Article
Chemistry, Medicinal
Pureum Kang, Chang-Keun Cho, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee, Chang-Ik Choi, Jung-Woo Bae
Summary: The study investigated the effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of gliclazide. The results showed that CYP2C9 and CYP2C19 genetic polymorphisms significantly affected the pharmacokinetics of gliclazide. However, the effects on plasma glucose and insulin responses were not significant, suggesting further research is needed.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Chang-Keun Cho, Ji-Young Byeon, Pureum Kang, Hye-Jung Park, Eunvin Ko, Chou Yen Mu, Choon-Gon Jang, Seok-Yong Lee, Yun Jeong Lee
Summary: Tolperisone hydrochloride is a centrally-acting muscle relaxant that is used to relieve spasticities and muscle spasms. The pharmacokinetics of tolperisone are significantly affected by the genetic polymorphism of CYP2C19, resulting in higher plasma concentration and lower clearance values in individuals with the CYP2C19PM genotype.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Gonjin Song, Jee-Eun Chung, Jeong Yee, Kyung-Eun Lee, Kyungsoo Park, Hye-Sun Gwak
Summary: The study found that plasma exposure to valsartan is significantly decreased in carriers of SLCO1B1*1B and the rs4149153 T allele of SLCO1B3, possibly due to increased hepatic uptake.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nutrition & Dietetics
Monia Cecati, Arianna Vignini, Francesca Borroni, Sofia Pugnaloni, Sonila Alia, Jacopo Sabbatinelli, Giulia Nicolai, Marina Taus, Andrea Santarelli, Mara Fabri, Laura Mazzanti, Monica Emanuelli
Summary: This study confirmed that genetic variations may account for inter-individual taste perception differences. Individuals carrying specific SNPs were less sensitive to sweet taste recognition, and overall taste recognition was influenced by age and BMI.
Article
Pharmacology & Pharmacy
Robert Hoerr, Andrea Zimmermann, Friedeborg Seitz, Angelika Dienel
Summary: The study confirmed that both single and repeated doses of EGb 761 (R) do not impact the plasma concentrations of rivaroxaban or anti-Factor Xa activity in healthy subjects, and the treatments are safe and well-tolerated.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Haojing Song, Wanjun Bai, Xue Sun, Bo Qiu, Nini Guo, Caihui Guo, Yiting Hu, Zhanjun Dong
Summary: This study aimed to evaluate the impact of genetic polymorphisms on the pharmacokinetics of lenvatinib in the Chinese population. The results showed that ABCB1 3435 C>T and ABCB1 2677 G>T/A polymorphisms were associated with the pharmacokinetic variability of lenvatinib in Chinese individuals.
Article
Pharmacology & Pharmacy
Shanshan Nie, Kaifeng Chen, Chengxian Guo, Qi Pei, Chan Zou, Liangyuan Yao, Hongbo Yuan, Xia Zhao, Ran Xie, Xu He, Jie Huang, Guoping Yang
Summary: This study reveals the impact of CYP4F2 rs2074900 SNP on ticagrelor pharmacokinetics (PK) and provides new insights into the pharmacogenetics of ticagrelor.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Yaxin Fan, Yi Li, Yuancheng Chen, Jicheng Yu, Xiaofen Liu, Wanzhen Li, Beining Guo, Xin Li, Jingjing Wang, Hailan Wu, Yu Wang, Jiali Hu, Yan Guo, Fupin Hu, Xiaoyong Xu, Guoying Cao, Jufang Wu, Yingyuan Zhang, Jing Zhang, Xiaojie Wu
Summary: This study evaluated the pharmacokinetic/pharmacodynamic profiles and safety of CMS in Chinese subjects following a recommended dosage. The results showed that CMS may be effective against most carbapenem-resistant organisms, but inadequate for some carbapenem-resistant Acinetobacter baumannii.
Article
Pharmacology & Pharmacy
Lucy H. Her, Xinwen Wang, Jian Shi, Hee Jae Choi, Sun Min Jung, Logan S. Smith, Audrey H. Wu, Barry E. Bleske, Hao-Jie Zhu
Summary: The CES1 loss-of-function G143E variant significantly impaired enalapril activation and its systolic blood pressure-lowering effect in healthy volunteers, as demonstrated in a prospective multi-dose PK/PD study.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lei Gao, Qingmei Li, Hong Zhang, Min Wu, Min Fang, Lizhi Yang, Xiaojiao Li, Jingrui Liu, Cuiyun Li, Hong Chen, Xiaoxue Zhu, Yanhua Ding, Mingwei Zhou
Summary: The study confirmed pharmacokinetic biosimilarity between QX001S and ustekinumab, with high variability between subjects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Qi Pan, Xiaoxia Wang, Wenjia Li, Xiaofeng Chen, Yulei Zhuang, Qinghong Zhou, Yuhui Huang, Yijie Zhou, Li Lan, Zhijie Wang, Wenjia Wang, Juan Hong, Wei-Hua Hao, Yu-Tsai Yang, Lixin Guo
Summary: This study aimed to verify whether the oral insulin N11005 is used as a prandial insulin by comparing its pharmacokinetics (PK), pharmacodynamics (PD), and safety profiles with a short-acting biosynthetic human insulin (Novolin R). A total of 12 healthy Chinese male subjects were enrolled in the study, and the results showed that N11005 has similar PD characteristics to prandial insulins, with a faster onset of action and comparable duration of action to the reference insulin. The study also demonstrated the safety and tolerability of N11005.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Infectious Diseases
Yingying Hu, Qiong Wei, Xingchen Bian, Xinyi Yang, Jicheng Yu, Jingjing Wang, Haijing Yang, Guoying Cao, Xiaojie Wu, Jing Zhang
Summary: This study investigated the pharmacokinetics and safety of oral and intravenous lefamulin in healthy Chinese subjects, and evaluated the efficacy of the intravenous administration regimen. The results showed that lefamulin exhibited extensive distribution, and the PK parameters were consistent between oral and intravenous administration. The regimen was found to be microbiologically effective and well-tolerated.
Article
Chemistry, Medicinal
Wanjun Bai, Haojing Song, Yiting Hu, Xueyuan Zhang, Xiaoru Wang, Caihui Guo, Bo Qiu, Zhanjun Dong
Summary: This study compared the pharmacokinetics and safety of generic and original vortioxetine hydrobromide tablets under fasting and fed conditions. The results showed that the pharmacokinetic parameters of the test drug were similar to those of the reference drug, indicating bioequivalence. Both formulations were safe and well-tolerated in healthy Chinese subjects.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Health Care Sciences & Services
Maria C. Ovejero-Benito, Dolores Ochoa, Teresa Enrique-Benedito, Miriam del Peso-Casado, Pablo Zubiaur, Marcos Navares, Manuel Roman, Francisco Abad-Santos
Summary: This study aimed to identify SNPs associated with the pharmacokinetics, pharmacodynamics, and safety of donepezil and memantine. Through genotyping and statistical analysis, no significant association was found between these SNPs and the pharmacokinetics or ADRs of the drugs. Therefore, current evidence does not support the inclusion of donepezil and memantine in pharmacogenetic guidelines.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Rui Chen, Xiaoduo Guan, Pei Hu, Yanli Dong, Yi Zhu, Tengfei Zhang, Jianjun Zou, Shuyang Zhang
Summary: This study assessed the safety, pharmacokinetics, and pharmacodynamics of SHR2285, a novel FXIa inhibitor, in healthy subjects. The results demonstrated favorable safety, PK, and PD profiles of SHR2285 in the dose range of 50 mg-400 mg, supporting further development of the drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Edgar Schuck, Tonika Bohnert, Arijit Chakravarty, Valeriu Damian-Iordache, Christopher Gibson, Cheng-Pang Hsu, Tycho Heimbach, Anu Shilpa Krishnatry, Bianca M. Liederer, Jing Lin, Tristan Maurer, Jerome T. Mettetal, Daniel R. Mudra, Marjoleen J. M. A. Nijsen, Joseph Raybon, Patricia Schroeder, Virna Schuck, Satyendra Suryawanshi, Yaming Su, Patrick Trapa, Alice Tsai, Majid Vakilynejad, Shining Wang, Harvey Wong
Review
Pharmacology & Pharmacy
H. M. Jones, Y. Chen, C. Gibson, T. Heimbach, N. Parrott, S. A. Peters, J. Snoeys, V. V. Upreti, M. Zheng, S. D. Hall
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2015)
Review
Chemistry, Medicinal
Tjerk Bueters, Christopher Gibson, Sandra A. Visser
FUTURE MEDICINAL CHEMISTRY
(2015)
Article
Chemistry, Medicinal
Zhijian Zhao, Scott T. Harrison, Jeffrey W. Schubert, John M. Sanders, Stacey Polsky-Fisher, Nanyan Rena Zhang, Debra McLoughlin, Christopher R. Gibson, Ronald G. Robinson, Nancy A. Sachs, Monika Kandebo, Lihang Yao, Sean M. Smith, Pete H. Hutson, Scott E. Wolkenberg, James C. Barrow
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2016)
Article
Pharmacology & Pharmacy
S. Aubrey Stoch, Jeanine Ballard, Christopher Gibson, Filippos Kesisoglou, Rose Witter, Kelem Kassahun, Stefan Zajic, Anish Mehta, Christine Brandquist, Cynthia Dempsey, Daria Stypinski, Marc L. Reitman
JOURNAL OF CLINICAL PHARMACOLOGY
(2017)
Article
Chemistry, Medicinal
Douglas C. Beshore, Christina N. Di Marco, Ronald K. Chang, Thomas J. Greshock, Lei Ma, Marion Wittmann, Matthew A. Seager, Kenneth A. Koeplinger, Charles D. Thompson, Joy Fuerst, George D. Hartman, Mark T. Bilodeau, William J. Ray, Scott D. Kuduk
ACS MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Pharmacology & Pharmacy
H. J. Einolfl, L. Chen, O. A. Fahmi, C. R. Gibson, R. S. Obach, M. Shebley, J. Silva, M. W. Sinz, J. D. Unadkat, L. Zhang, P. Zhao
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2014)
Article
Pharmacology & Pharmacy
Yuki Matsumoto, Tamara Cabalu, Punam Sandhu, Georgy Hartmann, Takashi Iwasa, Hiroyuki Yoshitsugu, Christopher Gibson, Naoto Uemura
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Pharmacology & Pharmacy
Eugene E. Marcantonio, Jeanine Ballard, Christopher R. Gibson, Kelem Kassahun, Jairam Palamanda, Cuyue Tang, Raymond Evers, Chengcheng Liu, Stefan Zajic, Chantal Mahon, Kate Mostoller, David Hreniuk, Anish Mehta, Denise Morris, John A. Wagner, S. Aubrey Stoch
JOURNAL OF CLINICAL PHARMACOLOGY
(2014)
Article
Medicine, Research & Experimental
Yan Xu, Mei Ou, Ed Keough, Jeff Roberts, Ken Koeplinger, Mike Lyman, Scott Fauty, Ed Carlini, Melissa Stern, Rena Zhang, Suzie Yeh, Elizabeth Mahan, Yi Wang, Don Slaughter, Marian Gindy, Conrad Raab, Charles Thompson, Jerome Hochman
MOLECULAR PHARMACEUTICS
(2014)
Article
Chemistry, Multidisciplinary
Rob S. Burke, Inthirai Somasuntharam, Paul Rearden, Duncan Brown, Sujal V. Deshmukh, Martha A. DiPietro, Jillian DiMuzio, Roy Eisenhandler, Scott E. Fauty, Christopher Gibson, Marian E. Gindy, Kelly A. Hamilton, Ian Knemeyer, Kenneth A. Koeplinger, Hae Won Kwon, Traci Q. Lifsted, Karsten Menzel, Mihir Patel, Nicole Pudvah, Deanne Jackson Rudd, Jessica Seitzer, Walter R. Strapps, Thomayant Prueksaritanont, Charles D. Thompson, Jerome H. Hochman, Brian A. Carr
PHARMACEUTICAL RESEARCH
(2014)
Article
Chemistry, Multidisciplinary
Jeanine E. Ballard, Parul Pall, Joshua Vardigan, Fuqiang Zhao, Marie A. Holahan, Richard Kraus, Yuxing Li, Darrell Henze, Andrea Houghton, Christopher S. Burgey, Christopher Gibson
PHARMACEUTICAL RESEARCH
(2020)
Article
Pharmacology & Pharmacy
Christopher R. Gibson, Alexa Gleason, Eric Messina
Summary: This study measured total liver blood flow in laboratory rats using ultrasound imaging, finding that liver blood flow increased with body weight and female rats generally had lower body weight and total liver blood flow. There were no significant differences in total liver blood flow between different strains, sexes, and body weights of rats.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Review
Pharmacology & Pharmacy
Harvey Wong, Tonika Bohnert, Valeriu Damian-Lordache, Christopher Gibson, Cheng-Pang Hsu, Anu Shilpa Krishnatry, Bianca M. Liederer, Jing Lin, Qiang Lu, Jerome T. Mettetal, Daniel R. Mudra, Marjoleen J. M. A. Nijsen, Patricia Schroeder, Edgar Schuck, Satyendra Suryawanshi, Patrick Trapa, Alice Tsai, Haiqing Wang, Fan Wus
DRUG DISCOVERY TODAY
(2017)