Medicine
Massimiliano Greco, Thomas De Corte, Ari Ercole, Massimo Antonelli, Elie Azoulay, Giuseppe Citerio, Andy Conway Morris, Gennaro De Pascale, Frantisek Duska, Paul Elbers, Sharon Einav, Lui Forni, Laura Galarza, Armand R. J. Girbes, Giacomo Grasselli, Vitaly Gusarov, Alasdair Jubb, Jozef Kesecioglu, Andrea Lavinio, Maria Cruz Martin Delgado, Johannes Mellinghoff, Sheila Nainan Myatra, Marlies Ostermann, Mariangela Pellegrini, Pedro Povoa, Stefan J. Schaller, Jean-Louis Teboul, Adrian Wong, Jan J. De Waele, Maurizio Cecconi, Esicm UNITE-COVID Investigators
Summary: This study describes the global burden of COVID-19 admissions and factors associated with outcomes in critically ill patients. ICUs responded to the increase in patients by increasing capacity and admitting up to 40% of patients in surge capacity beds. Older age, invasive mechanical ventilation, and acute kidney injury were identified as the strongest predictors of mortality.
INTENSIVE CARE MEDICINE
(2022)
Article
Anesthesiology
Harm J. Scholten, Yomi Hoever, Fredericus H. J. van Loon, Elke Kanters, Tamara Hoveling, Marco de Wild, R. Arthur Bouwman, Erik H. M. Korsten
Summary: The study aimed to investigate the impact of the beam width artefact on the performance of ultrasound-guided needle-based procedures and provide a solution. The results showed that using an acoustic lens significantly improved the first pass success rate and reduced the number of punctures needed. Both experienced and inexperienced users benefited from the acoustic lens.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Psychology, Biological
John M. Karemaker
Summary: This paper reviews the various functions of the vagus nerve and explores their interactions in daily life, as well as the potential therapeutic applications of electrical stimulation. The study focuses on the physiological mechanisms behind heart rate variability and discusses the role of the vagus nerve in limiting inflammation. It also highlights the challenges in using whole vagus nerve stimulation due to the lack of specificity.
BIOLOGICAL PSYCHOLOGY
(2022)
Letter
Anesthesiology
Harm J. Scholten, Yomi Hoever, Elke Kanters, Tamara Hoveling, Marco De Wild, Erik H. M. Korsten, R. Arthur Bouwman
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Anesthesiology
Javier Ripolles-Melchor, Ane Abad-Motos, Maurizio Cecconi, Rupert Pearse, Samir Jaber, Karem Slim, Nader Francis, Antonino Spinelli, Jean Joris, Orestis Ioannidis, Eirini Zarzava, Nuzhet Mert Senturk, Seppe Koopman, Nicolai Goettel, Ottokar Stundner, Tomas Vymazal, Petr Kocian, Alaa El-Hussuna, Michal Pedziwiatr, Jurate Gudaityte, Tadas Latkauskas, Marisa D. Santos, Humberto Machado, Roman Zahorec, Ana Cvetkovic, Mirjana Miric, Maria Georgiou, Yolanda Diez-Remesal, Ib Jammer, Gabriel E. Mena, Andres Zorrilla-Vaca, Marco Marino, Alejandro Suarez-de-la-Rica, Jose A. Garcia-Erce, Margarita Logrono-Ejea, Carlos Ferrando-Ortola, Maria L. De-Fuenmayor-Valera, Bakarne Ugarte-Sierra, Jose De Andres-Ibanez, Alfredo Abad-Gurumeta, Gianluca Pellino, Manuel A. Gomez-Rios, Gilberto Poggioli, Albert Menzo-Wolthuis, Berta Castellano-Paulis, Patricia Galan-Menendez, Cesar Aldecoa, Jose M. Ramirez-Rodriguez
Summary: Treatment in a self-declared ERAS center does not improve outcomes after colorectal surgery, but increased adherence to the ERAS pathway is associated with a significant reduction in postoperative complications, shorter hospital stay, and lower 30-day mortality.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Computer Science, Interdisciplinary Applications
D. Collard, B. E. Westerhof, J. M. Karemaker, W. J. Stok, P. G. Postema, C. T. P. Krediet, L. Vogt, B. J. H. van den Born
Summary: Sympathovagal balance is crucial in hypertension and mortality. We investigated the automated analysis of xBRS and HRV in the HELIUS study and found their relationship with clinical factors. We determined the minimum required recording duration for xBRS, SDNN, and RMSDD. Linear decreases in xBRS, SDNN, and RMSDD were observed until age 50. A significant interaction between xBRS and sex was found, with greater decrease in women. Nonlinear relationships with BP, waist-to-hip ratio, and BMI were observed. Further studies are needed for predictive value assessment.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Medicine, Research & Experimental
Siebe G. Blok, Amne Mousa, Michelle G. Brouwer, Harm-Jan de Grooth, Ary Serpa Neto, Michiel J. Blans, Sylvia den Boer, Tom Dormans, Henrik Endeman, Timo Roeleveld, Harm Scholten, Eline R. van Slobbe-Bijlsma, Erik Scholten, Hugo Touw, Fleur Stefanie L. I. M. van der Ven, Evert-Jan Wils, David J. van Westerloo, Leo M. A. Heunks, Marcus J. Schultz, Frederique Paulus, Pieter R. Tuinman
Summary: This study aims to investigate the effectiveness of lung ultrasound-guided fluid deresuscitation in critically ill patients. The trial will take place in 10 ICUs in the Netherlands and enroll 1000 patients expected to undergo invasive ventilation for more than 24 hours. The study will compare the outcomes between LUS-guided deresuscitation and routine care, with the primary endpoints being the number of ventilator-free days and being alive at day 28.
Article
Oncology
Stefi Nordkamp, Davy M. J. Creemers, Sofie Glazemakers, Stijn H. J. Ketelaers, Harm J. Scholten, Silvie van de Calseijde, Grard A. P. Nieuwenhuijzen, Jip L. Tolenaar, Hendi W. Crezee, Harm J. T. Rutten, Jacobus W. A. Burger, Johanne G. Bloemen
Summary: The study aimed to evaluate the implementation of a tailored ERAS protocol for patients with LARC or LRRC, and the results demonstrated that the protocol was feasible and effective, with high compliance rate and reduced complications.
Article
Critical Care Medicine
Andrew Conway Morris, Katharina Kohler, Thomas De Corte, Ari Ercole, Harm-Jan De Grooth, Paul W. G. Elbers, Pedro Povoa, Rui Morais, Despoina Koulenti, Sameer Jog, Nathan Nielsen, Alasdair Jubb, Maurizio Cecconi, Jan De Waele
Summary: This study explored the patterns of co-infection and intensive care unit-acquired infections (ICU-AI) in critically ill COVID-19 patients, and found that ICU-AI was significantly associated with corticosteroid use; bacterial co-infection at admission was relatively rare, but antibiotic use was substantially beyond indication.