Article
Plant Sciences
Yajuan Bi, Xue Wang, Hui Ding, Feng He, Lifeng Han, Youcai Zhang
Summary: This review article summarizes recent progress in the research of natural product-drug interactions (NDIs), focusing on the main drug transporters and their interactions with natural products. The challenges and strategies of studying NDIs are also discussed.
Review
Biochemistry & Molecular Biology
Kexin Lin, Xiaorui Kong, Xufeng Tao, Xiaohan Zhai, Linlin Lv, Deshi Dong, Shilei Yang, Yanna Zhu
Summary: This article reviews the traditional research methods of renal transporter-mediated drug-drug interactions (DDIs) and updates the recent progress in the development of methods. Through the sorting work conducted in this paper, it will be convenient for researchers at different learning stages to choose the best method for their own research based on their own subject's situation when they are going to study DDIs mediated by renal transporters.
Article
Pharmacology & Pharmacy
Yunzhou Fan, Zhengxuan Liang, Jinghui Zhang, Guofeng You
Summary: This study revealed that oral anticancer drugs can upregulate the function of the important renal transporter protein OAT3, through their effects on the ubiquitin-proteasome system, suggesting the proteasome as a promising target for regulating OAT3. This study provides implications for OAT3-mediated drug-drug interactions, especially in combination therapies with proteasome inhibitor drugs.
Article
Chemistry, Multidisciplinary
Qian Chen, Zhisheng Xiao, Chao Wang, Guojun Chen, Yuqi Zhang, Xudong Zhang, Xiao Han, Jinqiang Wang, Xiao Ye, Mark R. Prausnitz, Song Li, Zhen Gu
Summary: A glucose-responsive insulin delivery microneedle array patch has been developed to achieve rapid release of insulin under high blood glucose conditions, effectively controlling blood glucose levels and avoiding hypoglycemia.
Article
Pharmacology & Pharmacy
Taiji Miyake, Haruka Tsutsui, Kenta Haraya, Tatsuhiko Tachibana, Kayoko Morimoto, Shoko Takehara, Miho Ayabe, Kaoru Kobayashi, Yasuhiro Kazuki
Summary: The study demonstrates that P-gp-mediated drug-drug interactions and non-linear absorption can be predicted using hMDR1-MAC mice. These mice serve as a valuable in vivo tool for quantitatively predicting P-gp-mediated disposition in drug discovery and development.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Jie Li, Shuting Wang, Fengjie Tian, Shuang-Qing Zhang, Hongtao Jin
Summary: As the use of herbs increases worldwide, there are more reports of interactions between herbs and drugs. The complex active components of herbs inevitably affect the pharmacokinetics of chemical drugs in vivo. The expression of drug transporters is closely related to the absorption, distribution, metabolism, and excretion of drugs. When herbs inhibit or induce the expression of transporters, it can result in changes in substrate pharmacokinetics, affecting the efficacy and toxicity of drugs. This article summarizes the tissue distribution and physiological functions of drug transporters, analyzes the effects of herbs on drug transporters, and discusses the possible mechanisms of herb-drug interactions, providing ideas and references for safe clinical drug use.
Article
Pharmacology & Pharmacy
Xue Bai, Jianxin Yang, Guiqin Liu, Junbo Zhu, Qian Wang, Wenqi Gu, Linli La, Xiangyang Li
Summary: Hypoxia, a key feature of high-altitude environments, has a significant impact on drug metabolism. This study investigated the mechanisms of gut microbial changes in response to hypoxia and found that hypoxia altered gut microbial diversity and composition, which subsequently affected the expressions of CYP3A1 and MDR1.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Nihan Izat, Selma Sahin
Summary: Transporter-mediated drug-drug interactions play a crucial role in pharmacokinetics, impacting drug safety and efficacy. Regulatory bodies emphasize the evaluation of transporter-mediated interactions in drug development. Hepatic transporters are determinant factors for drug pharmacokinetics and drug-drug interactions, with guidance updated to include detailed assay models and criteria.
BIOPHARMACEUTICS & DRUG DISPOSITION
(2021)
Article
Environmental Sciences
Valentin Tastet, Marc Le Vee, Marie Kerhoas, Anna Zerdoug, Elodie Jouan, Arnaud Bruyere, Olivier Fardel
Summary: This study investigates the possible interactions between organophosphate flame retardants (OPFRs) and human drug transporters, finding that OPFRs can inhibit the activities of certain transporters and block the passage of endogenous substances. OPFRs also repress the expression of certain transporters in human liver cells. However, the concentrations of OPFRs required to impact transporters are higher than those typically observed in humans exposed to these chemicals environmentally or through their diet.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Pharmacology & Pharmacy
Chung-Pu Wu, Sung-Han Hsiao, Yu-Shan Wu
Summary: The overexpression of human ATP-binding cassette (ABC) transporters in cancer cells can lead to multidrug resistance (MDR), which poses a significant obstacle to chemotherapy. Currently, there are no approved drugs specifically designed to treat multidrug-resistant cancers. However, drug repurposing has emerged as a practical approach to discover effective modulators of drug transporters.
DRUG RESISTANCE UPDATES
(2023)
Review
Biochemistry & Molecular Biology
Fangrui Xiu, Magdalena Rausch, Zhibo Gai, Shanshan Su, Shijun Wang, Michele Visentin
Summary: Tyrosine kinase inhibitors (TKIs) have made decisive contributions in revolutionizing cancer therapy by offering non-invasive and tolerable treatments for improved quality of life. However, the efficacy and durability of TKI therapy can vary due to factors such as cancer molecular features, drug resistance, pharmacokinetic alterations caused by genetic variants, and unwanted drug interactions. This article reviews the interactions between TKIs and organic cation transporters (OCTs) in vitro and in vivo, and discusses their potential clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ruhul Kayesh, Vishakha Tambe, Chao Xu, Wei Yue
Summary: Impaired transport activity of hepatic OATP1B1 and OATP1B3 due to drug-drug interactions (DDIs) often leads to increased systemic exposure to substrate drugs. This study aimed to assess the OATP1B1- and OATP1B3-mediated DDI potential of the calcium channel blocker nicardipine. The results showed that nicardipine has the potential to cause OATP1B1/3-mediated DDIs, and the consideration of optimal preincubation conditions is important when assessing these interactions in vitro.
Article
Infectious Diseases
Min Chen, Yujuan Yang, Yupeng Ying, Jiamin Huang, Mengyuan Sun, Mian Hong, Haizhen Wang, Shuyu Xie, Dongmei Chen
Summary: This study investigated the drug-drug interaction (DDI) of Enrofloxacin (ENR) and salinomycin (SAL) in broilers and the mechanism behind it. The results showed that SAL increased the exposure and half-life of ENR and CIP. CYP3A4, P-gp, and BCRP were identified as important factors for the DDI between ENR and SAL. Furthermore, ENR and SAL may lead to drug residues and resistance, highlighting the need for further research on their co-administration and other SAL-based drug-feed interactions.
Article
Agronomy
Chuanchuan Ning, Lei Wang, Rui Liu, Taowen Pan, Yixia Cai, Jihui Tian, Shiming Luo, Kunzheng Cai
Summary: Intercropping rice and water spinach can enhance silicon uptake by rice through promoting the secretion of organic acids by rice roots and reducing polymerization or adsorption of monosilicic acid through water spinach root exudates, which is significant for sustainable rice production in silicon-deficient soils.
Article
Pharmacology & Pharmacy
Wenyan Li, Zheng Jiao, Yanhui Liu, Jiacheng Yao, Guodong Li, Jing Dong
Summary: The study evaluated the renal excretion mechanism of Biapenem and its interactions with other drugs, indicating that it is primarily eliminated through glomerular filtration with minimal OAT3-mediated renal tubular secretion. Biapenem has low affinity for OAT3 and can be safely used with other drugs that act as substrates or inhibitors of OAT3.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
