Connecting the Dots: Applications of Network Medicine in Pharmacology and Disease

Analysis of a gene co-expression network establishes robust association between Col5a2 and ischemic heart disease

(2013) Francisco Azuaje et al.   BMC Medical Genomics

Cliques for the identification of gene signatures for colorectal cancer across population

(2013) Meeta P Pradhan et al.   BMC Systems Biology

Structural Systems Pharmacology: The Role of 3D Structures in Next-Generation Drug Development

(2013) Miquel Duran-Frigola et al.   CHEMISTRY & BIOLOGY

Integration of clinical data with a genome-scale metabolic model of the human adipocyte

(2013) A. Mardinoglu et al.   Molecular Systems Biology

Subpathway-GM: identification of metabolic subpathways via joint power of interesting genes and metabolites and their topologies within pathways

(2013) Chunquan Li et al.   NUCLEIC ACIDS RESEARCH

A Semi-Supervised Method for Drug-Target Interaction Prediction with Consistency in Networks

(2013) Hailin Chen et al.   PLoS One

Drug Target Prediction and Repositioning Using an Integrated Network-Based Approach

(2013) Dorothea Emig et al.   PLoS One

Pharmacointeraction Network Models Predict Unknown Drug-Drug Interactions

(2013) Aurel Cami et al.   PLoS One

On the exoneration of Dr. William H. Stewart: debunking an urban legend

(2013) Brad Spellberg et al.   Infectious Diseases of Poverty

Exploring the human diseasome: the human disease network

(2012) K.-I. Goh et al.   Briefings in Functional Genomics

Biological function through network topology: a survey of the human diseasome

(2012) V. Janjic et al.   Briefings in Functional Genomics

Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes

(2012) Rui Chen et al.   CELL

Heart Disease and Stroke Statistics—2013 Update

(2012) Alan S. Go et al.   CIRCULATION

Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins

(2012) Orit Rozenblatt-Rosen et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

A gene ontology inferred from molecular networks

(2012) Janusz Dutkowski et al.   NATURE BIOTECHNOLOGY

Identifying protein interaction subnetworks by a bagging Markov random field-based method

(2012) Li Chen et al.   NUCLEIC ACIDS RESEARCH

Update on activities at the Universal Protein Resource (UniProt) in 2013

(2012)   NUCLEIC ACIDS RESEARCH

Predicting adverse drug reaction profiles by integrating protein interaction networks with drug structures

(2012) Liang-Chin Huang et al.   PROTEOMICS

Unique topology of language processing brain network: A systems-level biomarker of schizophrenia

(2012) Xiaobo Li et al.   SCHIZOPHRENIA RESEARCH

Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia

(2012) Peilin Jia et al.   PLoS Computational Biology

Google Goes Cancer: Improving Outcome Prediction for Cancer Patients by Network-Based Ranking of Marker Genes

(2012) Christof Winter et al.   PLoS Computational Biology

Viral Perturbations of Host Networks Reflect Disease Etiology

(2012) Natali Gulbahce et al.   PLoS Computational Biology

Highly interconnected genes in disease-specific networks are enriched for disease-associated polymorphisms

(2012) Fredrik Barrenäs et al.   GENOME BIOLOGY

Novel Computational Approaches to Polypharmacology as a Means to Define Responses to Individual Drugs

(2011) Lei Xie et al.   Annual Review of Pharmacology and Toxicology

When the human viral infectome and diseasome networks collide: towards a systems biology platform for the aetiology of human diseases

(2011) Vincent Navratil et al.   BMC Systems Biology

Mutual exclusivity analysis identifies oncogenic network modules

(2011) G. Ciriello et al.   GENOME RESEARCH

A novel signal detection algorithm for identifying hidden drug-drug interactions in adverse event reports

(2011) Nicholas P Tatonetti et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Assessing the Biological Significance of Gene Expression Signatures and Co-Expression Modules by Studying Their Network Properties

(2011) Pablo Minguez et al.   PLoS One

Predicting Adverse Drug Events Using Pharmacological Network Models

(2011) A. Cami et al.   Science Translational Medicine

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

(2011) R. Huang et al.   Science Translational Medicine

Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome

(2011) David Venet et al.   PLoS Computational Biology

Systems Pharmacology

(2010) Aislyn D. W. Boran et al.   MOUNT SINAI JOURNAL OF MEDICINE

What is flux balance analysis?

(2010) Jeffrey D Orth et al.   NATURE BIOTECHNOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

The economic impact of obesity in the United States

(2010) Ross Hammond et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Mining protein networks for synthetic genetic interactions

(2008) Sri R Paladugu et al.   BMC BIOINFORMATICS

From Human Genetics and Genomics to Pharmacogenetics and Pharmacogenomics: Past Lessons, Future Directions

(2008) Daniel W. Nebert et al.   DRUG METABOLISM REVIEWS

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology