期刊
CLINICAL PHARMACOLOGY & THERAPEUTICS
卷 88, 期 4, 页码 457-459出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2010.171
关键词
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The usual objective during long-term pharmacotherapy is, in large part, to maintain continuity of action of the prescribed drug(s). Continuity of action arises from the continuity of execution of a prescribed dosing regimen that is pharmacologically sound in dose quantity and interval between successive doses. Interruptions in dosing can interrupt drug action, but the consequences vary according to length of interruption, drug, drug formulation, length of the patient's prior exposure to the drug, and the disease being treated.
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